Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7

Gene

B3gnt7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in keratane sulfate biosynthesis. Transfers N-acetylgalactosamine on to keratan sulfate-related glycans. May play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues (By similarity).By similarity1 Publication

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • acetylglucosaminyltransferase activity Source: MGI
  • galactosyltransferase activity Source: InterPro

GO - Biological processi

  • protein glycosylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.149. 3474.
ReactomeiR-MMU-2022854. Keratan sulfate biosynthesis.
R-MMU-913709. O-linked glycosylation of mucins.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 (EC:2.4.1.-)
Short name:
BGnT-7
Short name:
Beta-1,3-Gn-T7
Short name:
Beta-1,3-N-acetylglucosaminyltransferase 7
Short name:
Beta3Gn-T7
Gene namesi
Name:B3gnt7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2384394. B3gnt7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66CytoplasmicSequence analysis
Transmembranei7 – 2620HelicalSequence analysisAdd
BLAST
Topological domaini27 – 397371LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7PRO_0000264619Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi84 – 841N-linked (GlcNAc...)Sequence analysis
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence analysis
Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence analysis
Glycosylationi387 – 3871N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8K0J2.
PaxDbiQ8K0J2.
PRIDEiQ8K0J2.

PTM databases

PhosphoSiteiQ8K0J2.

Expressioni

Tissue specificityi

Strongly expressed in placenta and colon. Moderately expressed in lung, stomach, small intestine and kidney. Very weakly expressed in cerebrum, cerebellum, heart and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000079445.
ExpressionAtlasiQ8K0J2. baseline and differential.
GenevisibleiQ8K0J2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108931.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 31 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2287. Eukaryota.
ENOG410ZZ1B. LUCA.
GeneTreeiENSGT00760000118879.
HOGENOMiHOG000232195.
HOVERGENiHBG050653.
InParanoidiQ8K0J2.
KOiK09664.
OMAiRMNKEPC.
OrthoDBiEOG091G0AXM.
PhylomeDBiQ8K0J2.
TreeFamiTF318639.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 1 hit.
PfamiPF01762. Galactosyl_T. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K0J2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLWKKTLYK SVCLALALLV AVTVFQRSVT PGQFLQDPLP PTPGPAKTGN
60 70 80 90 100
LVNPNSFWKS SKDVAAPTPT VPRGPQVWDV ITTNCSININ LTHQPWFQSL
110 120 130 140 150
EPHFRQFLAY RHCRYFPMLL NHPEKCAGDV YMLVVVKSVI TQHDRREVIR
160 170 180 190 200
QTWGHEWESA GLGRGAVRTL FLLGTASKQE ERTHYQQLLA YEDRLYADIL
210 220 230 240 250
QWDFLDSFFN LTLKEIHFLK WLDIYCPNVP FVFKGDDDVF VNPTNLLEFL
260 270 280 290 300
SDRQPQENLF VGDVLKHARP IRKKDNKYYI PAVMYGKATY PPYAGGGGFL
310 320 330 340 350
MSGSLARQLH HACDTLELFP IDDVFLGMCL EVLGVKPTGH EGFKTFGISR
360 370 380 390
VRSSRMNKEP CFYRAMLVVH KLLPAELLAM WDLVHSNLTC SVKFQVL
Length:397
Mass (Da):45,379
Last modified:December 12, 2006 - v2
Checksum:iA6345D03412DD48B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti203 – 2031D → N in BAC37824 (PubMed:16141072).Curated
Sequence conflicti208 – 2081F → S in AAH31187 (PubMed:15489334).Curated
Sequence conflicti271 – 2711I → T in AAM61769 (PubMed:12061784).Curated
Sequence conflicti290 – 2901Y → H in BAE20915 (PubMed:16141072).Curated
Sequence conflicti395 – 3951Q → R in AAH31187 (PubMed:15489334).Curated
Sequence conflicti395 – 3951Q → R in AAH60507 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF502429 mRNA. Translation: AAM61769.1.
AK080081 mRNA. Translation: BAC37824.1.
AK131975 mRNA. Translation: BAE20915.1.
AK154691 mRNA. Translation: BAE32766.1.
BC031187 mRNA. Translation: AAH31187.1.
BC060507 mRNA. Translation: AAH60507.1.
CCDSiCCDS35645.1.
RefSeqiNP_660257.2. NM_145222.2.
UniGeneiMm.86467.

Genome annotation databases

EnsembliENSMUST00000113306; ENSMUSP00000108931; ENSMUSG00000079445.
GeneIDi227327.
KEGGimmu:227327.
UCSCiuc007bvk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF502429 mRNA. Translation: AAM61769.1.
AK080081 mRNA. Translation: BAC37824.1.
AK131975 mRNA. Translation: BAE20915.1.
AK154691 mRNA. Translation: BAE32766.1.
BC031187 mRNA. Translation: AAH31187.1.
BC060507 mRNA. Translation: AAH60507.1.
CCDSiCCDS35645.1.
RefSeqiNP_660257.2. NM_145222.2.
UniGeneiMm.86467.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108931.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

PTM databases

PhosphoSiteiQ8K0J2.

Proteomic databases

MaxQBiQ8K0J2.
PaxDbiQ8K0J2.
PRIDEiQ8K0J2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113306; ENSMUSP00000108931; ENSMUSG00000079445.
GeneIDi227327.
KEGGimmu:227327.
UCSCiuc007bvk.2. mouse.

Organism-specific databases

CTDi93010.
MGIiMGI:2384394. B3gnt7.

Phylogenomic databases

eggNOGiKOG2287. Eukaryota.
ENOG410ZZ1B. LUCA.
GeneTreeiENSGT00760000118879.
HOGENOMiHOG000232195.
HOVERGENiHBG050653.
InParanoidiQ8K0J2.
KOiK09664.
OMAiRMNKEPC.
OrthoDBiEOG091G0AXM.
PhylomeDBiQ8K0J2.
TreeFamiTF318639.

Enzyme and pathway databases

UniPathwayiUPA00378.
BRENDAi2.4.1.149. 3474.
ReactomeiR-MMU-2022854. Keratan sulfate biosynthesis.
R-MMU-913709. O-linked glycosylation of mucins.

Miscellaneous databases

PROiQ8K0J2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000079445.
ExpressionAtlasiQ8K0J2. baseline and differential.
GenevisibleiQ8K0J2. MM.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 1 hit.
PfamiPF01762. Galactosyl_T. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB3GN7_MOUSE
AccessioniPrimary (citable) accession number: Q8K0J2
Secondary accession number(s): Q3U3L9
, Q3V283, Q6PA02, Q8BJS5, Q8K437
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: September 7, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.