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Protein

COX assembly mitochondrial protein 2 homolog

Gene

Cmc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May be involved in cytochrome c oxidase biogenesis.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
COX assembly mitochondrial protein 2 homolog
Gene namesi
Name:Cmc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1913781. Cmc2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001929441 – 79COX assembly mitochondrial protein 2 homologAdd BLAST79

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi14 ↔ 47PROSITE-ProRule annotation
Disulfide bondi24 ↔ 37PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ8K199.
MaxQBiQ8K199.
PaxDbiQ8K199.
PeptideAtlasiQ8K199.
PRIDEiQ8K199.

PTM databases

iPTMnetiQ8K199.
PhosphoSitePlusiQ8K199.

Expressioni

Gene expression databases

BgeeiENSMUSG00000014633.
CleanExiMM_2310061C15RIK.
ExpressionAtlasiQ8K199. baseline and differential.
GenevisibleiQ8K199. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000120966.

Structurei

3D structure databases

ProteinModelPortaliQ8K199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 55CHCHPROSITE-ProRule annotationAdd BLAST45

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi14 – 24Cx9C motif 1PROSITE-ProRule annotationAdd BLAST11
Motifi37 – 47Cx9C motif 2PROSITE-ProRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the CMC family.Curated

Phylogenomic databases

eggNOGiKOG4148. Eukaryota.
ENOG41123JB. LUCA.
GeneTreeiENSGT00390000016908.
HOGENOMiHOG000212591.
HOVERGENiHBG045487.
InParanoidiQ8K199.
KOiK18172.
OMAiCHKEHNV.
TreeFamiTF314049.

Family and domain databases

InterProiView protein in InterPro
IPR013892. Cyt_c_biogenesis_Cmc1-like.
PfamiView protein in Pfam
PF08583. Cmc1. 1 hit.
PROSITEiView protein in PROSITE
PS51808. CHCH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K199-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPDLSPHLH TEECNVLINL LKECHKNHNI LKFFGHCNDL DREMRKCLKN
60 70
EYSERRTRSR EHGAAMRRRL SDPPEEAGR
Length:79
Mass (Da):9,419
Last modified:October 1, 2002 - v1
Checksum:i27B3EDBAEBB3F54A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002429 mRNA. Translation: BAC24989.1.
AK013475 mRNA. Translation: BAC25407.1.
BC027549 mRNA. Translation: AAH27549.1.
CCDSiCCDS40489.1.
RefSeqiNP_081120.2. NM_026844.3.
XP_006531345.1. XM_006531282.2.
XP_011246787.1. XM_011248485.2.
UniGeneiMm.4011.

Genome annotation databases

EnsembliENSMUST00000148235; ENSMUSP00000120966; ENSMUSG00000014633.
GeneIDi66531.
KEGGimmu:66531.
UCSCiuc009nom.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCOXM2_MOUSE
AccessioniPrimary (citable) accession number: Q8K199
Secondary accession number(s): Q8CEV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 1, 2002
Last modified: June 7, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families