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Q8K1K4

- CENPI_MOUSE

UniProt

Q8K1K4 - CENPI_MOUSE

Protein

Centromere protein I

Gene

Cenpi

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone By similarity.By similarity

    GO - Biological processi

    1. centromere complex assembly Source: InterPro

    Enzyme and pathway databases

    ReactomeiREACT_198597. Deposition of new CENPA-containing nucleosomes at the centromere.
    REACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_207679. Separation of Sister Chromatids.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Centromere protein I
    Short name:
    CENP-I
    Alternative name(s):
    FSH primary response protein 1
    Follicle-stimulating hormone primary response protein
    Gene namesi
    Name:Cenpi
    Synonyms:Fshprh1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:2147897. Cenpi.

    Subcellular locationi

    Nucleus By similarity. Chromosomecentromere By similarity
    Note: Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex By similarity.By similarity

    GO - Cellular componenti

    1. kinetochore Source: InterPro
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Centromere, Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 746746Centromere protein IPRO_0000087355Add
    BLAST

    Post-translational modificationi

    Sumoylated. Sumoylated form can be polyubiquitinated by RNF4, leading to its degradation. Desumoylation by SENP6 prevents its degradation By similarity.By similarity

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    PaxDbiQ8K1K4.
    PRIDEiQ8K1K4.

    PTM databases

    PhosphoSiteiQ8K1K4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8K1K4.
    BgeeiQ8K1K4.
    CleanExiMM_CENPI.
    GenevestigatoriQ8K1K4.

    Interactioni

    Subunit structurei

    Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. Interacts with SENP6 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ8K1K4. 3 interactions.
    MINTiMINT-4117036.
    STRINGi10090.ENSMUSP00000079851.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K1K4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the mis6 family.Curated

    Phylogenomic databases

    eggNOGiNOG16022.
    GeneTreeiENSGT00390000013235.
    HOGENOMiHOG000049199.
    HOVERGENiHBG080256.
    InParanoidiQ8K1K4.
    KOiK11501.
    OMAiLCPYVCH.
    OrthoDBiEOG70PBZG.
    PhylomeDBiQ8K1K4.
    TreeFamiTF101137.

    Family and domain databases

    InterProiIPR012485. CENP-I.
    [Graphical view]
    PANTHERiPTHR15408. PTHR15408. 1 hit.
    PfamiPF07778. CENP-I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K1K4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATQRVTRNS QQQNRISQGS NSRQTSLLDW MVKDKSGNFK SVLKESSSVE    50
    DSTRTDDRTE GALQVAVGYF QKGPKKASLS KDKVLEKHLT TVENVALSNG 100
    LAPEAIDILL NVALSGKFGN AVNSRILKCM IPESHISEDS VLKAVSWLCV 150
    DKCSGNTKVL FYRWLVAMFD FIDHKKQISS LYGFFFASLQ DDTLCPYVCH 200
    LLYLLTKREN VKPFRVRKLL DLQAKMGMQP HLQALLSLYK FFAPTLISVS 250
    LPVRKKIFFN NSKNLWTSAS LAVRLRNQGA FPEPLNLPLR PTTGRSLKRK 300
    WNSHSVIPAL NSANKEYGEK TASLFDYLSS ERSLPLEQLQ RFPQLLESIH 350
    CLELPSQMCS VLNSPLLLHY INCVKDESIL LRISYWLSQA LQEECVWYNI 400
    NNYEQEKEFI NFLDLVIRVQ CFLQEGFYSC EAFLYKSLPL WDGSSCRSQY 450
    LQLLAWIPFS SFSEVKPLLS DHLAPLFFTS SIYFKCSVLQ SLQELLQNWL 500
    LWLSTDAHVQ PTTDSPLETT LGGSMSSVSQ LIEYTGWLCV VAMRLESSST 550
    LLLHFILDFY EKVCDIYINY DLPIVVLFPP VIFHSALLSL DATILNQLCY 600
    IMYRYRNNWT AAKKNRYLQK AKPEFSLSSK ICKEYNYYLT AMVCCLWTSR 650
    PFKAGVYTDP ETIENTGGTQ YKSTLNIVYH PSLLSYAASF LLQESPEEMT 700
    EHLSSIQGKK WNWYLDYLYS EGFQGLKLFI KSSVHSSVPK PEENTE 746
    Length:746
    Mass (Da):85,403
    Last modified:October 1, 2002 - v1
    Checksum:i134CB0D40CC449F3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti42 – 421V → D in BAC31525. (PubMed:16141072)Curated
    Sequence conflicti566 – 5661I → V in BAC31525. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK043344 mRNA. Translation: BAC31525.1.
    BC030328 mRNA. Translation: AAH30328.1.
    CCDSiCCDS30393.1.
    RefSeqiNP_666036.1. NM_145924.2.
    XP_006528538.1. XM_006528475.1.
    XP_006528539.1. XM_006528476.1.
    UniGeneiMm.34903.

    Genome annotation databases

    EnsembliENSMUST00000081064; ENSMUSP00000079851; ENSMUSG00000031262.
    ENSMUST00000101251; ENSMUSP00000098809; ENSMUSG00000031262.
    GeneIDi102920.
    KEGGimmu:102920.
    UCSCiuc009ufu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK043344 mRNA. Translation: BAC31525.1 .
    BC030328 mRNA. Translation: AAH30328.1 .
    CCDSi CCDS30393.1.
    RefSeqi NP_666036.1. NM_145924.2.
    XP_006528538.1. XM_006528475.1.
    XP_006528539.1. XM_006528476.1.
    UniGenei Mm.34903.

    3D structure databases

    ProteinModelPortali Q8K1K4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8K1K4. 3 interactions.
    MINTi MINT-4117036.
    STRINGi 10090.ENSMUSP00000079851.

    PTM databases

    PhosphoSitei Q8K1K4.

    Proteomic databases

    PaxDbi Q8K1K4.
    PRIDEi Q8K1K4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000081064 ; ENSMUSP00000079851 ; ENSMUSG00000031262 .
    ENSMUST00000101251 ; ENSMUSP00000098809 ; ENSMUSG00000031262 .
    GeneIDi 102920.
    KEGGi mmu:102920.
    UCSCi uc009ufu.1. mouse.

    Organism-specific databases

    CTDi 2491.
    MGIi MGI:2147897. Cenpi.

    Phylogenomic databases

    eggNOGi NOG16022.
    GeneTreei ENSGT00390000013235.
    HOGENOMi HOG000049199.
    HOVERGENi HBG080256.
    InParanoidi Q8K1K4.
    KOi K11501.
    OMAi LCPYVCH.
    OrthoDBi EOG70PBZG.
    PhylomeDBi Q8K1K4.
    TreeFami TF101137.

    Enzyme and pathway databases

    Reactomei REACT_198597. Deposition of new CENPA-containing nucleosomes at the centromere.
    REACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_207679. Separation of Sister Chromatids.

    Miscellaneous databases

    NextBioi 355717.
    PROi Q8K1K4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K1K4.
    Bgeei Q8K1K4.
    CleanExi MM_CENPI.
    Genevestigatori Q8K1K4.

    Family and domain databases

    InterProi IPR012485. CENP-I.
    [Graphical view ]
    PANTHERi PTHR15408. PTHR15408. 1 hit.
    Pfami PF07778. CENP-I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N-3.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiCENPI_MOUSE
    AccessioniPrimary (citable) accession number: Q8K1K4
    Secondary accession number(s): Q8BXU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3