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Protein

Keratin, type I cuticular Ha3-I

Gene

Krt33a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei305 – 3051StutterSequence Analysis

GO - Molecular functioni

  1. structural molecule activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha3-IBy similarity
Alternative name(s):
Hair keratin, type I Ha3-I
Keratin-33ABy similarityImported
Short name:
K33A
Gene namesi
Name:Krt33aImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1919138. Krt33a.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
  2. extracellular vesicular exosome Source: MGI
  3. intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Keratin, type I cuticular Ha3-IPRO_0000366205Add
BLAST

Proteomic databases

PRIDEiQ8K0Y2.

PTM databases

PhosphoSiteiQ8K0Y2.

Expressioni

Gene expression databases

BgeeiQ8K0Y2.
GenevestigatoriQ8K0Y2.

Interactioni

Protein-protein interaction databases

IntActiQ8K0Y2. 1 interaction.
MINTiMINT-218150.
STRINGi10090.ENSMUSP00000018399.

Structurei

3D structure databases

ProteinModelPortaliQ8K0Y2.
SMRiQ8K0Y2. Positions 106-204, 274-361.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5656HeadSequence AnalysisAdd
BLAST
Regioni57 – 363307RodSequence AnalysisAdd
BLAST
Regioni57 – 9135Coil 1ASequence AnalysisAdd
BLAST
Regioni92 – 10211Linker 1Sequence AnalysisAdd
BLAST
Regioni103 – 203101Coil 1BSequence AnalysisAdd
BLAST
Regioni204 – 21916Linker 12Sequence AnalysisAdd
BLAST
Regioni220 – 363144Coil 2Sequence AnalysisAdd
BLAST
Regioni364 – 40441TailSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 4844Cys-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence Analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ8K0Y2.
KOiK07604.
OMAiWCGPCNT.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ8K0Y2.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K0Y2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYNCCLPAM SCRTSCSSRP CVPPSCHGCT LPGACNIPAN VGNCNWFCEG
60 70 80 90 100
SFNGNEKETM QFLNDRLASY MEKVRQLERE NAELECRIQE RNQQQDPLVC
110 120 130 140 150
PAYQAYFRTI EELQQKILCG KSENARLVVQ IDNAKLASDD FRTKYETELS
160 170 180 190 200
LRQLVEADIN SLRRILDELT LCKSDLEAQV ESLKEELLCL KQNHEQEVNT
210 220 230 240 250
LRCQLGDRLN VEVDAAPTVD LNRVLNETRC QYEALVETNR REVEEWYTTQ
260 270 280 290 300
TEELNKQVVS SSEQLQSCQA EIIELRRTVN ALEIELQAQH ELRNSLENTL
310 320 330 340 350
TESEARYSSQ LSQVQCLITN VESQLGEIRA DLERQNQEYQ VLLDIRSRLE
360 370 380 390 400
CEINTYRGLL ESEDCKLPCN PCATTNACDK PIGPCVPNPC VTRPRCGPCN

TFVR
Length:404
Mass (Da):46,137
Last modified:October 1, 2002 - v1
Checksum:i15C54491027291DF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti240 – 2401R → L in BAB26243 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009363 mRNA. Translation: BAB26243.1.
AK037251 mRNA. Translation: BAC29777.1.
AL592545 Genomic DNA. Translation: CAM22478.1.
CH466662 Genomic DNA. Translation: EDL02593.1.
BC029257 mRNA. Translation: AAH29257.1.
CCDSiCCDS25403.1.
RefSeqiNP_082259.2. NM_027983.3.
UniGeneiMm.440318.

Genome annotation databases

EnsembliENSMUST00000018399; ENSMUSP00000018399; ENSMUSG00000035592.
GeneIDi71888.
KEGGimmu:71888.
UCSCiuc007lka.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009363 mRNA. Translation: BAB26243.1.
AK037251 mRNA. Translation: BAC29777.1.
AL592545 Genomic DNA. Translation: CAM22478.1.
CH466662 Genomic DNA. Translation: EDL02593.1.
BC029257 mRNA. Translation: AAH29257.1.
CCDSiCCDS25403.1.
RefSeqiNP_082259.2. NM_027983.3.
UniGeneiMm.440318.

3D structure databases

ProteinModelPortaliQ8K0Y2.
SMRiQ8K0Y2. Positions 106-204, 274-361.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8K0Y2. 1 interaction.
MINTiMINT-218150.
STRINGi10090.ENSMUSP00000018399.

PTM databases

PhosphoSiteiQ8K0Y2.

Proteomic databases

PRIDEiQ8K0Y2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018399; ENSMUSP00000018399; ENSMUSG00000035592.
GeneIDi71888.
KEGGimmu:71888.
UCSCiuc007lka.2. mouse.

Organism-specific databases

CTDi3883.
MGIiMGI:1919138. Krt33a.

Phylogenomic databases

GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ8K0Y2.
KOiK07604.
OMAiWCGPCNT.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ8K0Y2.
TreeFamiTF332742.

Miscellaneous databases

NextBioi334856.
PROiQ8K0Y2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K0Y2.
GenevestigatoriQ8K0Y2.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported.
    Tissue: Neonatal skinImported and TongueImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: Salivary glandImported.

Entry informationi

Entry nameiKT33A_MOUSE
AccessioniPrimary (citable) accession number: Q8K0Y2
Secondary accession number(s): Q9D7C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: October 1, 2002
Last modified: February 4, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.