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Q8K120

- NFAC4_MOUSE

UniProt

Q8K120 - NFAC4_MOUSE

Protein

Nuclear factor of activated T-cells, cytoplasmic 4

Gene

Nfatc4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation By similarity. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons.By similarity3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi430 – 4378By similarity

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. protein binding Source: MGI
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: NTNU_SB
    5. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
    6. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. cellular respiration Source: MGI
    2. cellular response to lithium ion Source: MGI
    3. cellular response to UV Source: MGI
    4. heart development Source: MGI
    5. intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
    6. muscle cell development Source: MGI
    7. negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    8. patterning of blood vessels Source: MGI
    9. positive regulation of apoptotic process Source: MGI
    10. positive regulation of apoptotic signaling pathway Source: MGI
    11. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    12. positive regulation of tumor necrosis factor production Source: MGI
    13. regulation of synaptic plasticity Source: Ensembl
    14. regulation of transcription, DNA-templated Source: MGI
    15. smooth muscle cell differentiation Source: MGI
    16. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Differentiation, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear factor of activated T-cells, cytoplasmic 4By similarity
    Short name:
    NF-ATc4By similarity
    Short name:
    NFATc4By similarity1 Publication
    Alternative name(s):
    T-cell transcription factor NFAT3By similarity1 Publication
    Short name:
    NF-AT3By similarity
    Gene namesi
    Name:Nfatc4Imported
    Synonyms:Nfat31 Publication
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1920431. Nfatc4.

    Subcellular locationi

    Cytoplasm Curated. Nucleus Curated
    Note: Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.Curated

    GO - Cellular componenti

    1. cytosol Source: MGI
    2. intermediate filament cytoskeleton Source: Ensembl
    3. nucleus Source: MGI
    4. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 901901Nuclear factor of activated T-cells, cytoplasmic 4PRO_0000367433Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei168 – 1681Phosphoserine; by MAPK7 and MAPK141 Publication
    Modified residuei170 – 1701Phosphoserine; by MAPK7 and MAPK141 Publication
    Modified residuei213 – 2131Phosphoserine; by MAPK8 and MAPK9By similarity
    Modified residuei217 – 2171Phosphoserine; by MAPK8 and MAPK9By similarity
    Modified residuei289 – 2891Phosphoserine; by RPS6KA3By similarity
    Modified residuei334 – 3341Phosphoserine; by RPS6KA3By similarity
    Modified residuei344 – 3441PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated by NFATC-kinases; dephosphorylated by calcineurin. Phosphorylated on Ser-168 and Ser-170 by MTOR, IRAK1, MAPK7 and MAPK14, on Ser-213 and Ser-217 by MAPK8 and MAPK9, and on Ser-289 and Ser-344 by RPS6KA3. Phosphorylated by GSK3B.1 Publication
    Ubiquitinated, leading to its degradation by the proteasome and reduced transcriptional activity. Ubiquitination and reduction in transcriptional activity can be further facilitated through GSK3B-dependent phosphorylation. Polyubiquitin linkage is mainly through 'Lys-48' By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiQ8K120.

    PTM databases

    PhosphoSiteiQ8K120.

    Expressioni

    Tissue specificityi

    Expressed in all tissues analyzed including brain, lung, heart, testis and muscle.1 Publication

    Gene expression databases

    BgeeiQ8K120.
    GenevestigatoriQ8K120.

    Interactioni

    Subunit structurei

    Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4, NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex. NFATC proteins bind to DNA as monomers. Interacts with CREBBP, GATA4, IRAK1, MAPK8, MAPK9 and RPS6KA3.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi215821. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K120.
    SMRiQ8K120. Positions 405-691.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati213 – 22917SP 1Sequence AnalysisAdd
    BLAST
    Repeati277 – 29317SP 2; approximateSequence AnalysisAdd
    BLAST
    Domaini401 – 582182RHDPROSITE-ProRule annotationAdd
    BLAST
    Domaini586 – 68398IPT/TIGSequence AnalysisAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni114 – 1196Calcineurin-bindingBy similarity
    Regioni213 – 293812 approximate SP repeatsSequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi268 – 2703Nuclear localization signalSequence Analysis
    Motifi672 – 6743Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi23 – 327305Pro-richSequence AnalysisAdd
    BLAST
    Compositional biasi692 – 836145Pro-richSequence AnalysisAdd
    BLAST

    Domaini

    Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors.By similarity

    Sequence similaritiesi

    Contains 1 IPT/TIG domain.Sequence Analysis
    Contains 1 RHD (Rel-like) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG70055.
    GeneTreeiENSGT00550000074562.
    HOGENOMiHOG000231780.
    HOVERGENiHBG104364.
    InParanoidiQ3TXW7.
    KOiK17334.
    OMAiWTPDDPW.
    OrthoDBiEOG79PJND.
    PhylomeDBiQ8K120.
    TreeFamiTF326480.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    2.60.40.340. 1 hit.
    InterProiIPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR008366. NFAT.
    IPR008967. p53-like_TF_DNA-bd.
    IPR011539. RHD.
    [Graphical view]
    PANTHERiPTHR12533. PTHR12533. 1 hit.
    PfamiPF00554. RHD. 1 hit.
    PF01833. TIG. 1 hit.
    [Graphical view]
    PRINTSiPR01789. NUCFACTORATC.
    SMARTiSM00429. IPT. 1 hit.
    [Graphical view]
    SUPFAMiSSF49417. SSF49417. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS50254. REL_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 14 Publications (identifier: Q8K120-1) [UniParc]FASTAAdd to Basket

    Also known as: I-IXL1 Publication

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGAASCEDEE LEFKLVFGEE KEPPPLGPGG PGEELDSEDT PPCCRLALGE    50
    PLPYGAAPIG IPRPPPPRPG MHSPPPRPAP SPGTWESQPA RSVRLGGPGG 100
    NAGGAGGGRV LECPSIRITS ISPTPDPPTS LEDTSETWGD GSPRDYPPPE 150
    GFGGYREAGG QGGGAFFSPS PGSSSLSSWS FFSDASDEAA LYAACDEVES 200
    ELNEAASRFG LSSPLPSPRA SPRPWTPEDP WSLYGPSSGG RAPEDSWLLL 250
    SAPGPVPASP RPASPCGKRR YSSSGTPSSA SPALSRRGSL GEEGPEPPPP 300
    PPLPLVRDPS SPGPFDYVGA PPTESIPQKT RRTSSEQAVA LPRSEEPPSC 350
    NGKLPSGTED SVAAPGALRK EVAGMDYLAV PSPLAWSKAR IGGHSPIFRT 400
    SALPPLDWPL PSQYEQLELR IEVQPRAHHR AHYETEGSRG AVKAAPGGHP 450
    VVKLLGYSEK PLTLQMFIGT ADERSLRPHA FYQVHRITGK MVATASYEAV 500
    VSGTKVLEMT LLPENNMAAN IDCAGILKLR NSDIELRKGE TDIGRKNTRV 550
    RLVFRVHVPQ GGGKVVSVQA ASVPIECSQR SAQELPQVET YSPSACSVRG 600
    GEELVLTGSN FLPDSKVVFI ERGPDGKLQW EEEAAVNRLQ SSEVTLTLTI 650
    PEYSNKRVSR PVQVYFYVSN GRRKRSPTQS FKFLPVVFKE EPLPDSSLRG 700
    FPSTSGPPFG PDVDFSPPRP PYPSYPHEDP AYETPYLSEG FGYSTPALYP 750
    QTGPPPSYRS GLRMFPETGG TTGCARLPSV SFLPRPFPGD QYGGQGSSFA 800
    LGLPFSPPAP FRPPLPSSPP LEDPFHPQSA IHPLPPEGYN EVGPGYTPGE 850
    GASEQEKARG GYSSGFRDSV PIQGITLEEV SEIIGRDLSG FPARPGEEPP 900
    A 901
    Length:901
    Mass (Da):95,782
    Last modified:March 24, 2009 - v2
    Checksum:i5977695F888F6538
    GO
    Isoform 21 Publication (identifier: Q8K120-2) [UniParc]FASTAAdd to Basket

    Also known as: I-IXi1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         880-894: VSEIIGRDLSGFPAR → GGCGTGGCECK
         895-901: Missing.

    Show »
    Length:890
    Mass (Da):94,459
    Checksum:i1083BBF9972F0742
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti135 – 1351S → P in AAH28928. (PubMed:15489334)Curated
    Sequence conflicti379 – 3802AV → TM in AAG39446. (PubMed:11344309)Curated
    Sequence conflicti379 – 3802AV → TM in AAF98174. (PubMed:11344309)Curated
    Sequence conflicti394 – 3952HS → QT in AAG39446. (PubMed:11344309)Curated
    Sequence conflicti394 – 3952HS → QT in AAF98174. (PubMed:11344309)Curated
    Sequence conflicti562 – 5621G → S in AAH28928. (PubMed:15489334)Curated
    Sequence conflicti589 – 5902ET → GD in AAG39446. (PubMed:11344309)Curated
    Sequence conflicti589 – 5902ET → GD in AAF98174. (PubMed:11344309)Curated
    Sequence conflicti662 – 6621V → I in AAG39446. (PubMed:11344309)Curated
    Sequence conflicti662 – 6621V → I in AAF98174. (PubMed:11344309)Curated
    Sequence conflicti730 – 7301P → L in AAG39446. (PubMed:11344309)Curated
    Sequence conflicti730 – 7301P → L in AAF98174. (PubMed:11344309)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei880 – 89415VSEII…GFPAR → GGCGTGGCECK in isoform 2. 1 PublicationVSP_053054Add
    BLAST
    Alternative sequencei895 – 9017Missing in isoform 2. 1 PublicationVSP_053055

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF283284 mRNA. Translation: AAF98174.1.
    AF309389, AF309388 Genomic DNA. Translation: AAG39446.1.
    EU887656 mRNA. Translation: ACG55676.1.
    EU887657 mRNA. Translation: ACG55677.1.
    AK159078 mRNA. Translation: BAE34797.1.
    CH466535 Genomic DNA. Translation: EDL36234.1.
    BC028928 mRNA. Translation: AAH28928.1.
    CCDSiCCDS27132.1. [Q8K120-1]
    CCDS49500.1. [Q8K120-2]
    RefSeqiNP_001161818.1. NM_001168346.1. [Q8K120-2]
    NP_076188.3. NM_023699.3. [Q8K120-1]
    UniGeneiMm.27908.

    Genome annotation databases

    EnsembliENSMUST00000024179; ENSMUSP00000024179; ENSMUSG00000023411. [Q8K120-1]
    ENSMUST00000172271; ENSMUSP00000132763; ENSMUSG00000023411. [Q8K120-2]
    GeneIDi73181.
    KEGGimmu:73181.
    UCSCiuc007uax.2. mouse. [Q8K120-1]
    uc011zlq.1. mouse. [Q8K120-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF283284 mRNA. Translation: AAF98174.1 .
    AF309389 , AF309388 Genomic DNA. Translation: AAG39446.1 .
    EU887656 mRNA. Translation: ACG55676.1 .
    EU887657 mRNA. Translation: ACG55677.1 .
    AK159078 mRNA. Translation: BAE34797.1 .
    CH466535 Genomic DNA. Translation: EDL36234.1 .
    BC028928 mRNA. Translation: AAH28928.1 .
    CCDSi CCDS27132.1. [Q8K120-1 ]
    CCDS49500.1. [Q8K120-2 ]
    RefSeqi NP_001161818.1. NM_001168346.1. [Q8K120-2 ]
    NP_076188.3. NM_023699.3. [Q8K120-1 ]
    UniGenei Mm.27908.

    3D structure databases

    ProteinModelPortali Q8K120.
    SMRi Q8K120. Positions 405-691.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 215821. 2 interactions.

    PTM databases

    PhosphoSitei Q8K120.

    Proteomic databases

    PRIDEi Q8K120.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000024179 ; ENSMUSP00000024179 ; ENSMUSG00000023411 . [Q8K120-1 ]
    ENSMUST00000172271 ; ENSMUSP00000132763 ; ENSMUSG00000023411 . [Q8K120-2 ]
    GeneIDi 73181.
    KEGGi mmu:73181.
    UCSCi uc007uax.2. mouse. [Q8K120-1 ]
    uc011zlq.1. mouse. [Q8K120-2 ]

    Organism-specific databases

    CTDi 4776.
    MGIi MGI:1920431. Nfatc4.

    Phylogenomic databases

    eggNOGi NOG70055.
    GeneTreei ENSGT00550000074562.
    HOGENOMi HOG000231780.
    HOVERGENi HBG104364.
    InParanoidi Q3TXW7.
    KOi K17334.
    OMAi WTPDDPW.
    OrthoDBi EOG79PJND.
    PhylomeDBi Q8K120.
    TreeFami TF326480.

    Miscellaneous databases

    NextBioi 337621.
    PROi Q8K120.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8K120.
    Genevestigatori Q8K120.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    2.60.40.340. 1 hit.
    InterProi IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR008366. NFAT.
    IPR008967. p53-like_TF_DNA-bd.
    IPR011539. RHD.
    [Graphical view ]
    PANTHERi PTHR12533. PTHR12533. 1 hit.
    Pfami PF00554. RHD. 1 hit.
    PF01833. TIG. 1 hit.
    [Graphical view ]
    PRINTSi PR01789. NUCFACTORATC.
    SMARTi SM00429. IPT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49417. SSF49417. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS50254. REL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolutionary relationships among Rel domains indicate functional diversification by recombination."
      Graef I.A., Gastier J.M., Francke U., Crabtree G.R.
      Proc. Natl. Acad. Sci. U.S.A. 98:5740-5745(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
      Strain: 129/SvEvImported.
    2. "Alternative splicing and expression of human and mouse NFAT genes."
      Vihma H., Pruunsild P., Timmusk T.
      Genomics 92:279-291(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
      Strain: C57BL/6Imported.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Rathke glandImported.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Mammary tumorImported.
    6. "A calcineurin-dependent transcriptional pathway for cardiac hypertrophy."
      Molkentin J.D., Lu J.-R., Antos C.L., Markham B., Richardson J., Robbins J., Grant S.R., Olson E.N.
      Cell 93:215-228(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH GATA4.
    7. "Dosage-dependent transcriptional regulation by the calcineurin/NFAT signaling in developing myocardium transition."
      Yang X.Y., Yang T.T.C., Schubert W., Factor S.M., Chow C.-W.
      Dev. Biol. 303:825-837(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Deafferentation-induced activation of NFAT (nuclear factor of activated T-cells) in cochlear nucleus neurons during a developmental critical period: a role for NFATc4-dependent apoptosis in the CNS."
      Luoma J.I., Zirpel L.
      J. Neurosci. 28:3159-3169(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "The interleukin-1 receptor associated kinase 1 contributes to the regulation of NFAT."
      Wang D., Fasciano S., Li L.
      Mol. Immunol. 45:3902-3908(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-168 AND SER-170.

    Entry informationi

    Entry nameiNFAC4_MOUSE
    AccessioniPrimary (citable) accession number: Q8K120
    Secondary accession number(s): B5B2X2, Q3TXW7, Q9EP91
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3