ID   SNPC1_MOUSE             Reviewed;         389 AA.
AC   Q8K0S9;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 131.
DE   RecName: Full=snRNA-activating protein complex subunit 1;
DE            Short=SNAPc subunit 1;
DE   AltName: Full=Small nuclear RNA-activating complex polypeptide 1;
DE   AltName: Full=snRNA-activating protein complex 43 kDa subunit;
DE            Short=SNAPc 43 kDa subunit;
GN   Name=Snapc1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Bone marrow, and Hypothalamus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Part of the SNAPc complex required for the transcription of
CC       both RNA polymerase II and III small-nuclear RNA genes. Binds to the
CC       proximal sequence element (PSE), a non-TATA-box basal promoter element
CC       common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA
CC       TATA box (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of the SNAPc complex composed of 5 subunits: SNAPC1,
CC       SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC1 interacts with SNAPC3, SNAPC4
CC       and TBP (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK138261; BAE23598.1; -; mRNA.
DR   EMBL; AK152833; BAE31533.1; -; mRNA.
DR   EMBL; BC030456; AAH30456.1; -; mRNA.
DR   CCDS; CCDS25978.1; -.
DR   RefSeq; NP_848479.1; NM_178392.4.
DR   AlphaFoldDB; Q8K0S9; -.
DR   SMR; Q8K0S9; -.
DR   BioGRID; 217627; 2.
DR   STRING; 10090.ENSMUSP00000021532; -.
DR   iPTMnet; Q8K0S9; -.
DR   PhosphoSitePlus; Q8K0S9; -.
DR   EPD; Q8K0S9; -.
DR   MaxQB; Q8K0S9; -.
DR   PaxDb; 10090-ENSMUSP00000021532; -.
DR   ProteomicsDB; 261532; -.
DR   DNASU; 75627; -.
DR   Ensembl; ENSMUST00000021532.6; ENSMUSP00000021532.5; ENSMUSG00000021113.6.
DR   GeneID; 75627; -.
DR   KEGG; mmu:75627; -.
DR   UCSC; uc007nwt.1; mouse.
DR   AGR; MGI:1922877; -.
DR   CTD; 6617; -.
DR   MGI; MGI:1922877; Snapc1.
DR   VEuPathDB; HostDB:ENSMUSG00000021113; -.
DR   eggNOG; KOG4746; Eukaryota.
DR   GeneTree; ENSGT00390000018691; -.
DR   HOGENOM; CLU_067254_0_0_1; -.
DR   InParanoid; Q8K0S9; -.
DR   OMA; LNVHEHY; -.
DR   OrthoDB; 3045295at2759; -.
DR   PhylomeDB; Q8K0S9; -.
DR   TreeFam; TF324445; -.
DR   Reactome; R-MMU-6807505; RNA polymerase II transcribes snRNA genes.
DR   Reactome; R-MMU-76071; RNA Polymerase III Transcription Initiation From Type 3 Promoter.
DR   BioGRID-ORCS; 75627; 24 hits in 75 CRISPR screens.
DR   ChiTaRS; Snapc1; mouse.
DR   PRO; PR:Q8K0S9; -.
DR   Proteomes; UP000000589; Chromosome 12.
DR   RNAct; Q8K0S9; Protein.
DR   Bgee; ENSMUSG00000021113; Expressed in otolith organ and 226 other cell types or tissues.
DR   ExpressionAtlas; Q8K0S9; baseline and differential.
DR   GO; GO:0005730; C:nucleolus; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0019185; C:snRNA-activating protein complex; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0042795; P:snRNA transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0042796; P:snRNA transcription by RNA polymerase III; IBA:GO_Central.
DR   InterPro; IPR019188; SNAPC1.
DR   PANTHER; PTHR15131; SMALL NUCLEAR RNA ACTIVATING COMPLEX, POLYPEPTIDE 1; 1.
DR   PANTHER; PTHR15131:SF3; SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 1; 1.
DR   Pfam; PF09808; SNAPC1; 1.
DR   Genevisible; Q8K0S9; MM.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..389
FT                   /note="snRNA-activating protein complex subunit 1"
FT                   /id="PRO_0000072019"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          20..187
FT                   /note="SNAPC3-binding"
FT                   /evidence="ECO:0000250"
FT   REGION          183..287
FT                   /note="SNAPC4-binding"
FT                   /evidence="ECO:0000250"
FT   REGION          245..276
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          290..389
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        323..380
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         308
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q16533"
FT   MOD_RES         309
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q16533"
SQ   SEQUENCE   389 AA;  44576 MW;  89E9422F14A9193C CRC64;
     MGTPAGAGTR PTGAGTVEGV GIPPGLQTDY ETLLSRFQEM DSVRFEDFTE LWRSMKFATI
     FCGKMRNLKK NMFTKEALAL AWRYFLPPHT FQIRVGALYL LYGLYNTQLC QPKQKIRVAL
     KDWDEVIRFQ QDLMNAQHFD AAFVFRKLRL DRAFHFTAMP KLLSCRMKKK VQQTEVTQKF
     KDPNDRVMKL ITSDVLEEML NVHDHYQNMK HAISADKSMP DRALSLVKED FFENIKNIVL
     EHQEWHKERK NPSLKPKLKD GEENGEGSSE EPERCERAVS LAKIKAKAFS AVVPVSKSRR
     HRQSKLDSSD SDSGSGQVQG RAAKRKRTRE PAGPAGRKRS SRSKGNAPNE RKEEKSLHLS
     MPIITEEEEE DMGGVRKAEF TAPKRKRKC
//