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Protein

Katanin p60 ATPase-containing subunit A-like 1

Gene

Katnal1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.1 Publication

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi246 – 253ATPUniRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • microtubule-severing ATPase activity Source: MGI

GO - Biological processi

  • cytoplasmic microtubule organization Source: GO_Central
  • microtubule severing Source: MGI
  • spermatogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Katanin p60 ATPase-containing subunit A-like 1UniRule annotation (EC:3.6.4.3UniRule annotation)
Short name:
Katanin p60 subunit A-like 1UniRule annotation
Alternative name(s):
p60 katanin-like 1UniRule annotation
Gene namesi
Name:Katnal1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2387638. Katnal1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • microtubule Source: UniProtKB-KW
  • microtubule cytoskeleton Source: MGI
  • nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi286L → V: Males are infertile and show a significant reduction in the number of spermatids in testis, due to premature exfoliation of spermatids from the seminiferous epithelium. Sertoli cells contain reduced numbers of stable microtubules. The protein localizes exclusively to the basal compartment of Sertoli cells. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000846021 – 488Katanin p60 ATPase-containing subunit A-like 1Add BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei172PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8K0T4.
PaxDbiQ8K0T4.
PeptideAtlasiQ8K0T4.
PRIDEiQ8K0T4.

PTM databases

iPTMnetiQ8K0T4.
PhosphoSitePlusiQ8K0T4.

Expressioni

Tissue specificityi

Widely expressed, including in testis, brain, heart, lung, kidney, liver, spleen, seminal vesicles and ovary. In testis, restricted to Sertoli cells within the seminiferous epithelium (at protein level).1 Publication

Developmental stagei

Expressed in Sertoli cells from 15.5 dpc onwards (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000041298.
CleanExiMM_KATNAL1.
ExpressionAtlasiQ8K0T4. baseline and differential.
GenevisibleiQ8K0T4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043210.

Structurei

3D structure databases

ProteinModelPortaliQ8K0T4.
SMRiQ8K0T4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0738. Eukaryota.
ENOG410XPN7. LUCA.
GeneTreeiENSGT00550000074466.
HOGENOMiHOG000225142.
HOVERGENiHBG057074.
InParanoidiQ8K0T4.
KOiK07767.
OMAiGVMQQIQ.
OrthoDBiEOG091G0Q8J.
PhylomeDBiQ8K0T4.
TreeFamiTF323170.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_03023. Katanin_p60_A1. 1 hit.
MF_03024. Katanin_p60_AL1. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR028596. KATNA1.
IPR028594. Katnal1_chordates.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K0T4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLAEICENA KKGREYALLG NYDSSMVYYQ GVIQQIQRHC QSLRDPATKA
60 70 80 90 100
KWQQVRQELL EEYEQVKSIV STLESFKMDK PPDFPVSCRD EPFRDPAVWP
110 120 130 140 150
PPVPAEHRAP PQIRRPNREV RPLRKDVGAG ARGLVGRAHQ ISKSDKPASR
160 170 180 190 200
DKDYRARGRD DKARKNVQDG ASDSEIPKFD GAGYDKDLVE ALERDIVSRN
210 220 230 240 250
PSIHWDDIAD LEEAKKLLRE AVVLPMWMPD FFKGIRRPWK GVLMVGPPGT
260 270 280 290 300
GKTMLAKAVA TECGTTFFNV SSSTLTSKYR GESEKLVRLL FEMARFYAPT
310 320 330 340 350
TIFIDEIDSI CSRRGTSDEH EASRRVKSEL LIQMDGVGGA LENDDPSKMV
360 370 380 390 400
MVLAATNFPW DIDEALRRRL EKRIYIPLPT AKGRAELLKI SLREVELDPD
410 420 430 440 450
VHLEDIADKT EGYSGADITN ICRDASLMAM RRRINGLSPE EIRALSKEEL
460 470 480
QMPVTRGDLE LALKKIAKSV SAADLEKYEK WMVEFGSA
Length:488
Mass (Da):55,165
Last modified:October 1, 2002 - v1
Checksum:iA9BFF34DF2F44BAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC030434 mRNA. Translation: AAH30434.1.
CCDSiCCDS39404.1.
RefSeqiNP_705800.1. NM_153572.2.
XP_006504891.1. XM_006504828.3.
XP_006504892.1. XM_006504829.3.
UniGeneiMm.397405.

Genome annotation databases

EnsembliENSMUST00000047257; ENSMUSP00000043210; ENSMUSG00000041298.
GeneIDi231912.
KEGGimmu:231912.
UCSCiuc009aow.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC030434 mRNA. Translation: AAH30434.1.
CCDSiCCDS39404.1.
RefSeqiNP_705800.1. NM_153572.2.
XP_006504891.1. XM_006504828.3.
XP_006504892.1. XM_006504829.3.
UniGeneiMm.397405.

3D structure databases

ProteinModelPortaliQ8K0T4.
SMRiQ8K0T4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043210.

PTM databases

iPTMnetiQ8K0T4.
PhosphoSitePlusiQ8K0T4.

Proteomic databases

MaxQBiQ8K0T4.
PaxDbiQ8K0T4.
PeptideAtlasiQ8K0T4.
PRIDEiQ8K0T4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047257; ENSMUSP00000043210; ENSMUSG00000041298.
GeneIDi231912.
KEGGimmu:231912.
UCSCiuc009aow.2. mouse.

Organism-specific databases

CTDi84056.
MGIiMGI:2387638. Katnal1.

Phylogenomic databases

eggNOGiKOG0738. Eukaryota.
ENOG410XPN7. LUCA.
GeneTreeiENSGT00550000074466.
HOGENOMiHOG000225142.
HOVERGENiHBG057074.
InParanoidiQ8K0T4.
KOiK07767.
OMAiGVMQQIQ.
OrthoDBiEOG091G0Q8J.
PhylomeDBiQ8K0T4.
TreeFamiTF323170.

Miscellaneous databases

PROiQ8K0T4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041298.
CleanExiMM_KATNAL1.
ExpressionAtlasiQ8K0T4. baseline and differential.
GenevisibleiQ8K0T4. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_03023. Katanin_p60_A1. 1 hit.
MF_03024. Katanin_p60_AL1. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR028596. KATNA1.
IPR028594. Katnal1_chordates.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATL1_MOUSE
AccessioniPrimary (citable) accession number: Q8K0T4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.