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Protein

Reticulon-4 receptor-like 1

Gene

Rtn4rl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulon-4 receptor-like 1
Alternative name(s):
Nogo receptor-like 2
Nogo-66 receptor homolog 2
Nogo-66 receptor-related protein 3
Short name:
NgR3
Gene namesi
Name:Rtn4rl1Imported
Synonyms:Ngrl2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2661375. Rtn4rl1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei424 – 444HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000004604425 – 424Reticulon-4 receptor-like 1Add BLAST400
PropeptideiPRO_0000046045425 – 445Removed in mature formSequence analysisAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi424GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ8K0S5.
PaxDbiQ8K0S5.
PeptideAtlasiQ8K0S5.
PRIDEiQ8K0S5.

PTM databases

iPTMnetiQ8K0S5.
PhosphoSitePlusiQ8K0S5.

Expressioni

Developmental stagei

At E13.5, strongly expressed in PNS ganglia and developing heart, and weakly expressed in brain and spinal cord. By postnatal day 1, strongly expressed in dorsal root ganglia and in dorsal and gray matter areas of spinal cord. Expressed in various adult brain structures including the amygdala, caudate putamen, cerebellum, cerebral cortex, hippocampus, olfactory bulb and thalamus.1 Publication

Gene expression databases

BgeeiENSMUSG00000045287.
CleanExiMM_RTN4RL1.
GenevisibleiQ8K0S5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099572.

Structurei

3D structure databases

ProteinModelPortaliQ8K0S5.
SMRiQ8K0S5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 54LRRNTAdd BLAST30
Repeati55 – 76LRR 1Add BLAST22
Repeati77 – 98LRR 2Add BLAST22
Repeati101 – 123LRR 3Add BLAST23
Repeati126 – 147LRR 4Add BLAST22
Repeati150 – 171LRR 5Add BLAST22
Repeati174 – 195LRR 6Add BLAST22
Repeati198 – 219LRR 7Add BLAST22
Repeati222 – 243LRR 8Add BLAST22
Domaini255 – 306LRRCTAdd BLAST52

Sequence similaritiesi

Belongs to the Nogo receptor family.Curated
Contains 8 LRR (leucine-rich) repeats.Sequence analysis
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000116109.
HOVERGENiHBG063707.
InParanoidiQ8K0S5.
KOiK16660.
OMAiNCTSHRN.
OrthoDBiEOG091G08II.
PhylomeDBiQ8K0S5.
TreeFamiTF330080.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K0S5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRKGCCVEL LLLLLAGELP LGGGCPRDCV CYPAPMTVSC QAHNFAAIPE
60 70 80 90 100
GIPEDSERIF LQNNRITFLQ QGHFSPAMVT LWIYSNNITF IAPNTFEGFV
110 120 130 140 150
HLEELDLGDN RQLRTLAPET FQGLVKLHAL YLYKCGLSAL PAGIFGGLHS
160 170 180 190 200
LQYLYLQDNH IEYLQDDIFV DLVNLSHLFL HGNKLWSLGQ GIFRGLVNLD
210 220 230 240 250
RLLLHENQLQ WVHHKAFHDL HRLTTLFLFN NSLTELQGDC LAPLVALEFL
260 270 280 290 300
RLNGNAWDCG CRARSLWEWL RRFRGSSSAV PCATPELRQG QDLKLLRVED
310 320 330 340 350
FRNCTGPVSP HQIKSHTLTT SDRAARKEHH PSHGASRDKG HPHGHPPGSR
360 370 380 390 400
SGYKKAGKNC TSHRNRNQIS KVSSGKELTE LQDYAPDYQH KFSFDIMPTA
410 420 430 440
RPKRKGKCAR RTPIRAPSGV QQASSGTALG APLLAWILGL AVTLR
Length:445
Mass (Da):49,836
Last modified:October 1, 2002 - v1
Checksum:i8285A01C1250D18A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY250218 mRNA. Translation: AAP82835.1.
AK033286 mRNA. Translation: BAC28223.1.
AK140456 mRNA. Translation: BAE24396.1.
AL603905 Genomic DNA. Translation: CAI35092.1.
BC030471 mRNA. Translation: AAH30471.1.
BK001304 mRNA. Translation: DAA01387.1.
CCDSiCCDS25043.1.
RefSeqiNP_808376.1. NM_177708.5.
UniGeneiMm.82661.

Genome annotation databases

EnsembliENSMUST00000102514; ENSMUSP00000099572; ENSMUSG00000045287.
GeneIDi237847.
KEGGimmu:237847.
UCSCiuc007kdh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY250218 mRNA. Translation: AAP82835.1.
AK033286 mRNA. Translation: BAC28223.1.
AK140456 mRNA. Translation: BAE24396.1.
AL603905 Genomic DNA. Translation: CAI35092.1.
BC030471 mRNA. Translation: AAH30471.1.
BK001304 mRNA. Translation: DAA01387.1.
CCDSiCCDS25043.1.
RefSeqiNP_808376.1. NM_177708.5.
UniGeneiMm.82661.

3D structure databases

ProteinModelPortaliQ8K0S5.
SMRiQ8K0S5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099572.

PTM databases

iPTMnetiQ8K0S5.
PhosphoSitePlusiQ8K0S5.

Proteomic databases

MaxQBiQ8K0S5.
PaxDbiQ8K0S5.
PeptideAtlasiQ8K0S5.
PRIDEiQ8K0S5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102514; ENSMUSP00000099572; ENSMUSG00000045287.
GeneIDi237847.
KEGGimmu:237847.
UCSCiuc007kdh.1. mouse.

Organism-specific databases

CTDi146760.
MGIiMGI:2661375. Rtn4rl1.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000116109.
HOVERGENiHBG063707.
InParanoidiQ8K0S5.
KOiK16660.
OMAiNCTSHRN.
OrthoDBiEOG091G08II.
PhylomeDBiQ8K0S5.
TreeFamiTF330080.

Miscellaneous databases

PROiQ8K0S5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045287.
CleanExiMM_RTN4RL1.
GenevisibleiQ8K0S5. MM.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiR4RL1_MOUSE
AccessioniPrimary (citable) accession number: Q8K0S5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.