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Protein

Translational activator of cytochrome c oxidase 1

Gene

Taco1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Translation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Translational activator of cytochrome c oxidase 1
Alternative name(s):
Coiled-coil domain-containing protein 44
Translational activator of mitochondrially-encoded cytochrome c oxidase 1
Gene namesi
Name:Taco1
Synonyms:Ccdc44
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1917457. Taco1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001759431 – 294Translational activator of cytochrome c oxidase 1Add BLAST294

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei162N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8K0Z7.
MaxQBiQ8K0Z7.
PaxDbiQ8K0Z7.
PeptideAtlasiQ8K0Z7.
PRIDEiQ8K0Z7.

PTM databases

iPTMnetiQ8K0Z7.
PhosphoSitePlusiQ8K0Z7.
SwissPalmiQ8K0Z7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000001983.
CleanExiMM_CCDC44.

Interactioni

Protein-protein interaction databases

IntActiQ8K0Z7. 1 interactor.
MINTiMINT-4139010.
STRINGi10090.ENSMUSP00000002048.

Structurei

Secondary structure

1294
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi75 – 92Combined sources18
Turni96 – 98Combined sources3
Helixi100 – 111Combined sources12
Helixi116 – 123Combined sources8
Beta strandi129 – 138Combined sources10
Beta strandi144 – 152Combined sources9
Helixi154 – 167Combined sources14
Beta strandi180 – 191Combined sources12
Helixi200 – 210Combined sources11
Beta strandi213 – 219Combined sources7
Beta strandi225 – 232Combined sources8
Helixi233 – 235Combined sources3
Helixi236 – 245Combined sources10
Beta strandi250 – 261Combined sources12
Helixi267 – 282Combined sources16
Beta strandi286 – 291Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5EKZX-ray2.00A1-294[»]
ProteinModelPortaliQ8K0Z7.
SMRiQ8K0Z7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili190 – 224Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the TACO1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2972. Eukaryota.
COG0217. LUCA.
GeneTreeiENSGT00390000012820.
HOGENOMiHOG000228370.
InParanoidiQ8K0Z7.
KOiK18189.
OMAiMTRNGGS.
OrthoDBiEOG091G0I1M.
PhylomeDBiQ8K0Z7.
TreeFamiTF300070.

Family and domain databases

Gene3Di1.10.10.200. 1 hit.
3.30.1270.10. 2 hits.
3.30.70.980. 1 hit.
InterProiIPR017856. Integrase_Zn-bd_dom-like_N.
IPR002876. Transcrip_reg_TACO1-like.
IPR026563. Transcrip_reg_TACO1-like_dom2.
IPR026564. Transcrip_reg_TACO1-like_dom3.
IPR029072. YebC-like.
[Graphical view]
PANTHERiPTHR12532. PTHR12532. 1 hit.
PfamiPF01709. Transcrip_reg. 1 hit.
[Graphical view]
SUPFAMiSSF75625. SSF75625. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K0Z7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSWAAASLR MTAVPCFRVR CLGFRVGPWG ASQHANPGCG AAPHRTLHVS
60 70 80 90 100
ATASAGHNKW SKVRHIKGPK DMERSRIFSK LTLSIRLAVK EGGPNPENNS
110 120 130 140 150
SLANILELCR SKNMPKSTIE SALKTEKNKG IYLLYEGRGP GGSSLLIEAL
160 170 180 190 200
SNSGPKCHLD IKYILNKNGG MMAEGARHFF DKKGVVVVGV EDREKKAVNL
210 220 230 240 250
ERALELAIEA GAEDVKEAED EEEKNLFKFI CDASSLHQVR KKLDSLGLCP
260 270 280 290
VSCSMEFIPH SKVQLAEPEL EQAAHLIQAL NNYEDVIHVY DNIE
Length:294
Mass (Da):32,314
Last modified:October 1, 2002 - v1
Checksum:i8285D9FE52E7AA1B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti86R → G in BAE39960 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010072 mRNA. Translation: BAB26682.1.
AK047078 mRNA. Translation: BAC32953.1.
AK140143 mRNA. Translation: BAE24253.1.
AK167963 mRNA. Translation: BAE39960.1.
AL596331 Genomic DNA. Translation: CAM27012.1.
BC029182 mRNA. Translation: AAH29182.1.
CCDSiCCDS25547.1.
RefSeqiNP_081622.1. NM_027346.1.
UniGeneiMm.343857.

Genome annotation databases

EnsembliENSMUST00000002048; ENSMUSP00000002048; ENSMUSG00000001983.
GeneIDi70207.
KEGGimmu:70207.
UCSCiuc007lyb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010072 mRNA. Translation: BAB26682.1.
AK047078 mRNA. Translation: BAC32953.1.
AK140143 mRNA. Translation: BAE24253.1.
AK167963 mRNA. Translation: BAE39960.1.
AL596331 Genomic DNA. Translation: CAM27012.1.
BC029182 mRNA. Translation: AAH29182.1.
CCDSiCCDS25547.1.
RefSeqiNP_081622.1. NM_027346.1.
UniGeneiMm.343857.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5EKZX-ray2.00A1-294[»]
ProteinModelPortaliQ8K0Z7.
SMRiQ8K0Z7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8K0Z7. 1 interactor.
MINTiMINT-4139010.
STRINGi10090.ENSMUSP00000002048.

PTM databases

iPTMnetiQ8K0Z7.
PhosphoSitePlusiQ8K0Z7.
SwissPalmiQ8K0Z7.

Proteomic databases

EPDiQ8K0Z7.
MaxQBiQ8K0Z7.
PaxDbiQ8K0Z7.
PeptideAtlasiQ8K0Z7.
PRIDEiQ8K0Z7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002048; ENSMUSP00000002048; ENSMUSG00000001983.
GeneIDi70207.
KEGGimmu:70207.
UCSCiuc007lyb.1. mouse.

Organism-specific databases

CTDi51204.
MGIiMGI:1917457. Taco1.

Phylogenomic databases

eggNOGiKOG2972. Eukaryota.
COG0217. LUCA.
GeneTreeiENSGT00390000012820.
HOGENOMiHOG000228370.
InParanoidiQ8K0Z7.
KOiK18189.
OMAiMTRNGGS.
OrthoDBiEOG091G0I1M.
PhylomeDBiQ8K0Z7.
TreeFamiTF300070.

Miscellaneous databases

PROiQ8K0Z7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001983.
CleanExiMM_CCDC44.

Family and domain databases

Gene3Di1.10.10.200. 1 hit.
3.30.1270.10. 2 hits.
3.30.70.980. 1 hit.
InterProiIPR017856. Integrase_Zn-bd_dom-like_N.
IPR002876. Transcrip_reg_TACO1-like.
IPR026563. Transcrip_reg_TACO1-like_dom2.
IPR026564. Transcrip_reg_TACO1-like_dom3.
IPR029072. YebC-like.
[Graphical view]
PANTHERiPTHR12532. PTHR12532. 1 hit.
PfamiPF01709. Transcrip_reg. 1 hit.
[Graphical view]
SUPFAMiSSF75625. SSF75625. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTACO1_MOUSE
AccessioniPrimary (citable) accession number: Q8K0Z7
Secondary accession number(s): B1AR86
, Q3TI86, Q3USS8, Q9CV09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.