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Q8K0S9 (SNPC1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
snRNA-activating protein complex subunit 1

Short name=SNAPc subunit 1
Alternative name(s):
Small nuclear RNA-activating complex polypeptide 1
snRNA-activating protein complex 43 kDa subunit
Short name=SNAPc 43 kDa subunit
Gene names
Name:Snapc1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length389 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box By similarity.

Subunit structure

Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC1 interacts with SNAPC3, SNAPC4 and TBP By similarity.

Subcellular location

Nucleus By similarity.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 389389snRNA-activating protein complex subunit 1
PRO_0000072019

Regions

Region20 – 187168SNAPC3-binding By similarity
Region183 – 287105SNAPC4-binding By similarity
Compositional bias366 – 3705Poly-Glu

Amino acid modifications

Modified residue3081Phosphoserine By similarity
Modified residue3091Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8K0S9 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 89E9422F14A9193C

FASTA38944,576
        10         20         30         40         50         60 
MGTPAGAGTR PTGAGTVEGV GIPPGLQTDY ETLLSRFQEM DSVRFEDFTE LWRSMKFATI 

        70         80         90        100        110        120 
FCGKMRNLKK NMFTKEALAL AWRYFLPPHT FQIRVGALYL LYGLYNTQLC QPKQKIRVAL 

       130        140        150        160        170        180 
KDWDEVIRFQ QDLMNAQHFD AAFVFRKLRL DRAFHFTAMP KLLSCRMKKK VQQTEVTQKF 

       190        200        210        220        230        240 
KDPNDRVMKL ITSDVLEEML NVHDHYQNMK HAISADKSMP DRALSLVKED FFENIKNIVL 

       250        260        270        280        290        300 
EHQEWHKERK NPSLKPKLKD GEENGEGSSE EPERCERAVS LAKIKAKAFS AVVPVSKSRR 

       310        320        330        340        350        360 
HRQSKLDSSD SDSGSGQVQG RAAKRKRTRE PAGPAGRKRS SRSKGNAPNE RKEEKSLHLS 

       370        380 
MPIITEEEEE DMGGVRKAEF TAPKRKRKC 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone marrow and Hypothalamus.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK138261 mRNA. Translation: BAE23598.1.
AK152833 mRNA. Translation: BAE31533.1.
BC030456 mRNA. Translation: AAH30456.1.
CCDSCCDS25978.1.
RefSeqNP_848479.1. NM_178392.4.
UniGeneMm.25937.
Mm.470649.

3D structure databases

ProteinModelPortalQ8K0S9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000021532.

PTM databases

PhosphoSiteQ8K0S9.

Proteomic databases

PRIDEQ8K0S9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021532; ENSMUSP00000021532; ENSMUSG00000021113.
GeneID75627.
KEGGmmu:75627.
UCSCuc007nwt.1. mouse.

Organism-specific databases

CTD6617.
MGIMGI:1922877. Snapc1.

Phylogenomic databases

eggNOGNOG307105.
GeneTreeENSGT00390000018691.
HOGENOMHOG000294209.
HOVERGENHBG058831.
InParanoidQ8K0S9.
KOK15208.
OMASQETERC.
OrthoDBEOG7T7GTM.
PhylomeDBQ8K0S9.
TreeFamTF324445.

Gene expression databases

BgeeQ8K0S9.
GenevestigatorQ8K0S9.

Family and domain databases

InterProIPR019188. SNAPc_SNAP43.
[Graphical view]
PANTHERPTHR15131. PTHR15131. 1 hit.
PfamPF09808. SNAPc_SNAP43. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio343564.
PROQ8K0S9.
SOURCESearch...

Entry information

Entry nameSNPC1_MOUSE
AccessionPrimary (citable) accession number: Q8K0S9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot