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Q8K0K3

- Q8K0K3_MOUSE

UniProt

Q8K0K3 - Q8K0K3_MOUSE

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Protein
Submitted name:

Gli2 protein

Gene

Gli2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. DNA binding Source: MGI
  3. sequence-specific DNA binding Source: MGI
  4. sequence-specific DNA binding transcription factor activity Source: MGI
  5. transcription regulatory region DNA binding Source: MGI
  6. zinc ion binding Source: Ensembl

GO - Biological processi

  1. anatomical structure development Source: MGI
  2. anatomical structure formation involved in morphogenesis Source: MGI
  3. axon guidance Source: MGI
  4. branching morphogenesis of an epithelial tube Source: MGI
  5. cell differentiation Source: MGI
  6. cell proliferation Source: MGI
  7. cellular response to organic cyclic compound Source: MGI
  8. cerebellar cortex morphogenesis Source: MGI
  9. chondrocyte differentiation Source: MGI
  10. cochlea morphogenesis Source: MGI
  11. developmental growth Source: MGI
  12. dorsal/ventral neural tube patterning Source: MGI
  13. dorsal/ventral pattern formation Source: MGI
  14. embryonic digestive tract development Source: MGI
  15. embryonic digit morphogenesis Source: MGI
  16. epidermal cell differentiation Source: Ensembl
  17. floor plate formation Source: MGI
  18. head development Source: MGI
  19. heart development Source: MGI
  20. hindbrain development Source: MGI
  21. hindgut morphogenesis Source: MGI
  22. in utero embryonic development Source: MGI
  23. kidney development Source: MGI
  24. lung development Source: MGI
  25. mammary gland development Source: MGI
  26. mammary gland duct morphogenesis Source: MGI
  27. morphogenesis of an epithelium Source: MGI
  28. negative regulation of chondrocyte differentiation Source: MGI
  29. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  30. neural tube development Source: MGI
  31. neuron development Source: MGI
  32. notochord regression Source: MGI
  33. odontogenesis of dentin-containing tooth Source: MGI
  34. osteoblast development Source: MGI
  35. osteoblast differentiation Source: MGI
  36. pattern specification process Source: MGI
  37. pituitary gland development Source: MGI
  38. positive regulation of cell proliferation Source: MGI
  39. positive regulation of DNA replication Source: Ensembl
  40. positive regulation of neuron differentiation Source: MGI
  41. positive regulation of transcription, DNA-templated Source: MGI
  42. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  43. prostatic bud formation Source: MGI
  44. proximal/distal pattern formation Source: MGI
  45. regulation of smoothened signaling pathway Source: MGI
  46. response to mechanical stimulus Source: Ensembl
  47. skeletal system development Source: MGI
  48. smoothened signaling pathway Source: MGI
  49. smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: MGI
  50. smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Source: MGI
  51. smoothened signaling pathway involved in spinal cord motor neuron cell fate specification Source: MGI
  52. smoothened signaling pathway involved in ventral spinal cord interneuron specification Source: MGI
  53. spinal cord dorsal/ventral patterning Source: MGI
  54. spinal cord motor neuron differentiation Source: MGI
  55. spinal cord ventral commissure morphogenesis Source: MGI
  56. tube development Source: MGI
  57. ventral midline development Source: MGI
  58. ventral spinal cord development Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Gli2 proteinImported
Gene namesi
Name:Gli2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95728. Gli2.

Subcellular locationi

GO - Cellular componenti

  1. ciliary tip Source: MGI
  2. cilium Source: MGI
  3. cytoplasm Source: MGI
  4. membrane Source: MGI
  5. motile primary cilium Source: MGI
  6. nuclear speck Source: MGI
  7. nucleus Source: MGI
  8. primary cilium Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ8K0K3.
ExpressionAtlasiQ8K0K3. baseline and differential.
GenevestigatoriQ8K0K3.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Zic1P466842EBI-308039,EBI-308006

Protein-protein interaction databases

IntActiQ8K0K3. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8K0K3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

PhylomeDBiQ8K0K3.

Sequencei

Sequence statusi: Fragment.

Q8K0K3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
RNAYSPRPPS INENVVMEAV AAGVDGPGLE CDLGLVEDEL VLPDDVVQYI
60 70 80 90 100
KAHTGGTLDD GIRQGYPTEG TGFPENSKLP SPGLQGHRRL AAADSNMGPS
110 120 130 140 150
APGLGGCQLS YSPSSNLNKS NMPVQWNEVS SGTVDALPTQ VKPPPFPHSN
160 170 180 190 200
LAVVQQKPAF GQYPGYNPQS VQSSSGGLDS TQPHLQLRGA PSASRGSYTQ
210 220 230 240 250
QPRQPAAGSQ CLGMSAAMSP QASYSQAHPQ LSPNIVSGSL NQFSPSCSNM
260 270 280 290 300
AAKPSHLGLP QQMEVVPNAT IMNGHQREHG VPNSSLAAVS QPHPVLSYPQ
310 320 330 340 350
QDSYQQGSNL LSSHQPGFME SQQNAGFGLM QPRPPLEPNT ASRHRGVRSG
360 370 380 390 400
QQQLYARTTG QAMVTSANQE TAEAMPKGPA GTMVSLAPQP SQDTGRAQDQ
410 420 430 440 450
NTLYYYGQIH MYEQNGGCPA VQPQPPQPQA CSDSIQPEPL PSPGVNQVSS
460 470 480 490 500
TVDSQLLEPP QIDFDAIMDD GDHSSLFSGA LSPTLLHNLS QNSSRLTTPR
510 520 530
NSLTLPSIPA GISNMAVGDM SSMLTSLAEE SKFLNMMT
Length:538
Mass (Da):56,843
Last modified:October 1, 2002 - v1
Checksum:i3253823A31E8D6D7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC031171 mRNA. Translation: AAH31171.1.
UniGeneiMm.273292.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC031171 mRNA. Translation: AAH31171.1 .
UniGenei Mm.273292.

3D structure databases

ProteinModelPortali Q8K0K3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8K0K3. 3 interactions.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:95728. Gli2.

Phylogenomic databases

PhylomeDBi Q8K0K3.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

Bgeei Q8K0K3.
ExpressionAtlasi Q8K0K3. baseline and differential.
Genevestigatori Q8K0K3.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: ColonImported.

Entry informationi

Entry nameiQ8K0K3_MOUSE
AccessioniPrimary (citable) accession number: Q8K0K3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)