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Protein

Tail-anchored protein insertion receptor WRB

Gene

Wrb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tail-anchored protein insertion receptor WRB
Alternative name(s):
Tryptophan-rich basic protein
Short name:
WRB
Gene namesi
Name:Wrb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2136882. Wrb.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88LumenalSequence analysis
Transmembranei9 – 2921HelicalSequence analysisAdd
BLAST
Topological domaini30 – 9970CytoplasmicSequence analysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence analysisAdd
BLAST
Topological domaini121 – 14828LumenalSequence analysisAdd
BLAST
Transmembranei149 – 16921HelicalSequence analysisAdd
BLAST
Topological domaini170 – 1745CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 174174Tail-anchored protein insertion receptor WRBPRO_0000065980Add
BLAST

Proteomic databases

MaxQBiQ8K0D7.
PaxDbiQ8K0D7.
PRIDEiQ8K0D7.

PTM databases

PhosphoSiteiQ8K0D7.

Expressioni

Gene expression databases

BgeeiQ8K0D7.
CleanExiMM_WRB.
ExpressionAtlasiQ8K0D7. baseline and differential.
GenevisibleiQ8K0D7. MM.

Interactioni

Subunit structurei

Interacts with ASNA1/TRC40.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023913.

Structurei

3D structure databases

ProteinModelPortaliQ8K0D7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni39 – 9759Interaction with ASNA1/TRC40By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili39 – 9456Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the WRB/GET1 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4253. Eukaryota.
ENOG41120B0. LUCA.
GeneTreeiENSGT00390000002415.
HOGENOMiHOG000013223.
HOVERGENiHBG010388.
InParanoidiQ8K0D7.
OMAiITCWLVV.
OrthoDBiEOG7TJ3KG.
PhylomeDBiQ8K0D7.
TreeFamiTF314708.

Family and domain databases

InterProiIPR028945. WRB/Get1.
[Graphical view]
PfamiPF04420. CHD5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K0D7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASETDRWA WLLVLSFVFG CNLLRILLPS LSSFISRVLQ KDAEQESQMR
60 70 80 90 100
AEIQGMKQEL STVNMMDEFA RYARLERKIN KMTDKLKTHV KARTAQLAKI
110 120 130 140 150
KWFISVAFYI LQAALMISLI WKYYSVPVAV VPSKWITPLD RLVAFPTRVA
160 170
GGIGITCWIL VCNKVVAIVL HPFS
Length:174
Mass (Da):19,867
Last modified:October 1, 2002 - v1
Checksum:iE0ACE1A6951E4865
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172079 mRNA. Translation: BAE42815.1.
BC031769 mRNA. Translation: AAH31769.1.
CCDSiCCDS28354.1.
RefSeqiNP_997184.1. NM_207301.2.
UniGeneiMm.255063.

Genome annotation databases

EnsembliENSMUST00000023913; ENSMUSP00000023913; ENSMUSG00000023147.
GeneIDi71446.
KEGGimmu:71446.
UCSCiuc008acp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172079 mRNA. Translation: BAE42815.1.
BC031769 mRNA. Translation: AAH31769.1.
CCDSiCCDS28354.1.
RefSeqiNP_997184.1. NM_207301.2.
UniGeneiMm.255063.

3D structure databases

ProteinModelPortaliQ8K0D7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023913.

PTM databases

PhosphoSiteiQ8K0D7.

Proteomic databases

MaxQBiQ8K0D7.
PaxDbiQ8K0D7.
PRIDEiQ8K0D7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023913; ENSMUSP00000023913; ENSMUSG00000023147.
GeneIDi71446.
KEGGimmu:71446.
UCSCiuc008acp.1. mouse.

Organism-specific databases

CTDi7485.
MGIiMGI:2136882. Wrb.

Phylogenomic databases

eggNOGiKOG4253. Eukaryota.
ENOG41120B0. LUCA.
GeneTreeiENSGT00390000002415.
HOGENOMiHOG000013223.
HOVERGENiHBG010388.
InParanoidiQ8K0D7.
OMAiITCWLVV.
OrthoDBiEOG7TJ3KG.
PhylomeDBiQ8K0D7.
TreeFamiTF314708.

Miscellaneous databases

ChiTaRSiWrb. mouse.
PROiQ8K0D7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K0D7.
CleanExiMM_WRB.
ExpressionAtlasiQ8K0D7. baseline and differential.
GenevisibleiQ8K0D7. MM.

Family and domain databases

InterProiIPR028945. WRB/Get1.
[Graphical view]
PfamiPF04420. CHD5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Spleen.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Testis.

Entry informationi

Entry nameiWRB_MOUSE
AccessioniPrimary (citable) accession number: Q8K0D7
Secondary accession number(s): Q3TA55, Q9D1W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.