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Protein

Protein TSSC1

Gene

Eipr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • positive regulation of dense core granule transport Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TSSC1
Alternative name(s):
EARP-interacting proteinBy similarity
Endosome-associated recycling protein-interacting proteinBy similarity
Gene namesi
Name:Eipr1By similarity
Synonyms:Tssc1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1289332. Tssc1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513001 – 386Protein TSSC1Add BLAST386

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei320PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8K0G5.
MaxQBiQ8K0G5.
PaxDbiQ8K0G5.
PeptideAtlasiQ8K0G5.
PRIDEiQ8K0G5.

PTM databases

iPTMnetiQ8K0G5.
PhosphoSitePlusiQ8K0G5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036613.
CleanExiMM_TSSC1.
GenevisibleiQ8K0G5. MM.

Interactioni

Subunit structurei

Interacts with EARP complex components VPS50 and VPS51, and SNAP29.By similarity

Protein-protein interaction databases

IntActiQ8K0G5. 1 interactor.
MINTiMINT-4116753.
STRINGi10090.ENSMUSP00000038845.

Structurei

3D structure databases

ProteinModelPortaliQ8K0G5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati132 – 172WD 1Add BLAST41
Repeati182 – 222WD 2Add BLAST41
Repeati226 – 266WD 3Add BLAST41
Repeati270 – 310WD 4Add BLAST41
Repeati344 – 384WD 5Add BLAST41

Sequence similaritiesi

Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1007. Eukaryota.
ENOG410XRIE. LUCA.
GeneTreeiENSGT00730000111137.
HOGENOMiHOG000264967.
HOVERGENiHBG052937.
InParanoidiQ8K0G5.
OMAiHCAWSIS.
OrthoDBiEOG091G0DR3.
TreeFamiTF105847.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K0G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDDAPVIYG LEFQARALTP QTAETDAIRF LVGTQSLKYD NQIHIIDFDD
60 70 80 90 100
ENNIINKNVL LHQAGEIWHI SASPADKGVL ATCYNKTTDS RVQACAAVWR
110 120 130 140 150
MPKELESGSH ESPDDPASTA QTLELLCHLD NSAQGNVACV VWEPMGDGKK
160 170 180 190 200
VISLADSHIL LWDLQPSSSQ AVLASSATLE GRGQLKFTAG RWSPHHNCTQ
210 220 230 240 250
VATASDTTLR GWDTRSMSQI YCIENAHGQL VRDLDFNPNK QYYLASCGDD
260 270 280 290 300
CKVKFWDTRN VTEPVKTLEE HSHWVWSVRY NHSHDQLVLT GSSDSRVILS
310 320 330 340 350
NMVSISSEPF GHLVDDGDIS DPEEHHAEKS KEPLQDNVIA TYEEHEDSVY
360 370 380
AVDWASADPW LFASLSYDGR LVINRVPRAL KYHILL
Length:386
Mass (Da):43,127
Last modified:July 27, 2011 - v2
Checksum:iD555D19FB7D700F4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti317 – 319GDI → DDV in AAH31458 (PubMed:15489334).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136986 Genomic DNA. No translation available.
CT010449 Genomic DNA. No translation available.
BC031458 mRNA. Translation: AAH31458.1.
CCDSiCCDS25855.1.
RefSeqiNP_958745.2. NM_201357.2.
UniGeneiMm.273724.

Genome annotation databases

EnsembliENSMUST00000035657; ENSMUSP00000038845; ENSMUSG00000036613.
GeneIDi380752.
KEGGimmu:380752.
UCSCiuc007ngb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136986 Genomic DNA. No translation available.
CT010449 Genomic DNA. No translation available.
BC031458 mRNA. Translation: AAH31458.1.
CCDSiCCDS25855.1.
RefSeqiNP_958745.2. NM_201357.2.
UniGeneiMm.273724.

3D structure databases

ProteinModelPortaliQ8K0G5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8K0G5. 1 interactor.
MINTiMINT-4116753.
STRINGi10090.ENSMUSP00000038845.

PTM databases

iPTMnetiQ8K0G5.
PhosphoSitePlusiQ8K0G5.

Proteomic databases

EPDiQ8K0G5.
MaxQBiQ8K0G5.
PaxDbiQ8K0G5.
PeptideAtlasiQ8K0G5.
PRIDEiQ8K0G5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035657; ENSMUSP00000038845; ENSMUSG00000036613.
GeneIDi380752.
KEGGimmu:380752.
UCSCiuc007ngb.2. mouse.

Organism-specific databases

CTDi7260.
MGIiMGI:1289332. Tssc1.

Phylogenomic databases

eggNOGiKOG1007. Eukaryota.
ENOG410XRIE. LUCA.
GeneTreeiENSGT00730000111137.
HOGENOMiHOG000264967.
HOVERGENiHBG052937.
InParanoidiQ8K0G5.
OMAiHCAWSIS.
OrthoDBiEOG091G0DR3.
TreeFamiTF105847.

Miscellaneous databases

ChiTaRSiTssc1. mouse.
PROiQ8K0G5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036613.
CleanExiMM_TSSC1.
GenevisibleiQ8K0G5. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSSC1_MOUSE
AccessioniPrimary (citable) accession number: Q8K0G5
Secondary accession number(s): E9QN80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.