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Q8K0D0 (CDK17_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 17

EC=2.7.11.22
Alternative name(s):
Cell division protein kinase 17
PCTAIRE-motif protein kinase 2
Serine/threonine-protein kinase PCTAIRE-2
Gene names
Name:Cdk17
Synonyms:Pctaire2, Pctk2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length523 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Found in a complex containing CABLES1, CDK16 and TDRD7. Interacts with TDRD7. Ref.2

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence AAH31778.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8K0D0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8K0D0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.
     512-523: GHGKNRRQSMLF → ALS

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 523523Cyclin-dependent kinase 17
PRO_0000086488

Regions

Domain192 – 473282Protein kinase
Nucleotide binding198 – 2069ATP By similarity

Sites

Active site3131Proton acceptor By similarity
Binding site2211ATP By similarity

Amino acid modifications

Modified residue801Phosphoserine By similarity
Modified residue1051Phosphoserine By similarity
Modified residue1371Phosphoserine Ref.3
Modified residue1461Phosphoserine By similarity
Modified residue1651Phosphoserine Ref.3
Modified residue1801Phosphoserine Ref.3

Natural variations

Alternative sequence1 – 8484Missing in isoform 2.
VSP_010640
Alternative sequence512 – 52312GHGKN…QSMLF → ALS in isoform 2.
VSP_010641

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 21, 2004. Version 2.
Checksum: 847B045A3BCE4628

FASTA52359,506
        10         20         30         40         50         60 
MKKFKRRLSL TLRGSQTIDE SLSELAEQMT IEESSSKDNE PIVKNGRPPT SHSVHSFLHQ 

        70         80         90        100        110        120 
YTGSFKKPPL RRPHSVIGGS LGSFMAMPRN GSRLDIVHEN LKMGSDGESD QASGTSSDEV 

       130        140        150        160        170        180 
QSPTGVCLRN RIHRRISMED LNKRLSLPAD IRIPDGYLEK LQISSPPFDQ PMSRRSRRAS 

       190        200        210        220        230        240 
LSEIGFGKME TYIKLEKLGE GTYATVYKGR SKLTENLVAL KEIRLEHEEG APCTAIREVS 

       250        260        270        280        290        300 
LLKDLKHANI VTLHDIVHTD KSLTLVFEYL DKDLKQYMDD CGNIMSMHNV KLFLYQILRG 

       310        320        330        340        350        360 
LAYCHRRKVL HRDLKPQNLL INERGELKLA DFGLARAKSV PTKTYSNEVV TLWYRPPDVL 

       370        380        390        400        410        420 
LGSSEYSTQI DMWGVGCIFF EMASGRPLFP GSTVEDELHL IFRLLGTPSQ ETWPGVSSND 

       430        440        450        460        470        480 
EFKNYNFPKY KPQPLINHAP RLDSEGIELI TKFLQYESKK RVPAEEAMKH VYFRSLGPRI 

       490        500        510        520 
HALPESVSIF SLKEIQLQKD PGFRNSSYPE TGHGKNRRQS MLF 

« Hide

Isoform 2 [UniParc].

Checksum: A0386728D25CBC62
Show »

FASTA43048,974

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Limb and Retina.
[2]"ik3-1/Cables is associated with Trap and Pctaire2."
Yamochi T., Nishimoto I., Okuda T., Matsuoka M.
Biochem. Biophys. Res. Commun. 286:1045-1050(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN A COMPLEX WITH CABLES1 AND TDRD7.
[3]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137; SER-165 AND SER-180, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC031778 mRNA. Translation: AAH31778.1. Different initiation.
BC064815 mRNA. Translation: AAH64815.1.
CCDSCCDS48670.1. [Q8K0D0-1]
RefSeqNP_666351.2. NM_146239.2. [Q8K0D0-1]
XP_006513690.1. XM_006513627.1. [Q8K0D0-1]
UniGeneMm.217404.

3D structure databases

ProteinModelPortalQ8K0D0.
SMRQ8K0D0. Positions 142-499.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid231880. 1 interaction.

PTM databases

PhosphoSiteQ8K0D0.

Proteomic databases

MaxQBQ8K0D0.
PaxDbQ8K0D0.
PRIDEQ8K0D0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000069965; ENSMUSP00000070355; ENSMUSG00000020015. [Q8K0D0-1]
GeneID237459.
KEGGmmu:237459.
UCSCuc007gul.2. mouse. [Q8K0D0-1]

Organism-specific databases

CTD5128.
MGIMGI:97517. Cdk17.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00600000083998.
HOGENOMHOG000233024.
HOVERGENHBG014652.
InParanoidQ8K0D0.
KOK15595.
OMAMKHAYFR.
OrthoDBEOG7966H8.
PhylomeDBQ8K0D0.
TreeFamTF106508.

Gene expression databases

BgeeQ8K0D0.
CleanExMM_PCTK2.
GenevestigatorQ8K0D0.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCDK17. mouse.
NextBio383378.
PROQ8K0D0.
SOURCESearch...

Entry information

Entry nameCDK17_MOUSE
AccessionPrimary (citable) accession number: Q8K0D0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 21, 2004
Last modified: July 9, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot