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Protein

E3 ubiquitin-protein ligase PPP1R11

Gene

Ppp1r11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 (PubMed:27805901). Inhibitor of protein phosphatase 1 (By similarity).By similarity1 Publication

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • defense response to Gram-positive bacterium Source: UniProtKB
  • negative regulation of cytokine secretion Source: UniProtKB
  • negative regulation of phosphoprotein phosphatase activity Source: GO_Central
  • ubiquitin-dependent protein catabolic process Source: UniProtKB

Keywordsi

Molecular functionProtein phosphatase inhibitor, Transferase
Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase PPP1R111 Publication (EC:2.3.2.27)
Alternative name(s):
Protein phosphatase 1 regulatory subunit 11
T-complex testis expressed protein 5
Short name:
Tctex-5
Gene namesi
Name:Ppp1r11
Synonyms:Tctex5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1923747 Ppp1r11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002396212 – 131E3 ubiquitin-protein ligase PPP1R11Add BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei78PhosphoserineBy similarity1
Modified residuei79PhosphoserineCombined sources1
Modified residuei80PhosphothreonineCombined sources1
Modified residuei82PhosphoserineCombined sources1
Modified residuei114PhosphothreonineBy similarity1

Post-translational modificationi

Auto-ubiquitinated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8K1L5
MaxQBiQ8K1L5
PaxDbiQ8K1L5
PeptideAtlasiQ8K1L5
PRIDEiQ8K1L5

PTM databases

iPTMnetiQ8K1L5
PhosphoSitePlusiQ8K1L5

Expressioni

Tissue specificityi

Expressed in testis with high level during spermatogenesis.1 Publication

Interactioni

Subunit structurei

Interacts with TLR2 and UBE2D2.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047202

Structurei

3D structure databases

ProteinModelPortaliQ8K1L5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni57 – 67Atypical RING finger domain 1By similarityAdd BLAST11
Regioni90 – 99Atypical RING finger domain 2By similarity10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi105 – 128Pro-richAdd BLAST24

Phylogenomic databases

eggNOGiKOG4102 Eukaryota
ENOG41126IN LUCA
HOGENOMiHOG000232107
HOVERGENiHBG080560
InParanoidiQ8K1L5
KOiK17553
PhylomeDBiQ8K1L5

Family and domain databases

InterProiView protein in InterPro
IPR011107 PPI_Ypi1
PANTHERiPTHR20835 PTHR20835, 1 hit
PfamiView protein in Pfam
PF07491 PPI_Ypi1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K1L5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAETGAGISE TVTETTVTET TVTETTEPEN QSLIMKLRKR KPEKKVEWSS
60 70 80 90 100
DTVDNEHMGR RSSKCCCIYE KPRAFGESST ESDEDEEEGC SHKHCVRGHR
110 120 130
KGRRPTTPAP TPTTPPQPPD PSQPPPGPMQ H
Length:131
Mass (Da):14,544
Last modified:October 1, 2002 - v1
Checksum:i533FCEC7128FA14C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34I → T in BAB23986 (PubMed:16141072).Curated1
Sequence conflicti123Q → K in BAB23986 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005379 mRNA Translation: BAB23986.1
AK089107 mRNA Translation: BAC40754.1
AK170104 mRNA Translation: BAE41566.1
BC027737 mRNA Translation: AAH27737.1
CCDSiCCDS28729.1
RefSeqiNP_083908.1, NM_029632.3
UniGeneiMm.46176

Genome annotation databases

GeneIDi76497
KEGGimmu:76497

Similar proteinsi

Entry informationi

Entry nameiPP1RB_MOUSE
AccessioniPrimary (citable) accession number: Q8K1L5
Secondary accession number(s): Q9DB02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 1, 2002
Last modified: April 25, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health