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Protein

Protein unc-13 homolog C

Gene

Unc13c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. May be involved in the regulation of synaptic transmission at parallel fiber - Purkinje cell synapses.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1093 – 1143Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

GO - Molecular functioni

  • diacylglycerol binding Source: InterPro
  • metal ion binding Source: UniProtKB-KW
  • non-kinase phorbol ester receptor activity Source: MGI

GO - Biological processi

  • chemical synaptic transmission Source: MGI
  • intracellular signal transduction Source: InterPro
  • negative regulation of synaptic plasticity Source: ParkinsonsUK-UCL
  • synaptic vesicle exocytosis Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Exocytosis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein unc-13 homolog C
Alternative name(s):
Munc13-3
Gene namesi
Name:Unc13c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2149021. Unc13c.

Subcellular locationi

GO - Cellular componenti

  • calyx of Held Source: ParkinsonsUK-UCL
  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: UniProtKB-SubCell
  • glutamatergic synapse Source: GOC-OWL
  • plasma membrane Source: ParkinsonsUK-UCL
  • presynapse Source: ParkinsonsUK-UCL
  • presynaptic active zone Source: GO_Central
  • presynaptic membrane Source: UniProtKB-SubCell
  • terminal bouton Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Synapse

Pathology & Biotechi

Disruption phenotypei

Mutant mice showed no obvious physical or behavioral abnormalities. Some deficiency in motor learning can be observed, compared to wild type, in a motor performance and learning test on a rotating rod, but only at high rotation speed.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001885791 – 2210Protein unc-13 homolog CAdd BLAST2210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei89PhosphoserineBy similarity1
Modified residuei446PhosphoserineBy similarity1
Modified residuei450PhosphoserineBy similarity1
Modified residuei784PhosphoserineBy similarity1
Modified residuei1023Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ8K0T7.
PaxDbiQ8K0T7.
PeptideAtlasiQ8K0T7.
PRIDEiQ8K0T7.

PTM databases

iPTMnetiQ8K0T7.
PhosphoSitePlusiQ8K0T7.

Expressioni

Tissue specificityi

Restricted to cerebellum, predominantly in the granule cell layer. Almost exclusively present in the molecular layer in which the parallel fiber axons of granule cells terminate on dendrites of Purkinje neurons (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000062151.
CleanExiMM_UNC13C.
GenevisibleiQ8K0T7. MM.

Interactioni

Subunit structurei

Interacts with STX1A and/or STX1B1, VAMP2 and SNAP25.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074726.

Structurei

3D structure databases

ProteinModelPortaliQ8K0T7.
SMRiQ8K0T7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1203 – 1309C2 1PROSITE-ProRule annotationAdd BLAST107
Domaini1633 – 1776MHD1PROSITE-ProRule annotationAdd BLAST144
Domaini1882 – 2024MHD2PROSITE-ProRule annotationAdd BLAST143
Domaini2044 – 2149C2 2PROSITE-ProRule annotationAdd BLAST106

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili967 – 991Sequence analysisAdd BLAST25

Domaini

The C2 domains are not involved in calcium-dependent phospholipid binding.By similarity

Sequence similaritiesi

Belongs to the unc-13 family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation
Contains 1 MHD1 (MUNC13 homology domain 1) domain.PROSITE-ProRule annotation
Contains 1 MHD2 (MUNC13 homology domain 2) domain.PROSITE-ProRule annotation
Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1093 – 1143Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1011. Eukaryota.
ENOG410XS5D. LUCA.
GeneTreeiENSGT00850000132267.
HOGENOMiHOG000154775.
HOVERGENiHBG108648.
InParanoidiQ8K0T7.
KOiK15293.
OMAiNEPQGQW.
OrthoDBiEOG091G0527.
PhylomeDBiQ8K0T7.
TreeFamiTF312844.

Family and domain databases

CDDicd00029. C1. 1 hit.
Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR010439. CAPS_dom.
IPR014770. Munc13_1.
IPR014772. Munc13_dom-2.
IPR019558. Munc13_subgr_dom-2.
IPR002219. PE/DAG-bd.
IPR027080. Unc-13.
IPR027087. Unc13C.
[Graphical view]
PANTHERiPTHR10480. PTHR10480. 1 hit.
PTHR10480:SF2. PTHR10480:SF2. 1 hit.
PfamiPF00130. C1_1. 1 hit.
PF00168. C2. 2 hits.
PF06292. DUF1041. 1 hit.
PF10540. Membr_traf_MHD. 1 hit.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
SMARTiSM00109. C1. 1 hit.
SM00239. C2. 2 hits.
SM01145. DUF1041. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
PS51258. MHD1. 1 hit.
PS51259. MHD2. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K0T7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVASLFKSLI LAYIHKLCKG MFTKKLGNTT KKKENRQQKK DQDFPTAGHT
60 70 80 90 100
KPPKLSNALK STVKKIAKCS STRNFSIEDE EGHKDFSLSP TFSYRVAIAN
110 120 130 140 150
GLQTAVTNSD EDLLQELSSI ESSYSESFNE LRSSTENQVQ STHTMPVRRN
160 170 180 190 200
RKSSSSLAPS EGSSDGERTL HTLKLGALRK LRKWKKSQEC VSSDSELSTV
210 220 230 240 250
KKTWGIRSKS LDRTARNPKT NVLEPGFSSS GCISQTHDVM EMIFKELQGI
260 270 280 290 300
SQIETELSEL RGHVNALKYS IDEISSSVEV VQSEIEQLRT GFVQARRETR
310 320 330 340 350
DIHDYIKHLG HMGSKVSLRF LNVPEERHEY VESVVYQILI DKMGFSDVPN
360 370 380 390 400
AIKIEFAQRI GQQRDCPNAK PRPILVYFET PQQRDSVLKK SYKLKGTGIG
410 420 430 440 450
ISTDILTYDI RERKEKGVLP SSQTYESMDM KLSTPEPKAK KNAWLSPNDS
460 470 480 490 500
DRELESDLSR SSYADSPAKG SSSKSSSKSH SARSKNKAAN SRTSQKSDYN
510 520 530 540 550
KRPSQPPASS TPEKQTPHYV EATPPLWHSQ SDFFTLKLSR SESDFSKLCQ
560 570 580 590 600
SYSEDFSESQ FFCRTNGSSL LSSSDRELWQ RKQEGMPALY HRLQDQGLDE
610 620 630 640 650
TIPAVPGQAE IENTETVDSG MSNSMVCASG DRSNYSGSQL SLHEDLSPWK
660 670 680 690 700
EWNQAGQGTD DVGLDSSTQE PFDYDTNSLS DQQLDLSSKD LDDLGKCHSD
710 720 730 740 750
LQDDSESYDL TQDDNSSPCP GLDNEPQGQW VGQYDSYQEA NSNDLYPNQS
760 770 780 790 800
HPSMMYRSQS ELQSDDSEGA QPKSWHSRLS IDLSDKTFKF PKFGSTLQRA
810 820 830 840 850
KSALEVVWNK STQSLSGCED SGSSLMGRFR TLSQSTANES STTLDSDIYT
860 870 880 890 900
EPYYYKAEEE EDYCEPVADS ETDYVEVMEQ VLAKLENRTS ITEVNEHIKD
910 920 930 940 950
YDHPSYETPY ETPQDEGYDG QADDIISEGE LETLNEPAVE MELAEDENQN
960 970 980 990 1000
LPAESLEVMK PKRIRPSFKE AALRAYKKQM AELEEKILAG DSSSMDEKAR
1010 1020 1030 1040 1050
IVSGNDLDAS KFSALQVFGG AGRGLYGIDS MPDLRRKKTL PIVRDVAMTL
1060 1070 1080 1090 1100
AARKSGLSLA MVIRTSLNNE ELKMHVFRKT LQALIYPISS TTPHNFEVWT
1110 1120 1130 1140 1150
ATTPTYCYEC EGLLWGIARQ GMKCLECGVK CHEKCQDLLN ADCLQRAAEK
1160 1170 1180 1190 1200
SSKHGAEDKT QTIITAMKER MKIRERNRPE VFEVIQEMFQ ISKEDFVQYT
1210 1220 1230 1240 1250
KAAKQSVLDG TSKWSAKITI TVVSAQGLQA KDKTGSSDPY VTVQVGKNKR
1260 1270 1280 1290 1300
RTKTIFGNLN PVWDEKFFFE CHNSTDRIKV RVWDEDDDIK SRVKQHFKKE
1310 1320 1330 1340 1350
SDDFLGQTIV EVRTLSGEMD VWYNLEKRTD KSAVSGAIRL KINVEIKGEE
1360 1370 1380 1390 1400
KVAPYHIQYT CLHENLFHYL TEVKSNGSVK IPEVKGDEAW KVFFDDASQE
1410 1420 1430 1440 1450
IVDEFAMRYG VESIYQAMTH FSCLSSKYMC PGVPAVMSAL LANINAFYAH
1460 1470 1480 1490 1500
TTVSTNVQVS ASDRFAATNF GREKFIKLLD QLHNSLRIDL SKYRENFPAS
1510 1520 1530 1540 1550
NSERLQDLKS TVDLLTSITF FRMKVLELQS PPKASAVVKD CVRACLDSTY
1560 1570 1580 1590 1600
KYIFDNCHEL YSQLIDPSKK QDVPREDQGP TTKNLDFWPQ LITLMVTIID
1610 1620 1630 1640 1650
EDKTAYTPVL NQFPQELNMG KISAEIMWSL FALDMKYALE EHEKQRLCKS
1660 1670 1680 1690 1700
TDYMNLHFKV KWFYNEYVRE LPAFKDAVPE YSLWFEPFVM QWLDENEDVS
1710 1720 1730 1740 1750
MEFLHGALGR DKKDGFQQTS DHALFSCSVV DVFAQLNQSF EIIKKLECPN
1760 1770 1780 1790 1800
PEALSHLMRR FAKTINKVLV QYAAIVSNDF SSYCDKETVP CILMNNIQQL
1810 1820 1830 1840 1850
RVQLEKMFES MGGKELDPEA STILKELQIK LNGVLDALSI TYGESFQLTI
1860 1870 1880 1890 1900
EECIKQMGAE LNQMRANGNS TANKNSAAMD AEIVLRPLMD FLDKTLSLSA
1910 1920 1930 1940 1950
KICEKTVLKR VLKELWKLVL NKIEKQIVLP PLTDQTGPQM IFIAAKDLGQ
1960 1970 1980 1990 2000
LSKLKEHMIR EDAKGLTPRQ CAIVEVVLAT IKQYFHAGGN GLKKNFLEKS
2010 2020 2030 2040 2050
PDLHSLRYAL SLYTQTTDAL IKKFIETQGS QSRSSKDAVG QISVHVDVTT
2060 2070 2080 2090 2100
TPGTGDHKVT VKVIAINDLN WQTTAMFRPF VEVCMLGPSL GDKKRKQGTK
2110 2120 2130 2140 2150
TKSNTWSPKY NETFQFILGN ENRPGAYELH LSVKDYCFAR EDRIIGMTVI
2160 2170 2180 2190 2200
QLQNIAEKGS YGAWYPLLKN LSMDETGLTI LRILSQRTSD DVAKEFVRLK
2210
SETRSIEESA
Length:2,210
Mass (Da):249,844
Last modified:July 10, 2007 - v3
Checksum:iED6A02639FC6FA3F
GO

Sequence cautioni

The sequence AAH30416 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N- terminal and C-terminal parts.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112267 Genomic DNA. No translation available.
AC124451 Genomic DNA. No translation available.
AC131722 Genomic DNA. No translation available.
AC132267 Genomic DNA. No translation available.
AC153359 Genomic DNA. No translation available.
AK005367 mRNA. No translation available.
BC030416 mRNA. Translation: AAH30416.1. Sequence problems.
CCDSiCCDS40690.1.
RefSeqiNP_001074622.1. NM_001081153.1.
XP_006510996.1. XM_006510933.3.
UniGeneiMm.41035.

Genome annotation databases

EnsembliENSMUST00000075245; ENSMUSP00000074726; ENSMUSG00000062151.
ENSMUST00000184666; ENSMUSP00000139027; ENSMUSG00000062151.
GeneIDi208898.
KEGGimmu:208898.
UCSCiuc033jlk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112267 Genomic DNA. No translation available.
AC124451 Genomic DNA. No translation available.
AC131722 Genomic DNA. No translation available.
AC132267 Genomic DNA. No translation available.
AC153359 Genomic DNA. No translation available.
AK005367 mRNA. No translation available.
BC030416 mRNA. Translation: AAH30416.1. Sequence problems.
CCDSiCCDS40690.1.
RefSeqiNP_001074622.1. NM_001081153.1.
XP_006510996.1. XM_006510933.3.
UniGeneiMm.41035.

3D structure databases

ProteinModelPortaliQ8K0T7.
SMRiQ8K0T7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074726.

PTM databases

iPTMnetiQ8K0T7.
PhosphoSitePlusiQ8K0T7.

Proteomic databases

MaxQBiQ8K0T7.
PaxDbiQ8K0T7.
PeptideAtlasiQ8K0T7.
PRIDEiQ8K0T7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075245; ENSMUSP00000074726; ENSMUSG00000062151.
ENSMUST00000184666; ENSMUSP00000139027; ENSMUSG00000062151.
GeneIDi208898.
KEGGimmu:208898.
UCSCiuc033jlk.1. mouse.

Organism-specific databases

CTDi440279.
MGIiMGI:2149021. Unc13c.

Phylogenomic databases

eggNOGiKOG1011. Eukaryota.
ENOG410XS5D. LUCA.
GeneTreeiENSGT00850000132267.
HOGENOMiHOG000154775.
HOVERGENiHBG108648.
InParanoidiQ8K0T7.
KOiK15293.
OMAiNEPQGQW.
OrthoDBiEOG091G0527.
PhylomeDBiQ8K0T7.
TreeFamiTF312844.

Miscellaneous databases

ChiTaRSiUnc13c. mouse.
PROiQ8K0T7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062151.
CleanExiMM_UNC13C.
GenevisibleiQ8K0T7. MM.

Family and domain databases

CDDicd00029. C1. 1 hit.
Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR010439. CAPS_dom.
IPR014770. Munc13_1.
IPR014772. Munc13_dom-2.
IPR019558. Munc13_subgr_dom-2.
IPR002219. PE/DAG-bd.
IPR027080. Unc-13.
IPR027087. Unc13C.
[Graphical view]
PANTHERiPTHR10480. PTHR10480. 1 hit.
PTHR10480:SF2. PTHR10480:SF2. 1 hit.
PfamiPF00130. C1_1. 1 hit.
PF00168. C2. 2 hits.
PF06292. DUF1041. 1 hit.
PF10540. Membr_traf_MHD. 1 hit.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
SMARTiSM00109. C1. 1 hit.
SM00239. C2. 2 hits.
SM01145. DUF1041. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
PS51258. MHD1. 1 hit.
PS51259. MHD2. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUN13C_MOUSE
AccessioniPrimary (citable) accession number: Q8K0T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 10, 2007
Last modified: November 30, 2016
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.