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Q8K0D0

- CDK17_MOUSE

UniProt

Q8K0D0 - CDK17_MOUSE

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Protein
Cyclin-dependent kinase 17
Gene
Cdk17, Pctaire2, Pctk2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei221 – 2211ATP By similarity
Active sitei313 – 3131Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi198 – 2069ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 17 (EC:2.7.11.22)
    Alternative name(s):
    Cell division protein kinase 17
    PCTAIRE-motif protein kinase 2
    Serine/threonine-protein kinase PCTAIRE-2
    Gene namesi
    Name:Cdk17
    Synonyms:Pctaire2, Pctk2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:97517. Cdk17.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 523523Cyclin-dependent kinase 17
    PRO_0000086488Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei80 – 801Phosphoserine By similarity
    Modified residuei105 – 1051Phosphoserine By similarity
    Modified residuei137 – 1371Phosphoserine1 Publication
    Modified residuei146 – 1461Phosphoserine By similarity
    Modified residuei165 – 1651Phosphoserine1 Publication
    Modified residuei180 – 1801Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8K0D0.
    PaxDbiQ8K0D0.
    PRIDEiQ8K0D0.

    PTM databases

    PhosphoSiteiQ8K0D0.

    Expressioni

    Gene expression databases

    BgeeiQ8K0D0.
    CleanExiMM_PCTK2.
    GenevestigatoriQ8K0D0.

    Interactioni

    Subunit structurei

    Found in a complex containing CABLES1, CDK16 and TDRD7. Interacts with TDRD7.1 Publication

    Protein-protein interaction databases

    BioGridi231880. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K0D0.
    SMRiQ8K0D0. Positions 142-499.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini192 – 473282Protein kinase
    Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00600000083998.
    HOGENOMiHOG000233024.
    HOVERGENiHBG014652.
    InParanoidiQ8K0D0.
    KOiK15595.
    OMAiMKHAYFR.
    OrthoDBiEOG7966H8.
    PhylomeDBiQ8K0D0.
    TreeFamiTF106508.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8K0D0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKKFKRRLSL TLRGSQTIDE SLSELAEQMT IEESSSKDNE PIVKNGRPPT    50
    SHSVHSFLHQ YTGSFKKPPL RRPHSVIGGS LGSFMAMPRN GSRLDIVHEN 100
    LKMGSDGESD QASGTSSDEV QSPTGVCLRN RIHRRISMED LNKRLSLPAD 150
    IRIPDGYLEK LQISSPPFDQ PMSRRSRRAS LSEIGFGKME TYIKLEKLGE 200
    GTYATVYKGR SKLTENLVAL KEIRLEHEEG APCTAIREVS LLKDLKHANI 250
    VTLHDIVHTD KSLTLVFEYL DKDLKQYMDD CGNIMSMHNV KLFLYQILRG 300
    LAYCHRRKVL HRDLKPQNLL INERGELKLA DFGLARAKSV PTKTYSNEVV 350
    TLWYRPPDVL LGSSEYSTQI DMWGVGCIFF EMASGRPLFP GSTVEDELHL 400
    IFRLLGTPSQ ETWPGVSSND EFKNYNFPKY KPQPLINHAP RLDSEGIELI 450
    TKFLQYESKK RVPAEEAMKH VYFRSLGPRI HALPESVSIF SLKEIQLQKD 500
    PGFRNSSYPE TGHGKNRRQS MLF 523
    Length:523
    Mass (Da):59,506
    Last modified:June 21, 2004 - v2
    Checksum:i847B045A3BCE4628
    GO
    Isoform 2 (identifier: Q8K0D0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-84: Missing.
         512-523: GHGKNRRQSMLF → ALS

    Show »
    Length:430
    Mass (Da):48,974
    Checksum:iA0386728D25CBC62
    GO

    Sequence cautioni

    The sequence AAH31778.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8484Missing in isoform 2.
    VSP_010640Add
    BLAST
    Alternative sequencei512 – 52312GHGKN…QSMLF → ALS in isoform 2.
    VSP_010641Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC031778 mRNA. Translation: AAH31778.1. Different initiation.
    BC064815 mRNA. Translation: AAH64815.1.
    CCDSiCCDS48670.1. [Q8K0D0-1]
    RefSeqiNP_666351.2. NM_146239.2. [Q8K0D0-1]
    XP_006513690.1. XM_006513627.1. [Q8K0D0-1]
    UniGeneiMm.217404.

    Genome annotation databases

    EnsembliENSMUST00000069965; ENSMUSP00000070355; ENSMUSG00000020015. [Q8K0D0-1]
    GeneIDi237459.
    KEGGimmu:237459.
    UCSCiuc007gul.2. mouse. [Q8K0D0-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC031778 mRNA. Translation: AAH31778.1 . Different initiation.
    BC064815 mRNA. Translation: AAH64815.1 .
    CCDSi CCDS48670.1. [Q8K0D0-1 ]
    RefSeqi NP_666351.2. NM_146239.2. [Q8K0D0-1 ]
    XP_006513690.1. XM_006513627.1. [Q8K0D0-1 ]
    UniGenei Mm.217404.

    3D structure databases

    ProteinModelPortali Q8K0D0.
    SMRi Q8K0D0. Positions 142-499.
    ModBasei Search...

    Protein-protein interaction databases

    BioGridi 231880. 1 interaction.

    PTM databases

    PhosphoSitei Q8K0D0.

    Proteomic databases

    MaxQBi Q8K0D0.
    PaxDbi Q8K0D0.
    PRIDEi Q8K0D0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000069965 ; ENSMUSP00000070355 ; ENSMUSG00000020015 . [Q8K0D0-1 ]
    GeneIDi 237459.
    KEGGi mmu:237459.
    UCSCi uc007gul.2. mouse. [Q8K0D0-1 ]

    Organism-specific databases

    CTDi 5128.
    MGIi MGI:97517. Cdk17.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00600000083998.
    HOGENOMi HOG000233024.
    HOVERGENi HBG014652.
    InParanoidi Q8K0D0.
    KOi K15595.
    OMAi MKHAYFR.
    OrthoDBi EOG7966H8.
    PhylomeDBi Q8K0D0.
    TreeFami TF106508.

    Miscellaneous databases

    ChiTaRSi CDK17. mouse.
    NextBioi 383378.
    PROi Q8K0D0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8K0D0.
    CleanExi MM_PCTK2.
    Genevestigatori Q8K0D0.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Limb and Retina.
    2. Cited for: IDENTIFICATION IN A COMPLEX WITH CABLES1 AND TDRD7.
    3. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137; SER-165 AND SER-180, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCDK17_MOUSE
    AccessioniPrimary (citable) accession number: Q8K0D0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2004
    Last sequence update: June 21, 2004
    Last modified: July 9, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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