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Q8K1K4

- CENPI_MOUSE

UniProt

Q8K1K4 - CENPI_MOUSE

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Protein

Centromere protein I

Gene

Cenpi

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone (By similarity).By similarity

GO - Biological processi

  1. centromere complex assembly Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_198597. Deposition of new CENPA-containing nucleosomes at the centromere.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.
REACT_256756. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein I
Short name:
CENP-I
Alternative name(s):
FSH primary response protein 1
Follicle-stimulating hormone primary response protein
Gene namesi
Name:Cenpi
Synonyms:Fshprh1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:2147897. Cenpi.

Subcellular locationi

Nucleus By similarity. Chromosomecentromere By similarity
Note: Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex (By similarity).By similarity

GO - Cellular componenti

  1. kinetochore Source: InterPro
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 746746Centromere protein IPRO_0000087355Add
BLAST

Post-translational modificationi

Sumoylated. Sumoylated form can be polyubiquitinated by RNF4, leading to its degradation. Desumoylation by SENP6 prevents its degradation (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ8K1K4.
PaxDbiQ8K1K4.
PRIDEiQ8K1K4.

PTM databases

PhosphoSiteiQ8K1K4.

Expressioni

Gene expression databases

BgeeiQ8K1K4.
CleanExiMM_CENPI.
ExpressionAtlasiQ8K1K4. baseline and differential.
GenevestigatoriQ8K1K4.

Interactioni

Subunit structurei

Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. Interacts with SENP6 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ8K1K4. 3 interactions.
MINTiMINT-4117036.
STRINGi10090.ENSMUSP00000079851.

Structurei

3D structure databases

ProteinModelPortaliQ8K1K4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mis6 family.Curated

Phylogenomic databases

eggNOGiNOG16022.
GeneTreeiENSGT00390000013235.
HOGENOMiHOG000049199.
HOVERGENiHBG080256.
InParanoidiQ8K1K4.
KOiK11501.
OMAiLCPYVCH.
OrthoDBiEOG70PBZG.
PhylomeDBiQ8K1K4.
TreeFamiTF101137.

Family and domain databases

InterProiIPR012485. CENP-I.
[Graphical view]
PANTHERiPTHR15408. PTHR15408. 1 hit.
PfamiPF07778. CENP-I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K1K4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATQRVTRNS QQQNRISQGS NSRQTSLLDW MVKDKSGNFK SVLKESSSVE
60 70 80 90 100
DSTRTDDRTE GALQVAVGYF QKGPKKASLS KDKVLEKHLT TVENVALSNG
110 120 130 140 150
LAPEAIDILL NVALSGKFGN AVNSRILKCM IPESHISEDS VLKAVSWLCV
160 170 180 190 200
DKCSGNTKVL FYRWLVAMFD FIDHKKQISS LYGFFFASLQ DDTLCPYVCH
210 220 230 240 250
LLYLLTKREN VKPFRVRKLL DLQAKMGMQP HLQALLSLYK FFAPTLISVS
260 270 280 290 300
LPVRKKIFFN NSKNLWTSAS LAVRLRNQGA FPEPLNLPLR PTTGRSLKRK
310 320 330 340 350
WNSHSVIPAL NSANKEYGEK TASLFDYLSS ERSLPLEQLQ RFPQLLESIH
360 370 380 390 400
CLELPSQMCS VLNSPLLLHY INCVKDESIL LRISYWLSQA LQEECVWYNI
410 420 430 440 450
NNYEQEKEFI NFLDLVIRVQ CFLQEGFYSC EAFLYKSLPL WDGSSCRSQY
460 470 480 490 500
LQLLAWIPFS SFSEVKPLLS DHLAPLFFTS SIYFKCSVLQ SLQELLQNWL
510 520 530 540 550
LWLSTDAHVQ PTTDSPLETT LGGSMSSVSQ LIEYTGWLCV VAMRLESSST
560 570 580 590 600
LLLHFILDFY EKVCDIYINY DLPIVVLFPP VIFHSALLSL DATILNQLCY
610 620 630 640 650
IMYRYRNNWT AAKKNRYLQK AKPEFSLSSK ICKEYNYYLT AMVCCLWTSR
660 670 680 690 700
PFKAGVYTDP ETIENTGGTQ YKSTLNIVYH PSLLSYAASF LLQESPEEMT
710 720 730 740
EHLSSIQGKK WNWYLDYLYS EGFQGLKLFI KSSVHSSVPK PEENTE
Length:746
Mass (Da):85,403
Last modified:October 1, 2002 - v1
Checksum:i134CB0D40CC449F3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421V → D in BAC31525. (PubMed:16141072)Curated
Sequence conflicti566 – 5661I → V in BAC31525. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043344 mRNA. Translation: BAC31525.1.
BC030328 mRNA. Translation: AAH30328.1.
CCDSiCCDS30393.1.
RefSeqiNP_666036.1. NM_145924.2.
XP_006528538.1. XM_006528475.1.
XP_006528539.1. XM_006528476.1.
UniGeneiMm.34903.

Genome annotation databases

EnsembliENSMUST00000081064; ENSMUSP00000079851; ENSMUSG00000031262.
ENSMUST00000101251; ENSMUSP00000098809; ENSMUSG00000031262.
GeneIDi102920.
KEGGimmu:102920.
UCSCiuc009ufu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043344 mRNA. Translation: BAC31525.1 .
BC030328 mRNA. Translation: AAH30328.1 .
CCDSi CCDS30393.1.
RefSeqi NP_666036.1. NM_145924.2.
XP_006528538.1. XM_006528475.1.
XP_006528539.1. XM_006528476.1.
UniGenei Mm.34903.

3D structure databases

ProteinModelPortali Q8K1K4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8K1K4. 3 interactions.
MINTi MINT-4117036.
STRINGi 10090.ENSMUSP00000079851.

PTM databases

PhosphoSitei Q8K1K4.

Proteomic databases

MaxQBi Q8K1K4.
PaxDbi Q8K1K4.
PRIDEi Q8K1K4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000081064 ; ENSMUSP00000079851 ; ENSMUSG00000031262 .
ENSMUST00000101251 ; ENSMUSP00000098809 ; ENSMUSG00000031262 .
GeneIDi 102920.
KEGGi mmu:102920.
UCSCi uc009ufu.1. mouse.

Organism-specific databases

CTDi 2491.
MGIi MGI:2147897. Cenpi.

Phylogenomic databases

eggNOGi NOG16022.
GeneTreei ENSGT00390000013235.
HOGENOMi HOG000049199.
HOVERGENi HBG080256.
InParanoidi Q8K1K4.
KOi K11501.
OMAi LCPYVCH.
OrthoDBi EOG70PBZG.
PhylomeDBi Q8K1K4.
TreeFami TF101137.

Enzyme and pathway databases

Reactomei REACT_198597. Deposition of new CENPA-containing nucleosomes at the centromere.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.
REACT_256756. Mitotic Prometaphase.

Miscellaneous databases

NextBioi 355717.
PROi Q8K1K4.
SOURCEi Search...

Gene expression databases

Bgeei Q8K1K4.
CleanExi MM_CENPI.
ExpressionAtlasi Q8K1K4. baseline and differential.
Genevestigatori Q8K1K4.

Family and domain databases

InterProi IPR012485. CENP-I.
[Graphical view ]
PANTHERi PTHR15408. PTHR15408. 1 hit.
Pfami PF07778. CENP-I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiCENPI_MOUSE
AccessioniPrimary (citable) accession number: Q8K1K4
Secondary accession number(s): Q8BXU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3