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Q8K0S5

- R4RL1_MOUSE

UniProt

Q8K0S5 - R4RL1_MOUSE

Protein

Reticulon-4 receptor-like 1

Gene

Rtn4rl1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.By similarity

    GO - Molecular functioni

    1. receptor activity Source: UniProtKB

    GO - Biological processi

    1. axon regeneration Source: UniProtKB

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Reticulon-4 receptor-like 1
    Alternative name(s):
    Nogo receptor-like 2
    Nogo-66 receptor homolog 2
    Nogo-66 receptor-related protein 3
    Short name:
    NgR3
    Gene namesi
    Name:Rtn4rl1Imported
    Synonyms:Ngrl2Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2661375. Rtn4rl1.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchorGPI-anchor Curated
    Note: Localized to the surface of neurons, including axons.

    GO - Cellular componenti

    1. anchored component of plasma membrane Source: UniProtKB
    2. external side of plasma membrane Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW
    4. membrane raft Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 424400Reticulon-4 receptor-like 1PRO_0000046044Add
    BLAST
    Propeptidei425 – 44521Removed in mature formSequence AnalysisPRO_0000046045Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi424 – 4241GPI-anchor amidated serineSequence Analysis

    Keywords - PTMi

    Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PaxDbiQ8K0S5.
    PRIDEiQ8K0S5.

    Expressioni

    Developmental stagei

    At E13.5, strongly expressed in PNS ganglia and developing heart, and weakly expressed in brain and spinal cord. By postnatal day 1, strongly expressed in dorsal root ganglia and in dorsal and gray matter areas of spinal cord. Expressed in various adult brain structures including the amygdala, caudate putamen, cerebellum, cerebral cortex, hippocampus, olfactory bulb and thalamus.1 Publication

    Gene expression databases

    BgeeiQ8K0S5.
    CleanExiMM_RTN4RL1.
    GenevestigatoriQ8K0S5.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000099572.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K0S5.
    SMRiQ8K0S5. Positions 25-304.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei424 – 44421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 5430LRRNTAdd
    BLAST
    Repeati55 – 7622LRR 1Add
    BLAST
    Repeati77 – 9822LRR 2Add
    BLAST
    Repeati101 – 12323LRR 3Add
    BLAST
    Repeati126 – 14722LRR 4Add
    BLAST
    Repeati150 – 17122LRR 5Add
    BLAST
    Repeati174 – 19522LRR 6Add
    BLAST
    Repeati198 – 21922LRR 7Add
    BLAST
    Repeati222 – 24322LRR 8Add
    BLAST
    Domaini255 – 30652LRRCTAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Nogo receptor family.Curated
    Contains 8 LRR (leucine-rich) repeats.Sequence Analysis
    Contains 1 LRRCT domain.Curated
    Contains 1 LRRNT domain.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG254142.
    GeneTreeiENSGT00750000117338.
    HOGENOMiHOG000116109.
    HOVERGENiHBG063707.
    InParanoidiQ8K0S5.
    KOiK16660.
    OMAiNCTSHRN.
    OrthoDBiEOG7CZK5N.
    PhylomeDBiQ8K0S5.
    TreeFamiTF330080.

    Family and domain databases

    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view]
    PfamiPF13855. LRR_8. 2 hits.
    [Graphical view]
    SMARTiSM00369. LRR_TYP. 2 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view]
    PROSITEiPS51450. LRR. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8K0S5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRKGCCVEL LLLLLAGELP LGGGCPRDCV CYPAPMTVSC QAHNFAAIPE    50
    GIPEDSERIF LQNNRITFLQ QGHFSPAMVT LWIYSNNITF IAPNTFEGFV 100
    HLEELDLGDN RQLRTLAPET FQGLVKLHAL YLYKCGLSAL PAGIFGGLHS 150
    LQYLYLQDNH IEYLQDDIFV DLVNLSHLFL HGNKLWSLGQ GIFRGLVNLD 200
    RLLLHENQLQ WVHHKAFHDL HRLTTLFLFN NSLTELQGDC LAPLVALEFL 250
    RLNGNAWDCG CRARSLWEWL RRFRGSSSAV PCATPELRQG QDLKLLRVED 300
    FRNCTGPVSP HQIKSHTLTT SDRAARKEHH PSHGASRDKG HPHGHPPGSR 350
    SGYKKAGKNC TSHRNRNQIS KVSSGKELTE LQDYAPDYQH KFSFDIMPTA 400
    RPKRKGKCAR RTPIRAPSGV QQASSGTALG APLLAWILGL AVTLR 445
    Length:445
    Mass (Da):49,836
    Last modified:October 1, 2002 - v1
    Checksum:i8285A01C1250D18A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY250218 mRNA. Translation: AAP82835.1.
    AK033286 mRNA. Translation: BAC28223.1.
    AK140456 mRNA. Translation: BAE24396.1.
    AL603905 Genomic DNA. Translation: CAI35092.1.
    BC030471 mRNA. Translation: AAH30471.1.
    BK001304 mRNA. Translation: DAA01387.1.
    CCDSiCCDS25043.1.
    RefSeqiNP_808376.1. NM_177708.5.
    UniGeneiMm.82661.

    Genome annotation databases

    EnsembliENSMUST00000102514; ENSMUSP00000099572; ENSMUSG00000045287.
    GeneIDi237847.
    KEGGimmu:237847.
    UCSCiuc007kdh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY250218 mRNA. Translation: AAP82835.1 .
    AK033286 mRNA. Translation: BAC28223.1 .
    AK140456 mRNA. Translation: BAE24396.1 .
    AL603905 Genomic DNA. Translation: CAI35092.1 .
    BC030471 mRNA. Translation: AAH30471.1 .
    BK001304 mRNA. Translation: DAA01387.1 .
    CCDSi CCDS25043.1.
    RefSeqi NP_808376.1. NM_177708.5.
    UniGenei Mm.82661.

    3D structure databases

    ProteinModelPortali Q8K0S5.
    SMRi Q8K0S5. Positions 25-304.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000099572.

    Proteomic databases

    PaxDbi Q8K0S5.
    PRIDEi Q8K0S5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000102514 ; ENSMUSP00000099572 ; ENSMUSG00000045287 .
    GeneIDi 237847.
    KEGGi mmu:237847.
    UCSCi uc007kdh.1. mouse.

    Organism-specific databases

    CTDi 146760.
    MGIi MGI:2661375. Rtn4rl1.

    Phylogenomic databases

    eggNOGi NOG254142.
    GeneTreei ENSGT00750000117338.
    HOGENOMi HOG000116109.
    HOVERGENi HBG063707.
    InParanoidi Q8K0S5.
    KOi K16660.
    OMAi NCTSHRN.
    OrthoDBi EOG7CZK5N.
    PhylomeDBi Q8K0S5.
    TreeFami TF330080.

    Miscellaneous databases

    NextBioi 383518.
    PROi Q8K0S5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8K0S5.
    CleanExi MM_RTN4RL1.
    Genevestigatori Q8K0S5.

    Family and domain databases

    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view ]
    Pfami PF13855. LRR_8. 2 hits.
    [Graphical view ]
    SMARTi SM00369. LRR_TYP. 2 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view ]
    PROSITEi PS51450. LRR. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two novel mammalian nogo receptor homologs differentially expressed in the central and peripheral nervous systems."
      Lauren J., Airaksinen M.S., Saarma M., Timmusk T.
      Mol. Cell. Neurosci. 24:581-594(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
      Tissue: Brain1 Publication.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6JImported.
      Tissue: Medulla oblongataImported and TestisImported.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: EyeImported.
    5. "Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins."
      Barton W.A., Liu B.P., Tzvetkova D., Jeffrey P.D., Fournier A.E., Sah D., Cate R., Strittmatter S.M., Nikolov D.B.
      EMBO J. 22:3291-3302(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiR4RL1_MOUSE
    AccessioniPrimary (citable) accession number: Q8K0S5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3