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Protein
Submitted name:

Epidermal growth factor-containing fibulin-like extracellular matrix protein 1

Gene

Efemp1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandCalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Epidermal growth factor-containing fibulin-like extracellular matrix protein 1Imported
Gene namesi
Name:Efemp1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1339998. Efemp1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi112 ↔ 122PROSITE-ProRule annotation
Disulfide bondi152 ↔ 162PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDbiQ8K0J4.
PeptideAtlasiQ8K0J4.
PRIDEiQ8K0J4.

Structurei

3D structure databases

ProteinModelPortaliQ8K0J4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 107EGF-likeInterPro annotationAdd BLAST41
Domaini108 – 147EGF-likeInterPro annotationAdd BLAST40
Domaini148 – 187EGF-likeInterPro annotationAdd BLAST40
Domaini188 – 227EGF-likeInterPro annotationAdd BLAST40

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

eggNOGiENOG410KD9V. Eukaryota.
ENOG410YCRW. LUCA.
HOVERGENiHBG051560.

Family and domain databases

InterProiView protein in InterPro
IPR026823. cEGF.
IPR032973. EFEMP1.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR037287. Fibulin_3/4/5.
IPR009030. Growth_fac_rcpt_cys_sf.
PANTHERiPTHR44074. PTHR44074. 1 hit.
PTHR44074:SF2. PTHR44074:SF2. 1 hit.
PfamiView protein in Pfam
PF12662. cEGF. 2 hits.
PF07645. EGF_CA. 2 hits.
SMARTiView protein in SMART
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 5 hits.
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 4 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8K0J4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSGVVPGG GFMASATAVA GPEVQTGRNN FVIRRNPADP QRIPSNPSHR
60 70 80 90 100
IQCAAGYEQS EHNVCQDIDE CTSGTHNCRT DQVCINLRGS FTCQCLPGYQ
110 120 130 140 150
KRGEQCVDID ECTVPPYCHQ RCVNTPGSFY CQCSPGFQLA ANNYTCVDIN
160 170 180 190 200
ECDASNQCAQ QCYNILGSFI CQCNQGYELS SDRLNCEDID ECRTSSYLCQ
210 220 230 240 250
YQCVNEPGKF SCMCPQGYEV VRSRTCQDIN ECETTNECRE DEMCWNYHGG
260 270 280 290 300
FRCYPRNPCQ DHYVLTSENR CVCPVSNTMC RELPQSIVYK YMSIRSDRSV
310 320 330 340 350
PSDIFQIQAT MIYANTINTF RIKSGNENGE FYLRQTSPVS AMLVLVKSLS
360 370 380
GPREYIVDLE MLTVSSIGTF RTSSVLRLTI IVGPFSF
Length:387
Mass (Da):43,335
Last modified:October 1, 2002 - v1
Checksum:iEE88DC9D1422C1C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031184 mRNA. Translation: AAH31184.1.
UniGeneiMm.44176.

Similar proteinsi

Entry informationi

Entry nameiQ8K0J4_MOUSE
AccessioniPrimary (citable) accession number: Q8K0J4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: November 22, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation