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Q8K0S5

- R4RL1_MOUSE

UniProt

Q8K0S5 - R4RL1_MOUSE

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Protein

Reticulon-4 receptor-like 1

Gene
Rtn4rl1, Ngrl2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in regulating axonal regeneration and plasticity in the adult central nervous system By similarity.By similarity

GO - Molecular functioni

  1. receptor activity Source: UniProtKB

GO - Biological processi

  1. axon regeneration Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulon-4 receptor-like 1
Alternative name(s):
Nogo receptor-like 2
Nogo-66 receptor homolog 2
Nogo-66 receptor-related protein 3
Short name:
NgR3
Gene namesi
Name:Rtn4rl1
Synonyms:Ngrl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2661375. Rtn4rl1.

Subcellular locationi

Cell membrane; Lipid-anchorGPI-anchor Reviewed prediction
Note: Localized to the surface of neurons, including axons.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei424 – 44421Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. anchored component of plasma membrane Source: UniProtKB
  2. external side of plasma membrane Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. membrane raft Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed predictionAdd
BLAST
Chaini25 – 424400Reticulon-4 receptor-like 1PRO_0000046044Add
BLAST
Propeptidei425 – 44521Removed in mature form Reviewed predictionPRO_0000046045Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi424 – 4241GPI-anchor amidated serine Reviewed prediction

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ8K0S5.
PRIDEiQ8K0S5.

Expressioni

Developmental stagei

At E13.5, strongly expressed in PNS ganglia and developing heart, and weakly expressed in brain and spinal cord. By postnatal day 1, strongly expressed in dorsal root ganglia and in dorsal and gray matter areas of spinal cord. Expressed in various adult brain structures including the amygdala, caudate putamen, cerebellum, cerebral cortex, hippocampus, olfactory bulb and thalamus.1 Publication

Gene expression databases

BgeeiQ8K0S5.
CleanExiMM_RTN4RL1.
GenevestigatoriQ8K0S5.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099572.

Structurei

3D structure databases

ProteinModelPortaliQ8K0S5.
SMRiQ8K0S5. Positions 25-304.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 5430LRRNTAdd
BLAST
Repeati55 – 7622LRR 1Add
BLAST
Repeati77 – 9822LRR 2Add
BLAST
Repeati101 – 12323LRR 3Add
BLAST
Repeati126 – 14722LRR 4Add
BLAST
Repeati150 – 17122LRR 5Add
BLAST
Repeati174 – 19522LRR 6Add
BLAST
Repeati198 – 21922LRR 7Add
BLAST
Repeati222 – 24322LRR 8Add
BLAST
Domaini255 – 30652LRRCTAdd
BLAST

Sequence similaritiesi

Belongs to the Nogo receptor family.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG254142.
GeneTreeiENSGT00750000117338.
HOGENOMiHOG000116109.
HOVERGENiHBG063707.
InParanoidiQ8K0S5.
KOiK16660.
OMAiNCTSHRN.
OrthoDBiEOG7CZK5N.
PhylomeDBiQ8K0S5.
TreeFamiTF330080.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K0S5-1 [UniParc]FASTAAdd to Basket

« Hide

MLRKGCCVEL LLLLLAGELP LGGGCPRDCV CYPAPMTVSC QAHNFAAIPE    50
GIPEDSERIF LQNNRITFLQ QGHFSPAMVT LWIYSNNITF IAPNTFEGFV 100
HLEELDLGDN RQLRTLAPET FQGLVKLHAL YLYKCGLSAL PAGIFGGLHS 150
LQYLYLQDNH IEYLQDDIFV DLVNLSHLFL HGNKLWSLGQ GIFRGLVNLD 200
RLLLHENQLQ WVHHKAFHDL HRLTTLFLFN NSLTELQGDC LAPLVALEFL 250
RLNGNAWDCG CRARSLWEWL RRFRGSSSAV PCATPELRQG QDLKLLRVED 300
FRNCTGPVSP HQIKSHTLTT SDRAARKEHH PSHGASRDKG HPHGHPPGSR 350
SGYKKAGKNC TSHRNRNQIS KVSSGKELTE LQDYAPDYQH KFSFDIMPTA 400
RPKRKGKCAR RTPIRAPSGV QQASSGTALG APLLAWILGL AVTLR 445
Length:445
Mass (Da):49,836
Last modified:October 1, 2002 - v1
Checksum:i8285A01C1250D18A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY250218 mRNA. Translation: AAP82835.1.
AK033286 mRNA. Translation: BAC28223.1.
AK140456 mRNA. Translation: BAE24396.1.
AL603905 Genomic DNA. Translation: CAI35092.1.
BC030471 mRNA. Translation: AAH30471.1.
BK001304 mRNA. Translation: DAA01387.1.
CCDSiCCDS25043.1.
RefSeqiNP_808376.1. NM_177708.5.
UniGeneiMm.82661.

Genome annotation databases

EnsembliENSMUST00000102514; ENSMUSP00000099572; ENSMUSG00000045287.
GeneIDi237847.
KEGGimmu:237847.
UCSCiuc007kdh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY250218 mRNA. Translation: AAP82835.1 .
AK033286 mRNA. Translation: BAC28223.1 .
AK140456 mRNA. Translation: BAE24396.1 .
AL603905 Genomic DNA. Translation: CAI35092.1 .
BC030471 mRNA. Translation: AAH30471.1 .
BK001304 mRNA. Translation: DAA01387.1 .
CCDSi CCDS25043.1.
RefSeqi NP_808376.1. NM_177708.5.
UniGenei Mm.82661.

3D structure databases

ProteinModelPortali Q8K0S5.
SMRi Q8K0S5. Positions 25-304.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000099572.

Proteomic databases

PaxDbi Q8K0S5.
PRIDEi Q8K0S5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102514 ; ENSMUSP00000099572 ; ENSMUSG00000045287 .
GeneIDi 237847.
KEGGi mmu:237847.
UCSCi uc007kdh.1. mouse.

Organism-specific databases

CTDi 146760.
MGIi MGI:2661375. Rtn4rl1.

Phylogenomic databases

eggNOGi NOG254142.
GeneTreei ENSGT00750000117338.
HOGENOMi HOG000116109.
HOVERGENi HBG063707.
InParanoidi Q8K0S5.
KOi K16660.
OMAi NCTSHRN.
OrthoDBi EOG7CZK5N.
PhylomeDBi Q8K0S5.
TreeFami TF330080.

Miscellaneous databases

NextBioi 383518.
PROi Q8K0S5.
SOURCEi Search...

Gene expression databases

Bgeei Q8K0S5.
CleanExi MM_RTN4RL1.
Genevestigatori Q8K0S5.

Family and domain databases

InterProi IPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF13855. LRR_8. 2 hits.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two novel mammalian nogo receptor homologs differentially expressed in the central and peripheral nervous systems."
    Lauren J., Airaksinen M.S., Saarma M., Timmusk T.
    Mol. Cell. Neurosci. 24:581-594(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Medulla oblongata and Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  5. "Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins."
    Barton W.A., Liu B.P., Tzvetkova D., Jeffrey P.D., Fournier A.E., Sah D., Cate R., Strittmatter S.M., Nikolov D.B.
    EMBO J. 22:3291-3302(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiR4RL1_MOUSE
AccessioniPrimary (citable) accession number: Q8K0S5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi