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Protein

Histone H4 transcription factor

Gene

Hinfp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri17 – 39C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri125 – 149C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri165 – 189C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri195 – 217C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri251 – 274C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri280 – 302C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 333C2H2-type 8PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri341 – 364C2H2-type 9PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H4 transcription factor
Alternative name(s):
Histone nuclear factor P
Short name:
HiNF-P
MBD2-interacting zinc finger protein
Methyl-CpG-binding protein 2-interacting zinc finger protein
Gene namesi
Name:Hinfp
Synonyms:Mizf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2429620 Hinfp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472191 – 503Histone H4 transcription factorAdd BLAST503

Post-translational modificationi

Ubiquitinated. Ubiquitination may lead to proteasome-mediated degradation (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ8K1K9
PRIDEiQ8K1K9

PTM databases

iPTMnetiQ8K1K9
PhosphoSitePlusiQ8K1K9

Expressioni

Gene expression databases

BgeeiENSMUSG00000032119
CleanExiMM_MIZF
ExpressionAtlasiQ8K1K9 baseline and differential
GenevisibleiQ8K1K9 MM

Interactioni

Subunit structurei

Binds MBD2 and a histone deacetylase complex. Interacts with NPAT (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034629

Structurei

3D structure databases

ProteinModelPortaliQ8K1K9
SMRiQ8K1K9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni369 – 503Interaction with NPATBy similarityAdd BLAST135
Regioni370 – 403Required for activation of histone H4 transcription and contributes to DNA-bindingBy similarityAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi49 – 53Poly-Glu5

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri17 – 39C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri125 – 149C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri165 – 189C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri195 – 217C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri251 – 274C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri280 – 302C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 333C2H2-type 8PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri341 – 364C2H2-type 9PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG3608 Eukaryota
ENOG410XQF8 LUCA
GeneTreeiENSGT00870000136508
HOGENOMiHOG000232129
InParanoidiQ8K1K9
OMAiHSKEPAY
OrthoDBiEOG091G089B
TreeFamiTF350923

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequencei

Sequence statusi: Complete.

Q8K1K9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPPGKVPRK ENLGLQCEWG SCSFVCSAME EFFDHVTQHL QQHMHGSKEE
60 70 80 90 100
EEEDPLEEEF SCLWQECGFC SLDSSADLIR HVYFHCYHTK LKQWGLQALQ
110 120 130 140 150
SQADLSPCIL DFQSRNVIPD TPDHFLCLWE HCESVFDNPE WFYRHVDAHS
160 170 180 190 200
LCCEYQAVSK DNHVVQCGWK GCTCTFKDRC KLREHLRSHT QEKVVACPTC
210 220 230 240 250
GGMFANNTKF LDHIRRQTSL DQQRFQCSHC SKRFATERLL RDHMRNHVNH
260 270 280 290 300
YKCPLCDMTC PLPSSLRNHM RFRHSEDRPY KCDCCDYSCK NLIDLRKHLD
310 320 330 340 350
THSKESAYRC DFENCNFSAR SLSSVKSHHR KVHEGDSEPR YKCHVCDKCF
360 370 380 390 400
TRGNNLTVHL RKKHQFKWPS GHPRFRYKEH EDGYMRLQLV RYESVELTQQ
410 420 430 440 450
LLQQLQEGSD PGLALNESSL QGIVLETVLG GPGPEEETEE EGRVVEGTAL
460 470 480 490 500
SASQDNPSSA IHMVSQTDTQ GQRDIVYCVL SEGPGEPPPV SETLKRDGKA

RGT
Length:503
Mass (Da):58,076
Last modified:July 27, 2011 - v3
Checksum:iA2166A2522C4767B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7V → I in AAH29091 (PubMed:15489334).Curated1
Sequence conflicti467T → S in AAH29091 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124577 Genomic DNA No translation available.
BC029091 mRNA Translation: AAH29091.1
AK049633 mRNA Translation: BAC33849.1
CCDSiCCDS23102.1
RefSeqiNP_751894.2, NM_172162.3
XP_006509962.1, XM_006509899.2
UniGeneiMm.24570

Genome annotation databases

EnsembliENSMUST00000216508; ENSMUSP00000149879; ENSMUSG00000032119
GeneIDi102423
KEGGimmu:102423
UCSCiuc009pcr.2 mouse

Similar proteinsi

Entry informationi

Entry nameiHINFP_MOUSE
AccessioniPrimary (citable) accession number: Q8K1K9
Secondary accession number(s): E9QPQ4, Q8BWY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 114 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health