Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

BTB/POZ domain-containing protein KCTD15

Gene

Kctd15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

During embryonic development, interferes with neural crest formation. Inhibits AP2 transcriptional activity by interaction with its activation domain (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD15
Alternative name(s):
Potassium channel tetramerization domain-containing protein 15
Gene namesi
Name:Kctd15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2385276. Kctd15.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002472521 – 283BTB/POZ domain-containing protein KCTD15Add BLAST283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphoserineBy similarity1
Modified residuei35PhosphoserineCombined sources1
Modified residuei38PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8K0E1.
PaxDbiQ8K0E1.
PeptideAtlasiQ8K0E1.
PRIDEiQ8K0E1.

PTM databases

iPTMnetiQ8K0E1.
PhosphoSitePlusiQ8K0E1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030499.
ExpressionAtlasiQ8K0E1. baseline and differential.
GenevisibleiQ8K0E1. MM.

Interactioni

Subunit structurei

Interacts with TFAP2A; this interaction inhibits TFAP2A transcriptional activation.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8K0E1. 1 interactor.
STRINGi10090.ENSMUSP00000032709.

Structurei

3D structure databases

ProteinModelPortaliQ8K0E1.
SMRiQ8K0E1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 126BTBAdd BLAST71

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000232179.
HOVERGENiHBG055358.
InParanoidiQ8K0E1.
OMAiLCREERR.
OrthoDBiEOG091G0SU5.
PhylomeDBiQ8K0E1.
TreeFamiTF315332.

Family and domain databases

InterProiView protein in InterPro
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
PfamiView protein in Pfam
PF02214. BTB_2. 1 hit.
SMARTiView protein in SMART
SM00225. BTB. 1 hit.
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K0E1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHRKERPSG SSLNAHGSSG TAEGGNMSRL SLTRSPVSPL AAQGIPLPAQ
60 70 80 90 100
LTKANAPVHI DVGGHMYTSS LATLTKYPDS RISRLFNGTE PIVLDSLKQH
110 120 130 140 150
YFIDRDGEIF RYILSFLRTS KLLLPDDFKD FNLLYEEARY YQLQPMVREL
160 170 180 190 200
ERWQQDQEQR RRSRACDCLV VRVTPDLGER IALSGEKALI EEVFPETGDV
210 220 230 240 250
MCNSVNAGWN QDPTHVIRFP LNGYCRLNSV QVLERLFQRG FSVAASCGGG
260 270 280
VDSSQFSEYV LCREERRPQP TPTAVRIKQE PLD
Length:283
Mass (Da):31,886
Last modified:October 1, 2002 - v1
Checksum:i7D67029CD51B8E2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034731 mRNA. Translation: BAC28810.1.
BC031749 mRNA. Translation: AAH31749.1.
CCDSiCCDS21141.1.
RefSeqiNP_666300.1. NM_146188.1.
XP_006539963.1. XM_006539900.1.
XP_006539964.1. XM_006539901.3.
XP_006539965.1. XM_006539902.3.
XP_006539966.1. XM_006539903.3.
XP_006539967.1. XM_006539904.3.
XP_006539968.1. XM_006539905.1.
UniGeneiMm.486198.

Genome annotation databases

EnsembliENSMUST00000032709; ENSMUSP00000032709; ENSMUSG00000030499.
ENSMUST00000108069; ENSMUSP00000103704; ENSMUSG00000030499.
ENSMUST00000108070; ENSMUSP00000103705; ENSMUSG00000030499.
GeneIDi233107.
KEGGimmu:233107.
UCSCiuc009gjf.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKCD15_MOUSE
AccessioniPrimary (citable) accession number: Q8K0E1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2002
Last modified: May 10, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot