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Q8K0E7

- SERC2_MOUSE

UniProt

Q8K0E7 - SERC2_MOUSE

Protein

Serine incorporator 2

Gene

Serinc2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. phosphatidylserine metabolic process Source: Ensembl
    2. positive regulation of transferase activity Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine incorporator 2
    Alternative name(s):
    Tumor differentially expressed protein 2-like
    Gene namesi
    Name:Serinc2
    Synonyms:Tde2l
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1919132. Serinc2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 450450Serine incorporator 2PRO_0000218969Add
    BLAST

    Proteomic databases

    PRIDEiQ8K0E7.

    PTM databases

    PhosphoSiteiQ8K0E7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8K0E7.
    BgeeiQ8K0E7.
    CleanExiMM_SERINC2.
    GenevestigatoriQ8K0E7.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2723HelicalSequence AnalysisAdd
    BLAST
    Transmembranei40 – 5718HelicalSequence AnalysisAdd
    BLAST
    Transmembranei96 – 11823HelicalSequence AnalysisAdd
    BLAST
    Transmembranei131 – 15020HelicalSequence AnalysisAdd
    BLAST
    Transmembranei160 – 18223HelicalSequence AnalysisAdd
    BLAST
    Transmembranei203 – 22523HelicalSequence AnalysisAdd
    BLAST
    Transmembranei238 – 25720HelicalSequence AnalysisAdd
    BLAST
    Transmembranei264 – 28623HelicalSequence AnalysisAdd
    BLAST
    Transmembranei315 – 33723HelicalSequence AnalysisAdd
    BLAST
    Transmembranei380 – 40223HelicalSequence AnalysisAdd
    BLAST
    Transmembranei417 – 43923HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TDE1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG308011.
    GeneTreeiENSGT00550000074522.
    HOGENOMiHOG000165463.
    HOVERGENiHBG025699.
    TreeFamiTF312881.

    Family and domain databases

    InterProiIPR029554. SERINC2.
    IPR005016. TDE1/TMS.
    [Graphical view]
    PANTHERiPTHR10383. PTHR10383. 1 hit.
    PTHR10383:SF22. PTHR10383:SF22. 1 hit.
    PfamiPF03348. Serinc. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K0E7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGACLGACSL LSCASCLCGS APCILCGCCP STRNSTVSRL LFTSFLFLGV    50
    LVSIIMLSPG VESQLYKLPW VCEDRTQQPL VLQGPLDCGS LLGFRAVYRM 100
    CFATAAFFFF FMLLMICVRS SRDPRAAIQN GFWFFKFLIL VGITVGAFYI 150
    PDGSFPKIWF YFGVVGSFLF ILIQLILFVD FAHSWNQRWL CKAEECDSPA 200
    WYAGLFFFTF LFYLLSIAAV ALMFVYYTES GACHEGKVFI SLNLTFCVCV 250
    SIIAVLPKVQ DAQPNSGLLQ ASVITLYTMF VTWSALSNVP DQKCNPHLPT 300
    KNGTGQVDLE DYSTVWWDAP SIVGLVIFIL CTFFISLRSS DHRQVNSLMQ 350
    TEECPAEMVQ QQQVAVSDGR AYDNEQDGVT YSYSFFHFCL VLASLHVMMT 400
    LTNWYSPGET RKMISTWTSV WVKICASWAG LFLYLWTLVA PLLLPNRDFS 450
    Length:450
    Mass (Da):50,478
    Last modified:October 1, 2002 - v1
    Checksum:iBD9111690A875B45
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC031720 mRNA. Translation: AAH31720.1.
    CCDSiCCDS51310.1.
    RefSeqiNP_766290.2. NM_172702.3.
    UniGeneiMm.45132.

    Genome annotation databases

    EnsembliENSMUST00000105996; ENSMUSP00000101618; ENSMUSG00000023232.
    GeneIDi230779.
    KEGGimmu:230779.
    UCSCiuc008uzc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC031720 mRNA. Translation: AAH31720.1 .
    CCDSi CCDS51310.1.
    RefSeqi NP_766290.2. NM_172702.3.
    UniGenei Mm.45132.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8K0E7.

    Proteomic databases

    PRIDEi Q8K0E7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000105996 ; ENSMUSP00000101618 ; ENSMUSG00000023232 .
    GeneIDi 230779.
    KEGGi mmu:230779.
    UCSCi uc008uzc.1. mouse.

    Organism-specific databases

    CTDi 347735.
    MGIi MGI:1919132. Serinc2.

    Phylogenomic databases

    eggNOGi NOG308011.
    GeneTreei ENSGT00550000074522.
    HOGENOMi HOG000165463.
    HOVERGENi HBG025699.
    TreeFami TF312881.

    Miscellaneous databases

    NextBioi 380148.
    PROi Q8K0E7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K0E7.
    Bgeei Q8K0E7.
    CleanExi MM_SERINC2.
    Genevestigatori Q8K0E7.

    Family and domain databases

    InterProi IPR029554. SERINC2.
    IPR005016. TDE1/TMS.
    [Graphical view ]
    PANTHERi PTHR10383. PTHR10383. 1 hit.
    PTHR10383:SF22. PTHR10383:SF22. 1 hit.
    Pfami PF03348. Serinc. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.

    Entry informationi

    Entry nameiSERC2_MOUSE
    AccessioniPrimary (citable) accession number: Q8K0E7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3