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Protein

Zinc finger and BTB domain-containing protein 20

Gene

Zbtb20

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses (By similarity). Binds to DNA.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri578 – 600C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri606 – 628C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri634 – 656C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri662 – 684C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri715 – 737C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: MGI

GO - Biological processi

  • negative regulation of gene expression Source: CACAO
  • negative regulation of transcription, DNA-templated Source: CACAO
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of interferon-beta production Source: CACAO
  • positive regulation of interleukin-6 production Source: CACAO
  • positive regulation of tumor necrosis factor production Source: CACAO
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 20
Alternative name(s):
BTB/POZ domain zinc finger factor HOF
Zinc finger protein 288
Gene namesi
Name:Zbtb20
Synonyms:Zfp288
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1929213. Zbtb20.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003259611 – 741Zinc finger and BTB domain-containing protein 20Add BLAST741

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei211PhosphothreonineBy similarity1
Cross-linki330Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki330Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei353PhosphoserineCombined sources1
Modified residuei357PhosphothreonineCombined sources1
Modified residuei690PhosphothreonineCombined sources1
Modified residuei695PhosphothreonineCombined sources1

Post-translational modificationi

Sumoylated with SUMO1.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ8K0L9.
PeptideAtlasiQ8K0L9.
PRIDEiQ8K0L9.

PTM databases

iPTMnetiQ8K0L9.
PhosphoSitePlusiQ8K0L9.

Expressioni

Tissue specificityi

Specifically expressed in early hippocampal neurons, cerebellar granule cells and gliogenic progenitors as well as in differentiated glia.1 Publication

Gene expression databases

BgeeiENSMUSG00000022708.
CleanExiMM_ZBTB20.
ExpressionAtlasiQ8K0L9. baseline and differential.
GenevisibleiQ8K0L9. MM.

Interactioni

Subunit structurei

Can homodimerize. Binds to DNA.

Protein-protein interaction databases

IntActiQ8K0L9. 1 interactor.
STRINGi10090.ENSMUSP00000078410.

Structurei

3D structure databases

ProteinModelPortaliQ8K0L9.
SMRiQ8K0L9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 167BTBPROSITE-ProRule annotationAdd BLAST64

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri578 – 600C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri606 – 628C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri634 – 656C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri662 – 684C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri715 – 737C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000136747.
HOVERGENiHBG060183.
InParanoidiQ8K0L9.
KOiK10501.
OMAiTLMGNIH.
OrthoDBiEOG091G02AP.
PhylomeDBiQ8K0L9.
TreeFamiTF335684.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8K0L9-1) [UniParc]FASTAAdd to basket
Also known as: HOF-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLERKKPKTA ENQKASEENE ITQPGGSSAK PALPCLNFEA VLSPAPALIH
60 70 80 90 100
STHSLTNSHA HTGSSDCDIS CKGMTERIHS INLHNFSNSV LETLNEQRNR
110 120 130 140 150
GHFCDVTVRI HGSMLRAHRC VLAAGSPFFQ DKLLLGYSDI EIPSVVSVQS
160 170 180 190 200
VQKLIDFMYS GVLRVSQSEA LQILTAASIL QIKTVIDECT RIVSQNVGDV
210 220 230 240 250
FPGIQDSGQD TPRGTPESGT SGQSSDTESG YLQSHPQHSV DRIYSALYAC
260 270 280 290 300
SMQNGSGERS FYSGAVVSHH ETALGLPRDH HMEDPSWITR IHERSQQMER
310 320 330 340 350
YLSTTPETTH CRKQPRPVRI QTLVGNIHIK QEMEDDYDYY GQQRVQILER
360 370 380 390 400
NESEECTEDT DQAEGTESEP KGESFDSGVS SSIGTEPDSV EQQFGAAAPR
410 420 430 440 450
DGQAEPAQPE QAAEAPAESS AQPNQLEPGA SSPERSNESE MDNTVITVSN
460 470 480 490 500
SSDKGVLQQP SVNTSIGQPL PSTQLYLRQT ETLTSNLRMP LTLTSNTQVI
510 520 530 540 550
GTAGNTYLPA LFTTQPAGSG PKPFLFSLPQ PLTGQQTQFV TVSQPGLSTF
560 570 580 590 600
TAQLPAPQPL ASSAGHSTAS GQGDKKPYEC TLCNKTFTAK QNYVKHMFVH
610 620 630 640 650
TGEKPHQCSI CWRSFSLKDY LIKHMVTHTG VRAYQCSICN KRFTQKSSLN
660 670 680 690 700
VHMRLHRGEK SYECYICKKK FSHKTLLERH VALHSASNGT PPAGTPPGAR
710 720 730 740
AGPPGVVACT EGTTYVCSVC PAKFDQIEQF NDHMRMHVSD G
Length:741
Mass (Da):81,034
Last modified:October 1, 2002 - v1
Checksum:i04C0744D66BFE418
GO
Isoform 2 (identifier: Q8K0L9-2) [UniParc]FASTAAdd to basket
Also known as: HOF-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.

Show »
Length:668
Mass (Da):73,382
Checksum:i5A6FF5BEEA3963A3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88N → D in BAB23755 (PubMed:16141072).Curated1
Sequence conflicti421A → D in AAF06015 (PubMed:11744704).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0325041 – 73Missing in isoform 2. 2 PublicationsAdd BLAST73

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF194030 mRNA. Translation: AAF06015.1.
AK005028 mRNA. Translation: BAB23755.1.
CT010512 Genomic DNA. Translation: CAO77851.1.
CT010512 Genomic DNA. Translation: CAO77852.1.
BC031114 mRNA. Translation: AAH31114.1.
BC056446 mRNA. Translation: AAH56446.1.
CCDSiCCDS28178.1. [Q8K0L9-1]
CCDS49851.1. [Q8K0L9-2]
RefSeqiNP_001272734.1. NM_001285805.1. [Q8K0L9-1]
NP_062752.2. NM_019778.2. [Q8K0L9-1]
NP_851401.1. NM_181058.1. [Q8K0L9-2]
XP_006522475.1. XM_006522412.3. [Q8K0L9-1]
XP_006522476.1. XM_006522413.3. [Q8K0L9-1]
XP_006522477.1. XM_006522414.2. [Q8K0L9-1]
XP_006522478.1. XM_006522415.3. [Q8K0L9-1]
XP_006522479.1. XM_006522416.3. [Q8K0L9-1]
XP_006522481.1. XM_006522418.3. [Q8K0L9-1]
XP_006522485.1. XM_006522422.3. [Q8K0L9-2]
XP_006522487.1. XM_006522424.3. [Q8K0L9-2]
XP_011244291.1. XM_011245989.2. [Q8K0L9-1]
XP_011244292.1. XM_011245990.2. [Q8K0L9-1]
XP_017172580.1. XM_017317091.1. [Q8K0L9-1]
XP_017172581.1. XM_017317092.1. [Q8K0L9-1]
XP_017172582.1. XM_017317093.1. [Q8K0L9-1]
XP_017172583.1. XM_017317094.1. [Q8K0L9-1]
XP_017172584.1. XM_017317095.1. [Q8K0L9-1]
XP_017172585.1. XM_017317096.1. [Q8K0L9-1]
XP_017172586.1. XM_017317097.1. [Q8K0L9-1]
XP_017172587.1. XM_017317098.1. [Q8K0L9-1]
XP_017172588.1. XM_017317099.1. [Q8K0L9-2]
XP_017172589.1. XM_017317100.1. [Q8K0L9-2]
XP_017172590.1. XM_017317101.1. [Q8K0L9-2]
XP_017172591.1. XM_017317102.1. [Q8K0L9-2]
XP_017172592.1. XM_017317103.1. [Q8K0L9-2]
XP_017172593.1. XM_017317104.1. [Q8K0L9-2]
XP_017172594.1. XM_017317105.1. [Q8K0L9-2]
UniGeneiMm.136238.
Mm.441121.
Mm.441972.
Mm.460947.
Mm.487184.
Mm.491236.

Genome annotation databases

EnsembliENSMUST00000079441; ENSMUSP00000078410; ENSMUSG00000022708. [Q8K0L9-1]
ENSMUST00000114690; ENSMUSP00000110338; ENSMUSG00000022708. [Q8K0L9-2]
ENSMUST00000114691; ENSMUSP00000110339; ENSMUSG00000022708. [Q8K0L9-2]
ENSMUST00000114694; ENSMUSP00000110342; ENSMUSG00000022708. [Q8K0L9-1]
ENSMUST00000114695; ENSMUSP00000110343; ENSMUSG00000022708. [Q8K0L9-1]
GeneIDi56490.
KEGGimmu:56490.
UCSCiuc007zga.3. mouse. [Q8K0L9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF194030 mRNA. Translation: AAF06015.1.
AK005028 mRNA. Translation: BAB23755.1.
CT010512 Genomic DNA. Translation: CAO77851.1.
CT010512 Genomic DNA. Translation: CAO77852.1.
BC031114 mRNA. Translation: AAH31114.1.
BC056446 mRNA. Translation: AAH56446.1.
CCDSiCCDS28178.1. [Q8K0L9-1]
CCDS49851.1. [Q8K0L9-2]
RefSeqiNP_001272734.1. NM_001285805.1. [Q8K0L9-1]
NP_062752.2. NM_019778.2. [Q8K0L9-1]
NP_851401.1. NM_181058.1. [Q8K0L9-2]
XP_006522475.1. XM_006522412.3. [Q8K0L9-1]
XP_006522476.1. XM_006522413.3. [Q8K0L9-1]
XP_006522477.1. XM_006522414.2. [Q8K0L9-1]
XP_006522478.1. XM_006522415.3. [Q8K0L9-1]
XP_006522479.1. XM_006522416.3. [Q8K0L9-1]
XP_006522481.1. XM_006522418.3. [Q8K0L9-1]
XP_006522485.1. XM_006522422.3. [Q8K0L9-2]
XP_006522487.1. XM_006522424.3. [Q8K0L9-2]
XP_011244291.1. XM_011245989.2. [Q8K0L9-1]
XP_011244292.1. XM_011245990.2. [Q8K0L9-1]
XP_017172580.1. XM_017317091.1. [Q8K0L9-1]
XP_017172581.1. XM_017317092.1. [Q8K0L9-1]
XP_017172582.1. XM_017317093.1. [Q8K0L9-1]
XP_017172583.1. XM_017317094.1. [Q8K0L9-1]
XP_017172584.1. XM_017317095.1. [Q8K0L9-1]
XP_017172585.1. XM_017317096.1. [Q8K0L9-1]
XP_017172586.1. XM_017317097.1. [Q8K0L9-1]
XP_017172587.1. XM_017317098.1. [Q8K0L9-1]
XP_017172588.1. XM_017317099.1. [Q8K0L9-2]
XP_017172589.1. XM_017317100.1. [Q8K0L9-2]
XP_017172590.1. XM_017317101.1. [Q8K0L9-2]
XP_017172591.1. XM_017317102.1. [Q8K0L9-2]
XP_017172592.1. XM_017317103.1. [Q8K0L9-2]
XP_017172593.1. XM_017317104.1. [Q8K0L9-2]
XP_017172594.1. XM_017317105.1. [Q8K0L9-2]
UniGeneiMm.136238.
Mm.441121.
Mm.441972.
Mm.460947.
Mm.487184.
Mm.491236.

3D structure databases

ProteinModelPortaliQ8K0L9.
SMRiQ8K0L9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8K0L9. 1 interactor.
STRINGi10090.ENSMUSP00000078410.

PTM databases

iPTMnetiQ8K0L9.
PhosphoSitePlusiQ8K0L9.

Proteomic databases

PaxDbiQ8K0L9.
PeptideAtlasiQ8K0L9.
PRIDEiQ8K0L9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079441; ENSMUSP00000078410; ENSMUSG00000022708. [Q8K0L9-1]
ENSMUST00000114690; ENSMUSP00000110338; ENSMUSG00000022708. [Q8K0L9-2]
ENSMUST00000114691; ENSMUSP00000110339; ENSMUSG00000022708. [Q8K0L9-2]
ENSMUST00000114694; ENSMUSP00000110342; ENSMUSG00000022708. [Q8K0L9-1]
ENSMUST00000114695; ENSMUSP00000110343; ENSMUSG00000022708. [Q8K0L9-1]
GeneIDi56490.
KEGGimmu:56490.
UCSCiuc007zga.3. mouse. [Q8K0L9-1]

Organism-specific databases

CTDi26137.
MGIiMGI:1929213. Zbtb20.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000136747.
HOVERGENiHBG060183.
InParanoidiQ8K0L9.
KOiK10501.
OMAiTLMGNIH.
OrthoDBiEOG091G02AP.
PhylomeDBiQ8K0L9.
TreeFamiTF335684.

Miscellaneous databases

ChiTaRSiZbtb20. mouse.
PROiQ8K0L9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022708.
CleanExiMM_ZBTB20.
ExpressionAtlasiQ8K0L9. baseline and differential.
GenevisibleiQ8K0L9. MM.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZBT20_MOUSE
AccessioniPrimary (citable) accession number: Q8K0L9
Secondary accession number(s): A6X916, Q9DBD4, Q9QZ87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.