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Q8K0Y2

- KT33A_MOUSE

UniProt

Q8K0Y2 - KT33A_MOUSE

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Protein
Keratin, type I cuticular Ha3-I
Gene
Krt33a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei305 – 3051Stutter

GO - Molecular functioni

  1. protein binding Source: MGI
  2. structural molecule activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha3-I
Alternative name(s):
Hair keratin, type I Ha3-I
Keratin-33A
Short name:
K33A
Gene namesi
Name:Krt33a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1919138. Krt33a.

Subcellular locationi

GO - Cellular componenti

  1. intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Keratin, type I cuticular Ha3-I
PRO_0000366205Add
BLAST

Proteomic databases

PRIDEiQ8K0Y2.

PTM databases

PhosphoSiteiQ8K0Y2.

Expressioni

Gene expression databases

BgeeiQ8K0Y2.
GenevestigatoriQ8K0Y2.

Interactioni

Protein-protein interaction databases

IntActiQ8K0Y2. 1 interaction.
MINTiMINT-218150.
STRINGi10090.ENSMUSP00000018399.

Structurei

3D structure databases

ProteinModelPortaliQ8K0Y2.
SMRiQ8K0Y2. Positions 59-91, 106-204, 274-361.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5656Head
Add
BLAST
Regioni57 – 363307Rod
Add
BLAST
Regioni57 – 9135Coil 1A
Add
BLAST
Regioni92 – 10211Linker 1
Add
BLAST
Regioni103 – 203101Coil 1B
Add
BLAST
Regioni204 – 21916Linker 12
Add
BLAST
Regioni220 – 363144Coil 2
Add
BLAST
Regioni364 – 40441Tail
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 4844Cys-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00750000117494.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ9D7C4.
KOiK07604.
OMAiICLKRNH.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ8K0Y2.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K0Y2-1 [UniParc]FASTAAdd to Basket

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MPYNCCLPAM SCRTSCSSRP CVPPSCHGCT LPGACNIPAN VGNCNWFCEG    50
SFNGNEKETM QFLNDRLASY MEKVRQLERE NAELECRIQE RNQQQDPLVC 100
PAYQAYFRTI EELQQKILCG KSENARLVVQ IDNAKLASDD FRTKYETELS 150
LRQLVEADIN SLRRILDELT LCKSDLEAQV ESLKEELLCL KQNHEQEVNT 200
LRCQLGDRLN VEVDAAPTVD LNRVLNETRC QYEALVETNR REVEEWYTTQ 250
TEELNKQVVS SSEQLQSCQA EIIELRRTVN ALEIELQAQH ELRNSLENTL 300
TESEARYSSQ LSQVQCLITN VESQLGEIRA DLERQNQEYQ VLLDIRSRLE 350
CEINTYRGLL ESEDCKLPCN PCATTNACDK PIGPCVPNPC VTRPRCGPCN 400
TFVR 404
Length:404
Mass (Da):46,137
Last modified:October 1, 2002 - v1
Checksum:i15C54491027291DF
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti240 – 2401R → L in BAB26243. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK009363 mRNA. Translation: BAB26243.1.
AK037251 mRNA. Translation: BAC29777.1.
AL592545 Genomic DNA. Translation: CAM22478.1.
CH466662 Genomic DNA. Translation: EDL02593.1.
BC029257 mRNA. Translation: AAH29257.1.
CCDSiCCDS25403.1.
RefSeqiNP_082259.2. NM_027983.3.
UniGeneiMm.440318.

Genome annotation databases

EnsembliENSMUST00000018399; ENSMUSP00000018399; ENSMUSG00000035592.
GeneIDi71888.
KEGGimmu:71888.
UCSCiuc007lka.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK009363 mRNA. Translation: BAB26243.1 .
AK037251 mRNA. Translation: BAC29777.1 .
AL592545 Genomic DNA. Translation: CAM22478.1 .
CH466662 Genomic DNA. Translation: EDL02593.1 .
BC029257 mRNA. Translation: AAH29257.1 .
CCDSi CCDS25403.1.
RefSeqi NP_082259.2. NM_027983.3.
UniGenei Mm.440318.

3D structure databases

ProteinModelPortali Q8K0Y2.
SMRi Q8K0Y2. Positions 59-91, 106-204, 274-361.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8K0Y2. 1 interaction.
MINTi MINT-218150.
STRINGi 10090.ENSMUSP00000018399.

PTM databases

PhosphoSitei Q8K0Y2.

Proteomic databases

PRIDEi Q8K0Y2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000018399 ; ENSMUSP00000018399 ; ENSMUSG00000035592 .
GeneIDi 71888.
KEGGi mmu:71888.
UCSCi uc007lka.2. mouse.

Organism-specific databases

CTDi 3883.
MGIi MGI:1919138. Krt33a.

Phylogenomic databases

GeneTreei ENSGT00750000117494.
HOGENOMi HOG000230975.
HOVERGENi HBG013015.
InParanoidi Q9D7C4.
KOi K07604.
OMAi ICLKRNH.
OrthoDBi EOG7FV3Q8.
PhylomeDBi Q8K0Y2.
TreeFami TF332742.

Miscellaneous databases

NextBioi 334856.
PROi Q8K0Y2.
SOURCEi Search...

Gene expression databases

Bgeei Q8K0Y2.
Genevestigatori Q8K0Y2.

Family and domain databases

InterProi IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view ]
PANTHERi PTHR23239. PTHR23239. 1 hit.
Pfami PF00038. Filament. 1 hit.
[Graphical view ]
PRINTSi PR01248. TYPE1KERATIN.
PROSITEi PS00226. IF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Neonatal skin and Tongue.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.

Entry informationi

Entry nameiKT33A_MOUSE
AccessioniPrimary (citable) accession number: Q8K0Y2
Secondary accession number(s): Q9D7C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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