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Protein

Cyclic AMP-responsive element-binding protein 5

Gene

Creb5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to the cAMP response element and activates transcription.By similarity

GO - Molecular functioni

GO - Biological processi

  • adipose tissue development Source: MGI
  • fat cell differentiation Source: MGI
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-responsive element-binding protein 5
Short name:
CREB-5
Short name:
cAMP-responsive element-binding protein 5
Alternative name(s):
CRE-BPa
Gene namesi
Name:Creb5
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2443973. Creb5.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357Cyclic AMP-responsive element-binding protein 5PRO_0000076605Add
BLAST

Proteomic databases

MaxQBiQ8K1L0.
PaxDbiQ8K1L0.
PRIDEiQ8K1L0.

PTM databases

PhosphoSiteiQ8K1L0.

Expressioni

Gene expression databases

BgeeiQ8K1L0.
CleanExiMM_CREB5.

Interactioni

Subunit structurei

Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038532.

Structurei

3D structure databases

ProteinModelPortaliQ8K1L0.
SMRiQ8K1L0. Positions 226-285.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini224 – 28764bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni226 – 24621Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni252 – 28029Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi120 – 18566His-richAdd
BLAST
Compositional biasi214 – 2174Poly-Arg

Sequence similaritiesi

Belongs to the bZIP family.UniRule annotationCurated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
HOGENOMiHOG000220894.
HOVERGENiHBG004300.
InParanoidiQ8K1L0.
KOiK09047.
OrthoDBiEOG741Z31.
PhylomeDBiQ8K1L0.

Family and domain databases

InterProiIPR004827. bZIP.
IPR016378. TF_CRE-BP1-typ.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PIRSFiPIRSF003153. ATF2_CRE-BP1. 1 hit.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8K1L0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSMRPVPGSL SSLLHLHNRQ RQPMPASMPG TLPNPTMPGS SAVLMPMERQ
60 70 80 90 100
MSVNSSIMGM QGPNLSNPCA SPQVQPMHSE AKMRLKAALT HHPAAMSNGN
110 120 130 140 150
MSTIGHMMEM MGSRQDQTPH HHLHSHPHQH QTLPPHHPYP HQHQHPAHHP
160 170 180 190 200
HPQPHHQQNH PHHHSHSHLH AHPAHHQTSP HPPLHTGNQA QVSPATQQMQ
210 220 230 240 250
PTQTIQPPQP TGGRRRRVVD EDPDERRRKF LERNRAAATR CRQKRKVWVM
260 270 280 290 300
SLEKKAEELT QTNMQLQNEV SMLKNEVAQL KQLLLTHKDC PITAMQKESQ
310 320 330 340 350
GYLSPESSPP ASPVPACSQQ QVIQHNTITT SSSVSEVVGS STLSQLTTHR

TDLNPIL
Length:357
Mass (Da):39,955
Last modified:December 12, 2006 - v3
Checksum:i526F9818C81D7FB7
GO
Isoform 2 (identifier: Q8K1L0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MSMR → MNLEQERPFV...QAPSTNRQIG
     84-97: RLKAALTHHPAAMS → NLHRPSPLALCLHS
     98-357: Missing.

Show »
Length:241
Mass (Da):26,552
Checksum:iD155AC1E60FAFD99
GO

Sequence cautioni

The sequence AAH29022.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti185 – 1851H → P in BAC34998 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 44MSMR → MNLEQERPFVCSAPGCSQRF PTEDHLMIHRHKHEMTLKFP SIKTDNMLSDQTPTPTRFLK NCEEVGLFSELDCSFEHEFR KAQEEENSKRNISMHNTVGG TMTGPGAHQLGSTRMPNHDS SVVIQQAMPSPQSSSVITQA PSTNRQIG in isoform 2. 1 PublicationVSP_022061
Alternative sequencei84 – 9714RLKAA…PAAMS → NLHRPSPLALCLHS in isoform 2. 1 PublicationVSP_022062Add
BLAST
Alternative sequencei98 – 357260Missing in isoform 2. 1 PublicationVSP_022063Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052451 mRNA. Translation: BAC34998.1.
AK154148 mRNA. Translation: BAE32408.1.
AK155537 mRNA. Translation: BAE33314.1.
AK170766 mRNA. Translation: BAE42016.1.
BC029022 mRNA. Translation: AAH29022.1. Different initiation.
CCDSiCCDS20153.1. [Q8K1L0-1]
RefSeqiNP_766316.1. NM_172728.2.
UniGeneiMm.321138.

Genome annotation databases

GeneIDi231991.
KEGGimmu:231991.
UCSCiuc009bzf.2. mouse. [Q8K1L0-2]
uc009bzi.1. mouse. [Q8K1L0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052451 mRNA. Translation: BAC34998.1.
AK154148 mRNA. Translation: BAE32408.1.
AK155537 mRNA. Translation: BAE33314.1.
AK170766 mRNA. Translation: BAE42016.1.
BC029022 mRNA. Translation: AAH29022.1. Different initiation.
CCDSiCCDS20153.1. [Q8K1L0-1]
RefSeqiNP_766316.1. NM_172728.2.
UniGeneiMm.321138.

3D structure databases

ProteinModelPortaliQ8K1L0.
SMRiQ8K1L0. Positions 226-285.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038532.

PTM databases

PhosphoSiteiQ8K1L0.

Proteomic databases

MaxQBiQ8K1L0.
PaxDbiQ8K1L0.
PRIDEiQ8K1L0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi231991.
KEGGimmu:231991.
UCSCiuc009bzf.2. mouse. [Q8K1L0-2]
uc009bzi.1. mouse. [Q8K1L0-1]

Organism-specific databases

CTDi9586.
MGIiMGI:2443973. Creb5.

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
HOGENOMiHOG000220894.
HOVERGENiHBG004300.
InParanoidiQ8K1L0.
KOiK09047.
OrthoDBiEOG741Z31.
PhylomeDBiQ8K1L0.

Miscellaneous databases

ChiTaRSiCreb5. mouse.
PROiQ8K1L0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K1L0.
CleanExiMM_CREB5.

Family and domain databases

InterProiIPR004827. bZIP.
IPR016378. TF_CRE-BP1-typ.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PIRSFiPIRSF003153. ATF2_CRE-BP1. 1 hit.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: NOD.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-357 (ISOFORM 1).
    Tissue: Mammary gland1 Publication.

Entry informationi

Entry nameiCREB5_MOUSE
AccessioniPrimary (citable) accession number: Q8K1L0
Secondary accession number(s): Q3TCE1, Q3U228, Q8BWH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 12, 2006
Last modified: June 8, 2016
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.