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Q8K0X8 (FEZ1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fasciculation and elongation protein zeta-1
Alternative name(s):
Zygin I
Zygin-1
Gene names
Name:Fez1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. May participate in the transport of mitochondria and other cargos along microtubules By similarity.

Subunit structure

Homodimer. Interacts with the NH2-terminal variable region (V1) of PKC zeta and weakly with that of PKC epsilon. Interacts with UBE4B and SAP30L By similarity. Interacts with SCOC and ULK1; SCOC interferes with ULK1-binding to FEZ1 By similarity. Directly interacts with SCOC and UVRAG. Stabilizes the interaction between SCOC and UVRAG during amino acid starvation By similarity.

Subcellular location

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cell membrane By similarity. Note: Colocalizes with both, alpha- and gamma-tubulin. Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta By similarity.

Post-translational modification

Phosphorylated by protein kinase C zeta; which enhances interaction with UBE4B and polyubiquitination By similarity.

Polyubiquitinated in a UBE4B-dependent manner; which does not lead to proteasomal degradation and may be important for neurogenic activity. Polyubiquitin linkage seems to be mainly through Lys-26 By similarity.

Sequence similarities

Belongs to the zygin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 392392Fasciculation and elongation protein zeta-1
PRO_0000189526

Regions

Coiled coil230 – 29869 Potential
Compositional bias95 – 984Poly-Glu

Amino acid modifications

Modified residue581Phosphoserine Ref.3

Experimental info

Sequence conflict891N → I in AAH29629. Ref.2
Sequence conflict1711I → T in AAH29629. Ref.2
Sequence conflict2171N → D in AAH29629. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8K0X8 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 58907843A8D24B25

FASTA39245,215
        10         20         30         40         50         60 
MEAPLVSLDE EFEDIRPSCT EEPEEKPQCL YGTSPHHLED PSLSELENFS SEIISFKSME 

        70         80         90        100        110        120 
DLVNEFDEKL NVCFRNYNAK TESLAPVKNQ LQIQEEEETL RDEEVWDALT DNYIPSLSED 

       130        140        150        160        170        180 
WRDPNIEALN GNSSDIEIHE KEEEEFNEKS ENDSGINEEP LLTADQVIEE IEEMMQNSPD 

       190        200        210        220        230        240 
PEEEEEVLEE EDGGEISSQA DSVLLQEMQA LTQTFNNNWS YEGLRHMSGS ELTELLDRVE 

       250        260        270        280        290        300 
GAIRDFSEEL VHQLARRDEL EFEKEVKNSF ITVLIEVQNK QREQRELMKK RRKEKGLSLQ 

       310        320        330        340        350        360 
SNRIEKGSQM PLKRFSMEGI SNILQSGIRQ TFGSSGADRQ YLNTVIPYEK KSSPPSVEDL 

       370        380        390 
QMLTNILFAM KEDNEKVPTL LTDYILKVLC PT 

« Hide

References

« Hide 'large scale' references
[1]Li N., Yuan X.-B.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: Cerebellum.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
[3]"Phosphoproteomic analysis of the developing mouse brain."
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.
Mol. Cell. Proteomics 3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ141674 mRNA. Translation: AAZ74351.1.
BC029629 mRNA. Translation: AAH29629.1.
RefSeqNP_898994.2. NM_183171.4.
XP_006510290.1. XM_006510227.1.
XP_006510291.1. XM_006510228.1.
XP_006510292.1. XM_006510229.1.
UniGeneMm.5264.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid231627. 3 interactions.
STRING10090.ENSMUSP00000034630.

PTM databases

PhosphoSiteQ8K0X8.

Proteomic databases

PaxDbQ8K0X8.
PRIDEQ8K0X8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000034630; ENSMUSP00000034630; ENSMUSG00000032118.
ENSMUST00000163816; ENSMUSP00000126072; ENSMUSG00000032118.
GeneID235180.
KEGGmmu:235180.
UCSCuc009ouc.1. mouse.

Organism-specific databases

CTD9638.
MGIMGI:2670976. Fez1.

Phylogenomic databases

eggNOGNOG273183.
GeneTreeENSGT00390000017627.
HOGENOMHOG000019494.
HOVERGENHBG005657.
InParanoidQ3YE74.
OMAEMMENSP.
TreeFamTF313128.

Gene expression databases

ArrayExpressQ8K0X8.
BgeeQ8K0X8.
GenevestigatorQ8K0X8.

Family and domain databases

InterProIPR011680. FEZ.
IPR015642. FEZ_1.
[Graphical view]
PANTHERPTHR12394. PTHR12394. 1 hit.
PTHR12394:SF4. PTHR12394:SF4. 1 hit.
PfamPF07763. FEZ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio382536.
PROQ8K0X8.
SOURCESearch...

Entry information

Entry nameFEZ1_MOUSE
AccessionPrimary (citable) accession number: Q8K0X8
Secondary accession number(s): Q3YE74
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: July 27, 2011
Last modified: March 19, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot