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Protein

Dyslexia-associated protein KIAA0319-like protein

Gene

Kiaa0319l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Possible role in axon guidance through interaction with RTN4R.By similarity
(Microbial infection) Acts as a receptor for adeno-associated virus and is involved in adeno-associated virus infection through endocytosis system.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Dyslexia-associated protein KIAA0319-like proteinBy similarity
Alternative name(s):
Adeno-associated virus receptorBy similarity
Short name:
AAVRBy similarity
Gene namesi
Name:Kiaa0319lBy similarity
Synonyms:Aavr1 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2140475. AU040320.

Subcellular locationi

  • Cytoplasmic granule membrane By similarity; Multi-pass membrane protein By similarity
  • Golgi apparatus membrane By similarity; Multi-pass membrane protein
  • Golgi apparatustrans-Golgi network membrane By similarity; Multi-pass membrane protein By similarity
  • Cell membrane By similarity; Multi-pass membrane protein By similarity

  • Note: Traffics from the plasma membrane to the trans-Golgi network.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929CytoplasmicSequence analysisAdd
BLAST
Transmembranei30 – 5021HelicalSequence analysisAdd
BLAST
Topological domaini51 – 928878ExtracellularSequence analysisAdd
BLAST
Transmembranei929 – 94921HelicalSequence analysisAdd
BLAST
Topological domaini950 – 104899CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

Homozygous knockout mice Kiaa0319l are normal.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10481048Dyslexia-associated protein KIAA0319-like proteinPRO_0000329065Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi246 – 2461N-linked (GlcNAc...)Sequence analysis
Glycosylationi394 – 3941N-linked (GlcNAc...)Sequence analysis
Modified residuei1008 – 10081PhosphoserineCombined sources
Modified residuei1036 – 10361PhosphothreonineBy similarity

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8K135.
MaxQBiQ8K135.
PaxDbiQ8K135.
PRIDEiQ8K135.

PTM databases

iPTMnetiQ8K135.
PhosphoSiteiQ8K135.
SwissPalmiQ8K135.

Expressioni

Gene expression databases

BgeeiQ8K135.
ExpressionAtlasiQ8K135. baseline and differential.
GenevisibleiQ8K135. MM.

Interactioni

Subunit structurei

Interacts with RTN4R.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099667.

Structurei

3D structure databases

ProteinModelPortaliQ8K135.
SMRiQ8K135. Positions 599-687.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 12779MANSCPROSITE-ProRule annotationAdd
BLAST
Domaini309 – 40092PKD 1PROSITE-ProRule annotationAdd
BLAST
Domaini408 – 49790PKD 2PROSITE-ProRule annotationAdd
BLAST
Domaini503 – 59391PKD 3PROSITE-ProRule annotationAdd
BLAST
Domaini599 – 68789PKD 4PROSITE-ProRule annotationAdd
BLAST
Domaini693 – 78492PKD 5PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MANSC domain.PROSITE-ProRule annotation
Contains 5 PKD domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFQB. Eukaryota.
ENOG410XQ5Y. LUCA.
GeneTreeiENSGT00840000129825.
HOVERGENiHBG057130.
InParanoidiQ8K135.
OrthoDBiEOG79PJNJ.
PhylomeDBiQ8K135.
TreeFamiTF323356.

Family and domain databases

Gene3Di2.60.40.670. 2 hits.
InterProiIPR029865. KIAA0319-like.
IPR013980. MANSC_dom.
IPR022409. PKD/Chitinase_dom.
IPR000601. PKD_dom.
[Graphical view]
PANTHERiPTHR10083:SF166. PTHR10083:SF166. 1 hit.
SMARTiSM00089. PKD. 5 hits.
[Graphical view]
SUPFAMiSSF49299. SSF49299. 4 hits.
PROSITEiPS50986. MANSC. 1 hit.
PS50093. PKD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8K135-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKRLGVKPS PASWVLPGYC WQTSVKLPRS LYLLYSFFCF SVLWLSTDAD
60 70 80 90 100
ESRCQQGKTL YGAGLRTEGE NHLRLLAGSL PFHACRAACC RDSACHALWW
110 120 130 140 150
LEGMCFQADC SKPQSCQPFR TDSSNSMLII FQKSQTTDDL GLLPEDDEPH
160 170 180 190 200
LLRLGWGRTS WRRQSLLGAP LTLSVPSSHH QSLLRDRQKR DLSVVPTHGA
210 220 230 240 250
MQHSKVNHSE EAGALSPTSA EVRKTITVAG SFTSNHTTQT PEWPKNVSIH
260 270 280 290 300
PEPSEHSSPV SGTPQVKSTE HSPTDAPLPV APSYSYATPT PQASSQSTSA
310 320 330 340 350
PHPVVKELVV SAGKSVQITL PKNEVQLNAF VLPEAEPGET YTYDWQLITH
360 370 380 390 400
PTDYSGEVER KHSQSLQLSK LTPGLYEFKV TVDGQNAHGE GYVNVTVKPE
410 420 430 440 450
PRKNRPPVAV VSPQFQEISL PTTSTIIDGS QSTDDDKIVQ YHWEELKGPL
460 470 480 490 500
REEKISEDTA ILKLSKLVPG NYTFSLTVVD SDGATNSTTA SLTVNKAVDY
510 520 530 540 550
PPVANAGPNQ VITLPQNSIT LFGNQSTDDH GITSYEWSLS PSSKGKVVEM
560 570 580 590 600
QGVRTPALQL SAMQEGDYTY QLTVTDTAGQ QATAQVTVIV QPENNKPPQA
610 620 630 640 650
DAGPDKELTL PVDSTTLDGS KSTDDQRVVS YLWEQSRGPD GVQLENANSS
660 670 680 690 700
VATVTGLQVG TYVFTLTVKD ERNLQSQSSV NVIVKEEINK PPVAKIAGNV
710 720 730 740 750
VVTLPTSTAE LDGSRSSDDK GIVSYLWTRD ETSPAAGEVL NHSDHHPVLF
760 770 780 790 800
LSNLVEGTYT FHLKVTDAKG ESDTDRTTVE VKPDPRKSNL VEIILDVNVS
810 820 830 840 850
QLTERLKGML IRQIGVLLGV LDSDIIVQKI QPYTEQSTKM LFFVQNDPPH
860 870 880 890 900
QLFKGHEVAA MLKSELQKQK ADFLIFRALE ISTVTCQLNC SDHGHCDSFT
910 920 930 940 950
KRCVCDPFWM ENFIKVQLRD GDSNCEWSVL YVIIASFVIV VALGILSWTT
960 970 980 990 1000
ICCCKRQKGK PKRKSRYKIL DATDQESLEL KPTSRAGSKQ KGPTLSSSLM
1010 1020 1030 1040
HSESELDSDD AIFTWPDREK GKLLYGQNGS VPNGQTPLKS RSAREEIL
Length:1,048
Mass (Da):115,312
Last modified:October 1, 2002 - v1
Checksum:iF4D51DD6DE4C889D
GO
Isoform 2 (identifier: Q8K135-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1025-1048: YGQNGSVPNGQTPLKSRSAREEIL → ALHWCRSQSL...RTKSALVHGK

Note: No experimental confirmation available.
Show »
Length:1,085
Mass (Da):119,438
Checksum:i64CCADE9B26E84E0
GO

Sequence cautioni

The sequence AAH22154.1 differs from that shown.Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41R → G in BAC39244 (PubMed:16141072).Curated
Sequence conflicti579 – 5791Missing in BAE36422 (PubMed:16141072).Curated
Sequence conflicti656 – 6561G → V in BAC33818 (PubMed:16141072).Curated
Sequence conflicti684 – 6841V → A in BAC33818 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1025 – 104824YGQNG…REEIL → ALHWCRSQSLHHIGWWCRAP VCHETSSTNSTPGSDSGFCK GGKNLSSDYRTRTKSALVHG K in isoform 2. 1 PublicationVSP_032956Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043006 mRNA. Translation: BAC31432.1.
AK049570 mRNA. Translation: BAC33818.1.
AK084668 mRNA. Translation: BAC39244.1.
AK147569 mRNA. Translation: BAE27999.1.
AK161493 mRNA. Translation: BAE36422.1.
AK170261 mRNA. Translation: BAE41669.1.
AL606908 Genomic DNA. Translation: CAM19269.1.
AL606908 Genomic DNA. Translation: CAM19270.1.
BC022154 mRNA. Translation: AAH22154.1. Sequence problems.
BC028869 mRNA. Translation: AAH28869.1.
CCDSiCCDS18660.1. [Q8K135-2]
CCDS18661.1. [Q8K135-1]
RefSeqiNP_001030602.1. NM_001035525.1.
NP_001030603.1. NM_001035526.1.
NP_598647.1. NM_133886.2. [Q8K135-1]
UniGeneiMm.206206.

Genome annotation databases

EnsembliENSMUST00000047431; ENSMUSP00000037802; ENSMUSG00000028830. [Q8K135-1]
GeneIDi100317.
KEGGimmu:100317.
UCSCiuc008utw.1. mouse. [Q8K135-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043006 mRNA. Translation: BAC31432.1.
AK049570 mRNA. Translation: BAC33818.1.
AK084668 mRNA. Translation: BAC39244.1.
AK147569 mRNA. Translation: BAE27999.1.
AK161493 mRNA. Translation: BAE36422.1.
AK170261 mRNA. Translation: BAE41669.1.
AL606908 Genomic DNA. Translation: CAM19269.1.
AL606908 Genomic DNA. Translation: CAM19270.1.
BC022154 mRNA. Translation: AAH22154.1. Sequence problems.
BC028869 mRNA. Translation: AAH28869.1.
CCDSiCCDS18660.1. [Q8K135-2]
CCDS18661.1. [Q8K135-1]
RefSeqiNP_001030602.1. NM_001035525.1.
NP_001030603.1. NM_001035526.1.
NP_598647.1. NM_133886.2. [Q8K135-1]
UniGeneiMm.206206.

3D structure databases

ProteinModelPortaliQ8K135.
SMRiQ8K135. Positions 599-687.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099667.

PTM databases

iPTMnetiQ8K135.
PhosphoSiteiQ8K135.
SwissPalmiQ8K135.

Proteomic databases

EPDiQ8K135.
MaxQBiQ8K135.
PaxDbiQ8K135.
PRIDEiQ8K135.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047431; ENSMUSP00000037802; ENSMUSG00000028830. [Q8K135-1]
GeneIDi100317.
KEGGimmu:100317.
UCSCiuc008utw.1. mouse. [Q8K135-1]

Organism-specific databases

MGIiMGI:2140475. AU040320.

Phylogenomic databases

eggNOGiENOG410IFQB. Eukaryota.
ENOG410XQ5Y. LUCA.
GeneTreeiENSGT00840000129825.
HOVERGENiHBG057130.
InParanoidiQ8K135.
OrthoDBiEOG79PJNJ.
PhylomeDBiQ8K135.
TreeFamiTF323356.

Miscellaneous databases

PROiQ8K135.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K135.
ExpressionAtlasiQ8K135. baseline and differential.
GenevisibleiQ8K135. MM.

Family and domain databases

Gene3Di2.60.40.670. 2 hits.
InterProiIPR029865. KIAA0319-like.
IPR013980. MANSC_dom.
IPR022409. PKD/Chitinase_dom.
IPR000601. PKD_dom.
[Graphical view]
PANTHERiPTHR10083:SF166. PTHR10083:SF166. 1 hit.
SMARTiSM00089. PKD. 5 hits.
[Graphical view]
SUPFAMiSSF49299. SSF49299. 4 hits.
PROSITEiPS50986. MANSC. 1 hit.
PS50093. PKD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
    Tissue: Brain, Cerebellum, Embryo, Embryonic heart and Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Kidney and Liver.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1008, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney, Pancreas and Testis.
  5. Cited for: DISRUPTION PHENOTYPE, FUNCTION (MICROBIAL INFECTION).

Entry informationi

Entry nameiK319L_MOUSE
AccessioniPrimary (citable) accession number: Q8K135
Secondary accession number(s): A2A790
, Q3TTA3, Q8BHR5, Q8BHU7, Q8BHZ3, Q8VBZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.