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Protein

Epithelial splicing regulatory protein 2

Gene

Esrp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • alternative mRNA splicing, via spliceosome Source: MGI
  • branching involved in salivary gland morphogenesis Source: MGI
  • epithelial tube branching involved in lung morphogenesis Source: MGI
  • positive regulation of epithelial cell proliferation Source: MGI
  • regulation of RNA splicing Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-6803529. FGFR2 alternative splicing.

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial splicing regulatory protein 2
Alternative name(s):
RNA-binding motif protein 35B
RNA-binding protein 35B
Gene namesi
Name:Esrp2
Synonyms:Rbm35b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1924661. Esrp2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002730511 – 717Epithelial splicing regulatory protein 2Add BLAST717

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83PhosphoserineCombined sources1
Modified residuei563PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8K0G8.
PaxDbiQ8K0G8.
PRIDEiQ8K0G8.

PTM databases

iPTMnetiQ8K0G8.
PhosphoSitePlusiQ8K0G8.

Expressioni

Tissue specificityi

Epithelial cell-specific.1 Publication

Gene expression databases

BgeeiENSMUSG00000084128.
CleanExiMM_RBM35B.
ExpressionAtlasiQ8K0G8. baseline and differential.
GenevisibleiQ8K0G8. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8K0G8. 1 interactor.
STRINGi10090.ENSMUSP00000111639.

Structurei

3D structure databases

ProteinModelPortaliQ8K0G8.
SMRiQ8K0G8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini247 – 343RRM 1Add BLAST97
Domaini348 – 428RRM 2Add BLAST81
Domaini465 – 545RRM 3Add BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 27Pro-richAdd BLAST25

Sequence similaritiesi

Belongs to the ESRP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1365. Eukaryota.
ENOG410XPZU. LUCA.
GeneTreeiENSGT00760000119102.
HOGENOMiHOG000112401.
InParanoidiQ8K0G8.
KOiK14947.
OMAiREFHVQH.
OrthoDBiEOG091G06HY.
PhylomeDBiQ8K0G8.
TreeFamiTF316157.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR012337. RNaseH-like_dom.
IPR000504. RRM_dom.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
SSF54928. SSF54928. 3 hits.

Sequencei

Sequence statusi: Complete.

Q8K0G8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPPPPPPPP PGPDPAVDSA TDPCPEPQSL VVLFGATAGA LGPDLGSDET
60 70 80 90 100
DLILLVWQVV EPRSRQVGTL HKSLVRAEAA ALSPQCREAS GLSADSLARA
110 120 130 140 150
ESLDKVLQQF SQLVSGDVAL LGGGPYVLCT DGQQLLRQVL HPEASRKNLV
160 170 180 190 200
LPDTFFSFYD LRREFHMQHP STCSARDLTV GTMAQDLGLE TDATEDDFGV
210 220 230 240 250
WEVKTMVAVI LHLLEGSNGQ LFSKPEVVKQ KYETGPCSKA DVVDNETVVR
260 270 280 290 300
ARGLPWQSSD QDVARFFKGL NIARGGVALC LNAQGRRNGE ALIRFVDSEQ
310 320 330 340 350
RDLALQRHKH HMGVRYIEVY KATGEEFVKI AGGTSLEVAR FLSREDQVIL
360 370 380 390 400
RLRGLPFSAG PTDVLGFLGP ECPVTGGADG LLFVRHPDGR PTGDAFALFA
410 420 430 440 450
CEELAQAALR RHKGMLGKRY IELFRSTAAE VQQVLNRYAA SPLLPTLTAP
460 470 480 490 500
LLPIPFPLAG GTGRDCVRLR GLPYTATIED ILSFLGEAAA DIRPHGVHMV
510 520 530 540 550
LNQQGRPSGD AFIQMMSVER ALAAAQRCHK KMMKERYVEV VPCSTEEMSR
560 570 580 590 600
VLMGGSLSRS GLSPPPCKLP CLSPPTYATF QATPALIPTE TTALYPSSAL
610 620 630 640 650
LPAARVPAAA TPLAYYPGPA TQLYMNYTAY YPSPPVSPTT VGYLTTPPTA
660 670 680 690 700
LASTPTTMLS QPGALVRMQG VPYTAGMKDL LSVFQAYQLA PDDYTTLMPV
710
GDPPRTVLQA PKEWVCL
Length:717
Mass (Da):77,361
Last modified:October 1, 2002 - v1
Checksum:i121C06A0B8457340
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031444 mRNA. Translation: AAH31444.1.
AK020578 mRNA. Translation: BAC25635.1.
CCDSiCCDS22629.1.
RefSeqiNP_789808.1. NM_176838.2.
UniGeneiMm.183003.

Genome annotation databases

EnsembliENSMUST00000115979; ENSMUSP00000111639; ENSMUSG00000084128.
GeneIDi77411.
KEGGimmu:77411.
UCSCiuc009nff.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031444 mRNA. Translation: AAH31444.1.
AK020578 mRNA. Translation: BAC25635.1.
CCDSiCCDS22629.1.
RefSeqiNP_789808.1. NM_176838.2.
UniGeneiMm.183003.

3D structure databases

ProteinModelPortaliQ8K0G8.
SMRiQ8K0G8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8K0G8. 1 interactor.
STRINGi10090.ENSMUSP00000111639.

PTM databases

iPTMnetiQ8K0G8.
PhosphoSitePlusiQ8K0G8.

Proteomic databases

MaxQBiQ8K0G8.
PaxDbiQ8K0G8.
PRIDEiQ8K0G8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115979; ENSMUSP00000111639; ENSMUSG00000084128.
GeneIDi77411.
KEGGimmu:77411.
UCSCiuc009nff.1. mouse.

Organism-specific databases

CTDi80004.
MGIiMGI:1924661. Esrp2.

Phylogenomic databases

eggNOGiKOG1365. Eukaryota.
ENOG410XPZU. LUCA.
GeneTreeiENSGT00760000119102.
HOGENOMiHOG000112401.
InParanoidiQ8K0G8.
KOiK14947.
OMAiREFHVQH.
OrthoDBiEOG091G06HY.
PhylomeDBiQ8K0G8.
TreeFamiTF316157.

Enzyme and pathway databases

ReactomeiR-MMU-6803529. FGFR2 alternative splicing.

Miscellaneous databases

PROiQ8K0G8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000084128.
CleanExiMM_RBM35B.
ExpressionAtlasiQ8K0G8. baseline and differential.
GenevisibleiQ8K0G8. MM.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR012337. RNaseH-like_dom.
IPR000504. RRM_dom.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
SSF54928. SSF54928. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiESRP2_MOUSE
AccessioniPrimary (citable) accession number: Q8K0G8
Secondary accession number(s): Q8CEK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.