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Q8K0L9

- ZBT20_MOUSE

UniProt

Q8K0L9 - ZBT20_MOUSE

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Protein

Zinc finger and BTB domain-containing protein 20

Gene

Zbtb20

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses (By similarity). Binds to DNA.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri578 – 60023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri606 – 62823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri634 – 65623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri662 – 68423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri715 – 73723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. metal ion binding Source: UniProtKB-KW
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: MGI

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 20
Alternative name(s):
BTB/POZ domain zinc finger factor HOF
Zinc finger protein 288
Gene namesi
Name:Zbtb20
Synonyms:Zfp288
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1929213. Zbtb20.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 741741Zinc finger and BTB domain-containing protein 20PRO_0000325961Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei465 – 4651PhosphoserineBy similarity
Modified residuei472 – 4721PhosphoserineBy similarity

Post-translational modificationi

Sumoylated with SUMO1.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8K0L9.
PaxDbiQ8K0L9.
PRIDEiQ8K0L9.

Expressioni

Tissue specificityi

Specifically expressed in early hippocampal neurons, cerebellar granule cells and gliogenic progenitors as well as in differentiated glia.1 Publication

Gene expression databases

BgeeiQ8K0L9.
CleanExiMM_ZBTB20.
ExpressionAtlasiQ8K0L9. baseline and differential.
GenevestigatoriQ8K0L9.

Interactioni

Subunit structurei

Can homodimerize. Binds to DNA.

Protein-protein interaction databases

IntActiQ8K0L9. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8K0L9.
SMRiQ8K0L9. Positions 81-190, 569-737.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini104 – 16764BTBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri578 – 60023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri606 – 62823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri634 – 65623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri662 – 68423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri715 – 73723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000136747.
HOVERGENiHBG060183.
InParanoidiQ8K0L9.
KOiK10501.
OMAiQIEHFND.
OrthoDBiEOG7GQXV7.
PhylomeDBiQ8K0L9.
TreeFamiTF335684.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8K0L9-1) [UniParc]FASTAAdd to Basket

Also known as: HOF-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLERKKPKTA ENQKASEENE ITQPGGSSAK PALPCLNFEA VLSPAPALIH
60 70 80 90 100
STHSLTNSHA HTGSSDCDIS CKGMTERIHS INLHNFSNSV LETLNEQRNR
110 120 130 140 150
GHFCDVTVRI HGSMLRAHRC VLAAGSPFFQ DKLLLGYSDI EIPSVVSVQS
160 170 180 190 200
VQKLIDFMYS GVLRVSQSEA LQILTAASIL QIKTVIDECT RIVSQNVGDV
210 220 230 240 250
FPGIQDSGQD TPRGTPESGT SGQSSDTESG YLQSHPQHSV DRIYSALYAC
260 270 280 290 300
SMQNGSGERS FYSGAVVSHH ETALGLPRDH HMEDPSWITR IHERSQQMER
310 320 330 340 350
YLSTTPETTH CRKQPRPVRI QTLVGNIHIK QEMEDDYDYY GQQRVQILER
360 370 380 390 400
NESEECTEDT DQAEGTESEP KGESFDSGVS SSIGTEPDSV EQQFGAAAPR
410 420 430 440 450
DGQAEPAQPE QAAEAPAESS AQPNQLEPGA SSPERSNESE MDNTVITVSN
460 470 480 490 500
SSDKGVLQQP SVNTSIGQPL PSTQLYLRQT ETLTSNLRMP LTLTSNTQVI
510 520 530 540 550
GTAGNTYLPA LFTTQPAGSG PKPFLFSLPQ PLTGQQTQFV TVSQPGLSTF
560 570 580 590 600
TAQLPAPQPL ASSAGHSTAS GQGDKKPYEC TLCNKTFTAK QNYVKHMFVH
610 620 630 640 650
TGEKPHQCSI CWRSFSLKDY LIKHMVTHTG VRAYQCSICN KRFTQKSSLN
660 670 680 690 700
VHMRLHRGEK SYECYICKKK FSHKTLLERH VALHSASNGT PPAGTPPGAR
710 720 730 740
AGPPGVVACT EGTTYVCSVC PAKFDQIEQF NDHMRMHVSD G
Length:741
Mass (Da):81,034
Last modified:October 1, 2002 - v1
Checksum:i04C0744D66BFE418
GO
Isoform 2 (identifier: Q8K0L9-2) [UniParc]FASTAAdd to Basket

Also known as: HOF-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.

Show »
Length:668
Mass (Da):73,382
Checksum:i5A6FF5BEEA3963A3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti88 – 881N → D in BAB23755. (PubMed:16141072)Curated
Sequence conflicti421 – 4211A → D in AAF06015. (PubMed:11744704)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7373Missing in isoform 2. 2 PublicationsVSP_032504Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF194030 mRNA. Translation: AAF06015.1.
AK005028 mRNA. Translation: BAB23755.1.
CT010512 Genomic DNA. Translation: CAO77851.1.
CT010512 Genomic DNA. Translation: CAO77852.1.
BC031114 mRNA. Translation: AAH31114.1.
BC056446 mRNA. Translation: AAH56446.1.
CCDSiCCDS28178.1. [Q8K0L9-1]
CCDS49851.1. [Q8K0L9-2]
RefSeqiNP_001272734.1. NM_001285805.1. [Q8K0L9-1]
NP_062752.2. NM_019778.2. [Q8K0L9-1]
NP_851401.1. NM_181058.1. [Q8K0L9-2]
XP_006522475.1. XM_006522412.1. [Q8K0L9-1]
XP_006522476.1. XM_006522413.1. [Q8K0L9-1]
XP_006522477.1. XM_006522414.1. [Q8K0L9-1]
XP_006522478.1. XM_006522415.1. [Q8K0L9-1]
XP_006522479.1. XM_006522416.1. [Q8K0L9-1]
XP_006522480.1. XM_006522417.1. [Q8K0L9-1]
XP_006522481.1. XM_006522418.1. [Q8K0L9-1]
XP_006522482.1. XM_006522419.1. [Q8K0L9-2]
XP_006522483.1. XM_006522420.1. [Q8K0L9-2]
XP_006522484.1. XM_006522421.1. [Q8K0L9-2]
XP_006522485.1. XM_006522422.1. [Q8K0L9-2]
XP_006522486.1. XM_006522423.1. [Q8K0L9-2]
XP_006522487.1. XM_006522424.1. [Q8K0L9-2]
UniGeneiMm.136238.
Mm.441121.
Mm.441972.
Mm.460947.
Mm.491236.

Genome annotation databases

EnsembliENSMUST00000079441; ENSMUSP00000078410; ENSMUSG00000022708. [Q8K0L9-1]
ENSMUST00000114690; ENSMUSP00000110338; ENSMUSG00000022708. [Q8K0L9-2]
ENSMUST00000114691; ENSMUSP00000110339; ENSMUSG00000022708. [Q8K0L9-2]
ENSMUST00000114694; ENSMUSP00000110342; ENSMUSG00000022708. [Q8K0L9-1]
ENSMUST00000114695; ENSMUSP00000110343; ENSMUSG00000022708. [Q8K0L9-1]
GeneIDi56490.
KEGGimmu:56490.
UCSCiuc007zga.2. mouse. [Q8K0L9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF194030 mRNA. Translation: AAF06015.1 .
AK005028 mRNA. Translation: BAB23755.1 .
CT010512 Genomic DNA. Translation: CAO77851.1 .
CT010512 Genomic DNA. Translation: CAO77852.1 .
BC031114 mRNA. Translation: AAH31114.1 .
BC056446 mRNA. Translation: AAH56446.1 .
CCDSi CCDS28178.1. [Q8K0L9-1 ]
CCDS49851.1. [Q8K0L9-2 ]
RefSeqi NP_001272734.1. NM_001285805.1. [Q8K0L9-1 ]
NP_062752.2. NM_019778.2. [Q8K0L9-1 ]
NP_851401.1. NM_181058.1. [Q8K0L9-2 ]
XP_006522475.1. XM_006522412.1. [Q8K0L9-1 ]
XP_006522476.1. XM_006522413.1. [Q8K0L9-1 ]
XP_006522477.1. XM_006522414.1. [Q8K0L9-1 ]
XP_006522478.1. XM_006522415.1. [Q8K0L9-1 ]
XP_006522479.1. XM_006522416.1. [Q8K0L9-1 ]
XP_006522480.1. XM_006522417.1. [Q8K0L9-1 ]
XP_006522481.1. XM_006522418.1. [Q8K0L9-1 ]
XP_006522482.1. XM_006522419.1. [Q8K0L9-2 ]
XP_006522483.1. XM_006522420.1. [Q8K0L9-2 ]
XP_006522484.1. XM_006522421.1. [Q8K0L9-2 ]
XP_006522485.1. XM_006522422.1. [Q8K0L9-2 ]
XP_006522486.1. XM_006522423.1. [Q8K0L9-2 ]
XP_006522487.1. XM_006522424.1. [Q8K0L9-2 ]
UniGenei Mm.136238.
Mm.441121.
Mm.441972.
Mm.460947.
Mm.491236.

3D structure databases

ProteinModelPortali Q8K0L9.
SMRi Q8K0L9. Positions 81-190, 569-737.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8K0L9. 1 interaction.

Proteomic databases

MaxQBi Q8K0L9.
PaxDbi Q8K0L9.
PRIDEi Q8K0L9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000079441 ; ENSMUSP00000078410 ; ENSMUSG00000022708 . [Q8K0L9-1 ]
ENSMUST00000114690 ; ENSMUSP00000110338 ; ENSMUSG00000022708 . [Q8K0L9-2 ]
ENSMUST00000114691 ; ENSMUSP00000110339 ; ENSMUSG00000022708 . [Q8K0L9-2 ]
ENSMUST00000114694 ; ENSMUSP00000110342 ; ENSMUSG00000022708 . [Q8K0L9-1 ]
ENSMUST00000114695 ; ENSMUSP00000110343 ; ENSMUSG00000022708 . [Q8K0L9-1 ]
GeneIDi 56490.
KEGGi mmu:56490.
UCSCi uc007zga.2. mouse. [Q8K0L9-1 ]

Organism-specific databases

CTDi 26137.
MGIi MGI:1929213. Zbtb20.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000119063.
HOGENOMi HOG000136747.
HOVERGENi HBG060183.
InParanoidi Q8K0L9.
KOi K10501.
OMAi QIEHFND.
OrthoDBi EOG7GQXV7.
PhylomeDBi Q8K0L9.
TreeFami TF335684.

Miscellaneous databases

ChiTaRSi ZBTB20. mouse.
NextBioi 312770.
PROi Q8K0L9.
SOURCEi Search...

Gene expression databases

Bgeei Q8K0L9.
CleanExi MM_ZBTB20.
ExpressionAtlasi Q8K0L9. baseline and differential.
Genevestigatori Q8K0L9.

Family and domain databases

Gene3Di 3.30.160.60. 4 hits.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00651. BTB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view ]
SMARTi SM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of two novel nuclear BTB/POZ domain zinc finger isoforms. Association with differentiation of hippocampal neurons, cerebellar granule cells, and macroglia."
    Mitchelmore C., Kjaerulff K.M., Pedersen H.C., Nielsen J.V., Rasmussen T.E., Fisker M.F., Finsen B., Pedersen K.M., Jensen N.A.
    J. Biol. Chem. 277:7598-7609(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING, SUBCELLULAR LOCATION, HOMODIMERIZATION, TISSUE SPECIFICITY.
    Tissue: Oligodendroglioma.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Liver.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6 and FVB/N.
    Tissue: Brain and Kidney.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "In vivo localization and identification of SUMOylated proteins in the brain of His6-HA-SUMO1 knock-in mice."
    Tirard M., Hsiao H.H., Nikolov M., Urlaub H., Melchior F., Brose N.
    Proc. Natl. Acad. Sci. U.S.A. 109:21122-21127(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION WITH SUMO1.

Entry informationi

Entry nameiZBT20_MOUSE
AccessioniPrimary (citable) accession number: Q8K0L9
Secondary accession number(s): A6X916, Q9DBD4, Q9QZ87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3