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Q8K1K4 (CENPI_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Centromere protein I

Short name=CENP-I
Alternative name(s):
FSH primary response protein 1
Follicle-stimulating hormone primary response protein
Gene names
Name:Cenpi
Synonyms:Fshprh1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length746 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone By similarity.

Subunit structure

Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. Interacts with SENP6 By similarity.

Subcellular location

Nucleus By similarity. Chromosomecentromere By similarity. Note: Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex By similarity.

Post-translational modification

Sumoylated. Sumoylated form can be polyubiquitinated by RNF4, leading to its degradation. Desumoylation by SENP6 prevents its degradation By similarity.

Sequence similarities

Belongs to the mis6 family.

Ontologies

Keywords
   Cellular componentCentromere
Chromosome
Nucleus
   PTMUbl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcentromere complex assembly

Inferred from electronic annotation. Source: InterPro

   Cellular_componentkinetochore

Inferred from electronic annotation. Source: InterPro

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 746746Centromere protein I
PRO_0000087355

Experimental info

Sequence conflict421V → D in BAC31525. Ref.1
Sequence conflict5661I → V in BAC31525. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8K1K4 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 134CB0D40CC449F3

FASTA74685,403
        10         20         30         40         50         60 
MATQRVTRNS QQQNRISQGS NSRQTSLLDW MVKDKSGNFK SVLKESSSVE DSTRTDDRTE 

        70         80         90        100        110        120 
GALQVAVGYF QKGPKKASLS KDKVLEKHLT TVENVALSNG LAPEAIDILL NVALSGKFGN 

       130        140        150        160        170        180 
AVNSRILKCM IPESHISEDS VLKAVSWLCV DKCSGNTKVL FYRWLVAMFD FIDHKKQISS 

       190        200        210        220        230        240 
LYGFFFASLQ DDTLCPYVCH LLYLLTKREN VKPFRVRKLL DLQAKMGMQP HLQALLSLYK 

       250        260        270        280        290        300 
FFAPTLISVS LPVRKKIFFN NSKNLWTSAS LAVRLRNQGA FPEPLNLPLR PTTGRSLKRK 

       310        320        330        340        350        360 
WNSHSVIPAL NSANKEYGEK TASLFDYLSS ERSLPLEQLQ RFPQLLESIH CLELPSQMCS 

       370        380        390        400        410        420 
VLNSPLLLHY INCVKDESIL LRISYWLSQA LQEECVWYNI NNYEQEKEFI NFLDLVIRVQ 

       430        440        450        460        470        480 
CFLQEGFYSC EAFLYKSLPL WDGSSCRSQY LQLLAWIPFS SFSEVKPLLS DHLAPLFFTS 

       490        500        510        520        530        540 
SIYFKCSVLQ SLQELLQNWL LWLSTDAHVQ PTTDSPLETT LGGSMSSVSQ LIEYTGWLCV 

       550        560        570        580        590        600 
VAMRLESSST LLLHFILDFY EKVCDIYINY DLPIVVLFPP VIFHSALLSL DATILNQLCY 

       610        620        630        640        650        660 
IMYRYRNNWT AAKKNRYLQK AKPEFSLSSK ICKEYNYYLT AMVCCLWTSR PFKAGVYTDP 

       670        680        690        700        710        720 
ETIENTGGTQ YKSTLNIVYH PSLLSYAASF LLQESPEEMT EHLSSIQGKK WNWYLDYLYS 

       730        740 
EGFQGLKLFI KSSVHSSVPK PEENTE 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Cerebellum.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N-3.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK043344 mRNA. Translation: BAC31525.1.
BC030328 mRNA. Translation: AAH30328.1.
CCDSCCDS30393.1.
RefSeqNP_666036.1. NM_145924.2.
XP_006528538.1. XM_006528475.1.
XP_006528539.1. XM_006528476.1.
UniGeneMm.34903.

3D structure databases

ProteinModelPortalQ8K1K4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8K1K4. 3 interactions.
MINTMINT-4117036.
STRING10090.ENSMUSP00000079851.

PTM databases

PhosphoSiteQ8K1K4.

Proteomic databases

PaxDbQ8K1K4.
PRIDEQ8K1K4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000081064; ENSMUSP00000079851; ENSMUSG00000031262.
ENSMUST00000101251; ENSMUSP00000098809; ENSMUSG00000031262.
GeneID102920.
KEGGmmu:102920.
UCSCuc009ufu.1. mouse.

Organism-specific databases

CTD2491.
MGIMGI:2147897. Cenpi.

Phylogenomic databases

eggNOGNOG16022.
GeneTreeENSGT00390000013235.
HOGENOMHOG000049199.
HOVERGENHBG080256.
InParanoidQ8K1K4.
KOK11501.
OMALCPYVCH.
OrthoDBEOG70PBZG.
PhylomeDBQ8K1K4.
TreeFamTF101137.

Gene expression databases

ArrayExpressQ8K1K4.
BgeeQ8K1K4.
CleanExMM_CENPI.
GenevestigatorQ8K1K4.

Family and domain databases

InterProIPR012485. CENP-I.
[Graphical view]
PANTHERPTHR15408. PTHR15408. 1 hit.
PfamPF07778. CENP-I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio355717.
PROQ8K1K4.
SOURCESearch...

Entry information

Entry nameCENPI_MOUSE
AccessionPrimary (citable) accession number: Q8K1K4
Secondary accession number(s): Q8BXU9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot