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Protein

Probable G-protein coupled receptor 153

Gene

Gpr153

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 153
Alternative name(s):
G-protein coupled receptor PGR1
Gene namesi
Name:Gpr153
Synonyms:Pgr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1916157. Gpr153.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111ExtracellularSequence analysisAdd
BLAST
Transmembranei12 – 3221Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini33 – 419CytoplasmicSequence analysis
Transmembranei42 – 6221Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini63 – 8422ExtracellularSequence analysisAdd
BLAST
Transmembranei85 – 10521Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini106 – 12621CytoplasmicSequence analysisAdd
BLAST
Transmembranei127 – 14721Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini148 – 16215ExtracellularSequence analysisAdd
BLAST
Transmembranei163 – 18321Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini184 – 24360CytoplasmicSequence analysisAdd
BLAST
Transmembranei244 – 26421Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini265 – 27612ExtracellularSequence analysisAdd
BLAST
Transmembranei277 – 29721Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini298 – 631334CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 631631Probable G-protein coupled receptor 153PRO_0000069638Add
BLAST

Proteomic databases

MaxQBiQ8K0Z9.
PaxDbiQ8K0Z9.
PRIDEiQ8K0Z9.

PTM databases

iPTMnetiQ8K0Z9.
PhosphoSiteiQ8K0Z9.

Expressioni

Gene expression databases

BgeeiQ8K0Z9.
CleanExiMM_GPR153.
ExpressionAtlasiQ8K0Z9. baseline and differential.
GenevisibleiQ8K0Z9. MM.

Interactioni

Protein-protein interaction databases

MINTiMINT-4997733.
STRINGi10090.ENSMUSP00000052742.

Structurei

3D structure databases

ProteinModelPortaliQ8K0Z9.
SMRiQ8K0Z9. Positions 21-154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFBH. Eukaryota.
ENOG410XST7. LUCA.
GeneTreeiENSGT00390000017213.
HOGENOMiHOG000231123.
HOVERGENiHBG080132.
InParanoidiQ8K0Z9.
KOiK08437.
OMAiFECEPQA.
PhylomeDBiQ8K0Z9.
TreeFamiTF330832.

Family and domain databases

InterProiIPR022347. GCR_153/162.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR022335. GPR153.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01992. GPR153.
PR01991. GPR153GPR162.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K0Z9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDERRLPSS AVGWLACGGL SLLANAWGIL SVGAKQKKWK PLEFLLCTLA
60 70 80 90 100
ATHMLNVAVP IATYAVVQLR RQRPDYEWNE GLCKVFVSTF YTLTLATCFS
110 120 130 140 150
VTSISYHRMW MVRWPVNYRL SNAKKQAVHT VMGIWMVSFI LSALPAVGWH
160 170 180 190 200
DTSERFYTHG CRFIVAEIGL GFGVCFLLLV GGSVAMGMVC TAIALFQTLA
210 220 230 240 250
TQVGHRADRR TFTVPTIVVE DAQGKRRSSI DGSEPARTSL QITGLVATIV
260 270 280 290 300
VIYDCLMGFP VLVVSFSSLR ADASAPWMAL CVLWCSVTQA LLLPLFLWTC
310 320 330 340 350
DRYRADLKAV WEKCVALMAN DEDSDNETSL EGSISPDMVL ERSLDYSYGG
360 370 380 390 400
DFVALDRMAK YELSALEGGL PQLYPLRPLQ EDRMQYLQGA GRHRCGFPGG
410 420 430 440 450
QPCFSPAGCS QVPPTRRFSH DDADVWAAVP LPTFLPRWSS GEDLAALAHL
460 470 480 490 500
MLPAGSDRRR GSLLAFAEDA PPFRPRRRSA ESLLSLQPSS LDGGPRHAQD
510 520 530 540 550
SPPGSPRRRP GPGARSASVS LLPDAFALTA FEREPQALRR VPAPAQPFPA
560 570 580 590 600
ARDSAEPAEV PTPPGGRTQR SQGRRAARTH VGPLQSSLSA SWGEPGGLHA
610 620 630
AGCGSISSFL SSPSESSGYV TLHSDSLGSA S
Length:631
Mass (Da):68,459
Last modified:November 23, 2004 - v2
Checksum:iAC171D496D66A797
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029098 mRNA. Translation: AAH29098.2.
BC037650 mRNA. Translation: AAH37650.1.
AY255610 mRNA. Translation: AAO85122.1.
CCDSiCCDS18996.1.
RefSeqiNP_848493.1. NM_178406.2.
UniGeneiMm.23235.

Genome annotation databases

EnsembliENSMUST00000055754; ENSMUSP00000052742; ENSMUSG00000042804.
ENSMUST00000105651; ENSMUSP00000101276; ENSMUSG00000042804.
GeneIDi100129.
KEGGimmu:100129.
UCSCiuc008wab.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029098 mRNA. Translation: AAH29098.2.
BC037650 mRNA. Translation: AAH37650.1.
AY255610 mRNA. Translation: AAO85122.1.
CCDSiCCDS18996.1.
RefSeqiNP_848493.1. NM_178406.2.
UniGeneiMm.23235.

3D structure databases

ProteinModelPortaliQ8K0Z9.
SMRiQ8K0Z9. Positions 21-154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4997733.
STRINGi10090.ENSMUSP00000052742.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8K0Z9.
PhosphoSiteiQ8K0Z9.

Proteomic databases

MaxQBiQ8K0Z9.
PaxDbiQ8K0Z9.
PRIDEiQ8K0Z9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055754; ENSMUSP00000052742; ENSMUSG00000042804.
ENSMUST00000105651; ENSMUSP00000101276; ENSMUSG00000042804.
GeneIDi100129.
KEGGimmu:100129.
UCSCiuc008wab.1. mouse.

Organism-specific databases

CTDi387509.
MGIiMGI:1916157. Gpr153.

Phylogenomic databases

eggNOGiENOG410IFBH. Eukaryota.
ENOG410XST7. LUCA.
GeneTreeiENSGT00390000017213.
HOGENOMiHOG000231123.
HOVERGENiHBG080132.
InParanoidiQ8K0Z9.
KOiK08437.
OMAiFECEPQA.
PhylomeDBiQ8K0Z9.
TreeFamiTF330832.

Miscellaneous databases

PROiQ8K0Z9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K0Z9.
CleanExiMM_GPR153.
ExpressionAtlasiQ8K0Z9. baseline and differential.
GenevisibleiQ8K0Z9. MM.

Family and domain databases

InterProiIPR022347. GCR_153/162.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR022335. GPR153.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01992. GPR153.
PR01991. GPR153GPR162.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-84.

Entry informationi

Entry nameiGP153_MOUSE
AccessioniPrimary (citable) accession number: Q8K0Z9
Secondary accession number(s): Q80T37, Q8CFK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.