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Q8K0Y2

- KT33A_MOUSE

UniProt

Q8K0Y2 - KT33A_MOUSE

Protein

Keratin, type I cuticular Ha3-I

Gene

Krt33a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei305 – 3051StutterSequence Analysis

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. structural molecule activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin, type I cuticular Ha3-IBy similarity
    Alternative name(s):
    Hair keratin, type I Ha3-I
    Keratin-33AImportedBy similarity
    Short name:
    K33A
    Gene namesi
    Name:Krt33aImported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1919138. Krt33a.

    Subcellular locationi

    GO - Cellular componenti

    1. intermediate filament Source: UniProtKB-KW

    Keywords - Cellular componenti

    Intermediate filament, Keratin

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 404404Keratin, type I cuticular Ha3-IPRO_0000366205Add
    BLAST

    Proteomic databases

    PRIDEiQ8K0Y2.

    PTM databases

    PhosphoSiteiQ8K0Y2.

    Expressioni

    Gene expression databases

    BgeeiQ8K0Y2.
    GenevestigatoriQ8K0Y2.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8K0Y2. 1 interaction.
    MINTiMINT-218150.
    STRINGi10090.ENSMUSP00000018399.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K0Y2.
    SMRiQ8K0Y2. Positions 59-91, 106-204, 274-361.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 5656HeadSequence AnalysisAdd
    BLAST
    Regioni57 – 363307RodSequence AnalysisAdd
    BLAST
    Regioni57 – 9135Coil 1ASequence AnalysisAdd
    BLAST
    Regioni92 – 10211Linker 1Sequence AnalysisAdd
    BLAST
    Regioni103 – 203101Coil 1BSequence AnalysisAdd
    BLAST
    Regioni204 – 21916Linker 12Sequence AnalysisAdd
    BLAST
    Regioni220 – 363144Coil 2Sequence AnalysisAdd
    BLAST
    Regioni364 – 40441TailSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi5 – 4844Cys-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the intermediate filament family.Sequence Analysis

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    GeneTreeiENSGT00750000117494.
    HOGENOMiHOG000230975.
    HOVERGENiHBG013015.
    InParanoidiQ9D7C4.
    KOiK07604.
    OMAiICLKRNH.
    OrthoDBiEOG7FV3Q8.
    PhylomeDBiQ8K0Y2.
    TreeFamiTF332742.

    Family and domain databases

    InterProiIPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR002957. Keratin_I.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    [Graphical view]
    PRINTSiPR01248. TYPE1KERATIN.
    PROSITEiPS00226. IF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K0Y2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPYNCCLPAM SCRTSCSSRP CVPPSCHGCT LPGACNIPAN VGNCNWFCEG    50
    SFNGNEKETM QFLNDRLASY MEKVRQLERE NAELECRIQE RNQQQDPLVC 100
    PAYQAYFRTI EELQQKILCG KSENARLVVQ IDNAKLASDD FRTKYETELS 150
    LRQLVEADIN SLRRILDELT LCKSDLEAQV ESLKEELLCL KQNHEQEVNT 200
    LRCQLGDRLN VEVDAAPTVD LNRVLNETRC QYEALVETNR REVEEWYTTQ 250
    TEELNKQVVS SSEQLQSCQA EIIELRRTVN ALEIELQAQH ELRNSLENTL 300
    TESEARYSSQ LSQVQCLITN VESQLGEIRA DLERQNQEYQ VLLDIRSRLE 350
    CEINTYRGLL ESEDCKLPCN PCATTNACDK PIGPCVPNPC VTRPRCGPCN 400
    TFVR 404
    Length:404
    Mass (Da):46,137
    Last modified:October 1, 2002 - v1
    Checksum:i15C54491027291DF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti240 – 2401R → L in BAB26243. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK009363 mRNA. Translation: BAB26243.1.
    AK037251 mRNA. Translation: BAC29777.1.
    AL592545 Genomic DNA. Translation: CAM22478.1.
    CH466662 Genomic DNA. Translation: EDL02593.1.
    BC029257 mRNA. Translation: AAH29257.1.
    CCDSiCCDS25403.1.
    RefSeqiNP_082259.2. NM_027983.3.
    UniGeneiMm.440318.

    Genome annotation databases

    EnsembliENSMUST00000018399; ENSMUSP00000018399; ENSMUSG00000035592.
    GeneIDi71888.
    KEGGimmu:71888.
    UCSCiuc007lka.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK009363 mRNA. Translation: BAB26243.1 .
    AK037251 mRNA. Translation: BAC29777.1 .
    AL592545 Genomic DNA. Translation: CAM22478.1 .
    CH466662 Genomic DNA. Translation: EDL02593.1 .
    BC029257 mRNA. Translation: AAH29257.1 .
    CCDSi CCDS25403.1.
    RefSeqi NP_082259.2. NM_027983.3.
    UniGenei Mm.440318.

    3D structure databases

    ProteinModelPortali Q8K0Y2.
    SMRi Q8K0Y2. Positions 59-91, 106-204, 274-361.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8K0Y2. 1 interaction.
    MINTi MINT-218150.
    STRINGi 10090.ENSMUSP00000018399.

    PTM databases

    PhosphoSitei Q8K0Y2.

    Proteomic databases

    PRIDEi Q8K0Y2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000018399 ; ENSMUSP00000018399 ; ENSMUSG00000035592 .
    GeneIDi 71888.
    KEGGi mmu:71888.
    UCSCi uc007lka.2. mouse.

    Organism-specific databases

    CTDi 3883.
    MGIi MGI:1919138. Krt33a.

    Phylogenomic databases

    GeneTreei ENSGT00750000117494.
    HOGENOMi HOG000230975.
    HOVERGENi HBG013015.
    InParanoidi Q9D7C4.
    KOi K07604.
    OMAi ICLKRNH.
    OrthoDBi EOG7FV3Q8.
    PhylomeDBi Q8K0Y2.
    TreeFami TF332742.

    Miscellaneous databases

    NextBioi 334856.
    PROi Q8K0Y2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8K0Y2.
    Genevestigatori Q8K0Y2.

    Family and domain databases

    InterProi IPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR002957. Keratin_I.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    [Graphical view ]
    PRINTSi PR01248. TYPE1KERATIN.
    PROSITEi PS00226. IF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6JImported.
      Tissue: Neonatal skinImported and TongueImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/NImported.
      Tissue: Salivary glandImported.

    Entry informationi

    Entry nameiKT33A_MOUSE
    AccessioniPrimary (citable) accession number: Q8K0Y2
    Secondary accession number(s): Q9D7C4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 3, 2009
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3