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Protein

Methyltransferase-like protein 5

Gene

Mettl5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable methyltransferase.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase-like protein 5 (EC:2.1.1.-)
Gene namesi
Name:Mettl5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1922672. Mettl5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Methyltransferase-like protein 5PRO_0000251920Add
BLAST

Proteomic databases

EPDiQ8K1A0.
MaxQBiQ8K1A0.
PaxDbiQ8K1A0.
PeptideAtlasiQ8K1A0.
PRIDEiQ8K1A0.

PTM databases

PhosphoSiteiQ8K1A0.

Expressioni

Gene expression databases

BgeeiQ8K1A0.
CleanExiMM_METTL5.
ExpressionAtlasiQ8K1A0. baseline and differential.
GenevisibleiQ8K1A0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050907.

Structurei

3D structure databases

ProteinModelPortaliQ8K1A0.
SMRiQ8K1A0. Positions 7-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3420. Eukaryota.
COG2263. LUCA.
GeneTreeiENSGT00390000000227.
HOGENOMiHOG000222792.
HOVERGENiHBG054508.
InParanoidiQ8K1A0.
OMAiINPPFGT.
OrthoDBiEOG7SV0WZ.
PhylomeDBiQ8K1A0.
TreeFamiTF314953.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR029063. SAM-dependent_MTases.
IPR007848. Small_mtfrase_dom.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K1A0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLKLKELE SRLQEVDGFE KPKLLLEQYP TRPHIAACML YTIHNTYDDI
60 70 80 90 100
ENKAVADLGC GCGVLSIGAA MLGAGLCVGF DIDEDALEIF NKNVEEFELT
110 120 130 140 150
NVDMIQCDVY SLSNRMSKLF DTVIMNPPFG TKNNKGTDMA FLKTALGMAR
160 170 180 190 200
TAVYSLHKSS TREHIQKKAA EWKVKIEIIA ELRYDLPALY NFHKKKSVDI

EVDLIRFSF
Length:209
Mass (Da):23,662
Last modified:October 3, 2006 - v2
Checksum:i3BA9EB63B7D1CD7B
GO

Sequence cautioni

The sequence AAH27547.1 differs from that shown. Reason: Frameshift at position 157. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC027547 mRNA. Translation: AAH27547.1. Frameshift.
CCDSiCCDS16103.2.
RefSeqiNP_083556.2. NM_029280.4.
UniGeneiMm.10508.
Mm.268657.

Genome annotation databases

EnsembliENSMUST00000060447; ENSMUSP00000050907; ENSMUSG00000051730.
GeneIDi75422.
KEGGimmu:75422.
UCSCiuc008jyv.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC027547 mRNA. Translation: AAH27547.1. Frameshift.
CCDSiCCDS16103.2.
RefSeqiNP_083556.2. NM_029280.4.
UniGeneiMm.10508.
Mm.268657.

3D structure databases

ProteinModelPortaliQ8K1A0.
SMRiQ8K1A0. Positions 7-208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050907.

PTM databases

PhosphoSiteiQ8K1A0.

Proteomic databases

EPDiQ8K1A0.
MaxQBiQ8K1A0.
PaxDbiQ8K1A0.
PeptideAtlasiQ8K1A0.
PRIDEiQ8K1A0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060447; ENSMUSP00000050907; ENSMUSG00000051730.
GeneIDi75422.
KEGGimmu:75422.
UCSCiuc008jyv.3. mouse.

Organism-specific databases

CTDi29081.
MGIiMGI:1922672. Mettl5.

Phylogenomic databases

eggNOGiKOG3420. Eukaryota.
COG2263. LUCA.
GeneTreeiENSGT00390000000227.
HOGENOMiHOG000222792.
HOVERGENiHBG054508.
InParanoidiQ8K1A0.
OMAiINPPFGT.
OrthoDBiEOG7SV0WZ.
PhylomeDBiQ8K1A0.
TreeFamiTF314953.

Miscellaneous databases

PROiQ8K1A0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K1A0.
CleanExiMM_METTL5.
ExpressionAtlasiQ8K1A0. baseline and differential.
GenevisibleiQ8K1A0. MM.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR029063. SAM-dependent_MTases.
IPR007848. Small_mtfrase_dom.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.

Entry informationi

Entry nameiMETL5_MOUSE
AccessioniPrimary (citable) accession number: Q8K1A0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: July 6, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.