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Protein

Reticulon-1

Gene

Rtn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulon-1
Alternative name(s):
Neuroendocrine-specific protein
Gene namesi
Name:Rtn1
Synonyms:Nsp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1933947. Rtn1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei607 – 62721HelicalSequence analysisAdd
BLAST
Transmembranei709 – 72921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 780780Reticulon-1PRO_0000168159Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei13 – 131PhosphoserineBy similarity
Modified residuei70 – 701PhosphoserineBy similarity
Modified residuei327 – 3271PhosphoserineBy similarity
Modified residuei350 – 3501PhosphoserineCombined sources
Modified residuei352 – 3521PhosphoserineCombined sources
Modified residuei487 – 4871PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8K0T0.
PaxDbiQ8K0T0.
PRIDEiQ8K0T0.

PTM databases

iPTMnetiQ8K0T0.
PhosphoSiteiQ8K0T0.
SwissPalmiQ8K0T0.

Expressioni

Developmental stagei

At E12.5-E14.5, strongly expressed in radial glial fibers, which are a scaffold for migrating neurons (at protein level).1 Publication

Gene expression databases

BgeeiQ8K0T0.
CleanExiMM_RTN1.
ExpressionAtlasiQ8K0T0. baseline and differential.
GenevisibleiQ8K0T0. MM.

Interactioni

Subunit structurei

Interacts with NDRG1. Interacts with TMEM33.By similarity

Protein-protein interaction databases

IntActiQ8K0T0. 5 interactions.
MINTiMINT-4117935.
STRINGi10090.ENSMUSP00000077594.

Structurei

3D structure databases

ProteinModelPortaliQ8K0T0.
SMRiQ8K0T0. Positions 643-708.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini593 – 780188ReticulonPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 reticulon domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1792. Eukaryota.
ENOG410XPKH. LUCA.
GeneTreeiENSGT00390000009934.
HOGENOMiHOG000134444.
HOVERGENiHBG008971.
InParanoidiQ8K0T0.
OrthoDBiEOG7CZK7J.
PhylomeDBiQ8K0T0.
TreeFamiTF105431.

Family and domain databases

InterProiIPR003388. Reticulon.
[Graphical view]
PfamiPF02453. Reticulon. 1 hit.
[Graphical view]
PROSITEiPS50845. RETICULON. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K0T0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPPDLQDE PLSLGSPGSQ WFGGRGDGED EATAVMGARP AQQDGEPAWG
60 70 80 90 100
SGAGAGVTSS RELCSGPARS PPVAMETAST GMAAVPDALD HSPSSTLKDG
110 120 130 140 150
EGACYTSLIS DVCYPPREDS AYFTGILQKE NGHITTSESP EEPETPGPSL
160 170 180 190 200
PEVPGMEPQG LLSSDSGIEM TPAESTEVNK ILADPLDQMK AEAYKYIDIT
210 220 230 240 250
RPQEAKGQEE QHPGLEDKDL DFKDKDTEVS TKAEGVRAPN QPAPVEGKLI
260 270 280 290 300
KDHLFEESTF APYIDELSDE QHRVSLVTAP VKITLTEIEP PLMTATQETI
310 320 330 340 350
PEKQDLCLKP SPDTVPTVTV SEPEDDSPGS VTPPSSGTEP SAAESQGKGS
360 370 380 390 400
VSEDELIAAI KEAKGLSYET TESPRPVGQV ADKPKTKTRS GLPTIPSPLD
410 420 430 440 450
QEASSAESGD SEIELVSEDP MASEDALPSG YVSFGHVSGP PPSPASPSIQ
460 470 480 490 500
YSILREEREA ELDSELIIES CDASSASEES PKREQDSPPM KPGALDAIRE
510 520 530 540 550
ETGSRATEER APSHQGPVEP DPMLSFAPAA ALQSRPEPSS GDGASVPEPP
560 570 580 590 600
RSQQQKPEEE AVSSSQSPTA TEIPGPLGSG LMPPLPFFNK QKAIDLLYWR
610 620 630 640 650
DIKQTGIVFG SFLLLLFSLT QFSVVSVVAY LALAALSATI SFRIYKSVLQ
660 670 680 690 700
AVQKTDEGHP FKAYLELEIT LSQEQIQKYT DCLQLYVNST LKELRRLFLV
710 720 730 740 750
QDLVDSLKFA VLMWLLTYVG ALFNGLTLLL MAVVSMFTLP VVYVKHQAQV
760 770 780
DQYLGLVRTH INTVVAKIQA KIPGAKRHAE
Length:780
Mass (Da):83,572
Last modified:October 1, 2002 - v1
Checksum:i29B47A58FC2F2027
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711P → S in BAB96551 (PubMed:12036513).Curated
Sequence conflicti226 – 2261D → G in BAB96551 (PubMed:12036513).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB074899 mRNA. Translation: BAB96551.1.
BC030455 mRNA. Translation: AAH30455.1.
BC053926 mRNA. Translation: AAH53926.1.
BC058579 mRNA. Translation: AAH58579.1.
BK001694 mRNA. Translation: DAA01939.1.
CCDSiCCDS25968.1.
RefSeqiNP_001273377.1. NM_001286448.1.
NP_703187.2. NM_153457.7.
UniGeneiMm.221275.

Genome annotation databases

EnsembliENSMUST00000078505; ENSMUSP00000077594; ENSMUSG00000021087.
GeneIDi104001.
KEGGimmu:104001.
UCSCiuc007nvk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB074899 mRNA. Translation: BAB96551.1.
BC030455 mRNA. Translation: AAH30455.1.
BC053926 mRNA. Translation: AAH53926.1.
BC058579 mRNA. Translation: AAH58579.1.
BK001694 mRNA. Translation: DAA01939.1.
CCDSiCCDS25968.1.
RefSeqiNP_001273377.1. NM_001286448.1.
NP_703187.2. NM_153457.7.
UniGeneiMm.221275.

3D structure databases

ProteinModelPortaliQ8K0T0.
SMRiQ8K0T0. Positions 643-708.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8K0T0. 5 interactions.
MINTiMINT-4117935.
STRINGi10090.ENSMUSP00000077594.

PTM databases

iPTMnetiQ8K0T0.
PhosphoSiteiQ8K0T0.
SwissPalmiQ8K0T0.

Proteomic databases

MaxQBiQ8K0T0.
PaxDbiQ8K0T0.
PRIDEiQ8K0T0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078505; ENSMUSP00000077594; ENSMUSG00000021087.
GeneIDi104001.
KEGGimmu:104001.
UCSCiuc007nvk.2. mouse.

Organism-specific databases

CTDi6252.
MGIiMGI:1933947. Rtn1.

Phylogenomic databases

eggNOGiKOG1792. Eukaryota.
ENOG410XPKH. LUCA.
GeneTreeiENSGT00390000009934.
HOGENOMiHOG000134444.
HOVERGENiHBG008971.
InParanoidiQ8K0T0.
OrthoDBiEOG7CZK7J.
PhylomeDBiQ8K0T0.
TreeFamiTF105431.

Miscellaneous databases

PROiQ8K0T0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K0T0.
CleanExiMM_RTN1.
ExpressionAtlasiQ8K0T0. baseline and differential.
GenevisibleiQ8K0T0. MM.

Family and domain databases

InterProiIPR003388. Reticulon.
[Graphical view]
PfamiPF02453. Reticulon. 1 hit.
[Graphical view]
PROSITEiPS50845. RETICULON. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mosaic development of the olfactory cortex with Pax6-dependent and -independent components."
    Hirata T., Nomura T., Takagi Y., Sato Y., Tomioka N., Fujisawa H., Osumi N.
    Brain Res. Dev. Brain Res. 136:17-26(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
    Strain: ICR.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye and Olfactory epithelium.
  4. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 181-190; 238-248; 647-654 AND 759-767, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Brain.
  5. "A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family."
    Oertle T., Klinger M., Stuermer C.A.O., Schwab M.E.
    FASEB J. 17:1238-1247(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-350; SER-352 AND SER-487, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Heart, Lung, Spleen and Testis.

Entry informationi

Entry nameiRTN1_MOUSE
AccessioniPrimary (citable) accession number: Q8K0T0
Secondary accession number(s): Q8K4S4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.