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Protein

DPH3 homolog

Gene

Dph3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2.
Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the secretion process. Stimulates binding of GNEFR to SEC5 (By similarity).By similarity

Pathwayi: peptidyl-diphthamide biosynthesis

This protein is involved in the pathway peptidyl-diphthamide biosynthesis, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway peptidyl-diphthamide biosynthesis and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 60DPH-typePROSITE-ProRule annotationAdd BLAST57

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-5358493. Synthesis of diphthamide-EEF2.
UniPathwayiUPA00559.

Names & Taxonomyi

Protein namesi
Recommended name:
DPH3 homolog
Alternative name(s):
CSL-type zinc finger-containing protein 2
DelGEF-interacting protein 1
Short name:
DelGIP1
Gene namesi
Name:Dph3
Synonyms:Desr1, Zcsl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1922658. Dph3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryonic lethal about 11.5 days after fertilization.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000826211 – 82DPH3 homologAdd BLAST82

Proteomic databases

PaxDbiQ8K0W9.
PRIDEiQ8K0W9.

PTM databases

iPTMnetiQ8K0W9.
PhosphoSitePlusiQ8K0W9.

Expressioni

Tissue specificityi

Widely expressed with highest levels in heart, liver, kidney and testis.1 Publication

Developmental stagei

In the embryo, expressed during all stages of development.1 Publication

Gene expression databases

BgeeiENSMUSG00000021905.
CleanExiMM_DPH3.
ExpressionAtlasiQ8K0W9. baseline and differential.
GenevisibleiQ8K0W9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022461.

Structurei

Secondary structure

182
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 9Combined sources3
Helixi10 – 12Combined sources3
Turni17 – 19Combined sources3
Beta strandi21 – 24Combined sources4
Beta strandi27 – 30Combined sources4
Beta strandi32 – 35Combined sources4
Helixi36 – 40Combined sources5
Beta strandi45 – 47Combined sources3
Turni49 – 51Combined sources3
Beta strandi54 – 58Combined sources5
Helixi61 – 65Combined sources5
Turni66 – 68Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WGENMR-A1-70[»]
ProteinModelPortaliQ8K0W9.
SMRiQ8K0W9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8K0W9.

Family & Domainsi

Sequence similaritiesi

Belongs to the DPH3 family.Curated
Contains 1 DPH-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 60DPH-typePROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2923. Eukaryota.
COG5216. LUCA.
GeneTreeiENSGT00390000007225.
HOGENOMiHOG000190740.
HOVERGENiHBG056007.
InParanoidiQ8K0W9.
KOiK15455.
OMAiREMLEMG.
OrthoDBiEOG091G16WK.
PhylomeDBiQ8K0W9.
TreeFamiTF315102.

Family and domain databases

InterProiIPR007872. Znf_DHP.
[Graphical view]
PfamiPF05207. zf-CSL. 1 hit.
[Graphical view]
PROSITEiPS51074. ZF_DPH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K0W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVFHDEVEI EDFQYDEDSE TYFYPCPCGD NFAITKEDLE NGEDVATCPS
60 70 80
CSLIIKVIYD KDQFMCGETV PAPSTNKELV KC
Length:82
Mass (Da):9,286
Last modified:October 1, 2002 - v1
Checksum:i3BC612EFE72E7670
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048097 mRNA. Translation: BAC33240.1.
AK011448 mRNA. Translation: BAC25335.1.
BC029910 mRNA. Translation: AAH29910.1.
BC039954 mRNA. Translation: AAH39954.1.
CCDSiCCDS36861.1.
RefSeqiNP_001040898.1. NM_001047433.2.
NP_001271275.1. NM_001284346.1.
NP_758458.1. NM_172254.4.
UniGeneiMm.2519.

Genome annotation databases

EnsembliENSMUST00000022461; ENSMUSP00000022461; ENSMUSG00000021905.
ENSMUST00000067955; ENSMUSP00000068491; ENSMUSG00000021905.
GeneIDi105638.
KEGGimmu:105638.
UCSCiuc007syc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048097 mRNA. Translation: BAC33240.1.
AK011448 mRNA. Translation: BAC25335.1.
BC029910 mRNA. Translation: AAH29910.1.
BC039954 mRNA. Translation: AAH39954.1.
CCDSiCCDS36861.1.
RefSeqiNP_001040898.1. NM_001047433.2.
NP_001271275.1. NM_001284346.1.
NP_758458.1. NM_172254.4.
UniGeneiMm.2519.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WGENMR-A1-70[»]
ProteinModelPortaliQ8K0W9.
SMRiQ8K0W9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022461.

PTM databases

iPTMnetiQ8K0W9.
PhosphoSitePlusiQ8K0W9.

Proteomic databases

PaxDbiQ8K0W9.
PRIDEiQ8K0W9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022461; ENSMUSP00000022461; ENSMUSG00000021905.
ENSMUST00000067955; ENSMUSP00000068491; ENSMUSG00000021905.
GeneIDi105638.
KEGGimmu:105638.
UCSCiuc007syc.2. mouse.

Organism-specific databases

CTDi285381.
MGIiMGI:1922658. Dph3.

Phylogenomic databases

eggNOGiKOG2923. Eukaryota.
COG5216. LUCA.
GeneTreeiENSGT00390000007225.
HOGENOMiHOG000190740.
HOVERGENiHBG056007.
InParanoidiQ8K0W9.
KOiK15455.
OMAiREMLEMG.
OrthoDBiEOG091G16WK.
PhylomeDBiQ8K0W9.
TreeFamiTF315102.

Enzyme and pathway databases

UniPathwayiUPA00559.
ReactomeiR-MMU-5358493. Synthesis of diphthamide-EEF2.

Miscellaneous databases

ChiTaRSiDph3. mouse.
EvolutionaryTraceiQ8K0W9.
PROiQ8K0W9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021905.
CleanExiMM_DPH3.
ExpressionAtlasiQ8K0W9. baseline and differential.
GenevisibleiQ8K0W9. MM.

Family and domain databases

InterProiIPR007872. Znf_DHP.
[Graphical view]
PfamiPF05207. zf-CSL. 1 hit.
[Graphical view]
PROSITEiPS51074. ZF_DPH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPH3_MOUSE
AccessioniPrimary (citable) accession number: Q8K0W9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.