Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cyclin-dependent kinase 17

Gene

Cdk17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei221ATPPROSITE-ProRule annotation1
Active sitei313Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi198 – 206ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 17 (EC:2.7.11.22)
Alternative name(s):
Cell division protein kinase 17
PCTAIRE-motif protein kinase 2
Serine/threonine-protein kinase PCTAIRE-2
Gene namesi
Name:Cdk17
Synonyms:Pctaire2, Pctk2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:97517. Cdk17.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000864881 – 523Cyclin-dependent kinase 17Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineBy similarity1
Modified residuei80PhosphoserineBy similarity1
Modified residuei92PhosphoserineBy similarity1
Modified residuei105PhosphoserineBy similarity1
Modified residuei109PhosphoserineBy similarity1
Modified residuei122PhosphoserineBy similarity1
Modified residuei137PhosphoserineCombined sources1
Modified residuei146PhosphoserineBy similarity1
Modified residuei165PhosphoserineCombined sources1
Modified residuei180PhosphoserineCombined sources1
Modified residuei182PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8K0D0.
PaxDbiQ8K0D0.
PRIDEiQ8K0D0.

PTM databases

iPTMnetiQ8K0D0.
PhosphoSitePlusiQ8K0D0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020015.
CleanExiMM_PCTK2.
GenevisibleiQ8K0D0. MM.

Interactioni

Subunit structurei

Found in a complex containing CABLES1, CDK16 and TDRD7. Interacts with TDRD7.1 Publication

Protein-protein interaction databases

BioGridi231880. 1 interactor.
STRINGi10090.ENSMUSP00000070355.

Structurei

3D structure databases

ProteinModelPortaliQ8K0D0.
SMRiQ8K0D0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini192 – 473Protein kinasePROSITE-ProRule annotationAdd BLAST282

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0594. Eukaryota.
ENOG410XPP3. LUCA.
GeneTreeiENSGT00790000122986.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ8K0D0.
KOiK15595.
OMAiQETWPGV.
OrthoDBiEOG091G0CH0.
PhylomeDBiQ8K0D0.
TreeFamiTF106508.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8K0D0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKFKRRLSL TLRGSQTIDE SLSELAEQMT IEESSSKDNE PIVKNGRPPT
60 70 80 90 100
SHSVHSFLHQ YTGSFKKPPL RRPHSVIGGS LGSFMAMPRN GSRLDIVHEN
110 120 130 140 150
LKMGSDGESD QASGTSSDEV QSPTGVCLRN RIHRRISMED LNKRLSLPAD
160 170 180 190 200
IRIPDGYLEK LQISSPPFDQ PMSRRSRRAS LSEIGFGKME TYIKLEKLGE
210 220 230 240 250
GTYATVYKGR SKLTENLVAL KEIRLEHEEG APCTAIREVS LLKDLKHANI
260 270 280 290 300
VTLHDIVHTD KSLTLVFEYL DKDLKQYMDD CGNIMSMHNV KLFLYQILRG
310 320 330 340 350
LAYCHRRKVL HRDLKPQNLL INERGELKLA DFGLARAKSV PTKTYSNEVV
360 370 380 390 400
TLWYRPPDVL LGSSEYSTQI DMWGVGCIFF EMASGRPLFP GSTVEDELHL
410 420 430 440 450
IFRLLGTPSQ ETWPGVSSND EFKNYNFPKY KPQPLINHAP RLDSEGIELI
460 470 480 490 500
TKFLQYESKK RVPAEEAMKH VYFRSLGPRI HALPESVSIF SLKEIQLQKD
510 520
PGFRNSSYPE TGHGKNRRQS MLF
Length:523
Mass (Da):59,506
Last modified:June 21, 2004 - v2
Checksum:i847B045A3BCE4628
GO
Isoform 2 (identifier: Q8K0D0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.
     512-523: GHGKNRRQSMLF → ALS

Show »
Length:430
Mass (Da):48,974
Checksum:iA0386728D25CBC62
GO

Sequence cautioni

The sequence AAH31778 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0106401 – 84Missing in isoform 2. 1 PublicationAdd BLAST84
Alternative sequenceiVSP_010641512 – 523GHGKN…QSMLF → ALS in isoform 2. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031778 mRNA. Translation: AAH31778.1. Different initiation.
BC064815 mRNA. Translation: AAH64815.1.
CCDSiCCDS48670.1. [Q8K0D0-1]
RefSeqiNP_666351.2. NM_146239.2. [Q8K0D0-1]
XP_006513690.1. XM_006513627.2. [Q8K0D0-1]
XP_011241749.1. XM_011243447.2. [Q8K0D0-1]
UniGeneiMm.217404.
Mm.479520.

Genome annotation databases

EnsembliENSMUST00000069965; ENSMUSP00000070355; ENSMUSG00000020015. [Q8K0D0-1]
GeneIDi237459.
KEGGimmu:237459.
UCSCiuc007gul.2. mouse. [Q8K0D0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031778 mRNA. Translation: AAH31778.1. Different initiation.
BC064815 mRNA. Translation: AAH64815.1.
CCDSiCCDS48670.1. [Q8K0D0-1]
RefSeqiNP_666351.2. NM_146239.2. [Q8K0D0-1]
XP_006513690.1. XM_006513627.2. [Q8K0D0-1]
XP_011241749.1. XM_011243447.2. [Q8K0D0-1]
UniGeneiMm.217404.
Mm.479520.

3D structure databases

ProteinModelPortaliQ8K0D0.
SMRiQ8K0D0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231880. 1 interactor.
STRINGi10090.ENSMUSP00000070355.

PTM databases

iPTMnetiQ8K0D0.
PhosphoSitePlusiQ8K0D0.

Proteomic databases

EPDiQ8K0D0.
PaxDbiQ8K0D0.
PRIDEiQ8K0D0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069965; ENSMUSP00000070355; ENSMUSG00000020015. [Q8K0D0-1]
GeneIDi237459.
KEGGimmu:237459.
UCSCiuc007gul.2. mouse. [Q8K0D0-1]

Organism-specific databases

CTDi5128.
MGIiMGI:97517. Cdk17.

Phylogenomic databases

eggNOGiKOG0594. Eukaryota.
ENOG410XPP3. LUCA.
GeneTreeiENSGT00790000122986.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ8K0D0.
KOiK15595.
OMAiQETWPGV.
OrthoDBiEOG091G0CH0.
PhylomeDBiQ8K0D0.
TreeFamiTF106508.

Miscellaneous databases

ChiTaRSiCdk17. mouse.
PROiQ8K0D0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020015.
CleanExiMM_PCTK2.
GenevisibleiQ8K0D0. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDK17_MOUSE
AccessioniPrimary (citable) accession number: Q8K0D0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 21, 2004
Last modified: November 2, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.