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Protein

Peptide chain release factor 1, mitochondrial

Gene

Mtrf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-cognate termination stop codons AGG and AGA.By similarity

GO - Molecular functioni

Keywordsi

Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide chain release factor 1, mitochondrial
Short name:
MRF-1
Short name:
MtRF-1
Gene namesi
Name:Mtrf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2384815 Mtrf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000030334? – 446Peptide chain release factor 1, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei314N5-methylglutamineBy similarity1

Post-translational modificationi

Methylation of glutamine in the GGQ triplet is conserved from bacteria to mammals.By similarity

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiQ8K126
PaxDbiQ8K126
PRIDEiQ8K126

PTM databases

iPTMnetiQ8K126
PhosphoSitePlusiQ8K126

Expressioni

Gene expression databases

BgeeiENSMUSG00000022022
CleanExiMM_MTRF1

Interactioni

Protein-protein interaction databases

IntActiQ8K126, 1 interactor
STRINGi10090.ENSMUSP00000022600

Structurei

3D structure databases

ProteinModelPortaliQ8K126
SMRiQ8K126
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2726 Eukaryota
COG0216 LUCA
GeneTreeiENSGT00390000011879
HOGENOMiHOG000074815
HOVERGENiHBG017071
InParanoidiQ8K126
KOiK02835
OMAiFLCGEKC
OrthoDBiEOG091G0O7T
PhylomeDBiQ8K126
TreeFamiTF313720

Family and domain databases

InterProiView protein in InterPro
IPR005139 PCRF
IPR000352 Pep_chain_release_fac_I_II
PfamiView protein in Pfam
PF03462 PCRF, 1 hit
PF00472 RF-1, 1 hit
SMARTiView protein in SMART
SM00937 PCRF, 1 hit
PROSITEiView protein in PROSITE
PS00745 RF_PROK_I, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K126-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHHLCIWLF RNPFLRACPQ RHVFLSCQQF RQISLDTRPW NFRQKKTHVL
60 70 80 90 100
YQLLNKSWSR GCCHQGTRKL WKHKALQKYM EDLNKEYQTL DQCLQGISEN
110 120 130 140 150
EGDRRALHRR HAQLAPLAAV YQEIQEAEQA IEELESLCKS LNKQDEKQLQ
160 170 180 190 200
ELVSEERQII DQKIHRLYSE LLERLVPKEK YDWSDVILEV TSGRTTGGDI
210 220 230 240 250
CQQFTREIFD MYQNYSYYKH WKFELLNYTP ADYGGLHHAA ARISGDSVYK
260 270 280 290 300
HLKYEGGIHR VQRIPEVGLS SRMQRIHTGT MSVIVLPQPD EVDVKVDPKD
310 320 330 340 350
LRVDTFRARG AGGQHVNTTD SAVRLVHIPT GLVVECQQER SQLKNKEIAL
360 370 380 390 400
RVLRARLYQQ IIEKDRCQQQ NARKLQVGTR AQSERIRTYN FTQDRVTDHR
410 420 430 440
IAYEVRDIKE FLRGEKCLDQ LIERLLQSAD EEAISEFLDE SLQSVK
Length:446
Mass (Da):52,458
Last modified:October 1, 2002 - v1
Checksum:iFC25AFF242025DE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043981 mRNA Translation: BAC31724.1
BC028898 mRNA Translation: AAH28898.1
CCDSiCCDS27297.1
RefSeqiNP_666072.3, NM_145960.4
UniGeneiMm.35306

Genome annotation databases

EnsembliENSMUST00000022600; ENSMUSP00000022600; ENSMUSG00000022022
GeneIDi211253
KEGGimmu:211253
UCSCiuc007usw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRF1M_MOUSE
AccessioniPrimary (citable) accession number: Q8K126
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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