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Protein

Reticulon-1

Gene

Rtn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulon-1
Alternative name(s):
Neuroendocrine-specific protein
Gene namesi
Name:Rtn1
Synonyms:Nsp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1933947. Rtn1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei607 – 627HelicalSequence analysisAdd BLAST21
Transmembranei709 – 729HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001681591 – 780Reticulon-1Add BLAST780

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineBy similarity1
Modified residuei70PhosphoserineBy similarity1
Modified residuei327PhosphoserineBy similarity1
Modified residuei350PhosphoserineCombined sources1
Modified residuei352PhosphoserineCombined sources1
Modified residuei487PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8K0T0.
PaxDbiQ8K0T0.
PRIDEiQ8K0T0.

PTM databases

iPTMnetiQ8K0T0.
PhosphoSitePlusiQ8K0T0.
SwissPalmiQ8K0T0.

Expressioni

Developmental stagei

At E12.5-E14.5, strongly expressed in radial glial fibers, which are a scaffold for migrating neurons (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000021087.
CleanExiMM_RTN1.
ExpressionAtlasiQ8K0T0. baseline and differential.
GenevisibleiQ8K0T0. MM.

Interactioni

Subunit structurei

Interacts with NDRG1. Interacts with TMEM33.By similarity

Protein-protein interaction databases

BioGridi222271. 1 interactor.
IntActiQ8K0T0. 5 interactors.
MINTiMINT-4117935.
STRINGi10090.ENSMUSP00000077594.

Structurei

3D structure databases

ProteinModelPortaliQ8K0T0.
SMRiQ8K0T0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini593 – 780ReticulonPROSITE-ProRule annotationAdd BLAST188

Sequence similaritiesi

Contains 1 reticulon domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1792. Eukaryota.
ENOG410XPKH. LUCA.
GeneTreeiENSGT00390000009934.
HOGENOMiHOG000134444.
HOVERGENiHBG008971.
InParanoidiQ8K0T0.
KOiK20721.
OrthoDBiEOG091G0TIO.
PhylomeDBiQ8K0T0.
TreeFamiTF105431.

Family and domain databases

InterProiIPR003388. Reticulon.
[Graphical view]
PfamiPF02453. Reticulon. 1 hit.
[Graphical view]
PROSITEiPS50845. RETICULON. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K0T0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPPDLQDE PLSLGSPGSQ WFGGRGDGED EATAVMGARP AQQDGEPAWG
60 70 80 90 100
SGAGAGVTSS RELCSGPARS PPVAMETAST GMAAVPDALD HSPSSTLKDG
110 120 130 140 150
EGACYTSLIS DVCYPPREDS AYFTGILQKE NGHITTSESP EEPETPGPSL
160 170 180 190 200
PEVPGMEPQG LLSSDSGIEM TPAESTEVNK ILADPLDQMK AEAYKYIDIT
210 220 230 240 250
RPQEAKGQEE QHPGLEDKDL DFKDKDTEVS TKAEGVRAPN QPAPVEGKLI
260 270 280 290 300
KDHLFEESTF APYIDELSDE QHRVSLVTAP VKITLTEIEP PLMTATQETI
310 320 330 340 350
PEKQDLCLKP SPDTVPTVTV SEPEDDSPGS VTPPSSGTEP SAAESQGKGS
360 370 380 390 400
VSEDELIAAI KEAKGLSYET TESPRPVGQV ADKPKTKTRS GLPTIPSPLD
410 420 430 440 450
QEASSAESGD SEIELVSEDP MASEDALPSG YVSFGHVSGP PPSPASPSIQ
460 470 480 490 500
YSILREEREA ELDSELIIES CDASSASEES PKREQDSPPM KPGALDAIRE
510 520 530 540 550
ETGSRATEER APSHQGPVEP DPMLSFAPAA ALQSRPEPSS GDGASVPEPP
560 570 580 590 600
RSQQQKPEEE AVSSSQSPTA TEIPGPLGSG LMPPLPFFNK QKAIDLLYWR
610 620 630 640 650
DIKQTGIVFG SFLLLLFSLT QFSVVSVVAY LALAALSATI SFRIYKSVLQ
660 670 680 690 700
AVQKTDEGHP FKAYLELEIT LSQEQIQKYT DCLQLYVNST LKELRRLFLV
710 720 730 740 750
QDLVDSLKFA VLMWLLTYVG ALFNGLTLLL MAVVSMFTLP VVYVKHQAQV
760 770 780
DQYLGLVRTH INTVVAKIQA KIPGAKRHAE
Length:780
Mass (Da):83,572
Last modified:October 1, 2002 - v1
Checksum:i29B47A58FC2F2027
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71P → S in BAB96551 (PubMed:12036513).Curated1
Sequence conflicti226D → G in BAB96551 (PubMed:12036513).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB074899 mRNA. Translation: BAB96551.1.
BC030455 mRNA. Translation: AAH30455.1.
BC053926 mRNA. Translation: AAH53926.1.
BC058579 mRNA. Translation: AAH58579.1.
BK001694 mRNA. Translation: DAA01939.1.
CCDSiCCDS25968.1.
RefSeqiNP_001273377.1. NM_001286448.1.
NP_703187.2. NM_153457.7.
UniGeneiMm.221275.

Genome annotation databases

EnsembliENSMUST00000078505; ENSMUSP00000077594; ENSMUSG00000021087.
GeneIDi104001.
KEGGimmu:104001.
UCSCiuc007nvk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB074899 mRNA. Translation: BAB96551.1.
BC030455 mRNA. Translation: AAH30455.1.
BC053926 mRNA. Translation: AAH53926.1.
BC058579 mRNA. Translation: AAH58579.1.
BK001694 mRNA. Translation: DAA01939.1.
CCDSiCCDS25968.1.
RefSeqiNP_001273377.1. NM_001286448.1.
NP_703187.2. NM_153457.7.
UniGeneiMm.221275.

3D structure databases

ProteinModelPortaliQ8K0T0.
SMRiQ8K0T0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222271. 1 interactor.
IntActiQ8K0T0. 5 interactors.
MINTiMINT-4117935.
STRINGi10090.ENSMUSP00000077594.

PTM databases

iPTMnetiQ8K0T0.
PhosphoSitePlusiQ8K0T0.
SwissPalmiQ8K0T0.

Proteomic databases

MaxQBiQ8K0T0.
PaxDbiQ8K0T0.
PRIDEiQ8K0T0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078505; ENSMUSP00000077594; ENSMUSG00000021087.
GeneIDi104001.
KEGGimmu:104001.
UCSCiuc007nvk.2. mouse.

Organism-specific databases

CTDi6252.
MGIiMGI:1933947. Rtn1.

Phylogenomic databases

eggNOGiKOG1792. Eukaryota.
ENOG410XPKH. LUCA.
GeneTreeiENSGT00390000009934.
HOGENOMiHOG000134444.
HOVERGENiHBG008971.
InParanoidiQ8K0T0.
KOiK20721.
OrthoDBiEOG091G0TIO.
PhylomeDBiQ8K0T0.
TreeFamiTF105431.

Miscellaneous databases

PROiQ8K0T0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021087.
CleanExiMM_RTN1.
ExpressionAtlasiQ8K0T0. baseline and differential.
GenevisibleiQ8K0T0. MM.

Family and domain databases

InterProiIPR003388. Reticulon.
[Graphical view]
PfamiPF02453. Reticulon. 1 hit.
[Graphical view]
PROSITEiPS50845. RETICULON. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRTN1_MOUSE
AccessioniPrimary (citable) accession number: Q8K0T0
Secondary accession number(s): Q8K4S4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.