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Protein

Fibrinogen beta chain

Gene

Fgb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Blood coagulation, Hemostasis, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-140875 Common Pathway of Fibrin Clot Formation
R-MMU-216083 Integrin cell surface interactions
R-MMU-354192 Integrin alphaIIb beta3 signaling
R-MMU-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-MMU-372708 p130Cas linkage to MAPK signaling for integrins
R-MMU-5674135 MAP2K and MAPK activation
R-MMU-5686938 Regulation of TLR by endogenous ligand

Names & Taxonomyi

Protein namesi
Recommended name:
Fibrinogen beta chain
Cleaved into the following 2 chains:
Gene namesi
Name:Fgb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:99501 Fgb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
PeptideiPRO_000000907820 – 34Fibrinopeptide BBy similarityAdd BLAST15
ChainiPRO_000000907735 – 481Fibrinogen beta chainAdd BLAST447

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi213Interchain (with alpha chain)PROSITE-ProRule annotation
Disulfide bondi217Interchain (with gamma chain)PROSITE-ProRule annotation
Disulfide bondi221 ↔ 306PROSITE-ProRule annotation
Disulfide bondi231 ↔ 260PROSITE-ProRule annotation
Glycosylationi384N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi414 ↔ 427PROSITE-ProRule annotation

Post-translational modificationi

Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei34 – 35Cleavage; by thrombin; to release fibrinopeptide BBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8K0E8
PaxDbiQ8K0E8
PeptideAtlasiQ8K0E8
PRIDEiQ8K0E8

2D gel databases

REPRODUCTION-2DPAGEIPI00279079
Q8K0E8

PTM databases

iPTMnetiQ8K0E8
PhosphoSitePlusiQ8K0E8

Expressioni

Gene expression databases

BgeeiENSMUSG00000033831
CleanExiMM_FGB
ExpressionAtlasiQ8K0E8 baseline and differential
GenevisibleiQ8K0E8 MM

Interactioni

Subunit structurei

Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi225325, 2 interactors
IntActiQ8K0E8, 5 interactors
MINTiQ8K0E8
STRINGi10090.ENSMUSP00000039472

Structurei

3D structure databases

ProteinModelPortaliQ8K0E8
SMRiQ8K0E8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini222 – 478Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST257

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni35 – 37Beta-chain polymerization, binding distal domain of another fibrinBy similarity3

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili149 – 213Sequence analysisAdd BLAST65

Domaini

A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure (By similarity).By similarity

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00760000118809
HOGENOMiHOG000059561
HOVERGENiHBG005707
InParanoidiQ8K0E8
KOiK03904
OMAiTIHNGMF
OrthoDBiEOG091G03M1
PhylomeDBiQ8K0E8
TreeFamiTF336658

Family and domain databases

CDDicd00087 FReD, 1 hit
InterProiView protein in InterPro
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR012290 Fibrinogen_a/b/g_coil_dom
IPR037580 Fibrinogen_beta
IPR020837 Fibrinogen_CS
PANTHERiPTHR19143:SF332 PTHR19143:SF332, 1 hit
PfamiView protein in Pfam
PF08702 Fib_alpha, 1 hit
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SM01212 Fib_alpha, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K0E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHLWLLLLL CVFSVQTQAA DDDYDEPTDS LDARGHRPVD RRKEEPPSLR
60 70 80 90 100
PAPPPISGGG YRARPAKATA NQKKVERRPP DAGGCLHADT DMGVLCPTGC
110 120 130 140 150
TLQQTLLNQE RPIKSSIAEL NNNIQSVSDT SSVTFQYLTL LKDMWKKKQA
160 170 180 190 200
QVKENENVIN EYSSILEDQR LYIDETVNDN IPLNLRVLRS ILEDLRSKIQ
210 220 230 240 250
KLESDISAQM EYCRTPCTVS CNIPVVSGKE CEEIIRKGGE TSEMYLIQPD
260 270 280 290 300
TSIKPYRVYC DMKTENGGWT VIQNRQDGSV DFGRKWDPYK KGFGNIATNE
310 320 330 340 350
DAKKYCGLPG EYWLGNDKIS QLTRMGPTEL LIEMEDWKGD KVKAHYGGFT
360 370 380 390 400
VQNEASKYQV SVNKYKGTAG NALMDGASQL VGENRTMTIH NGMFFSTYDR
410 420 430 440 450
DNDGWVTTDP RKQCSKEDGG GWWYNRCHAA NPNGRYYWGG LYSWDMSKHG
460 470 480
TDDGVVWMNW KGSWYSMRRM SMKIRPFFPQ Q
Length:481
Mass (Da):54,753
Last modified:October 1, 2002 - v1
Checksum:i9902830CF708A155
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031715 mRNA Translation: AAH31715.1
AF413205 mRNA Translation: AAL02225.1
CCDSiCCDS17432.1
RefSeqiNP_862897.1, NM_181849.3
UniGeneiMm.30063

Genome annotation databases

EnsembliENSMUST00000048246; ENSMUSP00000039472; ENSMUSG00000033831
GeneIDi110135
KEGGimmu:110135
UCSCiuc008pph.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFIBB_MOUSE
AccessioniPrimary (citable) accession number: Q8K0E8
Secondary accession number(s): Q91ZP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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