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Q8K0S9

- SNPC1_MOUSE

UniProt

Q8K0S9 - SNPC1_MOUSE

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Protein

snRNA-activating protein complex subunit 1

Gene

Snapc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity).By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
snRNA-activating protein complex subunit 1
Short name:
SNAPc subunit 1
Alternative name(s):
Small nuclear RNA-activating complex polypeptide 1
snRNA-activating protein complex 43 kDa subunit
Short name:
SNAPc 43 kDa subunit
Gene namesi
Name:Snapc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1922877. Snapc1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389snRNA-activating protein complex subunit 1PRO_0000072019Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei308 – 3081PhosphoserineBy similarity
Modified residuei309 – 3091PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ8K0S9.

PTM databases

PhosphoSiteiQ8K0S9.

Expressioni

Gene expression databases

BgeeiQ8K0S9.
GenevestigatoriQ8K0S9.

Interactioni

Subunit structurei

Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC1 interacts with SNAPC3, SNAPC4 and TBP (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021532.

Structurei

3D structure databases

ProteinModelPortaliQ8K0S9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 187168SNAPC3-bindingBy similarityAdd
BLAST
Regioni183 – 287105SNAPC4-bindingBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi366 – 3705Poly-Glu

Phylogenomic databases

eggNOGiNOG307105.
GeneTreeiENSGT00390000018691.
HOGENOMiHOG000294209.
HOVERGENiHBG058831.
InParanoidiQ8K0S9.
KOiK15208.
OMAiSQETERC.
OrthoDBiEOG7T7GTM.
PhylomeDBiQ8K0S9.
TreeFamiTF324445.

Family and domain databases

InterProiIPR019188. SNAPc_SNAP43.
[Graphical view]
PANTHERiPTHR15131. PTHR15131. 1 hit.
PfamiPF09808. SNAPc_SNAP43. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K0S9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGTPAGAGTR PTGAGTVEGV GIPPGLQTDY ETLLSRFQEM DSVRFEDFTE
60 70 80 90 100
LWRSMKFATI FCGKMRNLKK NMFTKEALAL AWRYFLPPHT FQIRVGALYL
110 120 130 140 150
LYGLYNTQLC QPKQKIRVAL KDWDEVIRFQ QDLMNAQHFD AAFVFRKLRL
160 170 180 190 200
DRAFHFTAMP KLLSCRMKKK VQQTEVTQKF KDPNDRVMKL ITSDVLEEML
210 220 230 240 250
NVHDHYQNMK HAISADKSMP DRALSLVKED FFENIKNIVL EHQEWHKERK
260 270 280 290 300
NPSLKPKLKD GEENGEGSSE EPERCERAVS LAKIKAKAFS AVVPVSKSRR
310 320 330 340 350
HRQSKLDSSD SDSGSGQVQG RAAKRKRTRE PAGPAGRKRS SRSKGNAPNE
360 370 380
RKEEKSLHLS MPIITEEEEE DMGGVRKAEF TAPKRKRKC
Length:389
Mass (Da):44,576
Last modified:October 1, 2002 - v1
Checksum:i89E9422F14A9193C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK138261 mRNA. Translation: BAE23598.1.
AK152833 mRNA. Translation: BAE31533.1.
BC030456 mRNA. Translation: AAH30456.1.
CCDSiCCDS25978.1.
RefSeqiNP_848479.1. NM_178392.4.
UniGeneiMm.25937.
Mm.470649.

Genome annotation databases

EnsembliENSMUST00000021532; ENSMUSP00000021532; ENSMUSG00000021113.
GeneIDi75627.
KEGGimmu:75627.
UCSCiuc007nwt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK138261 mRNA. Translation: BAE23598.1 .
AK152833 mRNA. Translation: BAE31533.1 .
BC030456 mRNA. Translation: AAH30456.1 .
CCDSi CCDS25978.1.
RefSeqi NP_848479.1. NM_178392.4.
UniGenei Mm.25937.
Mm.470649.

3D structure databases

ProteinModelPortali Q8K0S9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000021532.

PTM databases

PhosphoSitei Q8K0S9.

Proteomic databases

PRIDEi Q8K0S9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021532 ; ENSMUSP00000021532 ; ENSMUSG00000021113 .
GeneIDi 75627.
KEGGi mmu:75627.
UCSCi uc007nwt.1. mouse.

Organism-specific databases

CTDi 6617.
MGIi MGI:1922877. Snapc1.

Phylogenomic databases

eggNOGi NOG307105.
GeneTreei ENSGT00390000018691.
HOGENOMi HOG000294209.
HOVERGENi HBG058831.
InParanoidi Q8K0S9.
KOi K15208.
OMAi SQETERC.
OrthoDBi EOG7T7GTM.
PhylomeDBi Q8K0S9.
TreeFami TF324445.

Miscellaneous databases

NextBioi 343564.
PROi Q8K0S9.
SOURCEi Search...

Gene expression databases

Bgeei Q8K0S9.
Genevestigatori Q8K0S9.

Family and domain databases

InterProi IPR019188. SNAPc_SNAP43.
[Graphical view ]
PANTHERi PTHR15131. PTHR15131. 1 hit.
Pfami PF09808. SNAPc_SNAP43. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow and Hypothalamus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiSNPC1_MOUSE
AccessioniPrimary (citable) accession number: Q8K0S9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3