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Q8K0E7

- SERC2_MOUSE

UniProt

Q8K0E7 - SERC2_MOUSE

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Protein

Serine incorporator 2

Gene

Serinc2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. L-serine transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. phosphatidylserine metabolic process Source: Ensembl
  2. positive regulation of transferase activity Source: Ensembl
  3. sphingolipid metabolic process Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Serine incorporator 2
Alternative name(s):
Tumor differentially expressed protein 2-like
Gene namesi
Name:Serinc2
Synonyms:Tde2l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1919132. Serinc2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2723HelicalSequence AnalysisAdd
BLAST
Transmembranei40 – 5718HelicalSequence AnalysisAdd
BLAST
Transmembranei96 – 11823HelicalSequence AnalysisAdd
BLAST
Transmembranei131 – 15020HelicalSequence AnalysisAdd
BLAST
Transmembranei160 – 18223HelicalSequence AnalysisAdd
BLAST
Transmembranei203 – 22523HelicalSequence AnalysisAdd
BLAST
Transmembranei238 – 25720HelicalSequence AnalysisAdd
BLAST
Transmembranei264 – 28623HelicalSequence AnalysisAdd
BLAST
Transmembranei315 – 33723HelicalSequence AnalysisAdd
BLAST
Transmembranei380 – 40223HelicalSequence AnalysisAdd
BLAST
Transmembranei417 – 43923HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Serine incorporator 2PRO_0000218969Add
BLAST

Proteomic databases

PRIDEiQ8K0E7.

PTM databases

PhosphoSiteiQ8K0E7.

Expressioni

Gene expression databases

BgeeiQ8K0E7.
CleanExiMM_SERINC2.
ExpressionAtlasiQ8K0E7. baseline and differential.
GenevestigatoriQ8K0E7.

Family & Domainsi

Sequence similaritiesi

Belongs to the TDE1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG308011.
GeneTreeiENSGT00550000074522.
HOGENOMiHOG000165463.
HOVERGENiHBG025699.
InParanoidiQ8K0E7.
TreeFamiTF312881.

Family and domain databases

InterProiIPR029554. SERINC2.
IPR005016. TDE1/TMS.
[Graphical view]
PANTHERiPTHR10383. PTHR10383. 1 hit.
PTHR10383:SF22. PTHR10383:SF22. 1 hit.
PfamiPF03348. Serinc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K0E7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGACLGACSL LSCASCLCGS APCILCGCCP STRNSTVSRL LFTSFLFLGV
60 70 80 90 100
LVSIIMLSPG VESQLYKLPW VCEDRTQQPL VLQGPLDCGS LLGFRAVYRM
110 120 130 140 150
CFATAAFFFF FMLLMICVRS SRDPRAAIQN GFWFFKFLIL VGITVGAFYI
160 170 180 190 200
PDGSFPKIWF YFGVVGSFLF ILIQLILFVD FAHSWNQRWL CKAEECDSPA
210 220 230 240 250
WYAGLFFFTF LFYLLSIAAV ALMFVYYTES GACHEGKVFI SLNLTFCVCV
260 270 280 290 300
SIIAVLPKVQ DAQPNSGLLQ ASVITLYTMF VTWSALSNVP DQKCNPHLPT
310 320 330 340 350
KNGTGQVDLE DYSTVWWDAP SIVGLVIFIL CTFFISLRSS DHRQVNSLMQ
360 370 380 390 400
TEECPAEMVQ QQQVAVSDGR AYDNEQDGVT YSYSFFHFCL VLASLHVMMT
410 420 430 440 450
LTNWYSPGET RKMISTWTSV WVKICASWAG LFLYLWTLVA PLLLPNRDFS
Length:450
Mass (Da):50,478
Last modified:October 1, 2002 - v1
Checksum:iBD9111690A875B45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031720 mRNA. Translation: AAH31720.1.
CCDSiCCDS51310.1.
RefSeqiNP_766290.2. NM_172702.3.
UniGeneiMm.45132.

Genome annotation databases

EnsembliENSMUST00000105996; ENSMUSP00000101618; ENSMUSG00000023232.
GeneIDi230779.
KEGGimmu:230779.
UCSCiuc008uzc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031720 mRNA. Translation: AAH31720.1 .
CCDSi CCDS51310.1.
RefSeqi NP_766290.2. NM_172702.3.
UniGenei Mm.45132.

3D structure databases

ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8K0E7.

Proteomic databases

PRIDEi Q8K0E7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000105996 ; ENSMUSP00000101618 ; ENSMUSG00000023232 .
GeneIDi 230779.
KEGGi mmu:230779.
UCSCi uc008uzc.1. mouse.

Organism-specific databases

CTDi 347735.
MGIi MGI:1919132. Serinc2.

Phylogenomic databases

eggNOGi NOG308011.
GeneTreei ENSGT00550000074522.
HOGENOMi HOG000165463.
HOVERGENi HBG025699.
InParanoidi Q8K0E7.
TreeFami TF312881.

Miscellaneous databases

NextBioi 380148.
PROi Q8K0E7.
SOURCEi Search...

Gene expression databases

Bgeei Q8K0E7.
CleanExi MM_SERINC2.
ExpressionAtlasi Q8K0E7. baseline and differential.
Genevestigatori Q8K0E7.

Family and domain databases

InterProi IPR029554. SERINC2.
IPR005016. TDE1/TMS.
[Graphical view ]
PANTHERi PTHR10383. PTHR10383. 1 hit.
PTHR10383:SF22. PTHR10383:SF22. 1 hit.
Pfami PF03348. Serinc. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.

Entry informationi

Entry nameiSERC2_MOUSE
AccessioniPrimary (citable) accession number: Q8K0E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3