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Protein

Fasciculation and elongation protein zeta-1

Gene

Fez1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. May participate in the transport of mitochondria and other cargos along microtubules (By similarity).By similarity

GO - Molecular functioni

  • gamma-tubulin binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Fasciculation and elongation protein zeta-1
Alternative name(s):
Zygin I
Zygin-1
Gene namesi
Name:Fez1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2670976. Fez1.

Subcellular locationi

GO - Cellular componenti

  • axon Source: Ensembl
  • centrosome Source: MGI
  • cytoplasm Source: MGI
  • dendrite Source: Ensembl
  • microtubule Source: UniProtKB-KW
  • microtubule cytoskeleton Source: MGI
  • mitochondrion Source: Ensembl
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Fasciculation and elongation protein zeta-1PRO_0000189526Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei58 – 581Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated by protein kinase C zeta; which enhances interaction with UBE4B and polyubiquitination.By similarity
Polyubiquitinated in a UBE4B-dependent manner; which does not lead to proteasomal degradation and may be important for neurogenic activity. Polyubiquitin linkage seems to be mainly through Lys-26 (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8K0X8.
PaxDbiQ8K0X8.
PRIDEiQ8K0X8.

PTM databases

PhosphoSiteiQ8K0X8.

Expressioni

Gene expression databases

BgeeiQ8K0X8.
ExpressionAtlasiQ8K0X8. baseline and differential.
GenevisibleiQ8K0X8. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with the NH2-terminal variable region (V1) of PKC zeta and weakly with that of PKC epsilon. Interacts with UBE4B and SAP30L (By similarity). Interacts with SCOC and ULK1; SCOC interferes with ULK1-binding to FEZ1 (By similarity). Directly interacts with SCOC and UVRAG. Stabilizes the interaction between SCOC and UVRAG during amino acid starvation (By similarity).By similarity

Protein-protein interaction databases

BioGridi231627. 5 interactions.
STRINGi10090.ENSMUSP00000034630.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili230 – 29869Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi95 – 984Poly-Glu

Sequence similaritiesi

Belongs to the zygin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG273183.
GeneTreeiENSGT00390000017627.
HOGENOMiHOG000019494.
HOVERGENiHBG005657.
InParanoidiQ8K0X8.
OMAiEMMENSP.
TreeFamiTF313128.

Family and domain databases

InterProiIPR011680. FEZ.
IPR015642. FEZ_1.
[Graphical view]
PANTHERiPTHR12394. PTHR12394. 1 hit.
PTHR12394:SF4. PTHR12394:SF4. 1 hit.
PfamiPF07763. FEZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K0X8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAPLVSLDE EFEDIRPSCT EEPEEKPQCL YGTSPHHLED PSLSELENFS
60 70 80 90 100
SEIISFKSME DLVNEFDEKL NVCFRNYNAK TESLAPVKNQ LQIQEEEETL
110 120 130 140 150
RDEEVWDALT DNYIPSLSED WRDPNIEALN GNSSDIEIHE KEEEEFNEKS
160 170 180 190 200
ENDSGINEEP LLTADQVIEE IEEMMQNSPD PEEEEEVLEE EDGGEISSQA
210 220 230 240 250
DSVLLQEMQA LTQTFNNNWS YEGLRHMSGS ELTELLDRVE GAIRDFSEEL
260 270 280 290 300
VHQLARRDEL EFEKEVKNSF ITVLIEVQNK QREQRELMKK RRKEKGLSLQ
310 320 330 340 350
SNRIEKGSQM PLKRFSMEGI SNILQSGIRQ TFGSSGADRQ YLNTVIPYEK
360 370 380 390
KSSPPSVEDL QMLTNILFAM KEDNEKVPTL LTDYILKVLC PT
Length:392
Mass (Da):45,215
Last modified:July 27, 2011 - v2
Checksum:i58907843A8D24B25
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti89 – 891N → I in AAH29629 (PubMed:15489334).Curated
Sequence conflicti171 – 1711I → T in AAH29629 (PubMed:15489334).Curated
Sequence conflicti217 – 2171N → D in AAH29629 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ141674 mRNA. Translation: AAZ74351.1.
BC029629 mRNA. Translation: AAH29629.1.
CCDSiCCDS40581.1.
RefSeqiNP_898994.2. NM_183171.4.
XP_006510290.1. XM_006510227.2.
XP_006510291.1. XM_006510228.2.
XP_006510292.1. XM_006510229.2.
UniGeneiMm.5264.

Genome annotation databases

EnsembliENSMUST00000034630; ENSMUSP00000034630; ENSMUSG00000032118.
ENSMUST00000163816; ENSMUSP00000126072; ENSMUSG00000032118.
GeneIDi235180.
KEGGimmu:235180.
UCSCiuc009ouc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ141674 mRNA. Translation: AAZ74351.1.
BC029629 mRNA. Translation: AAH29629.1.
CCDSiCCDS40581.1.
RefSeqiNP_898994.2. NM_183171.4.
XP_006510290.1. XM_006510227.2.
XP_006510291.1. XM_006510228.2.
XP_006510292.1. XM_006510229.2.
UniGeneiMm.5264.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231627. 5 interactions.
STRINGi10090.ENSMUSP00000034630.

PTM databases

PhosphoSiteiQ8K0X8.

Proteomic databases

MaxQBiQ8K0X8.
PaxDbiQ8K0X8.
PRIDEiQ8K0X8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034630; ENSMUSP00000034630; ENSMUSG00000032118.
ENSMUST00000163816; ENSMUSP00000126072; ENSMUSG00000032118.
GeneIDi235180.
KEGGimmu:235180.
UCSCiuc009ouc.1. mouse.

Organism-specific databases

CTDi9638.
MGIiMGI:2670976. Fez1.

Phylogenomic databases

eggNOGiNOG273183.
GeneTreeiENSGT00390000017627.
HOGENOMiHOG000019494.
HOVERGENiHBG005657.
InParanoidiQ8K0X8.
OMAiEMMENSP.
TreeFamiTF313128.

Miscellaneous databases

NextBioi382536.
PROiQ8K0X8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K0X8.
ExpressionAtlasiQ8K0X8. baseline and differential.
GenevisibleiQ8K0X8. MM.

Family and domain databases

InterProiIPR011680. FEZ.
IPR015642. FEZ_1.
[Graphical view]
PANTHERiPTHR12394. PTHR12394. 1 hit.
PTHR12394:SF4. PTHR12394:SF4. 1 hit.
PfamiPF07763. FEZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Li N., Yuan X.-B.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Cerebellum.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.

Entry informationi

Entry nameiFEZ1_MOUSE
AccessioniPrimary (citable) accession number: Q8K0X8
Secondary accession number(s): Q3YE74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: July 27, 2011
Last modified: June 24, 2015
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.