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Q8K1M4

- GLIS1_MOUSE

UniProt

Q8K1M4 - GLIS1_MOUSE

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Protein

Zinc finger protein GLIS1

Gene

Glis1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3'.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri366 – 39126C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42728C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri433 – 45725C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri463 – 48725C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri493 – 51725C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. metal ion binding Source: UniProtKB-KW
  3. RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  4. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: NTNU_SB
  5. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  2. positive regulation of transcription, DNA-templated Source: MGI
  3. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  4. regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein GLIS1
Alternative name(s):
GLI-similar 1
Gli homologous protein 1
Short name:
GliH1
Gene namesi
Name:Glis1Imported
Synonyms:Gli5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:2386723. Glis1.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 789789Zinc finger protein GLIS1PRO_0000047210Add
BLAST

Proteomic databases

MaxQBiQ8K1M4.
PaxDbiQ8K1M4.
PRIDEiQ8K1M4.

PTM databases

PhosphoSiteiQ8K1M4.

Expressioni

Tissue specificityi

In the adult, expressed highly in placenta and kidney and at lower levels in the testis, brain, colon, brown fat tissue and thymus. During embryo development, expressed in the frontal nasal region, branchial arches, somites, vibrissal and hair follicles, limb buds, craniofacial regions, ventral part of the tail, intervertebral disks, teeth, eyes and kidney.2 Publications

Developmental stagei

In the embryo, expression is detected at 10 dpc becoming stronger by 11 dpc and continuing through to 16.5 dpc.2 Publications

Gene expression databases

BgeeiQ8K1M4.
CleanExiMM_GLIS1.
ExpressionAtlasiQ8K1M4. baseline and differential.
GenevestigatoriQ8K1M4.

Structurei

3D structure databases

ProteinModelPortaliQ8K1M4.
SMRiQ8K1M4. Positions 368-553.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi511 – 52717Bipartite nuclear localization signalSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi627 – 68054Pro-richAdd
BLAST

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri366 – 39126C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42728C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri433 – 45725C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri463 – 48725C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri493 – 51725C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118771.
HOGENOMiHOG000231136.
HOVERGENiHBG051736.
InParanoidiQ8K1M4.
KOiK09232.
OMAiLRPNGYH.
OrthoDBiEOG70S75H.
PhylomeDBiQ8K1M4.
TreeFamiTF350216.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q8K1M4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHCEVAEALS DKRPKEAPGA PGQGRGPVSL GAHMAFRIAV SGGGCGDGNP
60 70 80 90 100
LDLLPRLPVP PPRAHDLLRP RSPRDYGVSK TGSGKVNGSY GHSSEKSLLD
110 120 130 140 150
LDLAEGPSPS CHQGLFLPAG TPPPRGHPPV CEKLLHFPHP NRSPRPQATF
160 170 180 190 200
VNGSLPAAQH IKQEALPDYQ AMVSAHTPLP THCRAPSSMG LPSDLDFPDR
210 220 230 240 250
GLTNPAPSCY LLGNEPISDL GPQPEAHLPE GSLKRCCLLG LPPTSSASSS
260 270 280 290 300
PCASSDINPV IHSSQTALVS CVNGLRSPPL PGDLGGPPKR SRPGPASSDG
310 320 330 340 350
QEGSLQLEAC RKSGFLKQEP MDEFSELFAP HHQGLPPPYP LPQLPTGPGL
360 370 380 390 400
GGLGLGLAGR MVAGRQACRW VDCCAAYEQQ EELVRHIEKS HIDQRKGEDF
410 420 430 440 450
TCFWAGCVRR YKPFNARYKL LIHMRVHSGE KPNKCMFEGC SKAFSRLENL
460 470 480 490 500
KIHLRSHTGE KPYLCQHPGC QKAFSNSSDR AKHQRTHLDT KPYACQIPGC
510 520 530 540 550
SKRYTDPSSL RKHVKAHSAK EQQVRKKLHT GADPEADVLS ECLSLQQLQA
560 570 580 590 600
STLLPASRGK GSQTLSQELL PGVYPGSVTP QNGLASGILS PSHDVPSRHH
610 620 630 640 650
PLEVPTGSHH HLSPLPTAES TRDGLGPSLL SPMVSPLKGL GPPPLPPASQ
660 670 680 690 700
SQSPGGQSFS TVPSKPTYPS FQSPPPLPSP QGYQGSFHSI QNCFPYADCY
710 720 730 740 750
RATEPAASRD GLVGDAHGFN PLRPSTYSSL STPLSAPGYE TLAETPCPPA
760 770 780
LQPQPAEDLV PSGPEDCGFF PNGAFDHCLS HIPSIYTDT
Length:789
Mass (Da):84,172
Last modified:December 21, 2004 - v2
Checksum:i98D87D9EA20D38FD
GO
Isoform 21 Publication (identifier: Q8K1M4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-171: Missing.

Show »
Length:618
Mass (Da):66,209
Checksum:i25055F3D35CECBF1
GO

Sequence cautioni

The sequence AAH66157.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti173 – 1731V → A in AAM93156. (PubMed:12042312)Curated
Sequence conflicti354 – 3541G → R in AAM93156. (PubMed:12042312)Curated
Sequence conflicti378 – 3781E → G in AAH66157. (PubMed:15489334)Curated
Sequence conflicti384 – 3841V → E in AAH66157. (PubMed:15489334)Curated
Sequence conflicti466 – 4661Q → R in AAM93156. (PubMed:12042312)Curated
Sequence conflicti634 – 6341V → A in AAH66157. (PubMed:15489334)Curated
Sequence conflicti668 – 6681Y → S in AAH66157. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 171171Missing in isoform 2. 1 PublicationVSP_051623Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF486579 mRNA. Translation: AAM93156.1.
AF220434 mRNA. Translation: AAM12150.1.
BC066157 mRNA. Translation: AAH66157.1. Different initiation.
CCDSiCCDS38831.1. [Q8K1M4-1]
RefSeqiNP_671754.2. NM_147221.2. [Q8K1M4-1]
XP_006503036.1. XM_006502973.1. [Q8K1M4-1]
XP_006503037.1. XM_006502974.1. [Q8K1M4-1]
XP_006503038.1. XM_006502975.1. [Q8K1M4-1]
UniGeneiMm.331757.

Genome annotation databases

EnsembliENSMUST00000046005; ENSMUSP00000035650; ENSMUSG00000034762. [Q8K1M4-1]
GeneIDi230587.
KEGGimmu:230587.
UCSCiuc008tzv.1. mouse. [Q8K1M4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF486579 mRNA. Translation: AAM93156.1 .
AF220434 mRNA. Translation: AAM12150.1 .
BC066157 mRNA. Translation: AAH66157.1 . Different initiation.
CCDSi CCDS38831.1. [Q8K1M4-1 ]
RefSeqi NP_671754.2. NM_147221.2. [Q8K1M4-1 ]
XP_006503036.1. XM_006502973.1. [Q8K1M4-1 ]
XP_006503037.1. XM_006502974.1. [Q8K1M4-1 ]
XP_006503038.1. XM_006502975.1. [Q8K1M4-1 ]
UniGenei Mm.331757.

3D structure databases

ProteinModelPortali Q8K1M4.
SMRi Q8K1M4. Positions 368-553.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8K1M4.

Proteomic databases

MaxQBi Q8K1M4.
PaxDbi Q8K1M4.
PRIDEi Q8K1M4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000046005 ; ENSMUSP00000035650 ; ENSMUSG00000034762 . [Q8K1M4-1 ]
GeneIDi 230587.
KEGGi mmu:230587.
UCSCi uc008tzv.1. mouse. [Q8K1M4-1 ]

Organism-specific databases

CTDi 148979.
MGIi MGI:2386723. Glis1.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000118771.
HOGENOMi HOG000231136.
HOVERGENi HBG051736.
InParanoidi Q8K1M4.
KOi K09232.
OMAi LRPNGYH.
OrthoDBi EOG70S75H.
PhylomeDBi Q8K1M4.
TreeFami TF350216.

Miscellaneous databases

NextBioi 379951.
PROi Q8K1M4.
SOURCEi Search...

Gene expression databases

Bgeei Q8K1M4.
CleanExi MM_GLIS1.
ExpressionAtlasi Q8K1M4. baseline and differential.
Genevestigatori Q8K1M4.

Family and domain databases

Gene3Di 3.30.160.60. 5 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of Glis1, a novel Gli-related, Kruppel-like zinc finger protein containing transactivation and repressor functions."
    Kim Y.-S., Lewandoski M., Perantoni A.O., Kurebayashi S., Nakanishi G., Jetten A.M.
    J. Biol. Chem. 277:30901-30913(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: BALB/cImported.
    Tissue: Kidney1 Publication.
  2. "A novel gene, GliH1, with homology to the Gli zinc finger domain not required for mouse development."
    Nakashima M., Tanese N., Ito M., Auerbach W., Bai C., Furukawa T., Toyono T., Akamine A., Joyner A.L.
    Mech. Dev. 119:21-34(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 116-789 (ISOFORM 1).
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.

Entry informationi

Entry nameiGLIS1_MOUSE
AccessioniPrimary (citable) accession number: Q8K1M4
Secondary accession number(s): Q6NZF6, Q8R4Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3