Q8K0S5 (R4RL1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Reticulon-4 receptor-like 1

Alternative name(s):
Nogo receptor-like 2
Nogo-66 receptor homolog 2
Nogo-66 receptor-related protein 3
Short name=NgR3

Gene names

Name:	Rtn4rl1
Synonyms:	Ngrl2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	445 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in regulating axonal regeneration and plasticity in the adult central nervous system By similarity. UniProtKB Q86UN2
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor Potential. Note: Localized to the surface of neurons, including axons.
Developmental stage	At E13.5, strongly expressed in PNS ganglia and developing heart, and weakly expressed in brain and spinal cord. By postnatal day 1, strongly expressed in dorsal root ganglia and in dorsal and gray matter areas of spinal cord. Expressed in various adult brain structures including the amygdala, caudate putamen, cerebellum, cerebral cortex, hippocampus, olfactory bulb and thalamus. Ref.1
Sequence similarities	Belongs to the Nogo receptor family. Contains 8 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Leucine-rich repeat Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	GPI-anchor Glycoprotein Lipoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon regeneration Traceable author statement Ref.1. Source: UniProtKB
Cellular_component	anchored to plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB external side of plasma membrane Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane raft Inferred from electronic annotation. Source: Compara
Molecular_function	receptor activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 424	400	Reticulon-4 receptor-like 1		PRO_0000046044
	Propeptide	425 – 445	21	Removed in mature form Potential		PRO_0000046045
Regions
	Transmembrane	424 – 444	21	Helical; Potential
	Domain	25 – 54	30	LRRNT
	Repeat	55 – 76	22	LRR 1
	Repeat	77 – 98	22	LRR 2
	Repeat	101 – 123	23	LRR 3
	Repeat	126 – 147	22	LRR 4
	Repeat	150 – 171	22	LRR 5
	Repeat	174 – 195	22	LRR 6
	Repeat	198 – 219	22	LRR 7
	Repeat	222 – 243	22	LRR 8
	Domain	255 – 306	52	LRRCT
Amino acid modifications
	Lipidation	424	1	GPI-anchor amidated serine Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8K0S5 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 8285A01C1250D18A	FASTA	445	49,836
	10 20 30 40 50 60 MLRKGCCVEL LLLLLAGELP LGGGCPRDCV CYPAPMTVSC QAHNFAAIPE GIPEDSERIF 70 80 90 100 110 120 LQNNRITFLQ QGHFSPAMVT LWIYSNNITF IAPNTFEGFV HLEELDLGDN RQLRTLAPET 130 140 150 160 170 180 FQGLVKLHAL YLYKCGLSAL PAGIFGGLHS LQYLYLQDNH IEYLQDDIFV DLVNLSHLFL 190 200 210 220 230 240 HGNKLWSLGQ GIFRGLVNLD RLLLHENQLQ WVHHKAFHDL HRLTTLFLFN NSLTELQGDC 250 260 270 280 290 300 LAPLVALEFL RLNGNAWDCG CRARSLWEWL RRFRGSSSAV PCATPELRQG QDLKLLRVED 310 320 330 340 350 360 FRNCTGPVSP HQIKSHTLTT SDRAARKEHH PSHGASRDKG HPHGHPPGSR SGYKKAGKNC 370 380 390 400 410 420 TSHRNRNQIS KVSSGKELTE LQDYAPDYQH KFSFDIMPTA RPKRKGKCAR RTPIRAPSGV 430 440 QQASSGTALG APLLAWILGL AVTLR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two novel mammalian nogo receptor homologs differentially expressed in the central and peripheral nervous systems." Lauren J., Airaksinen M.S., Saarma M., Timmusk T. Mol. Cell. Neurosci. 24:581-594(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE. Tissue: Brain.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Medulla oblongata and Testis.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[5]	"Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins." Barton W.A., Liu B.P., Tzvetkova D., Jeffrey P.D., Fournier A.E., Sah D., Cate R., Strittmatter S.M., Nikolov D.B. EMBO J. 22:3291-3302(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY250218 mRNA. Translation: AAP82835.1. AK033286 mRNA. Translation: BAC28223.1. AK140456 mRNA. Translation: BAE24396.1. AL603905 Genomic DNA. Translation: CAI35092.1. BC030471 mRNA. Translation: AAH30471.1. BK001304 mRNA. Translation: DAA01387.1.
IPI	IPI00169628.
RefSeq	NP_808376.1. NM_177708.5.
UniGene	Mm.82661.
3D structure databases
ProteinModelPortal	Q8K0S5.
SMR	Q8K0S5. Positions 25-304.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000099572.
Proteomic databases
PaxDb	Q8K0S5.
PRIDE	Q8K0S5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000102514; ENSMUSP00000099572; ENSMUSG00000045287.
GeneID	237847.
KEGG	mmu:237847.
UCSC	uc007kdh.1. mouse.
Organism-specific databases
CTD	146760.
MGI	MGI:2661375. Rtn4rl1.
Phylogenomic databases
eggNOG	NOG254142.
GeneTree	ENSGT00690000101803.
HOGENOM	HOG000116109.
HOVERGEN	HBG063707.
InParanoid	Q8K0S5.
KO	K16660.
OMA	NCTSHRN.
OrthoDB	EOG4FXR7G.
Gene expression databases
Bgee	Q8K0S5.
CleanEx	MM_RTN4RL1.
Genevestigator	Q8K0S5.
GermOnline	ENSMUSG00000045287. Mus musculus.
Family and domain databases
InterPro	IPR000483. Cys-rich_flank_reg_C. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR000372. LRR-contain_N. [Graphical view]
SMART	SM00369. LRR_TYP. 2 hits. SM00082. LRRCT. 1 hit. SM00013. LRRNT. 1 hit. [Graphical view]
PROSITE	PS51450. LRR. 6 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	383518.
SOURCE	Search...

Entry information

Entry name

R4RL1_MOUSE

Accession

Primary (citable) accession number: Q8K0S5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 7, 2006
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program