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Protein

Leucine-rich repeat-containing protein 41

Gene

Lrrc41

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 41
Alternative name(s):
Protein Muf1
Gene namesi
Name:Lrrc41
Synonyms:Muf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2441984. Lrrc41.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • membrane Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi46 – 461L → P: No association with Elongin BC complex; when associated with F-50. 1 Publication
Mutagenesisi50 – 501C → F: No association with Elongin BC complex; when associated with P-46. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 807807Leucine-rich repeat-containing protein 41PRO_0000096646Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei276 – 2761PhosphoserineBy similarity
Modified residuei327 – 3271PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8K1C9.
MaxQBiQ8K1C9.
PaxDbiQ8K1C9.
PRIDEiQ8K1C9.

PTM databases

PhosphoSiteiQ8K1C9.

Expressioni

Gene expression databases

BgeeiQ8K1C9.
CleanExiMM_LRRC41.
GenevisibleiQ8K1C9. MM.

Interactioni

Subunit structurei

Part of an E3 ubiquitin-protein ligase complex with Elongin BC (TCEB1 and TCEB2), RBX1 and CUL5. Component of a probable ECS(LRRC41) complex which contains CUL5, RNF7/RBX2, Elongin BC and LRRC41. Interacts with CUL5, RNF7, TCEB1 and TCEB2 (By similarity).By similarity

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi230994. 10 interactions.
IntActiQ8K1C9. 4 interactions.
STRINGi10090.ENSMUSP00000030471.

Structurei

3D structure databases

ProteinModelPortaliQ8K1C9.
SMRiQ8K1C9. Positions 454-557, 607-772.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati482 – 50221LRR 1Add
BLAST
Repeati513 – 52513LRR 2Add
BLAST
Repeati526 – 55025LRR 3Add
BLAST
Repeati608 – 63225LRR 4Add
BLAST
Repeati638 – 66124LRR 5Add
BLAST
Repeati696 – 72328LRR 6Add
BLAST
Repeati726 – 74722LRR 7Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni45 – 5410Interaction with Elongin BC complexBy similarity

Domaini

The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].

Sequence similaritiesi

Contains 7 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IHRR. Eukaryota.
ENOG410YFW5. LUCA.
GeneTreeiENSGT00390000015908.
HOGENOMiHOG000013094.
HOVERGENiHBG102701.
InParanoidiQ8K1C9.
KOiK10347.
OMAiFADYISV.
OrthoDBiEOG7060QB.
PhylomeDBiQ8K1C9.
TreeFamiTF335481.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR026137. Leu_rpt_41.
[Graphical view]
PANTHERiPTHR15354. PTHR15354. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K1C9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPEAWRAR SCWFCEVAAA TTMEATSREA APAKSSASGP SAPPALFELC
60 70 80 90 100
GRAVSAHMGV LESGVWALPG PILQSILPLL NIYYLERIEE TALKKGLSTQ
110 120 130 140 150
AIWRRLWDEL MKTRPSSLES VTCWRAKFME AFFSHVLRGT IDVSSDKRLC
160 170 180 190 200
DQRFSPLLHS SRHVRQLTIC NMLQGATELV AEPNRRVLET LASSLHTLKF
210 220 230 240 250
RHLLFSDVAA QQSLRQLLHQ LIHHGAVSQV SLYSWPVPES ALFILILTMS
260 270 280 290 300
AGFWQPGPGS LPCRLCGEAS RGRAPSRDEG SLLLGSRRPR RDAAERCAAA
310 320 330 340 350
LMATRRKSEV KQMPRAVPPT RVTRRSTQES LAIGGTDSKL YLPATSYEAS
360 370 380 390 400
GTKQPSAPAA ASASSSTSSK RAPASSASQP KPLKRFKRAA GKKGPRTRQG
410 420 430 440 450
SGAESEDLYD FVFIVAGEKE DGEEMEIGEV ACGALDGSDP SCLGLPALEA
460 470 480 490 500
SQRFRSISTL ELFTVPLSTE AALTLCHLLS SWVSLESLTL SYNGLGSNIF
510 520 530 540 550
RLLDSLRALS GQAGCRLRAL HLSDLFSPLP ILELTRAIVR ALPLLRVLSI
560 570 580 590 600
RVDHPSQRDN PAVPENAGPP GHIVGDEEIP ENCLEQLEMG FPRGAQPAPL
610 620 630 640 650
LCSVLKASGS LQQLSLDSAT FASPQDFGLV LQTLKEHNLS LKRLSFHDMN
660 670 680 690 700
LADCQSEVLF LLKNLTLQEI TFSFCRLFEK RPVQFLPEMV AAMKGNSTLK
710 720 730 740 750
GLRLPGNRLG NAGLLALADV FSEDSSSSLC QLDISSNCIK PDGLLEFAKR
760 770 780 790 800
LERWGRGAFG HLRLFQNWLD QDAVTAREAI RRLRATCHVV SDSWDSTQAF

ADYVSTM
Length:807
Mass (Da):88,180
Last modified:June 26, 2007 - v3
Checksum:i79F6BBF2D4A33B97
GO

Sequence cautioni

The sequence AAH22976.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 509APPALFELC → RTRGSTHAS in AAH71258 (PubMed:15489334).Curated
Sequence conflicti51 – 511G → E in BAE32713 (PubMed:16141072).Curated
Sequence conflicti672 – 6721F → Y in BAE32713 (PubMed:16141072).Curated
Sequence conflicti733 – 7331D → G in BAE32713 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154613 mRNA. Translation: BAE32713.1.
AL627105 Genomic DNA. Translation: CAM22675.1.
BC007169 mRNA. Translation: AAH07169.1.
BC022976 mRNA. Translation: AAH22976.2. Different initiation.
BC071258 mRNA. Translation: AAH71258.1.
RefSeqiNP_705741.3. NM_153521.2.
UniGeneiMm.260786.
Mm.3655.

Genome annotation databases

EnsembliENSMUST00000030471; ENSMUSP00000030471; ENSMUSG00000028703.
GeneIDi230654.
KEGGimmu:230654.
UCSCiuc008ufx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154613 mRNA. Translation: BAE32713.1.
AL627105 Genomic DNA. Translation: CAM22675.1.
BC007169 mRNA. Translation: AAH07169.1.
BC022976 mRNA. Translation: AAH22976.2. Different initiation.
BC071258 mRNA. Translation: AAH71258.1.
RefSeqiNP_705741.3. NM_153521.2.
UniGeneiMm.260786.
Mm.3655.

3D structure databases

ProteinModelPortaliQ8K1C9.
SMRiQ8K1C9. Positions 454-557, 607-772.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230994. 10 interactions.
IntActiQ8K1C9. 4 interactions.
STRINGi10090.ENSMUSP00000030471.

PTM databases

PhosphoSiteiQ8K1C9.

Proteomic databases

EPDiQ8K1C9.
MaxQBiQ8K1C9.
PaxDbiQ8K1C9.
PRIDEiQ8K1C9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030471; ENSMUSP00000030471; ENSMUSG00000028703.
GeneIDi230654.
KEGGimmu:230654.
UCSCiuc008ufx.1. mouse.

Organism-specific databases

CTDi10489.
MGIiMGI:2441984. Lrrc41.

Phylogenomic databases

eggNOGiENOG410IHRR. Eukaryota.
ENOG410YFW5. LUCA.
GeneTreeiENSGT00390000015908.
HOGENOMiHOG000013094.
HOVERGENiHBG102701.
InParanoidiQ8K1C9.
KOiK10347.
OMAiFADYISV.
OrthoDBiEOG7060QB.
PhylomeDBiQ8K1C9.
TreeFamiTF335481.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiLrrc41. mouse.
NextBioi380025.
PROiQ8K1C9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K1C9.
CleanExiMM_LRRC41.
GenevisibleiQ8K1C9. MM.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR026137. Leu_rpt_41.
[Graphical view]
PANTHERiPTHR15354. PTHR15354. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-807.
    Strain: C57BL/6J.
    Tissue: Mammary gland and Retina.
  4. "Muf1, a novel elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase."
    Kamura T., Burian D., Yan Q., Schmidt S.L., Lane W.S., Querido E., Branton P.E., Shilatifard A., Conaway R.C., Conaway J.W.
    J. Biol. Chem. 276:29748-29753(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, RECONSTRUCTION FROM ESTS, MUTAGENESIS OF LEU-46 AND CYS-50, IDENTIFICATION IN E3 UBIQUITIN LIGASE COMPLEX WITH CUL5.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-327, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen and Testis.

Entry informationi

Entry nameiLRC41_MOUSE
AccessioniPrimary (citable) accession number: Q8K1C9
Secondary accession number(s): A2A911
, Q3U3S2, Q6IQY7, Q91VX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 26, 2007
Last modified: March 16, 2016
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-23 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.