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Protein

Sodium/myo-inositol cotransporter 2

Gene

Slc5a11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na+:MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Ion transport, Sodium transport, Sugar transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-MMU-429593. Inositol transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/myo-inositol cotransporter 2
Short name:
Na(+)/myo-inositol cotransporter 2
Alternative name(s):
Sodium-dependent glucose cotransporter
Sodium/glucose cotransporter KST1
Sodium/myo-inositol transporter 2
Short name:
SMIT2
Solute carrier family 5 member 11
Gene namesi
Name:Slc5a11Imported
Synonyms:Kst11 Publication, Smit2By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1919316. Slc5a11.

Subcellular locationi

  • Membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48HelicalSequence analysisAdd BLAST21
Topological domaini49 – 65CytoplasmicSequence analysisAdd BLAST17
Transmembranei66 – 88HelicalSequence analysisAdd BLAST23
Topological domaini89 – 102ExtracellularSequence analysisAdd BLAST14
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 148CytoplasmicSequence analysisAdd BLAST25
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 180ExtracellularSequence analysisAdd BLAST11
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Topological domaini202 – 208CytoplasmicSequence analysis7
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Topological domaini230 – 272ExtracellularSequence analysisAdd BLAST43
Transmembranei273 – 293HelicalSequence analysisAdd BLAST21
Topological domaini294 – 308CytoplasmicSequence analysisAdd BLAST15
Transmembranei309 – 329HelicalSequence analysisAdd BLAST21
Topological domaini330 – 375ExtracellularSequence analysisAdd BLAST46
Transmembranei376 – 396HelicalSequence analysisAdd BLAST21
Topological domaini397 – 418CytoplasmicSequence analysisAdd BLAST22
Transmembranei419 – 439HelicalSequence analysisAdd BLAST21
Topological domaini440 – 446ExtracellularSequence analysis7
Transmembranei447 – 467HelicalSequence analysisAdd BLAST21
Topological domaini468 – 479CytoplasmicSequence analysisAdd BLAST12
Transmembranei480 – 500HelicalSequence analysisAdd BLAST21
Topological domaini501 – 521ExtracellularSequence analysisAdd BLAST21
Transmembranei522 – 542HelicalSequence analysisAdd BLAST21
Topological domaini543 – 652CytoplasmicSequence analysisAdd BLAST110
Transmembranei653 – 673HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003315691 – 673Sodium/myo-inositol cotransporter 2Add BLAST673

Proteomic databases

PaxDbiQ8K0E3.
PRIDEiQ8K0E3.

PTM databases

PhosphoSitePlusiQ8K0E3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030769.
ExpressionAtlasiQ8K0E3. baseline and differential.
GenevisibleiQ8K0E3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033035.

Structurei

3D structure databases

ProteinModelPortaliQ8K0E3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiQ8K0E3.
KOiK14391.
OMAiKTHSCDM.
OrthoDBiEOG091G077U.
PhylomeDBiQ8K0E3.
TreeFamiTF352855.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q8K0E3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESATISPQP PQSDSLEAFP QKSMEPADIA VLVLYFLFVL AVGLWSTVRT
60 70 80 90 100
KRDTVKGYFL AGGDMVWWPV GASLFASNVG SGHFIGLAGS GAAVGISVAA
110 120 130 140 150
YELNGLFSVL MLAWVFLPIY IAGQVTTMPE YLRRRFGGNR ISITLAVLYL
160 170 180 190 200
FIYIFTKISV DMYAGAIFIQ QSLHLDLYLA IVGLLAITAL YTVAGGLAAV
210 220 230 240 250
IYTDALQTVI MLIGAFILMG YSFAAVGGME GLKDQYFLAL ASNRSENSSC
260 270 280 290 300
GLPREDAFHI FRDPLTSDLP WPGILFGMSI PSLWYWCTDQ VIVQRSLAAK
310 320 330 340 350
NLSHAKGGSL MAAYLKVLPL FLMVFPGMVS RVLFPDQVAC AHPDICQRVC
360 370 380 390 400
SNPSGCSDIA YPKLVLELLP TGLRGLMMAV MVAALMSSLT SIFNSASTIF
410 420 430 440 450
TMDLWNHIRP RASERELMIV GRIFVFALVL VSILWIPIVQ ASQGGQLFIY
460 470 480 490 500
IQSISSYLQP PVAMVFIMGC FWKRTNEKGA FSGLILGLLL GLVRLILDFV
510 520 530 540 550
YAQPRCDQPD DRPAVVKDVH YLYFSMILSF TTLITVVTVS WFTETPSKEM
560 570 580 590 600
VSRLTWFTRH EPVAQKDSAP PETPLSLTLS QNGTTEAPGT SIQLETVQES
610 620 630 640 650
TTKACGDGVS PRHSKVVRAI LWLCGMEKNK EEPPSKAEPV IVSLEENPLV
660 670
KTLLDVNCIV CISCAIFLWG YFA
Length:673
Mass (Da):73,798
Last modified:October 1, 2002 - v1
Checksum:iC00DA80F9F02140D
GO
Isoform 21 Publication (identifier: Q8K0E3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     403-626: Missing.

Show »
Length:449
Mass (Da):48,713
Checksum:i0742D5F93599B3C4
GO

Sequence cautioni

The sequence AAQ08402 differs from that shown. Reason: Frameshift at position 23.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22K → EG in AAQ08402 (Ref. 1) Curated1
Sequence conflicti247N → S in AAQ08402 (Ref. 1) Curated1
Sequence conflicti359I → V in AAQ08402 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_052788403 – 626Missing in isoform 2. 1 PublicationAdd BLAST224

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF518726 mRNA. Translation: AAQ08402.1. Frameshift.
BC031742 mRNA. Translation: AAH31742.1.
CCDSiCCDS21819.1. [Q8K0E3-1]
RefSeqiNP_666310.1. NM_146198.2. [Q8K0E3-1]
XP_006507775.1. XM_006507712.3. [Q8K0E3-1]
XP_011240068.1. XM_011241766.2. [Q8K0E3-1]
XP_011240069.1. XM_011241767.2. [Q8K0E3-1]
XP_011240070.1. XM_011241768.2. [Q8K0E3-1]
UniGeneiMm.211838.

Genome annotation databases

EnsembliENSMUST00000033035; ENSMUSP00000033035; ENSMUSG00000030769. [Q8K0E3-1]
ENSMUST00000167299; ENSMUSP00000127977; ENSMUSG00000030769. [Q8K0E3-1]
GeneIDi233836.
KEGGimmu:233836.
UCSCiuc009jpg.1. mouse. [Q8K0E3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF518726 mRNA. Translation: AAQ08402.1. Frameshift.
BC031742 mRNA. Translation: AAH31742.1.
CCDSiCCDS21819.1. [Q8K0E3-1]
RefSeqiNP_666310.1. NM_146198.2. [Q8K0E3-1]
XP_006507775.1. XM_006507712.3. [Q8K0E3-1]
XP_011240068.1. XM_011241766.2. [Q8K0E3-1]
XP_011240069.1. XM_011241767.2. [Q8K0E3-1]
XP_011240070.1. XM_011241768.2. [Q8K0E3-1]
UniGeneiMm.211838.

3D structure databases

ProteinModelPortaliQ8K0E3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033035.

PTM databases

PhosphoSitePlusiQ8K0E3.

Proteomic databases

PaxDbiQ8K0E3.
PRIDEiQ8K0E3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033035; ENSMUSP00000033035; ENSMUSG00000030769. [Q8K0E3-1]
ENSMUST00000167299; ENSMUSP00000127977; ENSMUSG00000030769. [Q8K0E3-1]
GeneIDi233836.
KEGGimmu:233836.
UCSCiuc009jpg.1. mouse. [Q8K0E3-1]

Organism-specific databases

CTDi115584.
MGIiMGI:1919316. Slc5a11.

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiQ8K0E3.
KOiK14391.
OMAiKTHSCDM.
OrthoDBiEOG091G077U.
PhylomeDBiQ8K0E3.
TreeFamiTF352855.

Enzyme and pathway databases

ReactomeiR-MMU-429593. Inositol transporters.

Miscellaneous databases

PROiQ8K0E3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030769.
ExpressionAtlasiQ8K0E3. baseline and differential.
GenevisibleiQ8K0E3. MM.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC5AB_MOUSE
AccessioniPrimary (citable) accession number: Q8K0E3
Secondary accession number(s): Q6EZ51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.