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Protein

CXADR-like membrane protein

Gene

Clmp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development (By similarity).By similarity1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
CXADR-like membrane protein
Alternative name(s):
Adipocyte adhesion molecule
Coxsackie- and adenovirus receptor-like membrane protein
Short name:
CAR-like membrane protein
Gene namesi
Name:Clmp
Synonyms:Acam, Asam
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi708569. Clmp.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 234ExtracellularSequence analysisAdd BLAST217
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Topological domaini256 – 372CytoplasmicSequence analysisAdd BLAST117

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000029302818 – 372CXADR-like membrane proteinAdd BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 110PROSITE-ProRule annotation
Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi152 ↔ 207PROSITE-ProRule annotation
Glycosylationi196N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8K1G0.
PRIDEiQ8K1G0.

Expressioni

Tissue specificityi

Predominantly expressed in the white adipose tissue.1 Publication

Developmental stagei

At 6 weeks of age, detected in mesenteric and retroperitoneal fat pads. Expression prominently increases in mesenteric and subdermal adipose tissues at 30 weeks and is barely detectable at 50 weeks.1 Publication

Inductioni

Up-regulated in mature adipocytes and adipocyte tissue of obese animals.1 Publication

Gene expression databases

BgeeiENSRNOG00000053239.
GenevisibleiQ8K1G0. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010607.

Structurei

3D structure databases

ProteinModelPortaliQ8K1G0.
SMRiQ8K1G0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 126Ig-like C2-type 1Add BLAST109
Domaini134 – 223Ig-like C2-type 2Add BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi287 – 319Ser-richAdd BLAST33

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEC5. Eukaryota.
ENOG4111I1J. LUCA.
GeneTreeiENSGT00760000119145.
HOVERGENiHBG060225.
InParanoidiQ8K1G0.
KOiK06789.
OMAiMVPAQTK.
OrthoDBiEOG091G05PI.
PhylomeDBiQ8K1G0.
TreeFamiTF330875.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
PfamiView protein in Pfam
PF07686. V-set. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00406. IGv. 1 hit.
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K1G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLFFLWLVT YYVGTLGTHT EIKRVAEEKV TLPCHHQLGL PEKDTLDIEW
60 70 80 90 100
LLTDNEGNQK VVITYSSRHV YNNLTEEQKG RVAFASNFLA GDASLQIEPL
110 120 130 140 150
KPSDEGRYTC KVKNSGRYVW SHVILKVLVR PSKPKCELEG EPTEGSDLTL
160 170 180 190 200
QCESASGTKP IVYYWQRIRE KEGEDEHLPP KSRIDYNNPG RVLLQNLTMA
210 220 230 240 250
SSGLYQCTAG NEAGKESCVV RVTVQYVQSI GMVAGAVTGI VAGALLIFLL
260 270 280 290 300
IWLLIRRKSK ERYEEEDRPN EIREDAEAPR ARLVKPSSSS SGSRSSRSGS
310 320 330 340 350
SSTRSTGNSA SRSQRTLSSE AAPQPGLATQ AYSLIGPEVR GSEPKKAHHT
360 370
TLTKAETTLS TMPSQSRAFQ TV
Length:372
Mass (Da):41,148
Last modified:October 1, 2002 - v1
Checksum:i439AB3C4D3E56346
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302047 mRNA. Translation: AAM76974.1.
RefSeqiNP_775177.1. NM_173154.1.
XP_017450986.1. XM_017595497.1.
UniGeneiRn.163013.
Rn.40141.

Genome annotation databases

EnsembliENSRNOT00000080288; ENSRNOP00000069336; ENSRNOG00000053239.
GeneIDi286939.
KEGGirno:286939.
UCSCiRGD:708569. rat.

Similar proteinsi

Entry informationi

Entry nameiCLMP_RAT
AccessioniPrimary (citable) accession number: Q8K1G0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 1, 2002
Last modified: February 28, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome