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Q8K0S9

- SNPC1_MOUSE

UniProt

Q8K0S9 - SNPC1_MOUSE

Protein

snRNA-activating protein complex subunit 1

Gene

Snapc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    snRNA-activating protein complex subunit 1
    Short name:
    SNAPc subunit 1
    Alternative name(s):
    Small nuclear RNA-activating complex polypeptide 1
    snRNA-activating protein complex 43 kDa subunit
    Short name:
    SNAPc 43 kDa subunit
    Gene namesi
    Name:Snapc1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1922877. Snapc1.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 389389snRNA-activating protein complex subunit 1PRO_0000072019Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei308 – 3081PhosphoserineBy similarity
    Modified residuei309 – 3091PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ8K0S9.

    PTM databases

    PhosphoSiteiQ8K0S9.

    Expressioni

    Gene expression databases

    BgeeiQ8K0S9.
    GenevestigatoriQ8K0S9.

    Interactioni

    Subunit structurei

    Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC1 interacts with SNAPC3, SNAPC4 and TBP By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000021532.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K0S9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni20 – 187168SNAPC3-bindingBy similarityAdd
    BLAST
    Regioni183 – 287105SNAPC4-bindingBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi366 – 3705Poly-Glu

    Phylogenomic databases

    eggNOGiNOG307105.
    GeneTreeiENSGT00390000018691.
    HOGENOMiHOG000294209.
    HOVERGENiHBG058831.
    InParanoidiQ8K0S9.
    KOiK15208.
    OMAiSQETERC.
    OrthoDBiEOG7T7GTM.
    PhylomeDBiQ8K0S9.
    TreeFamiTF324445.

    Family and domain databases

    InterProiIPR019188. SNAPc_SNAP43.
    [Graphical view]
    PANTHERiPTHR15131. PTHR15131. 1 hit.
    PfamiPF09808. SNAPc_SNAP43. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K0S9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTPAGAGTR PTGAGTVEGV GIPPGLQTDY ETLLSRFQEM DSVRFEDFTE    50
    LWRSMKFATI FCGKMRNLKK NMFTKEALAL AWRYFLPPHT FQIRVGALYL 100
    LYGLYNTQLC QPKQKIRVAL KDWDEVIRFQ QDLMNAQHFD AAFVFRKLRL 150
    DRAFHFTAMP KLLSCRMKKK VQQTEVTQKF KDPNDRVMKL ITSDVLEEML 200
    NVHDHYQNMK HAISADKSMP DRALSLVKED FFENIKNIVL EHQEWHKERK 250
    NPSLKPKLKD GEENGEGSSE EPERCERAVS LAKIKAKAFS AVVPVSKSRR 300
    HRQSKLDSSD SDSGSGQVQG RAAKRKRTRE PAGPAGRKRS SRSKGNAPNE 350
    RKEEKSLHLS MPIITEEEEE DMGGVRKAEF TAPKRKRKC 389
    Length:389
    Mass (Da):44,576
    Last modified:October 1, 2002 - v1
    Checksum:i89E9422F14A9193C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK138261 mRNA. Translation: BAE23598.1.
    AK152833 mRNA. Translation: BAE31533.1.
    BC030456 mRNA. Translation: AAH30456.1.
    CCDSiCCDS25978.1.
    RefSeqiNP_848479.1. NM_178392.4.
    UniGeneiMm.25937.
    Mm.470649.

    Genome annotation databases

    EnsembliENSMUST00000021532; ENSMUSP00000021532; ENSMUSG00000021113.
    GeneIDi75627.
    KEGGimmu:75627.
    UCSCiuc007nwt.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK138261 mRNA. Translation: BAE23598.1 .
    AK152833 mRNA. Translation: BAE31533.1 .
    BC030456 mRNA. Translation: AAH30456.1 .
    CCDSi CCDS25978.1.
    RefSeqi NP_848479.1. NM_178392.4.
    UniGenei Mm.25937.
    Mm.470649.

    3D structure databases

    ProteinModelPortali Q8K0S9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000021532.

    PTM databases

    PhosphoSitei Q8K0S9.

    Proteomic databases

    PRIDEi Q8K0S9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021532 ; ENSMUSP00000021532 ; ENSMUSG00000021113 .
    GeneIDi 75627.
    KEGGi mmu:75627.
    UCSCi uc007nwt.1. mouse.

    Organism-specific databases

    CTDi 6617.
    MGIi MGI:1922877. Snapc1.

    Phylogenomic databases

    eggNOGi NOG307105.
    GeneTreei ENSGT00390000018691.
    HOGENOMi HOG000294209.
    HOVERGENi HBG058831.
    InParanoidi Q8K0S9.
    KOi K15208.
    OMAi SQETERC.
    OrthoDBi EOG7T7GTM.
    PhylomeDBi Q8K0S9.
    TreeFami TF324445.

    Miscellaneous databases

    NextBioi 343564.
    PROi Q8K0S9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8K0S9.
    Genevestigatori Q8K0S9.

    Family and domain databases

    InterProi IPR019188. SNAPc_SNAP43.
    [Graphical view ]
    PANTHERi PTHR15131. PTHR15131. 1 hit.
    Pfami PF09808. SNAPc_SNAP43. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow and Hypothalamus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiSNPC1_MOUSE
    AccessioniPrimary (citable) accession number: Q8K0S9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3