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Q8K1E0

- STX5_MOUSE

UniProt

Q8K1E0 - STX5_MOUSE

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Protein

Syntaxin-5

Gene

Stx5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Mediates endoplasmic reticulum to Golgi transport.By similarity

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: Ensembl
  2. intracellular protein transport Source: InterPro
  3. retrograde transport, endosome to Golgi Source: Ensembl
  4. vesicle fusion with Golgi apparatus Source: Ensembl
  5. vesicle-mediated transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-5
Gene namesi
Name:Stx5
Synonyms:Stx5a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1928483. Stx5a.

Subcellular locationi

Endoplasmic reticulum-Golgi intermediate compartment membrane By similarity; Single-pass type IV membrane protein By similarity. Golgi apparatus membrane By similarity
Note: Localizes throughout the Golgi apparatus, but most abundant in the cis-most cisternae.By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. Golgi membrane Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
  4. nucleus Source: Ensembl
  5. SNARE complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 355355Syntaxin-5PRO_0000210206Add
BLAST

Proteomic databases

MaxQBiQ8K1E0.
PaxDbiQ8K1E0.
PRIDEiQ8K1E0.

PTM databases

PhosphoSiteiQ8K1E0.

Expressioni

Gene expression databases

BgeeiQ8K1E0.
CleanExiMM_STX5A.
ExpressionAtlasiQ8K1E0. baseline and differential.
GenevestigatoriQ8K1E0.

Interactioni

Subunit structurei

Part of a ternary complex containing STX5A, NSFL1C and VCP. Identified in a unique SNARE complex composed of the Golgi SNAREs GOSR1, GOSR2, YKT6 and VTI1A. Interacts with COG4 (By similarity).By similarity

Protein-protein interaction databases

BioGridi207947. 1 interaction.
IntActiQ8K1E0. 1 interaction.
MINTiMINT-4136014.

Structurei

3D structure databases

ProteinModelPortaliQ8K1E0.
SMRiQ8K1E0. Positions 263-354.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 333333CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini355 – 3551VesicularSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei334 – 35421Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini263 – 32563t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili287 – 31832Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG326964.
GeneTreeiENSGT00390000000652.
HOGENOMiHOG000194860.
HOVERGENiHBG001973.
InParanoidiQ8K1E0.
KOiK08490.
PhylomeDBiQ8K1E0.
TreeFamiTF315068.

Family and domain databases

InterProiIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. Align

Isoform 1 (identifier: Q8K1E0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIPRKRYGSK NTDQGVYLGL SKTQVLSPAT AISSSSDSTP LPTPVALVPS
60 70 80 90 100
PPDTMSCRDR TQEFQSACKS LQSRQNGIQT SKPALHAARQ CSEFTLMARR
110 120 130 140 150
IGKDLSNTFA KLEKLTILAK RKSLFDDKAV EIEELTYIIK QDINSLNKQI
160 170 180 190 200
AQLQDFVRAK GSQSGRHLQT HSNTIVVSLQ SKLASMSNDF KSVLEVRTEN
210 220 230 240 250
LKQQRNRREQ FSRAPVSALP LAPNNLGGGP IILGAESRAS RDVAIDMMDP
260 270 280 290 300
RTSQQLQLID EQDSYIQSRA DTMQNIESTI VELGSIFQQL AHMVKEQEET
310 320 330 340 350
IQRIDENVLG AQLDVEAAHS EILKYFQSVT SNRWLMVKIF LILIVFFIIF

VVFLA

Note: No experimental confirmation available.

Length:355
Mass (Da):39,713
Last modified:September 5, 2006 - v3
Checksum:i29CFD4EA5665CFEF
GO
Isoform 2 (identifier: Q8K1E0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.

Note: Produced by alternative initiation at Met-55 of isoform 1.

Show »
Length:301
Mass (Da):34,103
Checksum:i561706F552EB9D93
GO

Sequence cautioni

The sequence AAH04849.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAH21883.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti91 – 911C → S in AAH21883. (PubMed:15489334)Curated
Sequence conflicti179 – 1802LQ → FE in AAF36981. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5454Missing in isoform 2. 2 PublicationsVSP_020118Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF232709 mRNA. Translation: AAF36981.1.
AK166087 mRNA. Translation: BAE38563.1.
BC004849 mRNA. Translation: AAH04849.1. Different initiation.
BC021883 mRNA. Translation: AAH21883.1. Different initiation.
CCDSiCCDS29542.2. [Q8K1E0-1]
RefSeqiNP_001161271.1. NM_001167799.1. [Q8K1E0-1]
NP_062803.4. NM_019829.4. [Q8K1E0-1]
XP_006527287.1. XM_006527224.1. [Q8K1E0-1]
XP_006527288.1. XM_006527225.1. [Q8K1E0-1]
XP_006527289.1. XM_006527226.1. [Q8K1E0-1]
UniGeneiMm.153061.

Genome annotation databases

EnsembliENSMUST00000073430; ENSMUSP00000073136; ENSMUSG00000010110. [Q8K1E0-1]
ENSMUST00000176381; ENSMUSP00000134854; ENSMUSG00000010110. [Q8K1E0-1]
GeneIDi56389.
KEGGimmu:56389.
UCSCiuc008gmo.2. mouse. [Q8K1E0-1]

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF232709 mRNA. Translation: AAF36981.1 .
AK166087 mRNA. Translation: BAE38563.1 .
BC004849 mRNA. Translation: AAH04849.1 . Different initiation.
BC021883 mRNA. Translation: AAH21883.1 . Different initiation.
CCDSi CCDS29542.2. [Q8K1E0-1 ]
RefSeqi NP_001161271.1. NM_001167799.1. [Q8K1E0-1 ]
NP_062803.4. NM_019829.4. [Q8K1E0-1 ]
XP_006527287.1. XM_006527224.1. [Q8K1E0-1 ]
XP_006527288.1. XM_006527225.1. [Q8K1E0-1 ]
XP_006527289.1. XM_006527226.1. [Q8K1E0-1 ]
UniGenei Mm.153061.

3D structure databases

ProteinModelPortali Q8K1E0.
SMRi Q8K1E0. Positions 263-354.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 207947. 1 interaction.
IntActi Q8K1E0. 1 interaction.
MINTi MINT-4136014.

PTM databases

PhosphoSitei Q8K1E0.

Proteomic databases

MaxQBi Q8K1E0.
PaxDbi Q8K1E0.
PRIDEi Q8K1E0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000073430 ; ENSMUSP00000073136 ; ENSMUSG00000010110 . [Q8K1E0-1 ]
ENSMUST00000176381 ; ENSMUSP00000134854 ; ENSMUSG00000010110 . [Q8K1E0-1 ]
GeneIDi 56389.
KEGGi mmu:56389.
UCSCi uc008gmo.2. mouse. [Q8K1E0-1 ]

Organism-specific databases

CTDi 56389.
MGIi MGI:1928483. Stx5a.

Phylogenomic databases

eggNOGi NOG326964.
GeneTreei ENSGT00390000000652.
HOGENOMi HOG000194860.
HOVERGENi HBG001973.
InParanoidi Q8K1E0.
KOi K08490.
PhylomeDBi Q8K1E0.
TreeFami TF315068.

Miscellaneous databases

NextBioi 312484.
PROi Q8K1E0.
SOURCEi Search...

Gene expression databases

Bgeei Q8K1E0.
CleanExi MM_STX5A.
ExpressionAtlasi Q8K1E0. baseline and differential.
Genevestigatori Q8K1E0.

Family and domain databases

InterProi IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view ]
Pfami PF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view ]
SMARTi SM00397. t_SNARE. 1 hit.
[Graphical view ]
SUPFAMi SSF47661. SSF47661. 1 hit.
PROSITEi PS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse syntaxin 5."
    Low D.Y.H., Tang B.L., Hong W.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Lung.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N-3.
    Tissue: Mammary gland.
  4. "A 29-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (Vti1-rp2) implicated in protein trafficking in the secretory pathway."
    Xu Y., Wong S.H., Tang B.L., Subramaniam V.N., Zhang T., Hong W.
    J. Biol. Chem. 273:21783-21789(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN SNARE COMPLEX WITH VTI1A, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSTX5_MOUSE
AccessioniPrimary (citable) accession number: Q8K1E0
Secondary accession number(s): Q3TM79, Q99J28, Q9JKP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3