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Q8K0K3 (Q8K0K3_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesSubmitted name:
Gli2 protein EMBL AAH31171.1
Gene names
Name:Gli2 EMBL AAH31171.1 MGI 95728
OrganismMus musculus (Mouse) EMBL AAH31171.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length538 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

Ontologies

Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from genetic interaction PubMed 19056373. Source: MGI

axon guidance

Inferred from mutant phenotype PubMed 10409510. Source: MGI

branching morphogenesis of an epithelial tube

Inferred from mutant phenotype PubMed 9731531. Source: MGI

cell proliferation

Inferred from genetic interaction PubMed 19056373. Source: MGI

cellular response to organic cyclic compound

Inferred from direct assay PubMed 19103752. Source: MGI

cerebellar cortex morphogenesis

Inferred from mutant phenotype PubMed 16571625. Source: MGI

cochlea morphogenesis

Inferred from mutant phenotype PubMed 17395647. Source: MGI

developmental growth

Inferred from mutant phenotype PubMed 16571630. Source: MGI

embryonic digestive tract development

Inferred from mutant phenotype PubMed 10693670. Source: MGI

embryonic digit morphogenesis

Inferred from mutant phenotype PubMed 19056373. Source: MGI

epidermal cell differentiation

Inferred from electronic annotation. Source: Compara

floor plate formation

Inferred from mutant phenotype PubMed 9636069PubMed 9655799. Source: MGI

head development

Inferred from mutant phenotype PubMed 19056373. Source: MGI

heart development

Inferred from genetic interaction PubMed 11172440. Source: MGI

hindgut morphogenesis

Inferred from mutant phenotype PubMed 11485934. Source: MGI

in utero embryonic development

Inferred from mutant phenotype PubMed 19056373. Source: MGI

kidney development

Inferred from genetic interaction PubMed 11172440. Source: MGI

lung development

Inferred from mutant phenotype PubMed 9731531. Source: MGI

mammary gland duct morphogenesis

Inferred from mutant phenotype PubMed 11783999. Source: MGI

negative regulation of chondrocyte differentiation

Inferred from mutant phenotype PubMed 17328886. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from genetic interaction PubMed 16611981. Source: MGI

notochord regression

Inferred from genetic interaction PubMed 10725236. Source: MGI

odontogenesis of dentin-containing tooth

Inferred from mutant phenotype PubMed 9655803. Source: MGI

osteoblast development

Inferred from direct assay PubMed 16880529. Source: MGI

pituitary gland development

Inferred from genetic interaction PubMed 10725236. Source: MGI

positive regulation of DNA replication

Inferred from electronic annotation. Source: Compara

positive regulation of neuron differentiation

Inferred from genetic interaction PubMed 16950124. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 16611981PubMed 16880529PubMed 16950124. Source: MGI

prostatic bud formation

Inferred from mutant phenotype PubMed 16707121. Source: MGI

proximal/distal pattern formation

Inferred from genetic interaction PubMed 16342201. Source: MGI

regulation of smoothened signaling pathway

Inferred from mutant phenotype PubMed 19056373. Source: MGI

response to mechanical stimulus

Inferred from electronic annotation. Source: Compara

skeletal system development

Inferred from mutant phenotype PubMed 9006072. Source: MGI

smoothened signaling pathway involved in dorsal/ventral neural tube patterning

Inferred from genetic interaction PubMed 17395647. Source: MGI

smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation

Inferred from mutant phenotype PubMed 16571625. Source: MGI

smoothened signaling pathway involved in spinal cord motor neuron cell fate specification

Inferred from genetic interaction PubMed 15215207. Source: MGI

smoothened signaling pathway involved in ventral spinal cord interneuron specification

Inferred from genetic interaction PubMed 15215207. Source: MGI

spinal cord ventral commissure morphogenesis

Inferred from mutant phenotype PubMed 10409510. Source: MGI

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 19286674PubMed 19684112. Source: MGI

membrane

Inferred from direct assay PubMed 19286674. Source: MGI

motile primary cilium

Inferred from direct assay PubMed 18590716. Source: MGI

nuclear speck

Inferred from direct assay PubMed 19684112. Source: MGI

   Molecular_functionchromatin binding

Inferred from direct assay PubMed 16396903. Source: MGI

sequence-specific DNA binding

Inferred from direct assay PubMed 16611981. Source: MGI

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 16880529. Source: MGI

transcription regulatory region DNA binding

Inferred from direct assay PubMed 19124651. Source: MGI

zinc ion binding

Inferred from electronic annotation. Source: Compara

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Zic1P466842EBI-308039,EBI-308006

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL AAH31171.1

Sequences

Sequence LengthMass (Da)Tools
Q8K0K3 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 3253823A31E8D6D7

FASTA53856,843
        10         20         30         40         50         60 
RNAYSPRPPS INENVVMEAV AAGVDGPGLE CDLGLVEDEL VLPDDVVQYI KAHTGGTLDD 

        70         80         90        100        110        120 
GIRQGYPTEG TGFPENSKLP SPGLQGHRRL AAADSNMGPS APGLGGCQLS YSPSSNLNKS 

       130        140        150        160        170        180 
NMPVQWNEVS SGTVDALPTQ VKPPPFPHSN LAVVQQKPAF GQYPGYNPQS VQSSSGGLDS 

       190        200        210        220        230        240 
TQPHLQLRGA PSASRGSYTQ QPRQPAAGSQ CLGMSAAMSP QASYSQAHPQ LSPNIVSGSL 

       250        260        270        280        290        300 
NQFSPSCSNM AAKPSHLGLP QQMEVVPNAT IMNGHQREHG VPNSSLAAVS QPHPVLSYPQ 

       310        320        330        340        350        360 
QDSYQQGSNL LSSHQPGFME SQQNAGFGLM QPRPPLEPNT ASRHRGVRSG QQQLYARTTG 

       370        380        390        400        410        420 
QAMVTSANQE TAEAMPKGPA GTMVSLAPQP SQDTGRAQDQ NTLYYYGQIH MYEQNGGCPA 

       430        440        450        460        470        480 
VQPQPPQPQA CSDSIQPEPL PSPGVNQVSS TVDSQLLEPP QIDFDAIMDD GDHSSLFSGA 

       490        500        510        520        530 
LSPTLLHNLS QNSSRLTTPR NSLTLPSIPA GISNMAVGDM SSMLTSLAEE SKFLNMMT

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N EMBL AAH31171.1.
Tissue: Colon EMBL AAH31171.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC031171 mRNA. Translation: AAH31171.1.
IPIIPI00553380.
UniGeneMm.273292.

3D structure databases

ProteinModelPortalQ8K0K3.
ModBaseSearch...

Protein-protein interaction databases

IntActQ8K0K3. 3 interactions.
STRINGQ8K0K3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:95728. Gli2.

Phylogenomic databases

InParanoidQ8K0K3.

Gene expression databases

ArrayExpressQ8K0K3.
BgeeQ8K0K3.
GenevestigatorQ8K0K3.

Family and domain databases

ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameQ8K0K3_MOUSE
AccessionPrimary (citable) accession number: Q8K0K3
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info