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Q8K0L9

- ZBT20_MOUSE

UniProt

Q8K0L9 - ZBT20_MOUSE

Protein

Zinc finger and BTB domain-containing protein 20

Gene

Zbtb20

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses By similarity. Binds to DNA.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri578 – 60023C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri606 – 62823C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri634 – 65623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri662 – 68423C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri715 – 73723C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. metal ion binding Source: UniProtKB-KW
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: MGI

    GO - Biological processi

    1. negative regulation of transcription from RNA polymerase II promoter Source: MGI

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger and BTB domain-containing protein 20
    Alternative name(s):
    BTB/POZ domain zinc finger factor HOF
    Zinc finger protein 288
    Gene namesi
    Name:Zbtb20
    Synonyms:Zfp288
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1929213. Zbtb20.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 741741Zinc finger and BTB domain-containing protein 20PRO_0000325961Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei465 – 4651PhosphoserineBy similarity
    Modified residuei472 – 4721PhosphoserineBy similarity

    Post-translational modificationi

    Sumoylated with SUMO1.1 Publication

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ8K0L9.
    PRIDEiQ8K0L9.

    Expressioni

    Tissue specificityi

    Specifically expressed in early hippocampal neurons, cerebellar granule cells and gliogenic progenitors as well as in differentiated glia.1 Publication

    Gene expression databases

    ArrayExpressiQ8K0L9.
    BgeeiQ8K0L9.
    CleanExiMM_ZBTB20.
    GenevestigatoriQ8K0L9.

    Interactioni

    Subunit structurei

    Can homodimerize. Binds to DNA.

    Protein-protein interaction databases

    IntActiQ8K0L9. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K0L9.
    SMRiQ8K0L9. Positions 81-190, 529-737.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini104 – 16764BTBPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri578 – 60023C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri606 – 62823C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri634 – 65623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri662 – 68423C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri715 – 73723C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00750000117519.
    HOGENOMiHOG000136747.
    HOVERGENiHBG060183.
    InParanoidiQ8K0L9.
    KOiK10501.
    OMAiQIEHFND.
    OrthoDBiEOG7GQXV7.
    PhylomeDBiQ8K0L9.
    TreeFamiTF335684.

    Family and domain databases

    Gene3Di3.30.160.60. 4 hits.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00651. BTB. 1 hit.
    PF00096. zf-C2H2. 2 hits.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 5 hits.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8K0L9-1) [UniParc]FASTAAdd to Basket

    Also known as: HOF-L

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLERKKPKTA ENQKASEENE ITQPGGSSAK PALPCLNFEA VLSPAPALIH    50
    STHSLTNSHA HTGSSDCDIS CKGMTERIHS INLHNFSNSV LETLNEQRNR 100
    GHFCDVTVRI HGSMLRAHRC VLAAGSPFFQ DKLLLGYSDI EIPSVVSVQS 150
    VQKLIDFMYS GVLRVSQSEA LQILTAASIL QIKTVIDECT RIVSQNVGDV 200
    FPGIQDSGQD TPRGTPESGT SGQSSDTESG YLQSHPQHSV DRIYSALYAC 250
    SMQNGSGERS FYSGAVVSHH ETALGLPRDH HMEDPSWITR IHERSQQMER 300
    YLSTTPETTH CRKQPRPVRI QTLVGNIHIK QEMEDDYDYY GQQRVQILER 350
    NESEECTEDT DQAEGTESEP KGESFDSGVS SSIGTEPDSV EQQFGAAAPR 400
    DGQAEPAQPE QAAEAPAESS AQPNQLEPGA SSPERSNESE MDNTVITVSN 450
    SSDKGVLQQP SVNTSIGQPL PSTQLYLRQT ETLTSNLRMP LTLTSNTQVI 500
    GTAGNTYLPA LFTTQPAGSG PKPFLFSLPQ PLTGQQTQFV TVSQPGLSTF 550
    TAQLPAPQPL ASSAGHSTAS GQGDKKPYEC TLCNKTFTAK QNYVKHMFVH 600
    TGEKPHQCSI CWRSFSLKDY LIKHMVTHTG VRAYQCSICN KRFTQKSSLN 650
    VHMRLHRGEK SYECYICKKK FSHKTLLERH VALHSASNGT PPAGTPPGAR 700
    AGPPGVVACT EGTTYVCSVC PAKFDQIEQF NDHMRMHVSD G 741
    Length:741
    Mass (Da):81,034
    Last modified:October 1, 2002 - v1
    Checksum:i04C0744D66BFE418
    GO
    Isoform 2 (identifier: Q8K0L9-2) [UniParc]FASTAAdd to Basket

    Also known as: HOF-S

    The sequence of this isoform differs from the canonical sequence as follows:
         1-73: Missing.

    Show »
    Length:668
    Mass (Da):73,382
    Checksum:i5A6FF5BEEA3963A3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti88 – 881N → D in BAB23755. (PubMed:16141072)Curated
    Sequence conflicti421 – 4211A → D in AAF06015. (PubMed:11744704)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7373Missing in isoform 2. 2 PublicationsVSP_032504Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF194030 mRNA. Translation: AAF06015.1.
    AK005028 mRNA. Translation: BAB23755.1.
    CT010512 Genomic DNA. Translation: CAO77851.1.
    CT010512 Genomic DNA. Translation: CAO77852.1.
    BC031114 mRNA. Translation: AAH31114.1.
    BC056446 mRNA. Translation: AAH56446.1.
    CCDSiCCDS28178.1. [Q8K0L9-1]
    CCDS49851.1. [Q8K0L9-2]
    RefSeqiNP_001272734.1. NM_001285805.1. [Q8K0L9-1]
    NP_062752.2. NM_019778.2. [Q8K0L9-1]
    NP_851401.1. NM_181058.1. [Q8K0L9-2]
    XP_006522475.1. XM_006522412.1. [Q8K0L9-1]
    XP_006522476.1. XM_006522413.1. [Q8K0L9-1]
    XP_006522477.1. XM_006522414.1. [Q8K0L9-1]
    XP_006522478.1. XM_006522415.1. [Q8K0L9-1]
    XP_006522479.1. XM_006522416.1. [Q8K0L9-1]
    XP_006522480.1. XM_006522417.1. [Q8K0L9-1]
    XP_006522481.1. XM_006522418.1. [Q8K0L9-1]
    XP_006522482.1. XM_006522419.1. [Q8K0L9-2]
    XP_006522483.1. XM_006522420.1. [Q8K0L9-2]
    XP_006522484.1. XM_006522421.1. [Q8K0L9-2]
    XP_006522485.1. XM_006522422.1. [Q8K0L9-2]
    XP_006522486.1. XM_006522423.1. [Q8K0L9-2]
    XP_006522487.1. XM_006522424.1. [Q8K0L9-2]
    UniGeneiMm.136238.
    Mm.441121.
    Mm.441972.
    Mm.460947.
    Mm.491236.

    Genome annotation databases

    EnsembliENSMUST00000079441; ENSMUSP00000078410; ENSMUSG00000022708. [Q8K0L9-1]
    ENSMUST00000114690; ENSMUSP00000110338; ENSMUSG00000022708. [Q8K0L9-2]
    ENSMUST00000114691; ENSMUSP00000110339; ENSMUSG00000022708. [Q8K0L9-2]
    ENSMUST00000114694; ENSMUSP00000110342; ENSMUSG00000022708. [Q8K0L9-1]
    ENSMUST00000114695; ENSMUSP00000110343; ENSMUSG00000022708. [Q8K0L9-1]
    GeneIDi56490.
    KEGGimmu:56490.
    UCSCiuc007zga.2. mouse. [Q8K0L9-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF194030 mRNA. Translation: AAF06015.1 .
    AK005028 mRNA. Translation: BAB23755.1 .
    CT010512 Genomic DNA. Translation: CAO77851.1 .
    CT010512 Genomic DNA. Translation: CAO77852.1 .
    BC031114 mRNA. Translation: AAH31114.1 .
    BC056446 mRNA. Translation: AAH56446.1 .
    CCDSi CCDS28178.1. [Q8K0L9-1 ]
    CCDS49851.1. [Q8K0L9-2 ]
    RefSeqi NP_001272734.1. NM_001285805.1. [Q8K0L9-1 ]
    NP_062752.2. NM_019778.2. [Q8K0L9-1 ]
    NP_851401.1. NM_181058.1. [Q8K0L9-2 ]
    XP_006522475.1. XM_006522412.1. [Q8K0L9-1 ]
    XP_006522476.1. XM_006522413.1. [Q8K0L9-1 ]
    XP_006522477.1. XM_006522414.1. [Q8K0L9-1 ]
    XP_006522478.1. XM_006522415.1. [Q8K0L9-1 ]
    XP_006522479.1. XM_006522416.1. [Q8K0L9-1 ]
    XP_006522480.1. XM_006522417.1. [Q8K0L9-1 ]
    XP_006522481.1. XM_006522418.1. [Q8K0L9-1 ]
    XP_006522482.1. XM_006522419.1. [Q8K0L9-2 ]
    XP_006522483.1. XM_006522420.1. [Q8K0L9-2 ]
    XP_006522484.1. XM_006522421.1. [Q8K0L9-2 ]
    XP_006522485.1. XM_006522422.1. [Q8K0L9-2 ]
    XP_006522486.1. XM_006522423.1. [Q8K0L9-2 ]
    XP_006522487.1. XM_006522424.1. [Q8K0L9-2 ]
    UniGenei Mm.136238.
    Mm.441121.
    Mm.441972.
    Mm.460947.
    Mm.491236.

    3D structure databases

    ProteinModelPortali Q8K0L9.
    SMRi Q8K0L9. Positions 81-190, 529-737.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8K0L9. 1 interaction.

    Proteomic databases

    PaxDbi Q8K0L9.
    PRIDEi Q8K0L9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000079441 ; ENSMUSP00000078410 ; ENSMUSG00000022708 . [Q8K0L9-1 ]
    ENSMUST00000114690 ; ENSMUSP00000110338 ; ENSMUSG00000022708 . [Q8K0L9-2 ]
    ENSMUST00000114691 ; ENSMUSP00000110339 ; ENSMUSG00000022708 . [Q8K0L9-2 ]
    ENSMUST00000114694 ; ENSMUSP00000110342 ; ENSMUSG00000022708 . [Q8K0L9-1 ]
    ENSMUST00000114695 ; ENSMUSP00000110343 ; ENSMUSG00000022708 . [Q8K0L9-1 ]
    GeneIDi 56490.
    KEGGi mmu:56490.
    UCSCi uc007zga.2. mouse. [Q8K0L9-1 ]

    Organism-specific databases

    CTDi 26137.
    MGIi MGI:1929213. Zbtb20.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00750000117519.
    HOGENOMi HOG000136747.
    HOVERGENi HBG060183.
    InParanoidi Q8K0L9.
    KOi K10501.
    OMAi QIEHFND.
    OrthoDBi EOG7GQXV7.
    PhylomeDBi Q8K0L9.
    TreeFami TF335684.

    Miscellaneous databases

    ChiTaRSi ZBTB20. mouse.
    NextBioi 312770.
    PROi Q8K0L9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K0L9.
    Bgeei Q8K0L9.
    CleanExi MM_ZBTB20.
    Genevestigatori Q8K0L9.

    Family and domain databases

    Gene3Di 3.30.160.60. 4 hits.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00651. BTB. 1 hit.
    PF00096. zf-C2H2. 2 hits.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 5 hits.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of two novel nuclear BTB/POZ domain zinc finger isoforms. Association with differentiation of hippocampal neurons, cerebellar granule cells, and macroglia."
      Mitchelmore C., Kjaerulff K.M., Pedersen H.C., Nielsen J.V., Rasmussen T.E., Fisker M.F., Finsen B., Pedersen K.M., Jensen N.A.
      J. Biol. Chem. 277:7598-7609(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING, SUBCELLULAR LOCATION, HOMODIMERIZATION, TISSUE SPECIFICITY.
      Tissue: Oligodendroglioma.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Liver.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6 and FVB/N.
      Tissue: Brain and Kidney.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    6. "In vivo localization and identification of SUMOylated proteins in the brain of His6-HA-SUMO1 knock-in mice."
      Tirard M., Hsiao H.H., Nikolov M., Urlaub H., Melchior F., Brose N.
      Proc. Natl. Acad. Sci. U.S.A. 109:21122-21127(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUMOYLATION WITH SUMO1.

    Entry informationi

    Entry nameiZBT20_MOUSE
    AccessioniPrimary (citable) accession number: Q8K0L9
    Secondary accession number(s): A6X916, Q9DBD4, Q9QZ87
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3