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Protein

Protein phosphatase 1 regulatory subunit 11

Gene

Ppp1r11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of protein phosphatase 1.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 11
Alternative name(s):
T-complex testis expressed protein 5
Short name:
Tctex-5
Gene namesi
Name:Ppp1r11
Synonyms:Tctex5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1923747. Ppp1r11.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: GO_Central
  • protein phosphatase type 1 complex Source: GO_Central
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 131130Protein phosphatase 1 regulatory subunit 11PRO_0000239621Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei78 – 781PhosphoserineBy similarity
Modified residuei79 – 791PhosphoserineCombined sources
Modified residuei80 – 801PhosphothreonineCombined sources
Modified residuei82 – 821PhosphoserineCombined sources
Modified residuei114 – 1141PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8K1L5.
MaxQBiQ8K1L5.
PaxDbiQ8K1L5.
PeptideAtlasiQ8K1L5.
PRIDEiQ8K1L5.

PTM databases

iPTMnetiQ8K1L5.
PhosphoSiteiQ8K1L5.

Expressioni

Tissue specificityi

Expressed in testis with high level during spermatogenesis.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047202.

Structurei

3D structure databases

ProteinModelPortaliQ8K1L5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi105 – 12824Pro-richAdd
BLAST

Phylogenomic databases

eggNOGiKOG4102. Eukaryota.
ENOG41126IN. LUCA.
HOGENOMiHOG000232107.
HOVERGENiHBG080560.
InParanoidiQ8K1L5.
KOiK17553.
PhylomeDBiQ8K1L5.

Family and domain databases

InterProiIPR011107. PPI_Ypi1.
[Graphical view]
PANTHERiPTHR20835. PTHR20835. 1 hit.
PfamiPF07491. PPI_Ypi1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K1L5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAETGAGISE TVTETTVTET TVTETTEPEN QSLIMKLRKR KPEKKVEWSS
60 70 80 90 100
DTVDNEHMGR RSSKCCCIYE KPRAFGESST ESDEDEEEGC SHKHCVRGHR
110 120 130
KGRRPTTPAP TPTTPPQPPD PSQPPPGPMQ H
Length:131
Mass (Da):14,544
Last modified:October 1, 2002 - v1
Checksum:i533FCEC7128FA14C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341I → T in BAB23986 (PubMed:16141072).Curated
Sequence conflicti123 – 1231Q → K in BAB23986 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005379 mRNA. Translation: BAB23986.1.
AK089107 mRNA. Translation: BAC40754.1.
AK170104 mRNA. Translation: BAE41566.1.
BC027737 mRNA. Translation: AAH27737.1.
CCDSiCCDS28729.1.
RefSeqiNP_083908.1. NM_029632.3.
UniGeneiMm.46176.

Genome annotation databases

GeneIDi76497.
KEGGimmu:76497.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005379 mRNA. Translation: BAB23986.1.
AK089107 mRNA. Translation: BAC40754.1.
AK170104 mRNA. Translation: BAE41566.1.
BC027737 mRNA. Translation: AAH27737.1.
CCDSiCCDS28729.1.
RefSeqiNP_083908.1. NM_029632.3.
UniGeneiMm.46176.

3D structure databases

ProteinModelPortaliQ8K1L5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047202.

PTM databases

iPTMnetiQ8K1L5.
PhosphoSiteiQ8K1L5.

Proteomic databases

EPDiQ8K1L5.
MaxQBiQ8K1L5.
PaxDbiQ8K1L5.
PeptideAtlasiQ8K1L5.
PRIDEiQ8K1L5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi76497.
KEGGimmu:76497.

Organism-specific databases

CTDi6992.
MGIiMGI:1923747. Ppp1r11.

Phylogenomic databases

eggNOGiKOG4102. Eukaryota.
ENOG41126IN. LUCA.
HOGENOMiHOG000232107.
HOVERGENiHBG080560.
InParanoidiQ8K1L5.
KOiK17553.
PhylomeDBiQ8K1L5.

Miscellaneous databases

ChiTaRSiPpp1r11. mouse.
PROiQ8K1L5.
SOURCEiSearch...

Family and domain databases

InterProiIPR011107. PPI_Ypi1.
[Graphical view]
PANTHERiPTHR20835. PTHR20835. 1 hit.
PfamiPF07491. PPI_Ypi1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary tumor.
  3. "Several testis-expressed genes in the mouse T-complex have expression differences between wild-type and t-mutant mice."
    Ha H., Howard C.A., Yeom Y.I., Abe K., Uehara H., Artzt K., Bennett D.
    Dev. Genet. 12:318-332(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79; THR-80 AND SER-82, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Heart, Kidney, Liver, Lung, Spleen and Testis.

Entry informationi

Entry nameiPP1RB_MOUSE
AccessioniPrimary (citable) accession number: Q8K1L5
Secondary accession number(s): Q9DB02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.