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Protein

BTB/POZ domain-containing protein KCTD15

Gene

Kctd15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

During embryonic development, interferes with neural crest formation. Inhibits AP2 transcriptional activity by interaction with its activation domain (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD15
Alternative name(s):
Potassium channel tetramerization domain-containing protein 15
Gene namesi
Name:Kctd15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2385276 Kctd15

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002472521 – 283BTB/POZ domain-containing protein KCTD15Add BLAST283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphoserineBy similarity1
Modified residuei35PhosphoserineCombined sources1
Modified residuei38PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8K0E1
PaxDbiQ8K0E1
PeptideAtlasiQ8K0E1
PRIDEiQ8K0E1

PTM databases

iPTMnetiQ8K0E1
PhosphoSitePlusiQ8K0E1

Expressioni

Gene expression databases

BgeeiENSMUSG00000030499
ExpressionAtlasiQ8K0E1 baseline and differential
GenevisibleiQ8K0E1 MM

Interactioni

Subunit structurei

Interacts with TFAP2A; this interaction inhibits TFAP2A transcriptional activation.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8K0E1, 1 interactor
STRINGi10090.ENSMUSP00000032709

Structurei

3D structure databases

ProteinModelPortaliQ8K0E1
SMRiQ8K0E1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 126BTBAdd BLAST71

Phylogenomic databases

eggNOGiKOG2723 Eukaryota
ENOG410Z155 LUCA
GeneTreeiENSGT00760000119013
HOGENOMiHOG000232179
HOVERGENiHBG055358
InParanoidiQ8K0E1
KOiK21754
OMAiLCREERR
OrthoDBiEOG091G0SU5
PhylomeDBiQ8K0E1
TreeFamiTF315332

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K0E1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHRKERPSG SSLNAHGSSG TAEGGNMSRL SLTRSPVSPL AAQGIPLPAQ
60 70 80 90 100
LTKANAPVHI DVGGHMYTSS LATLTKYPDS RISRLFNGTE PIVLDSLKQH
110 120 130 140 150
YFIDRDGEIF RYILSFLRTS KLLLPDDFKD FNLLYEEARY YQLQPMVREL
160 170 180 190 200
ERWQQDQEQR RRSRACDCLV VRVTPDLGER IALSGEKALI EEVFPETGDV
210 220 230 240 250
MCNSVNAGWN QDPTHVIRFP LNGYCRLNSV QVLERLFQRG FSVAASCGGG
260 270 280
VDSSQFSEYV LCREERRPQP TPTAVRIKQE PLD
Length:283
Mass (Da):31,886
Last modified:October 1, 2002 - v1
Checksum:i7D67029CD51B8E2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034731 mRNA Translation: BAC28810.1
BC031749 mRNA Translation: AAH31749.1
CCDSiCCDS21141.1
RefSeqiNP_666300.1, NM_146188.1
XP_006539963.1, XM_006539900.1
XP_006539964.1, XM_006539901.3
XP_006539965.1, XM_006539902.3
XP_006539966.1, XM_006539903.3
XP_006539967.1, XM_006539904.3
XP_006539968.1, XM_006539905.1
UniGeneiMm.486198
Mm.76761

Genome annotation databases

EnsembliENSMUST00000032709; ENSMUSP00000032709; ENSMUSG00000030499
ENSMUST00000108069; ENSMUSP00000103704; ENSMUSG00000030499
ENSMUST00000108070; ENSMUSP00000103705; ENSMUSG00000030499
GeneIDi233107
KEGGimmu:233107
UCSCiuc009gjf.2 mouse

Similar proteinsi

Entry informationi

Entry nameiKCD15_MOUSE
AccessioniPrimary (citable) accession number: Q8K0E1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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