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Q8K1B9

- GLT18_MOUSE

UniProt

Q8K1B9 - GLT18_MOUSE

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Protein
Polypeptide N-acetylgalactosaminyltransferase 18
Gene
Galnt18, Galntl4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor By similarity.

Catalytic activityi

UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.

Cofactori

Manganese By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei194 – 1941Substrate By similarity
Metal bindingi251 – 2511Manganese By similarity
Metal bindingi253 – 2531Manganese By similarity
Metal bindingi397 – 3971Manganese By similarity
Binding sitei400 – 4001Substrate By similarity
Binding sitei405 – 4051Substrate By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. polypeptide N-acetylgalactosaminyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Lectin, Manganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiCBM13. Carbohydrate-Binding Module Family 13.
GT27. Glycosyltransferase Family 27.

Names & Taxonomyi

Protein namesi
Recommended name:
Polypeptide N-acetylgalactosaminyltransferase 18 (EC:2.4.1.41)
Alternative name(s):
Polypeptide GalNAc transferase 18
Short name:
GalNAc-T18
Polypeptide GalNAc transferase-like protein 4
Short name:
GalNAc-T-like protein 4
Short name:
pp-GaNTase-like protein 4
Polypeptide N-acetylgalactosaminyltransferase-like protein 4
Protein-UDP acetylgalactosaminyltransferase-like protein 4
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 4
Gene namesi
Name:Galnt18
Synonyms:Galntl4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:2446239. Galnt18.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei13 – 3523Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini36 – 622587Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 622622Polypeptide N-acetylgalactosaminyltransferase 18
PRO_0000059142Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi144 ↔ 392 By similarity
Glycosylationi146 – 1461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi195 – 1951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi320 – 3201N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi383 ↔ 462 By similarity
Disulfide bondi497 ↔ 513 By similarity
Disulfide bondi545 ↔ 558 By similarity
Disulfide bondi586 ↔ 606 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8K1B9.

PTM databases

PhosphoSiteiQ8K1B9.

Expressioni

Gene expression databases

ArrayExpressiQ8K1B9.
BgeeiQ8K1B9.
GenevestigatoriQ8K1B9.

Structurei

3D structure databases

ProteinModelPortaliQ8K1B9.
SMRiQ8K1B9. Positions 121-616.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini484 – 614131Ricin B-type lectin
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni153 – 267115Catalytic subdomain A
Add
BLAST
Regioni324 – 40077Catalytic subdomain B
Add
BLAST

Domaini

There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding By similarity.
The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity By similarity.

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG123124.
GeneTreeiENSGT00670000097647.
HOGENOMiHOG000038228.
HOVERGENiHBG051699.
InParanoidiQ8K1B9.
KOiK00710.
OMAiAPDKKLE.
OrthoDBiEOG70087G.
PhylomeDBiQ8K1B9.
TreeFamiTF313267.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF00535. Glycos_transf_2. 1 hit.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view]
SMARTiSM00458. RICIN. 1 hit.
[Graphical view]
SUPFAMiSSF50370. SSF50370. 1 hit.
SSF53448. SSF53448. 1 hit.
PROSITEiPS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K1B9-1 [UniParc]FASTAAdd to Basket

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MVCTRKTKTL VSTCVILSGM TNIICLLYVG WVTNYIASVY VRGQEPVPDK    50
KLEEDKGDTL KIIERLDHLE NVIKQHIQEA PAKPEEAEAE PFTDSSLFAH 100
WGQELSPEGR RVALKQFQYY GYNAYLSDRL PLDRPLPDLR PSGCRNLSFP 150
DSLPEVSIVF IFVNEALSVL LRSIHSAMER TPSHLLKEII LVDDNSSNEE 200
LKEKLTEYVD KVNGQKPGFI KVVRHSKQEG LIRSRVSGWR AATAPVVALF 250
DAHVEFNVGW AEPVLTRIKE NRKRIISPSF DNIKYDNFEI EEYPLAAQGF 300
DWELWCRYLN PPKAWWKLEN STAPIRSPAL IGCFIVDRQY FEEIGLLDEG 350
MEVYGGENVE LGIRVSEISH TGLSSAPMMV WQCGGSVEVL PCSRIAHIER 400
AHKPYTEDLT AHVRRNALRV AEVWMDEFKS HVYMAWNIPQ EDSGIDIGDI 450
TARKALRKQL QCKTFRWYLV SVYPEMRMYS DIIAYGVLQN SLKTDLCLDQ 500
GPDTENVPIV YICHGMTPQN VYYTSSQQIH VGILSPTVDD DDNRCLVDVN 550
SRPRLIECSY AKAKRMKLHW QFSQGGSIQN RKSKRCLELQ ENSDMEFGFQ 600
LVLQKCSGQH WTITNVLRSL VS 622
Length:622
Mass (Da):71,096
Last modified:October 1, 2002 - v1
Checksum:i4FE9493795E3A561
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC024988 mRNA. Translation: AAH24988.1.
CCDSiCCDS21751.1.
RefSeqiNP_776100.2. NM_173739.3.
UniGeneiMm.323322.

Genome annotation databases

EnsembliENSMUST00000049430; ENSMUSP00000043636; ENSMUSG00000038296.
GeneIDi233733.
KEGGimmu:233733.
UCSCiuc009jgc.1. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

Putative polypeptide N-acetylgalactosaminyltransferase-like protein 4

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC024988 mRNA. Translation: AAH24988.1 .
CCDSi CCDS21751.1.
RefSeqi NP_776100.2. NM_173739.3.
UniGenei Mm.323322.

3D structure databases

ProteinModelPortali Q8K1B9.
SMRi Q8K1B9. Positions 121-616.
ModBasei Search...

Protein family/group databases

CAZyi CBM13. Carbohydrate-Binding Module Family 13.
GT27. Glycosyltransferase Family 27.

PTM databases

PhosphoSitei Q8K1B9.

Proteomic databases

PRIDEi Q8K1B9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000049430 ; ENSMUSP00000043636 ; ENSMUSG00000038296 .
GeneIDi 233733.
KEGGi mmu:233733.
UCSCi uc009jgc.1. mouse.

Organism-specific databases

CTDi 374378.
MGIi MGI:2446239. Galnt18.

Phylogenomic databases

eggNOGi NOG123124.
GeneTreei ENSGT00670000097647.
HOGENOMi HOG000038228.
HOVERGENi HBG051699.
InParanoidi Q8K1B9.
KOi K00710.
OMAi APDKKLE.
OrthoDBi EOG70087G.
PhylomeDBi Q8K1B9.
TreeFami TF313267.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Miscellaneous databases

NextBioi 381803.
PROi Q8K1B9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8K1B9.
Bgeei Q8K1B9.
Genevestigatori Q8K1B9.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
IPR000772. Ricin_B_lectin.
[Graphical view ]
Pfami PF00535. Glycos_transf_2. 1 hit.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view ]
SMARTi SM00458. RICIN. 1 hit.
[Graphical view ]
SUPFAMi SSF50370. SSF50370. 1 hit.
SSF53448. SSF53448. 1 hit.
PROSITEi PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.

Entry informationi

Entry nameiGLT18_MOUSE
AccessioniPrimary (citable) accession number: Q8K1B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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