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Q8K0L9

- ZBT20_MOUSE

UniProt

Q8K0L9 - ZBT20_MOUSE

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Protein

Zinc finger and BTB domain-containing protein 20

Gene
Zbtb20, Zfp288
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses By similarity. Binds to DNA.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri578 – 60023C2H2-type 1Add
BLAST
Zinc fingeri606 – 62823C2H2-type 2Add
BLAST
Zinc fingeri634 – 65623C2H2-type 3Add
BLAST
Zinc fingeri662 – 68423C2H2-type 4Add
BLAST
Zinc fingeri715 – 73723C2H2-type 5Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. metal ion binding Source: UniProtKB-KW
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: MGI

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 20
Alternative name(s):
BTB/POZ domain zinc finger factor HOF
Zinc finger protein 288
Gene namesi
Name:Zbtb20
Synonyms:Zfp288
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1929213. Zbtb20.

Subcellular locationi

Nucleus Inferred 1 Publication

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 741741Zinc finger and BTB domain-containing protein 20PRO_0000325961Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei465 – 4651Phosphoserine By similarity
Modified residuei472 – 4721Phosphoserine By similarity

Post-translational modificationi

Sumoylated with SUMO1.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ8K0L9.
PRIDEiQ8K0L9.

Expressioni

Tissue specificityi

Specifically expressed in early hippocampal neurons, cerebellar granule cells and gliogenic progenitors as well as in differentiated glia.1 Publication

Gene expression databases

ArrayExpressiQ8K0L9.
BgeeiQ8K0L9.
CleanExiMM_ZBTB20.
GenevestigatoriQ8K0L9.

Interactioni

Subunit structurei

Can homodimerize. Binds to DNA.1 Publication

Protein-protein interaction databases

IntActiQ8K0L9. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8K0L9.
SMRiQ8K0L9. Positions 81-190, 529-737.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini104 – 16764BTBAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00750000117519.
HOGENOMiHOG000136747.
HOVERGENiHBG060183.
InParanoidiQ8K0L9.
KOiK10501.
OMAiQIEHFND.
OrthoDBiEOG7GQXV7.
PhylomeDBiQ8K0L9.
TreeFamiTF335684.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8K0L9-1) [UniParc]FASTAAdd to Basket

Also known as: HOF-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLERKKPKTA ENQKASEENE ITQPGGSSAK PALPCLNFEA VLSPAPALIH    50
STHSLTNSHA HTGSSDCDIS CKGMTERIHS INLHNFSNSV LETLNEQRNR 100
GHFCDVTVRI HGSMLRAHRC VLAAGSPFFQ DKLLLGYSDI EIPSVVSVQS 150
VQKLIDFMYS GVLRVSQSEA LQILTAASIL QIKTVIDECT RIVSQNVGDV 200
FPGIQDSGQD TPRGTPESGT SGQSSDTESG YLQSHPQHSV DRIYSALYAC 250
SMQNGSGERS FYSGAVVSHH ETALGLPRDH HMEDPSWITR IHERSQQMER 300
YLSTTPETTH CRKQPRPVRI QTLVGNIHIK QEMEDDYDYY GQQRVQILER 350
NESEECTEDT DQAEGTESEP KGESFDSGVS SSIGTEPDSV EQQFGAAAPR 400
DGQAEPAQPE QAAEAPAESS AQPNQLEPGA SSPERSNESE MDNTVITVSN 450
SSDKGVLQQP SVNTSIGQPL PSTQLYLRQT ETLTSNLRMP LTLTSNTQVI 500
GTAGNTYLPA LFTTQPAGSG PKPFLFSLPQ PLTGQQTQFV TVSQPGLSTF 550
TAQLPAPQPL ASSAGHSTAS GQGDKKPYEC TLCNKTFTAK QNYVKHMFVH 600
TGEKPHQCSI CWRSFSLKDY LIKHMVTHTG VRAYQCSICN KRFTQKSSLN 650
VHMRLHRGEK SYECYICKKK FSHKTLLERH VALHSASNGT PPAGTPPGAR 700
AGPPGVVACT EGTTYVCSVC PAKFDQIEQF NDHMRMHVSD G 741
Length:741
Mass (Da):81,034
Last modified:October 1, 2002 - v1
Checksum:i04C0744D66BFE418
GO
Isoform 2 (identifier: Q8K0L9-2) [UniParc]FASTAAdd to Basket

Also known as: HOF-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.

Show »
Length:668
Mass (Da):73,382
Checksum:i5A6FF5BEEA3963A3
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7373Missing in isoform 2. VSP_032504Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti88 – 881N → D in BAB23755. 1 Publication
Sequence conflicti421 – 4211A → D in AAF06015. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF194030 mRNA. Translation: AAF06015.1.
AK005028 mRNA. Translation: BAB23755.1.
CT010512 Genomic DNA. Translation: CAO77851.1.
CT010512 Genomic DNA. Translation: CAO77852.1.
BC031114 mRNA. Translation: AAH31114.1.
BC056446 mRNA. Translation: AAH56446.1.
CCDSiCCDS28178.1. [Q8K0L9-1]
CCDS49851.1. [Q8K0L9-2]
RefSeqiNP_001272734.1. NM_001285805.1. [Q8K0L9-1]
NP_062752.2. NM_019778.2. [Q8K0L9-1]
NP_851401.1. NM_181058.1. [Q8K0L9-2]
XP_006522475.1. XM_006522412.1. [Q8K0L9-1]
XP_006522476.1. XM_006522413.1. [Q8K0L9-1]
XP_006522477.1. XM_006522414.1. [Q8K0L9-1]
XP_006522478.1. XM_006522415.1. [Q8K0L9-1]
XP_006522479.1. XM_006522416.1. [Q8K0L9-1]
XP_006522480.1. XM_006522417.1. [Q8K0L9-1]
XP_006522481.1. XM_006522418.1. [Q8K0L9-1]
XP_006522482.1. XM_006522419.1. [Q8K0L9-2]
XP_006522483.1. XM_006522420.1. [Q8K0L9-2]
XP_006522484.1. XM_006522421.1. [Q8K0L9-2]
XP_006522485.1. XM_006522422.1. [Q8K0L9-2]
XP_006522486.1. XM_006522423.1. [Q8K0L9-2]
XP_006522487.1. XM_006522424.1. [Q8K0L9-2]
UniGeneiMm.136238.
Mm.441121.
Mm.441972.
Mm.460947.
Mm.491236.

Genome annotation databases

EnsembliENSMUST00000079441; ENSMUSP00000078410; ENSMUSG00000022708. [Q8K0L9-1]
ENSMUST00000114690; ENSMUSP00000110338; ENSMUSG00000022708. [Q8K0L9-2]
ENSMUST00000114691; ENSMUSP00000110339; ENSMUSG00000022708. [Q8K0L9-2]
ENSMUST00000114694; ENSMUSP00000110342; ENSMUSG00000022708. [Q8K0L9-1]
ENSMUST00000114695; ENSMUSP00000110343; ENSMUSG00000022708. [Q8K0L9-1]
GeneIDi56490.
KEGGimmu:56490.
UCSCiuc007zga.2. mouse. [Q8K0L9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF194030 mRNA. Translation: AAF06015.1 .
AK005028 mRNA. Translation: BAB23755.1 .
CT010512 Genomic DNA. Translation: CAO77851.1 .
CT010512 Genomic DNA. Translation: CAO77852.1 .
BC031114 mRNA. Translation: AAH31114.1 .
BC056446 mRNA. Translation: AAH56446.1 .
CCDSi CCDS28178.1. [Q8K0L9-1 ]
CCDS49851.1. [Q8K0L9-2 ]
RefSeqi NP_001272734.1. NM_001285805.1. [Q8K0L9-1 ]
NP_062752.2. NM_019778.2. [Q8K0L9-1 ]
NP_851401.1. NM_181058.1. [Q8K0L9-2 ]
XP_006522475.1. XM_006522412.1. [Q8K0L9-1 ]
XP_006522476.1. XM_006522413.1. [Q8K0L9-1 ]
XP_006522477.1. XM_006522414.1. [Q8K0L9-1 ]
XP_006522478.1. XM_006522415.1. [Q8K0L9-1 ]
XP_006522479.1. XM_006522416.1. [Q8K0L9-1 ]
XP_006522480.1. XM_006522417.1. [Q8K0L9-1 ]
XP_006522481.1. XM_006522418.1. [Q8K0L9-1 ]
XP_006522482.1. XM_006522419.1. [Q8K0L9-2 ]
XP_006522483.1. XM_006522420.1. [Q8K0L9-2 ]
XP_006522484.1. XM_006522421.1. [Q8K0L9-2 ]
XP_006522485.1. XM_006522422.1. [Q8K0L9-2 ]
XP_006522486.1. XM_006522423.1. [Q8K0L9-2 ]
XP_006522487.1. XM_006522424.1. [Q8K0L9-2 ]
UniGenei Mm.136238.
Mm.441121.
Mm.441972.
Mm.460947.
Mm.491236.

3D structure databases

ProteinModelPortali Q8K0L9.
SMRi Q8K0L9. Positions 81-190, 529-737.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8K0L9. 1 interaction.

Proteomic databases

PaxDbi Q8K0L9.
PRIDEi Q8K0L9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000079441 ; ENSMUSP00000078410 ; ENSMUSG00000022708 . [Q8K0L9-1 ]
ENSMUST00000114690 ; ENSMUSP00000110338 ; ENSMUSG00000022708 . [Q8K0L9-2 ]
ENSMUST00000114691 ; ENSMUSP00000110339 ; ENSMUSG00000022708 . [Q8K0L9-2 ]
ENSMUST00000114694 ; ENSMUSP00000110342 ; ENSMUSG00000022708 . [Q8K0L9-1 ]
ENSMUST00000114695 ; ENSMUSP00000110343 ; ENSMUSG00000022708 . [Q8K0L9-1 ]
GeneIDi 56490.
KEGGi mmu:56490.
UCSCi uc007zga.2. mouse. [Q8K0L9-1 ]

Organism-specific databases

CTDi 26137.
MGIi MGI:1929213. Zbtb20.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00750000117519.
HOGENOMi HOG000136747.
HOVERGENi HBG060183.
InParanoidi Q8K0L9.
KOi K10501.
OMAi QIEHFND.
OrthoDBi EOG7GQXV7.
PhylomeDBi Q8K0L9.
TreeFami TF335684.

Miscellaneous databases

ChiTaRSi ZBTB20. mouse.
NextBioi 312770.
PROi Q8K0L9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8K0L9.
Bgeei Q8K0L9.
CleanExi MM_ZBTB20.
Genevestigatori Q8K0L9.

Family and domain databases

Gene3Di 3.30.160.60. 4 hits.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00651. BTB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view ]
SMARTi SM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of two novel nuclear BTB/POZ domain zinc finger isoforms. Association with differentiation of hippocampal neurons, cerebellar granule cells, and macroglia."
    Mitchelmore C., Kjaerulff K.M., Pedersen H.C., Nielsen J.V., Rasmussen T.E., Fisker M.F., Finsen B., Pedersen K.M., Jensen N.A.
    J. Biol. Chem. 277:7598-7609(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING, SUBCELLULAR LOCATION, HOMODIMERIZATION, TISSUE SPECIFICITY.
    Tissue: Oligodendroglioma.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Liver.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6 and FVB/N.
    Tissue: Brain and Kidney.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "In vivo localization and identification of SUMOylated proteins in the brain of His6-HA-SUMO1 knock-in mice."
    Tirard M., Hsiao H.H., Nikolov M., Urlaub H., Melchior F., Brose N.
    Proc. Natl. Acad. Sci. U.S.A. 109:21122-21127(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION WITH SUMO1.

Entry informationi

Entry nameiZBT20_MOUSE
AccessioniPrimary (citable) accession number: Q8K0L9
Secondary accession number(s): A6X916, Q9DBD4, Q9QZ87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi