Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable G-protein coupled receptor 153

Gene

Gpr153

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 153
Alternative name(s):
G-protein coupled receptor PGR1
Gene namesi
Name:Gpr153
Synonyms:Pgr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1916157. Gpr153.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11ExtracellularSequence analysisAdd BLAST11
Transmembranei12 – 32Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini33 – 41CytoplasmicSequence analysis9
Transmembranei42 – 62Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini63 – 84ExtracellularSequence analysisAdd BLAST22
Transmembranei85 – 105Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini106 – 126CytoplasmicSequence analysisAdd BLAST21
Transmembranei127 – 147Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini148 – 162ExtracellularSequence analysisAdd BLAST15
Transmembranei163 – 183Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini184 – 243CytoplasmicSequence analysisAdd BLAST60
Transmembranei244 – 264Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini265 – 276ExtracellularSequence analysisAdd BLAST12
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 631CytoplasmicSequence analysisAdd BLAST334

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696381 – 631Probable G-protein coupled receptor 153Add BLAST631

Proteomic databases

MaxQBiQ8K0Z9.
PaxDbiQ8K0Z9.
PRIDEiQ8K0Z9.

PTM databases

iPTMnetiQ8K0Z9.
PhosphoSitePlusiQ8K0Z9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000042804.
CleanExiMM_GPR153.
ExpressionAtlasiQ8K0Z9. baseline and differential.
GenevisibleiQ8K0Z9. MM.

Interactioni

Protein-protein interaction databases

MINTiMINT-4997733.
STRINGi10090.ENSMUSP00000052742.

Structurei

3D structure databases

ProteinModelPortaliQ8K0Z9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFBH. Eukaryota.
ENOG410XST7. LUCA.
GeneTreeiENSGT00390000017213.
HOGENOMiHOG000231123.
HOVERGENiHBG080132.
InParanoidiQ8K0Z9.
KOiK08437.
OMAiFECEPQA.
OrthoDBiEOG091G02R9.
PhylomeDBiQ8K0Z9.
TreeFamiTF330832.

Family and domain databases

InterProiIPR022347. GCR_153/162.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR022335. GPR153.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01992. GPR153.
PR01991. GPR153GPR162.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K0Z9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDERRLPSS AVGWLACGGL SLLANAWGIL SVGAKQKKWK PLEFLLCTLA
60 70 80 90 100
ATHMLNVAVP IATYAVVQLR RQRPDYEWNE GLCKVFVSTF YTLTLATCFS
110 120 130 140 150
VTSISYHRMW MVRWPVNYRL SNAKKQAVHT VMGIWMVSFI LSALPAVGWH
160 170 180 190 200
DTSERFYTHG CRFIVAEIGL GFGVCFLLLV GGSVAMGMVC TAIALFQTLA
210 220 230 240 250
TQVGHRADRR TFTVPTIVVE DAQGKRRSSI DGSEPARTSL QITGLVATIV
260 270 280 290 300
VIYDCLMGFP VLVVSFSSLR ADASAPWMAL CVLWCSVTQA LLLPLFLWTC
310 320 330 340 350
DRYRADLKAV WEKCVALMAN DEDSDNETSL EGSISPDMVL ERSLDYSYGG
360 370 380 390 400
DFVALDRMAK YELSALEGGL PQLYPLRPLQ EDRMQYLQGA GRHRCGFPGG
410 420 430 440 450
QPCFSPAGCS QVPPTRRFSH DDADVWAAVP LPTFLPRWSS GEDLAALAHL
460 470 480 490 500
MLPAGSDRRR GSLLAFAEDA PPFRPRRRSA ESLLSLQPSS LDGGPRHAQD
510 520 530 540 550
SPPGSPRRRP GPGARSASVS LLPDAFALTA FEREPQALRR VPAPAQPFPA
560 570 580 590 600
ARDSAEPAEV PTPPGGRTQR SQGRRAARTH VGPLQSSLSA SWGEPGGLHA
610 620 630
AGCGSISSFL SSPSESSGYV TLHSDSLGSA S
Length:631
Mass (Da):68,459
Last modified:November 23, 2004 - v2
Checksum:iAC171D496D66A797
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029098 mRNA. Translation: AAH29098.2.
BC037650 mRNA. Translation: AAH37650.1.
AY255610 mRNA. Translation: AAO85122.1.
CCDSiCCDS18996.1.
RefSeqiNP_848493.1. NM_178406.2.
UniGeneiMm.23235.

Genome annotation databases

EnsembliENSMUST00000055754; ENSMUSP00000052742; ENSMUSG00000042804.
ENSMUST00000105651; ENSMUSP00000101276; ENSMUSG00000042804.
GeneIDi100129.
KEGGimmu:100129.
UCSCiuc008wab.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029098 mRNA. Translation: AAH29098.2.
BC037650 mRNA. Translation: AAH37650.1.
AY255610 mRNA. Translation: AAO85122.1.
CCDSiCCDS18996.1.
RefSeqiNP_848493.1. NM_178406.2.
UniGeneiMm.23235.

3D structure databases

ProteinModelPortaliQ8K0Z9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4997733.
STRINGi10090.ENSMUSP00000052742.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8K0Z9.
PhosphoSitePlusiQ8K0Z9.

Proteomic databases

MaxQBiQ8K0Z9.
PaxDbiQ8K0Z9.
PRIDEiQ8K0Z9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055754; ENSMUSP00000052742; ENSMUSG00000042804.
ENSMUST00000105651; ENSMUSP00000101276; ENSMUSG00000042804.
GeneIDi100129.
KEGGimmu:100129.
UCSCiuc008wab.1. mouse.

Organism-specific databases

CTDi387509.
MGIiMGI:1916157. Gpr153.

Phylogenomic databases

eggNOGiENOG410IFBH. Eukaryota.
ENOG410XST7. LUCA.
GeneTreeiENSGT00390000017213.
HOGENOMiHOG000231123.
HOVERGENiHBG080132.
InParanoidiQ8K0Z9.
KOiK08437.
OMAiFECEPQA.
OrthoDBiEOG091G02R9.
PhylomeDBiQ8K0Z9.
TreeFamiTF330832.

Miscellaneous databases

PROiQ8K0Z9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042804.
CleanExiMM_GPR153.
ExpressionAtlasiQ8K0Z9. baseline and differential.
GenevisibleiQ8K0Z9. MM.

Family and domain databases

InterProiIPR022347. GCR_153/162.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR022335. GPR153.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01992. GPR153.
PR01991. GPR153GPR162.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP153_MOUSE
AccessioniPrimary (citable) accession number: Q8K0Z9
Secondary accession number(s): Q80T37, Q8CFK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 23, 2004
Last modified: November 2, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.