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Protein
Submitted name:

Gli2 protein

Gene

Gli2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. DNA binding Source: MGI
  3. sequence-specific DNA binding Source: MGI
  4. sequence-specific DNA binding transcription factor activity Source: MGI
  5. transcription regulatory region DNA binding Source: MGI
  6. zinc ion binding Source: MGI

GO - Biological processi

  1. anatomical structure development Source: MGI
  2. anatomical structure formation involved in morphogenesis Source: MGI
  3. axon guidance Source: MGI
  4. branching morphogenesis of an epithelial tube Source: MGI
  5. cell differentiation Source: MGI
  6. cell proliferation Source: MGI
  7. cellular response to organic cyclic compound Source: MGI
  8. cellular response to virus Source: MGI
  9. cerebellar cortex morphogenesis Source: MGI
  10. chondrocyte differentiation Source: MGI
  11. cochlea morphogenesis Source: MGI
  12. developmental growth Source: MGI
  13. dorsal/ventral neural tube patterning Source: MGI
  14. dorsal/ventral pattern formation Source: MGI
  15. embryonic digestive tract development Source: MGI
  16. embryonic digit morphogenesis Source: MGI
  17. epidermal cell differentiation Source: MGI
  18. floor plate formation Source: MGI
  19. head development Source: MGI
  20. heart development Source: MGI
  21. hindbrain development Source: MGI
  22. hindgut morphogenesis Source: MGI
  23. in utero embryonic development Source: MGI
  24. kidney development Source: MGI
  25. lung development Source: MGI
  26. mammary gland development Source: MGI
  27. mammary gland duct morphogenesis Source: MGI
  28. morphogenesis of an epithelium Source: MGI
  29. negative regulation of chondrocyte differentiation Source: MGI
  30. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  31. neural tube development Source: MGI
  32. neuron development Source: MGI
  33. notochord regression Source: MGI
  34. odontogenesis of dentin-containing tooth Source: MGI
  35. osteoblast development Source: MGI
  36. osteoblast differentiation Source: MGI
  37. pattern specification process Source: MGI
  38. pituitary gland development Source: MGI
  39. positive regulation of cell proliferation Source: MGI
  40. positive regulation of DNA replication Source: MGI
  41. positive regulation of neuron differentiation Source: MGI
  42. positive regulation of transcription, DNA-templated Source: MGI
  43. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  44. prostatic bud formation Source: MGI
  45. proximal/distal pattern formation Source: MGI
  46. regulation of smoothened signaling pathway Source: MGI
  47. response to mechanical stimulus Source: Ensembl
  48. skeletal system development Source: MGI
  49. smoothened signaling pathway Source: MGI
  50. smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: MGI
  51. smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Source: MGI
  52. smoothened signaling pathway involved in spinal cord motor neuron cell fate specification Source: MGI
  53. smoothened signaling pathway involved in ventral spinal cord interneuron specification Source: MGI
  54. spinal cord dorsal/ventral patterning Source: MGI
  55. spinal cord motor neuron differentiation Source: MGI
  56. spinal cord ventral commissure morphogenesis Source: MGI
  57. tube development Source: MGI
  58. ventral midline development Source: MGI
  59. ventral spinal cord development Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Gli2 proteinImported
Gene namesi
Name:Gli2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95728. Gli2.

Subcellular locationi

GO - Cellular componenti

  1. ciliary tip Source: MGI
  2. cilium Source: MGI
  3. cytoplasm Source: MGI
  4. membrane Source: MGI
  5. motile primary cilium Source: MGI
  6. nuclear speck Source: MGI
  7. nucleus Source: MGI
  8. primary cilium Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ8K0K3.
ExpressionAtlasiQ8K0K3. baseline and differential.
GenevestigatoriQ8K0K3.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Zic1P466842EBI-308039,EBI-308006

Protein-protein interaction databases

IntActiQ8K0K3. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8K0K3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

PhylomeDBiQ8K0K3.

Sequencei

Sequence statusi: Fragment.

Q8K0K3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RNAYSPRPPS INENVVMEAV AAGVDGPGLE CDLGLVEDEL VLPDDVVQYI
60 70 80 90 100
KAHTGGTLDD GIRQGYPTEG TGFPENSKLP SPGLQGHRRL AAADSNMGPS
110 120 130 140 150
APGLGGCQLS YSPSSNLNKS NMPVQWNEVS SGTVDALPTQ VKPPPFPHSN
160 170 180 190 200
LAVVQQKPAF GQYPGYNPQS VQSSSGGLDS TQPHLQLRGA PSASRGSYTQ
210 220 230 240 250
QPRQPAAGSQ CLGMSAAMSP QASYSQAHPQ LSPNIVSGSL NQFSPSCSNM
260 270 280 290 300
AAKPSHLGLP QQMEVVPNAT IMNGHQREHG VPNSSLAAVS QPHPVLSYPQ
310 320 330 340 350
QDSYQQGSNL LSSHQPGFME SQQNAGFGLM QPRPPLEPNT ASRHRGVRSG
360 370 380 390 400
QQQLYARTTG QAMVTSANQE TAEAMPKGPA GTMVSLAPQP SQDTGRAQDQ
410 420 430 440 450
NTLYYYGQIH MYEQNGGCPA VQPQPPQPQA CSDSIQPEPL PSPGVNQVSS
460 470 480 490 500
TVDSQLLEPP QIDFDAIMDD GDHSSLFSGA LSPTLLHNLS QNSSRLTTPR
510 520 530
NSLTLPSIPA GISNMAVGDM SSMLTSLAEE SKFLNMMT
Length:538
Mass (Da):56,843
Last modified:October 1, 2002 - v1
Checksum:i3253823A31E8D6D7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031171 mRNA. Translation: AAH31171.1.
UniGeneiMm.273292.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031171 mRNA. Translation: AAH31171.1.
UniGeneiMm.273292.

3D structure databases

ProteinModelPortaliQ8K0K3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8K0K3. 3 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:95728. Gli2.

Phylogenomic databases

PhylomeDBiQ8K0K3.

Miscellaneous databases

ChiTaRSiGli2. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K0K3.
ExpressionAtlasiQ8K0K3. baseline and differential.
GenevestigatoriQ8K0K3.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: ColonImported.

Entry informationi

Entry nameiQ8K0K3_MOUSE
AccessioniPrimary (citable) accession number: Q8K0K3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: February 4, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.