Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fibrinogen beta chain

Gene

Fgb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei34 – 352Cleavage; by thrombin; to release fibrinopeptide BBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Blood coagulation, Hemostasis, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiREACT_286713. Common Pathway of Fibrin Clot Formation.
REACT_307071. Platelet degranulation.
REACT_316753. p130Cas linkage to MAPK signaling for integrins.
REACT_319261. Integrin cell surface interactions.
REACT_330010. Integrin alphaIIb beta3 signaling.
REACT_332492. GRB2:SOS provides linkage to MAPK signaling for Integrins.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibrinogen beta chain
Cleaved into the following 2 chains:
Gene namesi
Name:Fgb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:99501. Fgb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Peptidei20 – 3415Fibrinopeptide BBy similarityPRO_0000009078Add
BLAST
Chaini35 – 481447Fibrinogen beta chainPRO_0000009077Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi213 – 213Interchain (with alpha chain)PROSITE-ProRule annotation
Disulfide bondi217 – 217Interchain (with gamma chain)PROSITE-ProRule annotation
Disulfide bondi221 ↔ 306PROSITE-ProRule annotation
Disulfide bondi231 ↔ 260PROSITE-ProRule annotation
Glycosylationi384 – 3841N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi414 ↔ 427PROSITE-ProRule annotation

Post-translational modificationi

Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8K0E8.
PaxDbiQ8K0E8.
PRIDEiQ8K0E8.

2D gel databases

REPRODUCTION-2DPAGEIPI00279079.
Q8K0E8.

PTM databases

PhosphoSiteiQ8K0E8.

Expressioni

Gene expression databases

BgeeiQ8K0E8.
CleanExiMM_FGB.
ExpressionAtlasiQ8K0E8. baseline and differential.
GenevisibleiQ8K0E8. MM.

Interactioni

Subunit structurei

Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain (By similarity).By similarity

Protein-protein interaction databases

BioGridi225325. 1 interaction.
IntActiQ8K0E8. 5 interactions.
MINTiMINT-1863241.
STRINGi10090.ENSMUSP00000039472.

Structurei

3D structure databases

ProteinModelPortaliQ8K0E8.
SMRiQ8K0E8. Positions 78-479.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini222 – 478257Fibrinogen C-terminalPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni35 – 373Beta-chain polymerization, binding distal domain of another fibrinBy similarity

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili149 – 21365Sequence AnalysisAdd
BLAST

Domaini

A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure (By similarity).By similarity

Sequence similaritiesi

Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiNOG277105.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000059561.
HOVERGENiHBG005707.
InParanoidiQ8K0E8.
KOiK03904.
OMAiTIHNGMF.
OrthoDBiEOG7X9G60.
PhylomeDBiQ8K0E8.
TreeFamiTF336658.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR012290. Fibrinogen_a/b/g_coil_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF08702. Fib_alpha. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K0E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHLWLLLLL CVFSVQTQAA DDDYDEPTDS LDARGHRPVD RRKEEPPSLR
60 70 80 90 100
PAPPPISGGG YRARPAKATA NQKKVERRPP DAGGCLHADT DMGVLCPTGC
110 120 130 140 150
TLQQTLLNQE RPIKSSIAEL NNNIQSVSDT SSVTFQYLTL LKDMWKKKQA
160 170 180 190 200
QVKENENVIN EYSSILEDQR LYIDETVNDN IPLNLRVLRS ILEDLRSKIQ
210 220 230 240 250
KLESDISAQM EYCRTPCTVS CNIPVVSGKE CEEIIRKGGE TSEMYLIQPD
260 270 280 290 300
TSIKPYRVYC DMKTENGGWT VIQNRQDGSV DFGRKWDPYK KGFGNIATNE
310 320 330 340 350
DAKKYCGLPG EYWLGNDKIS QLTRMGPTEL LIEMEDWKGD KVKAHYGGFT
360 370 380 390 400
VQNEASKYQV SVNKYKGTAG NALMDGASQL VGENRTMTIH NGMFFSTYDR
410 420 430 440 450
DNDGWVTTDP RKQCSKEDGG GWWYNRCHAA NPNGRYYWGG LYSWDMSKHG
460 470 480
TDDGVVWMNW KGSWYSMRRM SMKIRPFFPQ Q
Length:481
Mass (Da):54,753
Last modified:October 1, 2002 - v1
Checksum:i9902830CF708A155
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031715 mRNA. Translation: AAH31715.1.
AF413205 mRNA. Translation: AAL02225.1.
CCDSiCCDS17432.1.
RefSeqiNP_862897.1. NM_181849.2.
UniGeneiMm.30063.

Genome annotation databases

EnsembliENSMUST00000048246; ENSMUSP00000039472; ENSMUSG00000033831.
GeneIDi110135.
KEGGimmu:110135.
UCSCiuc008pph.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031715 mRNA. Translation: AAH31715.1.
AF413205 mRNA. Translation: AAL02225.1.
CCDSiCCDS17432.1.
RefSeqiNP_862897.1. NM_181849.2.
UniGeneiMm.30063.

3D structure databases

ProteinModelPortaliQ8K0E8.
SMRiQ8K0E8. Positions 78-479.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi225325. 1 interaction.
IntActiQ8K0E8. 5 interactions.
MINTiMINT-1863241.
STRINGi10090.ENSMUSP00000039472.

PTM databases

PhosphoSiteiQ8K0E8.

2D gel databases

REPRODUCTION-2DPAGEIPI00279079.
Q8K0E8.

Proteomic databases

MaxQBiQ8K0E8.
PaxDbiQ8K0E8.
PRIDEiQ8K0E8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048246; ENSMUSP00000039472; ENSMUSG00000033831.
GeneIDi110135.
KEGGimmu:110135.
UCSCiuc008pph.1. mouse.

Organism-specific databases

CTDi2244.
MGIiMGI:99501. Fgb.

Phylogenomic databases

eggNOGiNOG277105.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000059561.
HOVERGENiHBG005707.
InParanoidiQ8K0E8.
KOiK03904.
OMAiTIHNGMF.
OrthoDBiEOG7X9G60.
PhylomeDBiQ8K0E8.
TreeFamiTF336658.

Enzyme and pathway databases

ReactomeiREACT_286713. Common Pathway of Fibrin Clot Formation.
REACT_307071. Platelet degranulation.
REACT_316753. p130Cas linkage to MAPK signaling for integrins.
REACT_319261. Integrin cell surface interactions.
REACT_330010. Integrin alphaIIb beta3 signaling.
REACT_332492. GRB2:SOS provides linkage to MAPK signaling for Integrins.

Miscellaneous databases

NextBioi363391.
PROiQ8K0E8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K0E8.
CleanExiMM_FGB.
ExpressionAtlasiQ8K0E8. baseline and differential.
GenevisibleiQ8K0E8. MM.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR012290. Fibrinogen_a/b/g_coil_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF08702. Fib_alpha. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  2. "Mouse fibrinogen B-beta-chain."
    Murakawa M., Freeman M.W.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 234-469.

Entry informationi

Entry nameiFIBB_MOUSE
AccessioniPrimary (citable) accession number: Q8K0E8
Secondary accession number(s): Q91ZP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 1, 2002
Last modified: June 24, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.