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Protein

Translational activator of cytochrome c oxidase 1

Gene

Taco1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1.By similarity

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranslation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Translational activator of cytochrome c oxidase 1
Alternative name(s):
Coiled-coil domain-containing protein 44
Translational activator of mitochondrially-encoded cytochrome c oxidase 1
Gene namesi
Name:Taco1
Synonyms:Ccdc44
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1917457 Taco1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001759431 – 294Translational activator of cytochrome c oxidase 1Add BLAST294

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei162N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8K0Z7
MaxQBiQ8K0Z7
PaxDbiQ8K0Z7
PeptideAtlasiQ8K0Z7
PRIDEiQ8K0Z7

PTM databases

iPTMnetiQ8K0Z7
PhosphoSitePlusiQ8K0Z7
SwissPalmiQ8K0Z7

Expressioni

Gene expression databases

BgeeiENSMUSG00000001983
CleanExiMM_CCDC44

Interactioni

Protein-protein interaction databases

IntActiQ8K0Z7, 1 interactor
MINTiQ8K0Z7
STRINGi10090.ENSMUSP00000002048

Structurei

Secondary structure

1294
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi75 – 92Combined sources18
Turni96 – 98Combined sources3
Helixi100 – 111Combined sources12
Helixi116 – 123Combined sources8
Beta strandi129 – 138Combined sources10
Beta strandi144 – 152Combined sources9
Helixi154 – 167Combined sources14
Beta strandi180 – 191Combined sources12
Helixi200 – 210Combined sources11
Beta strandi213 – 219Combined sources7
Beta strandi225 – 232Combined sources8
Helixi233 – 235Combined sources3
Helixi236 – 245Combined sources10
Beta strandi250 – 261Combined sources12
Helixi267 – 282Combined sources16
Beta strandi286 – 291Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5EKZX-ray2.00A1-294[»]
ProteinModelPortaliQ8K0Z7
SMRiQ8K0Z7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili190 – 224Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the TACO1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2972 Eukaryota
COG0217 LUCA
GeneTreeiENSGT00390000012820
HOGENOMiHOG000228370
InParanoidiQ8K0Z7
KOiK18189
OMAiKWSTIKH
OrthoDBiEOG091G0I1M
PhylomeDBiQ8K0Z7
TreeFamiTF300070

Family and domain databases

Gene3Di1.10.10.200, 1 hit
3.30.70.980, 3 hits
InterProiView protein in InterPro
IPR017856 Integrase-like_N
IPR002876 Transcrip_reg_TACO1-like
IPR026564 Transcrip_reg_TACO1-like_dom3
IPR029072 YebC-like
PANTHERiPTHR12532 PTHR12532, 1 hit
PfamiView protein in Pfam
PF01709 Transcrip_reg, 1 hit
SUPFAMiSSF75625 SSF75625, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K0Z7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSWAAASLR MTAVPCFRVR CLGFRVGPWG ASQHANPGCG AAPHRTLHVS
60 70 80 90 100
ATASAGHNKW SKVRHIKGPK DMERSRIFSK LTLSIRLAVK EGGPNPENNS
110 120 130 140 150
SLANILELCR SKNMPKSTIE SALKTEKNKG IYLLYEGRGP GGSSLLIEAL
160 170 180 190 200
SNSGPKCHLD IKYILNKNGG MMAEGARHFF DKKGVVVVGV EDREKKAVNL
210 220 230 240 250
ERALELAIEA GAEDVKEAED EEEKNLFKFI CDASSLHQVR KKLDSLGLCP
260 270 280 290
VSCSMEFIPH SKVQLAEPEL EQAAHLIQAL NNYEDVIHVY DNIE
Length:294
Mass (Da):32,314
Last modified:October 1, 2002 - v1
Checksum:i8285D9FE52E7AA1B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti86R → G in BAE39960 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010072 mRNA Translation: BAB26682.1
AK047078 mRNA Translation: BAC32953.1
AK140143 mRNA Translation: BAE24253.1
AK167963 mRNA Translation: BAE39960.1
AL596331 Genomic DNA No translation available.
BC029182 mRNA Translation: AAH29182.1
CCDSiCCDS25547.1
RefSeqiNP_081622.1, NM_027346.1
UniGeneiMm.343857

Genome annotation databases

EnsembliENSMUST00000002048; ENSMUSP00000002048; ENSMUSG00000001983
GeneIDi70207
KEGGimmu:70207
UCSCiuc007lyb.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTACO1_MOUSE
AccessioniPrimary (citable) accession number: Q8K0Z7
Secondary accession number(s): B1AR86
, Q3TI86, Q3USS8, Q9CV09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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