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Q8K126

- RF1M_MOUSE

UniProt

Q8K126 - RF1M_MOUSE

Protein

Peptide chain release factor 1, mitochondrial

Gene

Mtrf1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-cognate termination stop codons AGG and AGA.By similarity

    GO - Molecular functioni

    1. translation release factor activity, codon specific Source: InterPro

    Keywords - Biological processi

    Protein biosynthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide chain release factor 1, mitochondrial
    Short name:
    MRF-1
    Short name:
    MtRF-1
    Gene namesi
    Name:Mtrf1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:2384815. Mtrf1.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 446Peptide chain release factor 1, mitochondrialPRO_0000030334
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei314 – 3141N5-methylglutamineBy similarity

    Post-translational modificationi

    Methylation of glutamine in the GGQ triplet is conserved from bacteria to mammals.By similarity

    Keywords - PTMi

    Methylation

    Proteomic databases

    PaxDbiQ8K126.
    PRIDEiQ8K126.

    PTM databases

    PhosphoSiteiQ8K126.

    Expressioni

    Gene expression databases

    BgeeiQ8K126.
    CleanExiMM_MTRF1.
    GenevestigatoriQ8K126.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K126.
    SMRiQ8K126. Positions 115-438.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0216.
    GeneTreeiENSGT00390000011879.
    HOGENOMiHOG000074815.
    HOVERGENiHBG017071.
    InParanoidiQ8K126.
    KOiK02835.
    OMAiIKEFLCG.
    OrthoDBiEOG7DRJ33.
    PhylomeDBiQ8K126.
    TreeFamiTF313720.

    Family and domain databases

    Gene3Di3.30.160.20. 1 hit.
    InterProiIPR014720. dsRNA-bd_dom.
    IPR005139. PCRF.
    IPR000352. Pep_chain_release_fac_I_II.
    [Graphical view]
    PfamiPF03462. PCRF. 1 hit.
    PF00472. RF-1. 1 hit.
    [Graphical view]
    SMARTiSM00937. PCRF. 1 hit.
    [Graphical view]
    PROSITEiPS00745. RF_PROK_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8K126-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHHLCIWLF RNPFLRACPQ RHVFLSCQQF RQISLDTRPW NFRQKKTHVL    50
    YQLLNKSWSR GCCHQGTRKL WKHKALQKYM EDLNKEYQTL DQCLQGISEN 100
    EGDRRALHRR HAQLAPLAAV YQEIQEAEQA IEELESLCKS LNKQDEKQLQ 150
    ELVSEERQII DQKIHRLYSE LLERLVPKEK YDWSDVILEV TSGRTTGGDI 200
    CQQFTREIFD MYQNYSYYKH WKFELLNYTP ADYGGLHHAA ARISGDSVYK 250
    HLKYEGGIHR VQRIPEVGLS SRMQRIHTGT MSVIVLPQPD EVDVKVDPKD 300
    LRVDTFRARG AGGQHVNTTD SAVRLVHIPT GLVVECQQER SQLKNKEIAL 350
    RVLRARLYQQ IIEKDRCQQQ NARKLQVGTR AQSERIRTYN FTQDRVTDHR 400
    IAYEVRDIKE FLRGEKCLDQ LIERLLQSAD EEAISEFLDE SLQSVK 446
    Length:446
    Mass (Da):52,458
    Last modified:October 1, 2002 - v1
    Checksum:iFC25AFF242025DE5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK043981 mRNA. Translation: BAC31724.1.
    BC028898 mRNA. Translation: AAH28898.1.
    CCDSiCCDS27297.1.
    RefSeqiNP_666072.3. NM_145960.4.
    UniGeneiMm.35306.

    Genome annotation databases

    EnsembliENSMUST00000022600; ENSMUSP00000022600; ENSMUSG00000022022.
    GeneIDi211253.
    KEGGimmu:211253.
    UCSCiuc007usw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK043981 mRNA. Translation: BAC31724.1 .
    BC028898 mRNA. Translation: AAH28898.1 .
    CCDSi CCDS27297.1.
    RefSeqi NP_666072.3. NM_145960.4.
    UniGenei Mm.35306.

    3D structure databases

    ProteinModelPortali Q8K126.
    SMRi Q8K126. Positions 115-438.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8K126.

    Proteomic databases

    PaxDbi Q8K126.
    PRIDEi Q8K126.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022600 ; ENSMUSP00000022600 ; ENSMUSG00000022022 .
    GeneIDi 211253.
    KEGGi mmu:211253.
    UCSCi uc007usw.1. mouse.

    Organism-specific databases

    CTDi 9617.
    MGIi MGI:2384815. Mtrf1.

    Phylogenomic databases

    eggNOGi COG0216.
    GeneTreei ENSGT00390000011879.
    HOGENOMi HOG000074815.
    HOVERGENi HBG017071.
    InParanoidi Q8K126.
    KOi K02835.
    OMAi IKEFLCG.
    OrthoDBi EOG7DRJ33.
    PhylomeDBi Q8K126.
    TreeFami TF313720.

    Miscellaneous databases

    NextBioi 373184.
    PROi Q8K126.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8K126.
    CleanExi MM_MTRF1.
    Genevestigatori Q8K126.

    Family and domain databases

    Gene3Di 3.30.160.20. 1 hit.
    InterProi IPR014720. dsRNA-bd_dom.
    IPR005139. PCRF.
    IPR000352. Pep_chain_release_fac_I_II.
    [Graphical view ]
    Pfami PF03462. PCRF. 1 hit.
    PF00472. RF-1. 1 hit.
    [Graphical view ]
    SMARTi SM00937. PCRF. 1 hit.
    [Graphical view ]
    PROSITEi PS00745. RF_PROK_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Brain cortex.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.

    Entry informationi

    Entry nameiRF1M_MOUSE
    AccessioniPrimary (citable) accession number: Q8K126
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 13, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3