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Protein

Histone H4 transcription factor

Gene

Hinfp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri17 – 3923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri125 – 14925C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri165 – 18925C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri195 – 21723C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri225 – 24723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri251 – 27424C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri280 – 30223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri308 – 33326C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36424C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H4 transcription factor
Alternative name(s):
Histone nuclear factor P
Short name:
HiNF-P
MBD2-interacting zinc finger protein
Methyl-CpG-binding protein 2-interacting zinc finger protein
Gene namesi
Name:Hinfp
Synonyms:Mizf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2429620. Hinfp.

Subcellular locationi

  • Nucleus By similarity

  • Note: Associated with discrete nuclear foci.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Histone H4 transcription factorPRO_0000047219Add
BLAST

Post-translational modificationi

Ubiquitinated. Ubiquitination may lead to proteasome-mediated degradation (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ8K1K9.
PRIDEiQ8K1K9.

PTM databases

iPTMnetiQ8K1K9.
PhosphoSiteiQ8K1K9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032119.
CleanExiMM_MIZF.
GenevisibleiQ8K1K9. MM.

Interactioni

Subunit structurei

Binds MBD2 and a histone deacetylase complex. Interacts with NPAT (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034629.

Structurei

3D structure databases

ProteinModelPortaliQ8K1K9.
SMRiQ8K1K9. Positions 172-362.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni369 – 503135Interaction with NPATBy similarityAdd
BLAST
Regioni370 – 40334Required for activation of histone H4 transcription and contributes to DNA-bindingBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi49 – 535Poly-Glu

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri17 – 3923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri125 – 14925C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri165 – 18925C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri195 – 21723C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri225 – 24723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri251 – 27424C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri280 – 30223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri308 – 33326C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36424C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG3608. Eukaryota.
ENOG410XQF8. LUCA.
GeneTreeiENSGT00530000063079.
HOGENOMiHOG000232129.
InParanoidiQ8K1K9.
OMAiHSKEPAY.
OrthoDBiEOG091G089B.
TreeFamiTF350923.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K1K9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPPGKVPRK ENLGLQCEWG SCSFVCSAME EFFDHVTQHL QQHMHGSKEE
60 70 80 90 100
EEEDPLEEEF SCLWQECGFC SLDSSADLIR HVYFHCYHTK LKQWGLQALQ
110 120 130 140 150
SQADLSPCIL DFQSRNVIPD TPDHFLCLWE HCESVFDNPE WFYRHVDAHS
160 170 180 190 200
LCCEYQAVSK DNHVVQCGWK GCTCTFKDRC KLREHLRSHT QEKVVACPTC
210 220 230 240 250
GGMFANNTKF LDHIRRQTSL DQQRFQCSHC SKRFATERLL RDHMRNHVNH
260 270 280 290 300
YKCPLCDMTC PLPSSLRNHM RFRHSEDRPY KCDCCDYSCK NLIDLRKHLD
310 320 330 340 350
THSKESAYRC DFENCNFSAR SLSSVKSHHR KVHEGDSEPR YKCHVCDKCF
360 370 380 390 400
TRGNNLTVHL RKKHQFKWPS GHPRFRYKEH EDGYMRLQLV RYESVELTQQ
410 420 430 440 450
LLQQLQEGSD PGLALNESSL QGIVLETVLG GPGPEEETEE EGRVVEGTAL
460 470 480 490 500
SASQDNPSSA IHMVSQTDTQ GQRDIVYCVL SEGPGEPPPV SETLKRDGKA

RGT
Length:503
Mass (Da):58,076
Last modified:July 27, 2011 - v3
Checksum:iA2166A2522C4767B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71V → I in AAH29091 (PubMed:15489334).Curated
Sequence conflicti467 – 4671T → S in AAH29091 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124577 Genomic DNA. No translation available.
BC029091 mRNA. Translation: AAH29091.1.
AK049633 mRNA. Translation: BAC33849.1.
CCDSiCCDS23102.1.
RefSeqiNP_751894.2. NM_172162.3.
XP_006509962.1. XM_006509899.2.
UniGeneiMm.24570.

Genome annotation databases

EnsembliENSMUST00000034629; ENSMUSP00000034629; ENSMUSG00000032119.
GeneIDi102423.
KEGGimmu:102423.
UCSCiuc009pcr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124577 Genomic DNA. No translation available.
BC029091 mRNA. Translation: AAH29091.1.
AK049633 mRNA. Translation: BAC33849.1.
CCDSiCCDS23102.1.
RefSeqiNP_751894.2. NM_172162.3.
XP_006509962.1. XM_006509899.2.
UniGeneiMm.24570.

3D structure databases

ProteinModelPortaliQ8K1K9.
SMRiQ8K1K9. Positions 172-362.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034629.

PTM databases

iPTMnetiQ8K1K9.
PhosphoSiteiQ8K1K9.

Proteomic databases

PaxDbiQ8K1K9.
PRIDEiQ8K1K9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034629; ENSMUSP00000034629; ENSMUSG00000032119.
GeneIDi102423.
KEGGimmu:102423.
UCSCiuc009pcr.2. mouse.

Organism-specific databases

CTDi25988.
MGIiMGI:2429620. Hinfp.

Phylogenomic databases

eggNOGiKOG3608. Eukaryota.
ENOG410XQF8. LUCA.
GeneTreeiENSGT00530000063079.
HOGENOMiHOG000232129.
InParanoidiQ8K1K9.
OMAiHSKEPAY.
OrthoDBiEOG091G089B.
TreeFamiTF350923.

Miscellaneous databases

PROiQ8K1K9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032119.
CleanExiMM_MIZF.
GenevisibleiQ8K1K9. MM.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHINFP_MOUSE
AccessioniPrimary (citable) accession number: Q8K1K9
Secondary accession number(s): E9QPQ4, Q8BWY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.