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Q8K1M4

- GLIS1_MOUSE

UniProt

Q8K1M4 - GLIS1_MOUSE

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Protein
Zinc finger protein GLIS1
Gene
Glis1, Gli5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3'.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri366 – 39126C2H2-type 1
Add
BLAST
Zinc fingeri400 – 42728C2H2-type 2; atypical
Add
BLAST
Zinc fingeri433 – 45725C2H2-type 3
Add
BLAST
Zinc fingeri463 – 48725C2H2-type 4
Add
BLAST
Zinc fingeri493 – 51725C2H2-type 5
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  2. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  3. positive regulation of transcription, DNA-templated Source: MGI
  4. regulation of transcription from RNA polymerase II promoter Source: MGI
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein GLIS1
Alternative name(s):
GLI-similar 1
Gli homologous protein 1
Short name:
GliH1
Gene namesi
Name:Glis1
Synonyms:Gli5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:2386723. Glis1.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 789789Zinc finger protein GLIS1
PRO_0000047210Add
BLAST

Proteomic databases

MaxQBiQ8K1M4.
PaxDbiQ8K1M4.
PRIDEiQ8K1M4.

PTM databases

PhosphoSiteiQ8K1M4.

Expressioni

Tissue specificityi

In the adult, expressed highly in placenta and kidney and at lower levels in the testis, brain, colon, brown fat tissue and thymus. During embryo development, expressed in the frontal nasal region, branchial arches, somites, vibrissal and hair follicles, limb buds, craniofacial regions, ventral part of the tail, intervertebral disks, teeth, eyes and kidney.2 Publications

Developmental stagei

In the embryo, expression is detected at 10 dpc becoming stronger by 11 dpc and continuing through to 16.5 dpc.2 Publications

Gene expression databases

BgeeiQ8K1M4.
CleanExiMM_GLIS1.
GenevestigatoriQ8K1M4.

Structurei

3D structure databases

ProteinModelPortaliQ8K1M4.
SMRiQ8K1M4. Positions 338-553.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi511 – 52717Bipartite nuclear localization signal Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi627 – 68054Pro-rich
Add
BLAST

Sequence similaritiesi

Belongs to the GLI C2H2-type zinc-finger protein family.1 Publication

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00740000114893.
HOGENOMiHOG000231136.
HOVERGENiHBG051736.
InParanoidiQ8K1M4.
KOiK09232.
OMAiLRPNGYH.
OrthoDBiEOG70S75H.
PhylomeDBiQ8K1M4.
TreeFamiTF350216.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q8K1M4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MHCEVAEALS DKRPKEAPGA PGQGRGPVSL GAHMAFRIAV SGGGCGDGNP    50
LDLLPRLPVP PPRAHDLLRP RSPRDYGVSK TGSGKVNGSY GHSSEKSLLD 100
LDLAEGPSPS CHQGLFLPAG TPPPRGHPPV CEKLLHFPHP NRSPRPQATF 150
VNGSLPAAQH IKQEALPDYQ AMVSAHTPLP THCRAPSSMG LPSDLDFPDR 200
GLTNPAPSCY LLGNEPISDL GPQPEAHLPE GSLKRCCLLG LPPTSSASSS 250
PCASSDINPV IHSSQTALVS CVNGLRSPPL PGDLGGPPKR SRPGPASSDG 300
QEGSLQLEAC RKSGFLKQEP MDEFSELFAP HHQGLPPPYP LPQLPTGPGL 350
GGLGLGLAGR MVAGRQACRW VDCCAAYEQQ EELVRHIEKS HIDQRKGEDF 400
TCFWAGCVRR YKPFNARYKL LIHMRVHSGE KPNKCMFEGC SKAFSRLENL 450
KIHLRSHTGE KPYLCQHPGC QKAFSNSSDR AKHQRTHLDT KPYACQIPGC 500
SKRYTDPSSL RKHVKAHSAK EQQVRKKLHT GADPEADVLS ECLSLQQLQA 550
STLLPASRGK GSQTLSQELL PGVYPGSVTP QNGLASGILS PSHDVPSRHH 600
PLEVPTGSHH HLSPLPTAES TRDGLGPSLL SPMVSPLKGL GPPPLPPASQ 650
SQSPGGQSFS TVPSKPTYPS FQSPPPLPSP QGYQGSFHSI QNCFPYADCY 700
RATEPAASRD GLVGDAHGFN PLRPSTYSSL STPLSAPGYE TLAETPCPPA 750
LQPQPAEDLV PSGPEDCGFF PNGAFDHCLS HIPSIYTDT 789
Length:789
Mass (Da):84,172
Last modified:December 21, 2004 - v2
Checksum:i98D87D9EA20D38FD
GO
Isoform 21 Publication (identifier: Q8K1M4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-171: Missing.

Show »
Length:618
Mass (Da):66,209
Checksum:i25055F3D35CECBF1
GO

Sequence cautioni

The sequence AAH66157.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 171171Missing in isoform 2. 1 Publication
VSP_051623Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti173 – 1731V → A in AAM93156. 1 Publication
Sequence conflicti354 – 3541G → R in AAM93156. 1 Publication
Sequence conflicti378 – 3781E → G in AAH66157. 1 Publication
Sequence conflicti384 – 3841V → E in AAH66157. 1 Publication
Sequence conflicti466 – 4661Q → R in AAM93156. 1 Publication
Sequence conflicti634 – 6341V → A in AAH66157. 1 Publication
Sequence conflicti668 – 6681Y → S in AAH66157. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF486579 mRNA. Translation: AAM93156.1.
AF220434 mRNA. Translation: AAM12150.1.
BC066157 mRNA. Translation: AAH66157.1. Different initiation.
CCDSiCCDS38831.1. [Q8K1M4-1]
RefSeqiNP_671754.2. NM_147221.2. [Q8K1M4-1]
XP_006503036.1. XM_006502973.1. [Q8K1M4-1]
XP_006503037.1. XM_006502974.1. [Q8K1M4-1]
XP_006503038.1. XM_006502975.1. [Q8K1M4-1]
UniGeneiMm.331757.

Genome annotation databases

EnsembliENSMUST00000046005; ENSMUSP00000035650; ENSMUSG00000034762. [Q8K1M4-1]
GeneIDi230587.
KEGGimmu:230587.
UCSCiuc008tzv.1. mouse. [Q8K1M4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF486579 mRNA. Translation: AAM93156.1 .
AF220434 mRNA. Translation: AAM12150.1 .
BC066157 mRNA. Translation: AAH66157.1 . Different initiation.
CCDSi CCDS38831.1. [Q8K1M4-1 ]
RefSeqi NP_671754.2. NM_147221.2. [Q8K1M4-1 ]
XP_006503036.1. XM_006502973.1. [Q8K1M4-1 ]
XP_006503037.1. XM_006502974.1. [Q8K1M4-1 ]
XP_006503038.1. XM_006502975.1. [Q8K1M4-1 ]
UniGenei Mm.331757.

3D structure databases

ProteinModelPortali Q8K1M4.
SMRi Q8K1M4. Positions 338-553.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8K1M4.

Proteomic databases

MaxQBi Q8K1M4.
PaxDbi Q8K1M4.
PRIDEi Q8K1M4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000046005 ; ENSMUSP00000035650 ; ENSMUSG00000034762 . [Q8K1M4-1 ]
GeneIDi 230587.
KEGGi mmu:230587.
UCSCi uc008tzv.1. mouse. [Q8K1M4-1 ]

Organism-specific databases

CTDi 148979.
MGIi MGI:2386723. Glis1.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00740000114893.
HOGENOMi HOG000231136.
HOVERGENi HBG051736.
InParanoidi Q8K1M4.
KOi K09232.
OMAi LRPNGYH.
OrthoDBi EOG70S75H.
PhylomeDBi Q8K1M4.
TreeFami TF350216.

Miscellaneous databases

NextBioi 379951.
PROi Q8K1M4.
SOURCEi Search...

Gene expression databases

Bgeei Q8K1M4.
CleanExi MM_GLIS1.
Genevestigatori Q8K1M4.

Family and domain databases

Gene3Di 3.30.160.60. 5 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of Glis1, a novel Gli-related, Kruppel-like zinc finger protein containing transactivation and repressor functions."
    Kim Y.-S., Lewandoski M., Perantoni A.O., Kurebayashi S., Nakanishi G., Jetten A.M.
    J. Biol. Chem. 277:30901-30913(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: BALB/c.
    Tissue: Kidney.
  2. "A novel gene, GliH1, with homology to the Gli zinc finger domain not required for mouse development."
    Nakashima M., Tanese N., Ito M., Auerbach W., Bai C., Furukawa T., Toyono T., Akamine A., Joyner A.L.
    Mech. Dev. 119:21-34(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 116-789 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Kidney.

Entry informationi

Entry nameiGLIS1_MOUSE
AccessioniPrimary (citable) accession number: Q8K1M4
Secondary accession number(s): Q6NZF6, Q8R4Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi