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Protein

Peptide chain release factor 1, mitochondrial

Gene

Mtrf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-cognate termination stop codons AGG and AGA.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide chain release factor 1, mitochondrial
Short name:
MRF-1
Short name:
MtRF-1
Gene namesi
Name:Mtrf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2384815. Mtrf1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000030334? – 446Peptide chain release factor 1, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei314N5-methylglutamineBy similarity1

Post-translational modificationi

Methylation of glutamine in the GGQ triplet is conserved from bacteria to mammals.By similarity

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiQ8K126.
PaxDbiQ8K126.
PRIDEiQ8K126.

PTM databases

iPTMnetiQ8K126.
PhosphoSitePlusiQ8K126.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022022.
CleanExiMM_MTRF1.

Interactioni

Protein-protein interaction databases

IntActiQ8K126. 1 interactor.
STRINGi10090.ENSMUSP00000022600.

Structurei

3D structure databases

ProteinModelPortaliQ8K126.
SMRiQ8K126.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2726. Eukaryota.
COG0216. LUCA.
GeneTreeiENSGT00390000011879.
HOGENOMiHOG000074815.
HOVERGENiHBG017071.
InParanoidiQ8K126.
KOiK02835.
OMAiFLCGEKC.
OrthoDBiEOG091G0O7T.
PhylomeDBiQ8K126.
TreeFamiTF313720.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
[Graphical view]
PfamiPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTiSM00937. PCRF. 1 hit.
[Graphical view]
PROSITEiPS00745. RF_PROK_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K126-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHHLCIWLF RNPFLRACPQ RHVFLSCQQF RQISLDTRPW NFRQKKTHVL
60 70 80 90 100
YQLLNKSWSR GCCHQGTRKL WKHKALQKYM EDLNKEYQTL DQCLQGISEN
110 120 130 140 150
EGDRRALHRR HAQLAPLAAV YQEIQEAEQA IEELESLCKS LNKQDEKQLQ
160 170 180 190 200
ELVSEERQII DQKIHRLYSE LLERLVPKEK YDWSDVILEV TSGRTTGGDI
210 220 230 240 250
CQQFTREIFD MYQNYSYYKH WKFELLNYTP ADYGGLHHAA ARISGDSVYK
260 270 280 290 300
HLKYEGGIHR VQRIPEVGLS SRMQRIHTGT MSVIVLPQPD EVDVKVDPKD
310 320 330 340 350
LRVDTFRARG AGGQHVNTTD SAVRLVHIPT GLVVECQQER SQLKNKEIAL
360 370 380 390 400
RVLRARLYQQ IIEKDRCQQQ NARKLQVGTR AQSERIRTYN FTQDRVTDHR
410 420 430 440
IAYEVRDIKE FLRGEKCLDQ LIERLLQSAD EEAISEFLDE SLQSVK
Length:446
Mass (Da):52,458
Last modified:October 1, 2002 - v1
Checksum:iFC25AFF242025DE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043981 mRNA. Translation: BAC31724.1.
BC028898 mRNA. Translation: AAH28898.1.
CCDSiCCDS27297.1.
RefSeqiNP_666072.3. NM_145960.4.
UniGeneiMm.35306.

Genome annotation databases

EnsembliENSMUST00000022600; ENSMUSP00000022600; ENSMUSG00000022022.
GeneIDi211253.
KEGGimmu:211253.
UCSCiuc007usw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043981 mRNA. Translation: BAC31724.1.
BC028898 mRNA. Translation: AAH28898.1.
CCDSiCCDS27297.1.
RefSeqiNP_666072.3. NM_145960.4.
UniGeneiMm.35306.

3D structure databases

ProteinModelPortaliQ8K126.
SMRiQ8K126.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8K126. 1 interactor.
STRINGi10090.ENSMUSP00000022600.

PTM databases

iPTMnetiQ8K126.
PhosphoSitePlusiQ8K126.

Proteomic databases

MaxQBiQ8K126.
PaxDbiQ8K126.
PRIDEiQ8K126.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022600; ENSMUSP00000022600; ENSMUSG00000022022.
GeneIDi211253.
KEGGimmu:211253.
UCSCiuc007usw.1. mouse.

Organism-specific databases

CTDi9617.
MGIiMGI:2384815. Mtrf1.

Phylogenomic databases

eggNOGiKOG2726. Eukaryota.
COG0216. LUCA.
GeneTreeiENSGT00390000011879.
HOGENOMiHOG000074815.
HOVERGENiHBG017071.
InParanoidiQ8K126.
KOiK02835.
OMAiFLCGEKC.
OrthoDBiEOG091G0O7T.
PhylomeDBiQ8K126.
TreeFamiTF313720.

Miscellaneous databases

PROiQ8K126.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022022.
CleanExiMM_MTRF1.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
[Graphical view]
PfamiPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTiSM00937. PCRF. 1 hit.
[Graphical view]
PROSITEiPS00745. RF_PROK_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRF1M_MOUSE
AccessioniPrimary (citable) accession number: Q8K126
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.