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Q8K183 (PDXK_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyridoxal kinase
EC=2.7.1.35
Alternative name(s):
Pyridoxine kinase
Gene names
Name:Pdxk
Synonyms:Pkh
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for synthesis of pyridoxal-5-phosphate from vitamin B6 By similarity.

Catalytic activity

ATP + pyridoxal = ADP + pyridoxal 5'-phosphate.

Cofactor

Divalent cations. Zinc is more efficient than magnesium By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the pyridoxine kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Pyridoxal kinase
PRO_0000213336

Regions

Nucleotide binding186 – 1872ATP By similarity
Nucleotide binding223 – 23412ATP By similarity

Sites

Binding site121Substrate By similarity
Binding site471Substrate By similarity
Binding site1271Substrate By similarity
Binding site2351Substrate By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue591Phosphoserine By similarity
Modified residue841Phosphotyrosine By similarity
Modified residue1641Phosphoserine By similarity
Modified residue1961Phosphoserine By similarity
Modified residue2041Phosphoserine By similarity
Modified residue2131Phosphoserine By similarity
Modified residue2591Phosphothreonine By similarity
Modified residue2851Phosphoserine By similarity

Experimental info

Sequence conflict1881S → F in BAC38041. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8K183 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: C4F32E8A27E751AF

FASTA31235,015
        10         20         30         40         50         60 
MEGECRVLSI QSHVVRGYVG NRAAMFPLQV LGFEVDAVNS VQFSNHTGYA HWKGQVLKSQ 

        70         80         90        100        110        120 
ELHELYEGLK VNDVNKYDYV LTGYTRDKSF LAMVVDIVRE LKQQNSRLVY VCDPVMGDKW 

       130        140        150        160        170        180 
NGEGSMYVPQ DLLPVYRDKV VPVADIITPN QFEAELLSGR KIHSQEEAFE VMDMLHCMGP 

       190        200        210        220        230        240 
DTVVITSSDL PSSQGSDYLI ALGSQRMRKP DGSTVTQRIR MEMRKVEAVF VGTGDLFAAM 

       250        260        270        280        290        300 
LLAWTHKHPD NLKVACEKTV SAMQHVLQRT IRCAKAEAGE GQKPSPAQLE LRMVQSKRDI 

       310 
EDPEIVVQAT VL

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Brain, Hypothalamus, Lung and Mammary gland.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[3]Lubec G., Klug S.
Submitted (MAR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 140-160, MASS SPECTROMETRY.
Tissue: Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK039194 mRNA. Translation: BAC30274.1.
AK080846 mRNA. Translation: BAC38041.1.
AK145470 mRNA. Translation: BAE26454.1.
AK166078 mRNA. Translation: BAE38559.1.
AK166464 mRNA. Translation: BAE38792.1.
BC027745 mRNA. Translation: AAH27745.1.
IPIIPI00283511.
RefSeqNP_742146.1. NM_172134.2.
UniGeneMm.206159.

3D structure databases

ProteinModelPortalQ8K183.
SMRQ8K183. Positions 4-312.
ModBaseSearch...

Protein-protein interaction databases

IntActQ8K183. 2 interactions.
STRINGQ8K183.

PTM databases

PhosphoSiteQ8K183.

Proteomic databases

PRIDEQ8K183.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000041616; ENSMUSP00000038540; ENSMUSG00000032788.
GeneID216134.
KEGGmmu:216134.
NMPDRfig|10090.3.peg.13944.
UCSCuc007fxu.2. mouse.

Organism-specific databases

CTD8566.
MGIMGI:1351869. Pdxk.

Phylogenomic databases

eggNOGroNOG15867.
GeneTreeENSGT00390000003874.
HOGENOMHBG661459.
HOVERGENHBG000732.
InParanoidQ8K183.
OMALEIRLIQ.
OrthoDBEOG4XPQGC.
PhylomeDBQ8K183.

Gene expression databases

ArrayExpressQ8K183.
BgeeQ8K183.
CleanExMM_PDXK.
GenevestigatorQ8K183.
GermOnlineENSMUSG00000032788. Mus musculus.

Family and domain databases

InterProIPR011611. Carb/pur_kinase.
IPR004625. PyrdxlP_synth_PyrdxlKinase.
[Graphical view]
KOK00868.
PANTHERPTHR10534. PTHR10534. 1 hit.
PfamPF00294. PfkB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00687. Pyridox_kin. 1 hit.
ProtoNetSearch...

Other

NextBio374990.
SOURCESearch...

Entry information

Entry namePDXK_MOUSE
AccessionPrimary (citable) accession number: Q8K183
Secondary accession number(s): Q3TM83, Q8BJQ5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: October 1, 2002
Last modified: November 16, 2011
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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