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Q8K0X8

- FEZ1_MOUSE

UniProt

Q8K0X8 - FEZ1_MOUSE

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Protein

Fasciculation and elongation protein zeta-1

Gene

Fez1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. May participate in the transport of mitochondria and other cargos along microtubules (By similarity).By similarity

GO - Molecular functioni

  1. gamma-tubulin binding Source: MGI

GO - Biological processi

  1. cellular response to growth factor stimulus Source: Ensembl
  2. establishment of mitochondrion localization Source: Ensembl
  3. positive regulation of neuron differentiation Source: Ensembl
  4. positive regulation of neuron projection development Source: Ensembl
  5. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Fasciculation and elongation protein zeta-1
Alternative name(s):
Zygin I
Zygin-1
Gene namesi
Name:Fez1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:2670976. Fez1.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cell membrane By similarity
Note: Colocalizes with both, alpha- and gamma-tubulin. Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta (By similarity).By similarity

GO - Cellular componenti

  1. axon Source: Ensembl
  2. centrosome Source: MGI
  3. cytoplasm Source: MGI
  4. dendrite Source: Ensembl
  5. microtubule Source: UniProtKB-KW
  6. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Fasciculation and elongation protein zeta-1PRO_0000189526Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei58 – 581Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated by protein kinase C zeta; which enhances interaction with UBE4B and polyubiquitination.By similarity
Polyubiquitinated in a UBE4B-dependent manner; which does not lead to proteasomal degradation and may be important for neurogenic activity. Polyubiquitin linkage seems to be mainly through Lys-26 (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8K0X8.
PaxDbiQ8K0X8.
PRIDEiQ8K0X8.

PTM databases

PhosphoSiteiQ8K0X8.

Expressioni

Gene expression databases

BgeeiQ8K0X8.
ExpressionAtlasiQ8K0X8. baseline and differential.
GenevestigatoriQ8K0X8.

Interactioni

Subunit structurei

Homodimer. Interacts with the NH2-terminal variable region (V1) of PKC zeta and weakly with that of PKC epsilon. Interacts with UBE4B and SAP30L (By similarity). Interacts with SCOC and ULK1; SCOC interferes with ULK1-binding to FEZ1 (By similarity). Directly interacts with SCOC and UVRAG. Stabilizes the interaction between SCOC and UVRAG during amino acid starvation (By similarity).By similarity

Protein-protein interaction databases

BioGridi231627. 5 interactions.
STRINGi10090.ENSMUSP00000034630.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili230 – 29869Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi95 – 984Poly-Glu

Sequence similaritiesi

Belongs to the zygin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG273183.
GeneTreeiENSGT00390000017627.
HOGENOMiHOG000019494.
HOVERGENiHBG005657.
InParanoidiQ8K0X8.
OMAiEMMENSP.
TreeFamiTF313128.

Family and domain databases

InterProiIPR011680. FEZ.
IPR015642. FEZ_1.
[Graphical view]
PANTHERiPTHR12394. PTHR12394. 1 hit.
PTHR12394:SF4. PTHR12394:SF4. 1 hit.
PfamiPF07763. FEZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K0X8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEAPLVSLDE EFEDIRPSCT EEPEEKPQCL YGTSPHHLED PSLSELENFS
60 70 80 90 100
SEIISFKSME DLVNEFDEKL NVCFRNYNAK TESLAPVKNQ LQIQEEEETL
110 120 130 140 150
RDEEVWDALT DNYIPSLSED WRDPNIEALN GNSSDIEIHE KEEEEFNEKS
160 170 180 190 200
ENDSGINEEP LLTADQVIEE IEEMMQNSPD PEEEEEVLEE EDGGEISSQA
210 220 230 240 250
DSVLLQEMQA LTQTFNNNWS YEGLRHMSGS ELTELLDRVE GAIRDFSEEL
260 270 280 290 300
VHQLARRDEL EFEKEVKNSF ITVLIEVQNK QREQRELMKK RRKEKGLSLQ
310 320 330 340 350
SNRIEKGSQM PLKRFSMEGI SNILQSGIRQ TFGSSGADRQ YLNTVIPYEK
360 370 380 390
KSSPPSVEDL QMLTNILFAM KEDNEKVPTL LTDYILKVLC PT
Length:392
Mass (Da):45,215
Last modified:July 27, 2011 - v2
Checksum:i58907843A8D24B25
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti89 – 891N → I in AAH29629. (PubMed:15489334)Curated
Sequence conflicti171 – 1711I → T in AAH29629. (PubMed:15489334)Curated
Sequence conflicti217 – 2171N → D in AAH29629. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ141674 mRNA. Translation: AAZ74351.1.
BC029629 mRNA. Translation: AAH29629.1.
CCDSiCCDS40581.1.
RefSeqiNP_898994.2. NM_183171.4.
XP_006510290.1. XM_006510227.1.
XP_006510291.1. XM_006510228.1.
XP_006510292.1. XM_006510229.1.
UniGeneiMm.5264.

Genome annotation databases

EnsembliENSMUST00000034630; ENSMUSP00000034630; ENSMUSG00000032118.
ENSMUST00000163816; ENSMUSP00000126072; ENSMUSG00000032118.
GeneIDi235180.
KEGGimmu:235180.
UCSCiuc009ouc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ141674 mRNA. Translation: AAZ74351.1 .
BC029629 mRNA. Translation: AAH29629.1 .
CCDSi CCDS40581.1.
RefSeqi NP_898994.2. NM_183171.4.
XP_006510290.1. XM_006510227.1.
XP_006510291.1. XM_006510228.1.
XP_006510292.1. XM_006510229.1.
UniGenei Mm.5264.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 231627. 5 interactions.
STRINGi 10090.ENSMUSP00000034630.

PTM databases

PhosphoSitei Q8K0X8.

Proteomic databases

MaxQBi Q8K0X8.
PaxDbi Q8K0X8.
PRIDEi Q8K0X8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034630 ; ENSMUSP00000034630 ; ENSMUSG00000032118 .
ENSMUST00000163816 ; ENSMUSP00000126072 ; ENSMUSG00000032118 .
GeneIDi 235180.
KEGGi mmu:235180.
UCSCi uc009ouc.1. mouse.

Organism-specific databases

CTDi 9638.
MGIi MGI:2670976. Fez1.

Phylogenomic databases

eggNOGi NOG273183.
GeneTreei ENSGT00390000017627.
HOGENOMi HOG000019494.
HOVERGENi HBG005657.
InParanoidi Q8K0X8.
OMAi EMMENSP.
TreeFami TF313128.

Miscellaneous databases

NextBioi 382536.
PROi Q8K0X8.
SOURCEi Search...

Gene expression databases

Bgeei Q8K0X8.
ExpressionAtlasi Q8K0X8. baseline and differential.
Genevestigatori Q8K0X8.

Family and domain databases

InterProi IPR011680. FEZ.
IPR015642. FEZ_1.
[Graphical view ]
PANTHERi PTHR12394. PTHR12394. 1 hit.
PTHR12394:SF4. PTHR12394:SF4. 1 hit.
Pfami PF07763. FEZ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Li N., Yuan X.-B.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Cerebellum.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.

Entry informationi

Entry nameiFEZ1_MOUSE
AccessioniPrimary (citable) accession number: Q8K0X8
Secondary accession number(s): Q3YE74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3