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Q8K0E8 (FIBB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibrinogen beta chain

Cleaved into the following 2 chains:

  1. Fibrinopeptide B
  2. Fibrinogen beta chain
Gene names
Name:Fgb
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length481 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation By similarity.

Subunit structure

Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain By similarity.

Subcellular location

Secreted.

Domain

A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure By similarity.

Post-translational modification

Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot By similarity.

Sequence similarities

Contains 1 fibrinogen C-terminal domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 By similarity
Peptide20 – 3415Fibrinopeptide B By similarity
PRO_0000009078
Chain35 – 481447Fibrinogen beta chain
PRO_0000009077

Regions

Domain222 – 478257Fibrinogen C-terminal
Region35 – 373Beta-chain polymerization, binding distal domain of another fibrin By similarity
Coiled coil149 – 21365 Potential

Sites

Site34 – 352Cleavage; by thrombin; to release fibrinopeptide B By similarity

Amino acid modifications

Glycosylation3841N-linked (GlcNAc...) Potential
Disulfide bond213Interchain (with alpha chain) By similarity
Disulfide bond217Interchain (with gamma chain) By similarity
Disulfide bond221 ↔ 306 By similarity
Disulfide bond231 ↔ 260 By similarity
Disulfide bond414 ↔ 427 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8K0E8 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 9902830CF708A155

FASTA48154,753
        10         20         30         40         50         60 
MRHLWLLLLL CVFSVQTQAA DDDYDEPTDS LDARGHRPVD RRKEEPPSLR PAPPPISGGG 

        70         80         90        100        110        120 
YRARPAKATA NQKKVERRPP DAGGCLHADT DMGVLCPTGC TLQQTLLNQE RPIKSSIAEL 

       130        140        150        160        170        180 
NNNIQSVSDT SSVTFQYLTL LKDMWKKKQA QVKENENVIN EYSSILEDQR LYIDETVNDN 

       190        200        210        220        230        240 
IPLNLRVLRS ILEDLRSKIQ KLESDISAQM EYCRTPCTVS CNIPVVSGKE CEEIIRKGGE 

       250        260        270        280        290        300 
TSEMYLIQPD TSIKPYRVYC DMKTENGGWT VIQNRQDGSV DFGRKWDPYK KGFGNIATNE 

       310        320        330        340        350        360 
DAKKYCGLPG EYWLGNDKIS QLTRMGPTEL LIEMEDWKGD KVKAHYGGFT VQNEASKYQV 

       370        380        390        400        410        420 
SVNKYKGTAG NALMDGASQL VGENRTMTIH NGMFFSTYDR DNDGWVTTDP RKQCSKEDGG 

       430        440        450        460        470        480 
GWWYNRCHAA NPNGRYYWGG LYSWDMSKHG TDDGVVWMNW KGSWYSMRRM SMKIRPFFPQ 


Q 

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References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Liver.
[2]"Mouse fibrinogen B-beta-chain."
Murakawa M., Freeman M.W.
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 234-469.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC031715 mRNA. Translation: AAH31715.1.
AF413205 mRNA. Translation: AAL02225.1.
CCDSCCDS17432.1.
RefSeqNP_862897.1. NM_181849.2.
UniGeneMm.30063.

3D structure databases

ProteinModelPortalQ8K0E8.
SMRQ8K0E8. Positions 78-479.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8K0E8. 5 interactions.
MINTMINT-1863241.

PTM databases

PhosphoSiteQ8K0E8.

2D gel databases

REPRODUCTION-2DPAGEIPI00279079.
Q8K0E8.

Proteomic databases

MaxQBQ8K0E8.
PaxDbQ8K0E8.
PRIDEQ8K0E8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000048246; ENSMUSP00000039472; ENSMUSG00000033831.
GeneID110135.
KEGGmmu:110135.
UCSCuc008pph.1. mouse.

Organism-specific databases

CTD2244.
MGIMGI:99501. Fgb.

Phylogenomic databases

eggNOGNOG277105.
GeneTreeENSGT00750000117251.
HOGENOMHOG000059561.
HOVERGENHBG005707.
InParanoidQ8K0E8.
KOK03904.
OMATIHNGMF.
OrthoDBEOG7X9G60.
PhylomeDBQ8K0E8.
TreeFamTF336658.

Gene expression databases

BgeeQ8K0E8.
CleanExMM_FGB.
GenevestigatorQ8K0E8.

Family and domain databases

Gene3D3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR012290. Fibrinogen_a/b/g_coil_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamPF08702. Fib_alpha. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMSSF56496. SSF56496. 1 hit.
PROSITEPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFGB. mouse.
NextBio363391.
PROQ8K0E8.
SOURCESearch...

Entry information

Entry nameFIBB_MOUSE
AccessionPrimary (citable) accession number: Q8K0E8
Secondary accession number(s): Q91ZP1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot