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Protein

Tudor domain-containing protein 7

Gene

Tdrd7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.1 Publication

GO - Molecular functioni

GO - Biological processi

  • germ cell development Source: MGI
  • lens fiber cell differentiation Source: UniProtKB
  • lens morphogenesis in camera-type eye Source: UniProtKB
  • posttranscriptional regulation of gene expression Source: UniProtKB
  • spermatogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tudor domain-containing protein 7
Alternative name(s):
PCTAIRE2-binding protein
Tudor repeat associator with PCTAIRE-2
Short name:
Trap
Gene namesi
Name:Tdrd7
Synonyms:Pctaire2bp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2140279. Tdrd7.

Subcellular locationi

GO - Cellular componenti

  • chromatoid body Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • intracellular ribonucleoprotein complex Source: MGI
  • P granule Source: MGI
  • ribonucleoprotein granule Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Mice develop cataracts and glaucoma and males are sterile. Within 4 weeks of birth, mice develop a posterior cataract that becomes severe with age. At later stages, the lens fiber cell compartment develops vacuoles with lens capsule rupture and extrusion of fiber cell mass into the vitreous. In addition, the mass of fiber cells passes through the pupil into the anterior chamber of the eye. By 4 months of age, iris flattening is detected and anterior chamber depth increased. By 6 months of age, the intraocular pressure (IOP) is elevated in some mutants, and the incidence of elevated IOP increases with age, leading to glaucome. Severe optic nerve atrophy characterized by retinal ganglion cell axon loss and excavative remodeling of the optic nerve are observed. In addition, males display sterility due to an arrest in spermatogenesis at the round spermatid stage, likely due to a chromatoid body defect.1 Publication

Keywords - Diseasei

Cataract

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001831701 – 1086Tudor domain-containing protein 7Add BLAST1086

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei847PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8K1H1.
PaxDbiQ8K1H1.
PeptideAtlasiQ8K1H1.
PRIDEiQ8K1H1.

PTM databases

iPTMnetiQ8K1H1.
PhosphoSitePlusiQ8K1H1.

Expressioni

Tissue specificityi

Mainly expressed in testis. Expressed in spermatogonia, spermatocytes and round spermatids (at protein level). Also expressed in the developing lens.2 Publications

Developmental stagei

At embryonic day E12.5, it is expressed in differentiating fiber cells in the posterior lens, but not in the anterior epithelium of the lens (AEL).1 Publication

Gene expression databases

BgeeiENSMUSG00000035517.
CleanExiMM_TDRD7.
ExpressionAtlasiQ8K1H1. baseline and differential.
GenevisibleiQ8K1H1. MM.

Interactioni

Subunit structurei

Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1.3 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099993.

Structurei

Secondary structure

11086
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 17Combined sources15
Helixi24 – 35Combined sources12
Helixi41 – 44Combined sources4
Helixi49 – 54Combined sources6
Turni57 – 59Combined sources3
Beta strandi60 – 64Combined sources5
Beta strandi70 – 74Combined sources5
Helixi223 – 237Combined sources15
Turni243 – 245Combined sources3
Helixi246 – 254Combined sources9
Helixi260 – 268Combined sources9
Turni270 – 272Combined sources3
Beta strandi273 – 276Combined sources4
Turni279 – 281Combined sources3
Beta strandi286 – 289Combined sources4
Helixi290 – 292Combined sources3
Beta strandi294 – 296Combined sources3
Helixi301 – 304Combined sources4
Beta strandi309 – 312Combined sources4
Helixi313 – 315Combined sources3
Helixi328 – 338Combined sources11
Helixi348 – 357Combined sources10
Helixi363 – 366Combined sources4
Helixi369 – 375Combined sources7
Beta strandi376 – 383Combined sources8
Turni384 – 386Combined sources3
Beta strandi387 – 392Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LH9NMR-A1-76[»]
2LY1NMR-A223-400[»]
2LY2NMR-A223-400[»]
ProteinModelPortaliQ8K1H1.
SMRiQ8K1H1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 76HTH OST-type 1PROSITE-ProRule annotationAdd BLAST74
Domaini222 – 291HTH OST-type 2PROSITE-ProRule annotationAdd BLAST70
Domaini325 – 394HTH OST-type 3PROSITE-ProRule annotationAdd BLAST70
Domaini501 – 558Tudor 1PROSITE-ProRule annotationAdd BLAST58
Domaini691 – 748Tudor 2PROSITE-ProRule annotationAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni849 – 1086Interaction with CDK17By similarityAdd BLAST238
Regioni881 – 1086Interaction with CABLES11 PublicationAdd BLAST206

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi307 – 313Poly-Pro7

Sequence similaritiesi

Belongs to the TDRD7 family.Curated
Contains 3 HTH OST-type domains.PROSITE-ProRule annotation
Contains 2 Tudor domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IPR1. Eukaryota.
ENOG410XST4. LUCA.
GeneTreeiENSGT00850000132373.
HOGENOMiHOG000294063.
HOVERGENiHBG055704.
InParanoidiQ8K1H1.
KOiK18405.

Family and domain databases

InterProiIPR025605. OST-HTH/LOTUS_dom.
IPR002999. Tudor.
[Graphical view]
PfamiPF12872. OST-HTH. 1 hit.
PF00567. TUDOR. 3 hits.
[Graphical view]
SMARTiSM00333. TUDOR. 3 hits.
[Graphical view]
PROSITEiPS51644. HTH_OST. 3 hits.
PS50304. TUDOR. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K1H1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEADLVSKM LRAVLQSHKN GIVLPRLQGE YRSLTGDWIP FKQLGYPTLE
60 70 80 90 100
AYLRSVPAVV RIEASRSGEI VCYAVACTET ARIAQLVARQ RTSKRKIGRQ
110 120 130 140 150
INCQMRVKKA MPFFLEGKPK ATLRQPGFAS DYSISRKPNS ALLRDRGSAL
160 170 180 190 200
GVKADVDMPP YPDTPVQRHA SMSANSRFSP KSSLPASFQT HISRACPTEV
210 220 230 240 250
NDNLNQTVEK PNITPPASYT NKMDEVQNRI KEILDKHNNG IWISKLPHFY
260 270 280 290 300
KEFYKEDLNQ GVLQQFEHWP HICTVEKPCG GGQDSLLYPA RREQPLKSDQ
310 320 330 340 350
DPEKELPPPP PAPKQEVPSQ GSPAVMPDVK EKVAELLGKY SSGLWASALP
360 370 380 390 400
KAFEDMYKVK FPEDALKNLA SLSDVCTINY ISGNTQKAIL YAKLPLPTDK
410 420 430 440 450
ILKDEGQAQG DFDIKSMIEQ EYLQIEKNMA ESADEFLEDI TVPPLVIPTE
460 470 480 490 500
ASPSVLVVEL SNTNDVVIRY VGKDYSAAQE LMEDEMKEFY SKNPRVTPIQ
510 520 530 540 550
TVHVGQLLAV NAEEDAWLRA QIISTDENKI KVCYVDYGFC ENIEKSKAYR
560 570 580 590 600
LNPRFCSLSF QATKCKLAGL EVLNDDPDLV KAVESLTCGK IFAVEILDKS
610 620 630 640 650
DVPLVVLYDT SGEDDININA TCLKAICDRS LQVHLQVDAM YTNVKVTNIC
660 670 680 690 700
SDGTLYCQVP CKGLNKLNDL LHKTEDYFHC KHMTSEYFIS LPFCGKICLF
710 720 730 740 750
HCKGKWLRVE ITNVHSSRAL DVQFLDSGNS TSVKVSELRE IPPRFLQEML
760 770 780 790 800
AIPPQAIKCC LADLPQSIGM WTPDAVLWLR DSVLNCSDCS IKVTKMDETK
810 820 830 840 850
GVAYVYLFTP NNFPDPHRSI NRQITNADLW KHQKDVFLSA VSTAASSPGN
860 870 880 890 900
RNGGTPAPGS PAESLRKSHP EVIKKSVLDH TSSFSLEELP PPVHLSRSGE
910 920 930 940 950
HMDVYVPVAC HPGHFVIQPW QEIHKLEVLM EEMILYYSVS EERHIAVERD
960 970 980 990 1000
QVYAAKVENK WYRVLLKGIL TNGLVSVYEL DYGKHELVNI RKVQPLVDVF
1010 1020 1030 1040 1050
RKLPFQAVTA QLAGVKCSQW SEEASMVFRN HVEKKALVAL VQTVVEHTNP
1060 1070 1080
WDRKVVLYLV DTSLPDTDTW IHDFMSQYLL ELSKVN
Length:1,086
Mass (Da):122,174
Last modified:October 1, 2002 - v1
Checksum:i90FF74E1CDD24F86
GO

Sequence cautioni

The sequence CAM17034 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM22130 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732615 Genomic DNA. Translation: CAM17026.1.
AL732615, AL772381 Genomic DNA. Translation: CAM17034.1. Sequence problems.
AL772381, AL732615 Genomic DNA. Translation: CAM22130.1. Sequence problems.
BC025099 mRNA. Translation: AAH25099.1.
BC029689 mRNA. Translation: AAH29689.1.
CCDSiCCDS18142.1.
RefSeqiNP_001277404.1. NM_001290475.1.
NP_666254.1. NM_146142.2.
XP_006537580.1. XM_006537517.3.
UniGeneiMm.275413.

Genome annotation databases

EnsembliENSMUST00000102929; ENSMUSP00000099993; ENSMUSG00000035517.
GeneIDi100121.
KEGGimmu:100121.
UCSCiuc008stc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732615 Genomic DNA. Translation: CAM17026.1.
AL732615, AL772381 Genomic DNA. Translation: CAM17034.1. Sequence problems.
AL772381, AL732615 Genomic DNA. Translation: CAM22130.1. Sequence problems.
BC025099 mRNA. Translation: AAH25099.1.
BC029689 mRNA. Translation: AAH29689.1.
CCDSiCCDS18142.1.
RefSeqiNP_001277404.1. NM_001290475.1.
NP_666254.1. NM_146142.2.
XP_006537580.1. XM_006537517.3.
UniGeneiMm.275413.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LH9NMR-A1-76[»]
2LY1NMR-A223-400[»]
2LY2NMR-A223-400[»]
ProteinModelPortaliQ8K1H1.
SMRiQ8K1H1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099993.

PTM databases

iPTMnetiQ8K1H1.
PhosphoSitePlusiQ8K1H1.

Proteomic databases

MaxQBiQ8K1H1.
PaxDbiQ8K1H1.
PeptideAtlasiQ8K1H1.
PRIDEiQ8K1H1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102929; ENSMUSP00000099993; ENSMUSG00000035517.
GeneIDi100121.
KEGGimmu:100121.
UCSCiuc008stc.2. mouse.

Organism-specific databases

CTDi23424.
MGIiMGI:2140279. Tdrd7.

Phylogenomic databases

eggNOGiENOG410IPR1. Eukaryota.
ENOG410XST4. LUCA.
GeneTreeiENSGT00850000132373.
HOGENOMiHOG000294063.
HOVERGENiHBG055704.
InParanoidiQ8K1H1.
KOiK18405.

Miscellaneous databases

ChiTaRSiTdrd7. mouse.
PROiQ8K1H1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035517.
CleanExiMM_TDRD7.
ExpressionAtlasiQ8K1H1. baseline and differential.
GenevisibleiQ8K1H1. MM.

Family and domain databases

InterProiIPR025605. OST-HTH/LOTUS_dom.
IPR002999. Tudor.
[Graphical view]
PfamiPF12872. OST-HTH. 1 hit.
PF00567. TUDOR. 3 hits.
[Graphical view]
SMARTiSM00333. TUDOR. 3 hits.
[Graphical view]
PROSITEiPS51644. HTH_OST. 3 hits.
PS50304. TUDOR. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTDRD7_MOUSE
AccessioniPrimary (citable) accession number: Q8K1H1
Secondary accession number(s): B1AWG7, B1AWH5, Q8R181
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.