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Protein

Keratin, type I cuticular Ha3-I

Gene

Krt33a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei305StutterSequence analysis1

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha3-IBy similarity
Alternative name(s):
Hair keratin, type I Ha3-I
Keratin-33ABy similarityImported
Short name:
K33A
Gene namesi
Name:Krt33aImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1919138. Krt33a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003662051 – 404Keratin, type I cuticular Ha3-IAdd BLAST404

Proteomic databases

EPDiQ8K0Y2.
PaxDbiQ8K0Y2.
PeptideAtlasiQ8K0Y2.
PRIDEiQ8K0Y2.

PTM databases

PhosphoSitePlusiQ8K0Y2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035592.
GenevisibleiQ8K0Y2. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8K0Y2. 1 interactor.
MINTiMINT-218150.
STRINGi10090.ENSMUSP00000018399.

Structurei

3D structure databases

ProteinModelPortaliQ8K0Y2.
SMRiQ8K0Y2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 56HeadSequence analysisAdd BLAST56
Regioni57 – 363RodSequence analysisAdd BLAST307
Regioni57 – 91Coil 1ASequence analysisAdd BLAST35
Regioni92 – 102Linker 1Sequence analysisAdd BLAST11
Regioni103 – 203Coil 1BSequence analysisAdd BLAST101
Regioni204 – 219Linker 12Sequence analysisAdd BLAST16
Regioni220 – 363Coil 2Sequence analysisAdd BLAST144
Regioni364 – 404TailSequence analysisAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 48Cys-richSequence analysisAdd BLAST44

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF9P. Eukaryota.
ENOG410YK2A. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ8K0Y2.
KOiK07604.
OMAiTRCGPCN.
OrthoDBiEOG091G087I.
PhylomeDBiQ8K0Y2.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K0Y2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYNCCLPAM SCRTSCSSRP CVPPSCHGCT LPGACNIPAN VGNCNWFCEG
60 70 80 90 100
SFNGNEKETM QFLNDRLASY MEKVRQLERE NAELECRIQE RNQQQDPLVC
110 120 130 140 150
PAYQAYFRTI EELQQKILCG KSENARLVVQ IDNAKLASDD FRTKYETELS
160 170 180 190 200
LRQLVEADIN SLRRILDELT LCKSDLEAQV ESLKEELLCL KQNHEQEVNT
210 220 230 240 250
LRCQLGDRLN VEVDAAPTVD LNRVLNETRC QYEALVETNR REVEEWYTTQ
260 270 280 290 300
TEELNKQVVS SSEQLQSCQA EIIELRRTVN ALEIELQAQH ELRNSLENTL
310 320 330 340 350
TESEARYSSQ LSQVQCLITN VESQLGEIRA DLERQNQEYQ VLLDIRSRLE
360 370 380 390 400
CEINTYRGLL ESEDCKLPCN PCATTNACDK PIGPCVPNPC VTRPRCGPCN

TFVR
Length:404
Mass (Da):46,137
Last modified:October 1, 2002 - v1
Checksum:i15C54491027291DF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti240R → L in BAB26243 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009363 mRNA. Translation: BAB26243.1.
AK037251 mRNA. Translation: BAC29777.1.
AL592545 Genomic DNA. Translation: CAM22478.1.
CH466662 Genomic DNA. Translation: EDL02593.1.
BC029257 mRNA. Translation: AAH29257.1.
CCDSiCCDS25403.1.
RefSeqiNP_082259.2. NM_027983.3.
UniGeneiMm.440318.

Genome annotation databases

EnsembliENSMUST00000018399; ENSMUSP00000018399; ENSMUSG00000035592.
GeneIDi71888.
KEGGimmu:71888.
UCSCiuc007lka.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009363 mRNA. Translation: BAB26243.1.
AK037251 mRNA. Translation: BAC29777.1.
AL592545 Genomic DNA. Translation: CAM22478.1.
CH466662 Genomic DNA. Translation: EDL02593.1.
BC029257 mRNA. Translation: AAH29257.1.
CCDSiCCDS25403.1.
RefSeqiNP_082259.2. NM_027983.3.
UniGeneiMm.440318.

3D structure databases

ProteinModelPortaliQ8K0Y2.
SMRiQ8K0Y2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8K0Y2. 1 interactor.
MINTiMINT-218150.
STRINGi10090.ENSMUSP00000018399.

PTM databases

PhosphoSitePlusiQ8K0Y2.

Proteomic databases

EPDiQ8K0Y2.
PaxDbiQ8K0Y2.
PeptideAtlasiQ8K0Y2.
PRIDEiQ8K0Y2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018399; ENSMUSP00000018399; ENSMUSG00000035592.
GeneIDi71888.
KEGGimmu:71888.
UCSCiuc007lka.2. mouse.

Organism-specific databases

CTDi3883.
MGIiMGI:1919138. Krt33a.

Phylogenomic databases

eggNOGiENOG410IF9P. Eukaryota.
ENOG410YK2A. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ8K0Y2.
KOiK07604.
OMAiTRCGPCN.
OrthoDBiEOG091G087I.
PhylomeDBiQ8K0Y2.
TreeFamiTF332742.

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Miscellaneous databases

PROiQ8K0Y2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035592.
GenevisibleiQ8K0Y2. MM.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKT33A_MOUSE
AccessioniPrimary (citable) accession number: Q8K0Y2
Secondary accession number(s): Q9D7C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.