Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8K0X8

- FEZ1_MOUSE

UniProt

Q8K0X8 - FEZ1_MOUSE

Protein

Fasciculation and elongation protein zeta-1

Gene

Fez1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. May participate in the transport of mitochondria and other cargos along microtubules By similarity.By similarity

    GO - Molecular functioni

    1. gamma-tubulin binding Source: MGI
    2. protein binding Source: MGI

    GO - Biological processi

    1. cellular response to growth factor stimulus Source: Ensembl
    2. establishment of mitochondrion localization Source: Ensembl
    3. positive regulation of neuron differentiation Source: Ensembl
    4. positive regulation of neuron projection development Source: Ensembl
    5. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fasciculation and elongation protein zeta-1
    Alternative name(s):
    Zygin I
    Zygin-1
    Gene namesi
    Name:Fez1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:2670976. Fez1.

    Subcellular locationi

    Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cell membrane By similarity
    Note: Colocalizes with both, alpha- and gamma-tubulin. Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta By similarity.By similarity

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. centrosome Source: MGI
    3. cytoplasm Source: MGI
    4. dendrite Source: Ensembl
    5. microtubule Source: UniProtKB-KW
    6. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Microtubule

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 392392Fasciculation and elongation protein zeta-1PRO_0000189526Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei58 – 581Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylated by protein kinase C zeta; which enhances interaction with UBE4B and polyubiquitination.By similarity
    Polyubiquitinated in a UBE4B-dependent manner; which does not lead to proteasomal degradation and may be important for neurogenic activity. Polyubiquitin linkage seems to be mainly through Lys-26 By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ8K0X8.
    PaxDbiQ8K0X8.
    PRIDEiQ8K0X8.

    PTM databases

    PhosphoSiteiQ8K0X8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8K0X8.
    BgeeiQ8K0X8.
    GenevestigatoriQ8K0X8.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with the NH2-terminal variable region (V1) of PKC zeta and weakly with that of PKC epsilon. Interacts with UBE4B and SAP30L By similarity. Interacts with SCOC and ULK1; SCOC interferes with ULK1-binding to FEZ1 By similarity. Directly interacts with SCOC and UVRAG. Stabilizes the interaction between SCOC and UVRAG during amino acid starvation By similarity.By similarity

    Protein-protein interaction databases

    BioGridi231627. 5 interactions.
    STRINGi10090.ENSMUSP00000034630.

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili230 – 29869Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi95 – 984Poly-Glu

    Sequence similaritiesi

    Belongs to the zygin family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG273183.
    GeneTreeiENSGT00390000017627.
    HOGENOMiHOG000019494.
    HOVERGENiHBG005657.
    InParanoidiQ3YE74.
    OMAiEMMENSP.
    TreeFamiTF313128.

    Family and domain databases

    InterProiIPR011680. FEZ.
    IPR015642. FEZ_1.
    [Graphical view]
    PANTHERiPTHR12394. PTHR12394. 1 hit.
    PTHR12394:SF4. PTHR12394:SF4. 1 hit.
    PfamiPF07763. FEZ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K0X8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAPLVSLDE EFEDIRPSCT EEPEEKPQCL YGTSPHHLED PSLSELENFS    50
    SEIISFKSME DLVNEFDEKL NVCFRNYNAK TESLAPVKNQ LQIQEEEETL 100
    RDEEVWDALT DNYIPSLSED WRDPNIEALN GNSSDIEIHE KEEEEFNEKS 150
    ENDSGINEEP LLTADQVIEE IEEMMQNSPD PEEEEEVLEE EDGGEISSQA 200
    DSVLLQEMQA LTQTFNNNWS YEGLRHMSGS ELTELLDRVE GAIRDFSEEL 250
    VHQLARRDEL EFEKEVKNSF ITVLIEVQNK QREQRELMKK RRKEKGLSLQ 300
    SNRIEKGSQM PLKRFSMEGI SNILQSGIRQ TFGSSGADRQ YLNTVIPYEK 350
    KSSPPSVEDL QMLTNILFAM KEDNEKVPTL LTDYILKVLC PT 392
    Length:392
    Mass (Da):45,215
    Last modified:July 27, 2011 - v2
    Checksum:i58907843A8D24B25
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti89 – 891N → I in AAH29629. (PubMed:15489334)Curated
    Sequence conflicti171 – 1711I → T in AAH29629. (PubMed:15489334)Curated
    Sequence conflicti217 – 2171N → D in AAH29629. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ141674 mRNA. Translation: AAZ74351.1.
    BC029629 mRNA. Translation: AAH29629.1.
    CCDSiCCDS40581.1.
    RefSeqiNP_898994.2. NM_183171.4.
    XP_006510290.1. XM_006510227.1.
    XP_006510291.1. XM_006510228.1.
    XP_006510292.1. XM_006510229.1.
    UniGeneiMm.5264.

    Genome annotation databases

    EnsembliENSMUST00000034630; ENSMUSP00000034630; ENSMUSG00000032118.
    ENSMUST00000163816; ENSMUSP00000126072; ENSMUSG00000032118.
    GeneIDi235180.
    KEGGimmu:235180.
    UCSCiuc009ouc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ141674 mRNA. Translation: AAZ74351.1 .
    BC029629 mRNA. Translation: AAH29629.1 .
    CCDSi CCDS40581.1.
    RefSeqi NP_898994.2. NM_183171.4.
    XP_006510290.1. XM_006510227.1.
    XP_006510291.1. XM_006510228.1.
    XP_006510292.1. XM_006510229.1.
    UniGenei Mm.5264.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 231627. 5 interactions.
    STRINGi 10090.ENSMUSP00000034630.

    PTM databases

    PhosphoSitei Q8K0X8.

    Proteomic databases

    MaxQBi Q8K0X8.
    PaxDbi Q8K0X8.
    PRIDEi Q8K0X8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034630 ; ENSMUSP00000034630 ; ENSMUSG00000032118 .
    ENSMUST00000163816 ; ENSMUSP00000126072 ; ENSMUSG00000032118 .
    GeneIDi 235180.
    KEGGi mmu:235180.
    UCSCi uc009ouc.1. mouse.

    Organism-specific databases

    CTDi 9638.
    MGIi MGI:2670976. Fez1.

    Phylogenomic databases

    eggNOGi NOG273183.
    GeneTreei ENSGT00390000017627.
    HOGENOMi HOG000019494.
    HOVERGENi HBG005657.
    InParanoidi Q3YE74.
    OMAi EMMENSP.
    TreeFami TF313128.

    Miscellaneous databases

    NextBioi 382536.
    PROi Q8K0X8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K0X8.
    Bgeei Q8K0X8.
    Genevestigatori Q8K0X8.

    Family and domain databases

    InterProi IPR011680. FEZ.
    IPR015642. FEZ_1.
    [Graphical view ]
    PANTHERi PTHR12394. PTHR12394. 1 hit.
    PTHR12394:SF4. PTHR12394:SF4. 1 hit.
    Pfami PF07763. FEZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Li N., Yuan X.-B.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Cerebellum.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic brain.

    Entry informationi

    Entry nameiFEZ1_MOUSE
    AccessioniPrimary (citable) accession number: Q8K0X8
    Secondary accession number(s): Q3YE74
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3