Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8K0K3

- Q8K0K3_MOUSE

UniProt

Q8K0K3 - Q8K0K3_MOUSE

Protein
Submitted name:

Gli2 protein

Gene

Gli2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. DNA binding Source: MGI
    3. protein binding Source: IntAct
    4. sequence-specific DNA binding Source: MGI
    5. sequence-specific DNA binding transcription factor activity Source: MGI
    6. transcription regulatory region DNA binding Source: MGI
    7. zinc ion binding Source: Ensembl

    GO - Biological processi

    1. anatomical structure development Source: MGI
    2. anatomical structure formation involved in morphogenesis Source: MGI
    3. axon guidance Source: MGI
    4. branching morphogenesis of an epithelial tube Source: MGI
    5. cell differentiation Source: MGI
    6. cell proliferation Source: MGI
    7. cellular response to organic cyclic compound Source: MGI
    8. cerebellar cortex morphogenesis Source: MGI
    9. chondrocyte differentiation Source: MGI
    10. cochlea morphogenesis Source: MGI
    11. developmental growth Source: MGI
    12. dorsal/ventral neural tube patterning Source: MGI
    13. dorsal/ventral pattern formation Source: MGI
    14. embryonic digestive tract development Source: MGI
    15. embryonic digit morphogenesis Source: MGI
    16. epidermal cell differentiation Source: Ensembl
    17. floor plate formation Source: MGI
    18. head development Source: MGI
    19. heart development Source: MGI
    20. hindbrain development Source: MGI
    21. hindgut morphogenesis Source: MGI
    22. in utero embryonic development Source: MGI
    23. kidney development Source: MGI
    24. lung development Source: MGI
    25. mammary gland development Source: MGI
    26. mammary gland duct morphogenesis Source: MGI
    27. morphogenesis of an epithelium Source: MGI
    28. negative regulation of chondrocyte differentiation Source: MGI
    29. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    30. neural tube development Source: MGI
    31. neuron development Source: MGI
    32. notochord regression Source: MGI
    33. odontogenesis of dentin-containing tooth Source: MGI
    34. osteoblast development Source: MGI
    35. osteoblast differentiation Source: MGI
    36. pattern specification process Source: MGI
    37. pituitary gland development Source: MGI
    38. positive regulation of cell proliferation Source: MGI
    39. positive regulation of DNA replication Source: Ensembl
    40. positive regulation of neuron differentiation Source: MGI
    41. positive regulation of transcription, DNA-templated Source: MGI
    42. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    43. prostatic bud formation Source: MGI
    44. proximal/distal pattern formation Source: MGI
    45. regulation of smoothened signaling pathway Source: MGI
    46. response to mechanical stimulus Source: Ensembl
    47. skeletal system development Source: MGI
    48. smoothened signaling pathway Source: MGI
    49. smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: MGI
    50. smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Source: MGI
    51. smoothened signaling pathway involved in spinal cord motor neuron cell fate specification Source: MGI
    52. smoothened signaling pathway involved in ventral spinal cord interneuron specification Source: MGI
    53. spinal cord dorsal/ventral patterning Source: MGI
    54. spinal cord motor neuron differentiation Source: MGI
    55. spinal cord ventral commissure morphogenesis Source: MGI
    56. tube development Source: MGI
    57. ventral midline development Source: MGI
    58. ventral spinal cord development Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Gli2 proteinImported
    Gene namesi
    Name:Gli2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:95728. Gli2.

    Subcellular locationi

    GO - Cellular componenti

    1. ciliary tip Source: MGI
    2. cilium Source: MGI
    3. cytoplasm Source: MGI
    4. membrane Source: MGI
    5. motile primary cilium Source: MGI
    6. nuclear speck Source: MGI
    7. nucleus Source: MGI
    8. primary cilium Source: MGI

    Expressioni

    Gene expression databases

    ArrayExpressiQ8K0K3.
    BgeeiQ8K0K3.
    GenevestigatoriQ8K0K3.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Zic1P466842EBI-308039,EBI-308006

    Protein-protein interaction databases

    IntActiQ8K0K3. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K0K3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    InParanoidiQ8K0K3.
    PhylomeDBiQ8K0K3.

    Sequencei

    Sequence statusi: Fragment.

    Q8K0K3-1 [UniParc]FASTAAdd to Basket

    « Hide

    RNAYSPRPPS INENVVMEAV AAGVDGPGLE CDLGLVEDEL VLPDDVVQYI    50
    KAHTGGTLDD GIRQGYPTEG TGFPENSKLP SPGLQGHRRL AAADSNMGPS 100
    APGLGGCQLS YSPSSNLNKS NMPVQWNEVS SGTVDALPTQ VKPPPFPHSN 150
    LAVVQQKPAF GQYPGYNPQS VQSSSGGLDS TQPHLQLRGA PSASRGSYTQ 200
    QPRQPAAGSQ CLGMSAAMSP QASYSQAHPQ LSPNIVSGSL NQFSPSCSNM 250
    AAKPSHLGLP QQMEVVPNAT IMNGHQREHG VPNSSLAAVS QPHPVLSYPQ 300
    QDSYQQGSNL LSSHQPGFME SQQNAGFGLM QPRPPLEPNT ASRHRGVRSG 350
    QQQLYARTTG QAMVTSANQE TAEAMPKGPA GTMVSLAPQP SQDTGRAQDQ 400
    NTLYYYGQIH MYEQNGGCPA VQPQPPQPQA CSDSIQPEPL PSPGVNQVSS 450
    TVDSQLLEPP QIDFDAIMDD GDHSSLFSGA LSPTLLHNLS QNSSRLTTPR 500
    NSLTLPSIPA GISNMAVGDM SSMLTSLAEE SKFLNMMT 538
    Length:538
    Mass (Da):56,843
    Last modified:October 1, 2002 - v1
    Checksum:i3253823A31E8D6D7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC031171 mRNA. Translation: AAH31171.1.
    UniGeneiMm.273292.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC031171 mRNA. Translation: AAH31171.1 .
    UniGenei Mm.273292.

    3D structure databases

    ProteinModelPortali Q8K0K3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8K0K3. 3 interactions.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:95728. Gli2.

    Phylogenomic databases

    InParanoidi Q8K0K3.
    PhylomeDBi Q8K0K3.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K0K3.
    Bgeei Q8K0K3.
    Genevestigatori Q8K0K3.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/NImported.
      Tissue: ColonImported.

    Entry informationi

    Entry nameiQ8K0K3_MOUSE
    AccessioniPrimary (citable) accession number: Q8K0K3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)