Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8K1H1

- TDRD7_MOUSE

UniProt

Q8K1H1 - TDRD7_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Tudor domain-containing protein 7

Gene

Tdrd7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.1 Publication

GO - Molecular functioni

  1. mRNA binding Source: UniProtKB

GO - Biological processi

  1. germ cell development Source: MGI
  2. lens fiber cell differentiation Source: UniProtKB
  3. lens morphogenesis in camera-type eye Source: UniProtKB
  4. posttranscriptional regulation of gene expression Source: UniProtKB
  5. spermatogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tudor domain-containing protein 7
Alternative name(s):
PCTAIRE2-binding protein
Tudor repeat associator with PCTAIRE-2
Short name:
Trap
Gene namesi
Name:Tdrd7
Synonyms:Pctaire2bp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:2140279. Tdrd7.

Subcellular locationi

Cytoplasm 3 Publications
Note: Localizes to cytoplasmic RNA granules. Present in chromatoid body (CB) of spermatids (mammalian counterpart of germplasm, pole plasm or polar granules in Drosophila germ cells), also named processing bodies (P-bodies) in somatic cells. Detected in the multilobular cytoplasmic CBs (also called intermitochondrial cementin) in pachytene spermatocytes and as a single perinuclear CB in haploid round spermatids.

GO - Cellular componenti

  1. chromatoid body Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. mitochondrial matrix Source: Ensembl
  4. P granule Source: MGI
  5. ribonucleoprotein complex Source: MGI
  6. ribonucleoprotein granule Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Mice develop cataracts and glaucoma and males are sterile. Within 4 weeks of birth, mice develop a posterior cataract that becomes severe with age. At later stages, the lens fiber cell compartment develops vacuoles with lens capsule rupture and extrusion of fiber cell mass into the vitreous. In addition, the mass of fiber cells passes through the pupil into the anterior chamber of the eye. By 4 months of age, iris flattening is detected and anterior chamber depth increased. By 6 months of age, the intraocular pressure (IOP) is elevated in some mutants, and the incidence of elevated IOP increases with age, leading to glaucome. Severe optic nerve atrophy characterized by retinal ganglion cell axon loss and excavative remodeling of the optic nerve are observed. In addition, males display sterility due to an arrest in spermatogenesis at the round spermatid stage, likely due to a chromatoid body defect.1 Publication

Keywords - Diseasei

Cataract

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10861086Tudor domain-containing protein 7PRO_0000183170Add
BLAST

Proteomic databases

MaxQBiQ8K1H1.
PaxDbiQ8K1H1.
PRIDEiQ8K1H1.

PTM databases

PhosphoSiteiQ8K1H1.

Expressioni

Tissue specificityi

Mainly expressed in testis. Expressed in spermatogonia, spermatocytes and round spermatids (at protein level). Also expressed in the developing lens.2 Publications

Developmental stagei

At embryonic day E12.5, it is expressed in differentiating fiber cells in the posterior lens, but not in the anterior epithelium of the lens (AEL).1 Publication

Gene expression databases

BgeeiQ8K1H1.
CleanExiMM_TDRD7.
ExpressionAtlasiQ8K1H1. baseline and differential.
GenevestigatoriQ8K1H1.

Interactioni

Subunit structurei

Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1.3 Publications

Structurei

Secondary structure

1
1086
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1715Combined sources
Helixi24 – 3512Combined sources
Helixi41 – 444Combined sources
Helixi49 – 546Combined sources
Turni57 – 593Combined sources
Beta strandi60 – 645Combined sources
Beta strandi70 – 745Combined sources
Helixi223 – 23715Combined sources
Turni243 – 2453Combined sources
Helixi246 – 2549Combined sources
Helixi260 – 2689Combined sources
Turni270 – 2723Combined sources
Beta strandi273 – 2764Combined sources
Turni279 – 2813Combined sources
Beta strandi286 – 2894Combined sources
Helixi290 – 2923Combined sources
Beta strandi294 – 2963Combined sources
Helixi301 – 3044Combined sources
Beta strandi309 – 3124Combined sources
Helixi313 – 3153Combined sources
Helixi328 – 33811Combined sources
Helixi348 – 35710Combined sources
Helixi363 – 3664Combined sources
Helixi369 – 3757Combined sources
Beta strandi376 – 3838Combined sources
Turni384 – 3863Combined sources
Beta strandi387 – 3926Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LH9NMR-A1-76[»]
2LY1NMR-A223-400[»]
2LY2NMR-A223-400[»]
ProteinModelPortaliQ8K1H1.
SMRiQ8K1H1. Positions 1-76, 223-400, 651-775, 958-1029.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 7674HTH OST-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini222 – 29170HTH OST-type 2PROSITE-ProRule annotationAdd
BLAST
Domaini325 – 39470HTH OST-type 3PROSITE-ProRule annotationAdd
BLAST
Domaini501 – 55858Tudor 1PROSITE-ProRule annotationAdd
BLAST
Domaini691 – 74858Tudor 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni849 – 1086238Interacts with CDK17By similarityAdd
BLAST
Regioni881 – 1086206Interacts with CABLES1Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi307 – 3137Poly-Pro

Sequence similaritiesi

Belongs to the TDRD7 family.Curated
Contains 3 HTH OST-type domains.PROSITE-ProRule annotation
Contains 2 Tudor domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG256635.
GeneTreeiENSGT00760000119374.
HOGENOMiHOG000294063.
HOVERGENiHBG055704.
InParanoidiQ8K1H1.
KOiK18405.
OrthoDBiEOG7BW0HQ.

Family and domain databases

InterProiIPR025605. OST-HTH/LOTUS_dom.
IPR002999. Tudor.
[Graphical view]
PfamiPF12872. OST-HTH. 1 hit.
PF00567. TUDOR. 3 hits.
[Graphical view]
SMARTiSM00333. TUDOR. 3 hits.
[Graphical view]
PROSITEiPS51644. HTH_OST. 3 hits.
PS50304. TUDOR. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K1H1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLEADLVSKM LRAVLQSHKN GIVLPRLQGE YRSLTGDWIP FKQLGYPTLE
60 70 80 90 100
AYLRSVPAVV RIEASRSGEI VCYAVACTET ARIAQLVARQ RTSKRKIGRQ
110 120 130 140 150
INCQMRVKKA MPFFLEGKPK ATLRQPGFAS DYSISRKPNS ALLRDRGSAL
160 170 180 190 200
GVKADVDMPP YPDTPVQRHA SMSANSRFSP KSSLPASFQT HISRACPTEV
210 220 230 240 250
NDNLNQTVEK PNITPPASYT NKMDEVQNRI KEILDKHNNG IWISKLPHFY
260 270 280 290 300
KEFYKEDLNQ GVLQQFEHWP HICTVEKPCG GGQDSLLYPA RREQPLKSDQ
310 320 330 340 350
DPEKELPPPP PAPKQEVPSQ GSPAVMPDVK EKVAELLGKY SSGLWASALP
360 370 380 390 400
KAFEDMYKVK FPEDALKNLA SLSDVCTINY ISGNTQKAIL YAKLPLPTDK
410 420 430 440 450
ILKDEGQAQG DFDIKSMIEQ EYLQIEKNMA ESADEFLEDI TVPPLVIPTE
460 470 480 490 500
ASPSVLVVEL SNTNDVVIRY VGKDYSAAQE LMEDEMKEFY SKNPRVTPIQ
510 520 530 540 550
TVHVGQLLAV NAEEDAWLRA QIISTDENKI KVCYVDYGFC ENIEKSKAYR
560 570 580 590 600
LNPRFCSLSF QATKCKLAGL EVLNDDPDLV KAVESLTCGK IFAVEILDKS
610 620 630 640 650
DVPLVVLYDT SGEDDININA TCLKAICDRS LQVHLQVDAM YTNVKVTNIC
660 670 680 690 700
SDGTLYCQVP CKGLNKLNDL LHKTEDYFHC KHMTSEYFIS LPFCGKICLF
710 720 730 740 750
HCKGKWLRVE ITNVHSSRAL DVQFLDSGNS TSVKVSELRE IPPRFLQEML
760 770 780 790 800
AIPPQAIKCC LADLPQSIGM WTPDAVLWLR DSVLNCSDCS IKVTKMDETK
810 820 830 840 850
GVAYVYLFTP NNFPDPHRSI NRQITNADLW KHQKDVFLSA VSTAASSPGN
860 870 880 890 900
RNGGTPAPGS PAESLRKSHP EVIKKSVLDH TSSFSLEELP PPVHLSRSGE
910 920 930 940 950
HMDVYVPVAC HPGHFVIQPW QEIHKLEVLM EEMILYYSVS EERHIAVERD
960 970 980 990 1000
QVYAAKVENK WYRVLLKGIL TNGLVSVYEL DYGKHELVNI RKVQPLVDVF
1010 1020 1030 1040 1050
RKLPFQAVTA QLAGVKCSQW SEEASMVFRN HVEKKALVAL VQTVVEHTNP
1060 1070 1080
WDRKVVLYLV DTSLPDTDTW IHDFMSQYLL ELSKVN
Length:1,086
Mass (Da):122,174
Last modified:October 1, 2002 - v1
Checksum:i90FF74E1CDD24F86
GO

Sequence cautioni

The sequence CAM17034.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAM22130.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732615 Genomic DNA. Translation: CAM17026.1.
AL732615, AL772381 Genomic DNA. Translation: CAM17034.1. Sequence problems.
AL772381, AL732615 Genomic DNA. Translation: CAM22130.1. Sequence problems.
BC025099 mRNA. Translation: AAH25099.1.
BC029689 mRNA. Translation: AAH29689.1.
CCDSiCCDS18142.1.
RefSeqiNP_001277404.1. NM_001290475.1.
NP_666254.1. NM_146142.2.
XP_006537580.1. XM_006537517.1.
UniGeneiMm.275413.

Genome annotation databases

EnsembliENSMUST00000102929; ENSMUSP00000099993; ENSMUSG00000035517.
GeneIDi100121.
KEGGimmu:100121.
UCSCiuc008stb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732615 Genomic DNA. Translation: CAM17026.1 .
AL732615 , AL772381 Genomic DNA. Translation: CAM17034.1 . Sequence problems.
AL772381 , AL732615 Genomic DNA. Translation: CAM22130.1 . Sequence problems.
BC025099 mRNA. Translation: AAH25099.1 .
BC029689 mRNA. Translation: AAH29689.1 .
CCDSi CCDS18142.1.
RefSeqi NP_001277404.1. NM_001290475.1.
NP_666254.1. NM_146142.2.
XP_006537580.1. XM_006537517.1.
UniGenei Mm.275413.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2LH9 NMR - A 1-76 [» ]
2LY1 NMR - A 223-400 [» ]
2LY2 NMR - A 223-400 [» ]
ProteinModelPortali Q8K1H1.
SMRi Q8K1H1. Positions 1-76, 223-400, 651-775, 958-1029.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8K1H1.

Proteomic databases

MaxQBi Q8K1H1.
PaxDbi Q8K1H1.
PRIDEi Q8K1H1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102929 ; ENSMUSP00000099993 ; ENSMUSG00000035517 .
GeneIDi 100121.
KEGGi mmu:100121.
UCSCi uc008stb.1. mouse.

Organism-specific databases

CTDi 23424.
MGIi MGI:2140279. Tdrd7.

Phylogenomic databases

eggNOGi NOG256635.
GeneTreei ENSGT00760000119374.
HOGENOMi HOG000294063.
HOVERGENi HBG055704.
InParanoidi Q8K1H1.
KOi K18405.
OrthoDBi EOG7BW0HQ.

Miscellaneous databases

ChiTaRSi Tdrd7. mouse.
NextBioi 354271.
PROi Q8K1H1.
SOURCEi Search...

Gene expression databases

Bgeei Q8K1H1.
CleanExi MM_TDRD7.
ExpressionAtlasi Q8K1H1. baseline and differential.
Genevestigatori Q8K1H1.

Family and domain databases

InterProi IPR025605. OST-HTH/LOTUS_dom.
IPR002999. Tudor.
[Graphical view ]
Pfami PF12872. OST-HTH. 1 hit.
PF00567. TUDOR. 3 hits.
[Graphical view ]
SMARTi SM00333. TUDOR. 3 hits.
[Graphical view ]
PROSITEi PS51644. HTH_OST. 3 hits.
PS50304. TUDOR. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Eye and Retina.
  3. Cited for: SUBCELLULAR LOCATION, IDENTIFICATION IN A COMPLEX WITH CABLES1 AND CDK17, INTERACTION WITH CABLES1.
    Tissue: Brain.
  4. "Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain composition, intracellular localization, and function in male germ cells in mice."
    Hosokawa M., Shoji M., Kitamura K., Tanaka T., Noce T., Chuma S., Nakatsuji N.
    Dev. Biol. 301:38-52(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A MRNP COMPLEX, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  5. "Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members."
    Vagin V.V., Wohlschlegel J., Qu J., Jonsson Z., Huang X., Chuma S., Girard A., Sachidanandam R., Hannon G.J., Aravin A.A.
    Genes Dev. 23:1749-1762(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PIWIL1.
  6. Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiTDRD7_MOUSE
AccessioniPrimary (citable) accession number: Q8K1H1
Secondary accession number(s): B1AWG7, B1AWH5, Q8R181
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3