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Q8K0D0

- CDK17_MOUSE

UniProt

Q8K0D0 - CDK17_MOUSE

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Protein

Cyclin-dependent kinase 17

Gene
Cdk17, Pctaire2, Pctk2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei221 – 2211ATP By similarity
Active sitei313 – 3131Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi198 – 2069ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 17 (EC:2.7.11.22)
Alternative name(s):
Cell division protein kinase 17
PCTAIRE-motif protein kinase 2
Serine/threonine-protein kinase PCTAIRE-2
Gene namesi
Name:Cdk17
Synonyms:Pctaire2, Pctk2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:97517. Cdk17.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523Cyclin-dependent kinase 17PRO_0000086488Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei80 – 801Phosphoserine By similarity
Modified residuei105 – 1051Phosphoserine By similarity
Modified residuei137 – 1371Phosphoserine1 Publication
Modified residuei146 – 1461Phosphoserine By similarity
Modified residuei165 – 1651Phosphoserine1 Publication
Modified residuei180 – 1801Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8K0D0.
PaxDbiQ8K0D0.
PRIDEiQ8K0D0.

PTM databases

PhosphoSiteiQ8K0D0.

Expressioni

Gene expression databases

BgeeiQ8K0D0.
CleanExiMM_PCTK2.
GenevestigatoriQ8K0D0.

Interactioni

Subunit structurei

Found in a complex containing CABLES1, CDK16 and TDRD7. Interacts with TDRD7.1 Publication

Protein-protein interaction databases

BioGridi231880. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8K0D0.
SMRiQ8K0D0. Positions 142-499.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini192 – 473282Protein kinaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00600000083998.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ8K0D0.
KOiK15595.
OMAiMKHAYFR.
OrthoDBiEOG7966H8.
PhylomeDBiQ8K0D0.
TreeFamiTF106508.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8K0D0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKKFKRRLSL TLRGSQTIDE SLSELAEQMT IEESSSKDNE PIVKNGRPPT    50
SHSVHSFLHQ YTGSFKKPPL RRPHSVIGGS LGSFMAMPRN GSRLDIVHEN 100
LKMGSDGESD QASGTSSDEV QSPTGVCLRN RIHRRISMED LNKRLSLPAD 150
IRIPDGYLEK LQISSPPFDQ PMSRRSRRAS LSEIGFGKME TYIKLEKLGE 200
GTYATVYKGR SKLTENLVAL KEIRLEHEEG APCTAIREVS LLKDLKHANI 250
VTLHDIVHTD KSLTLVFEYL DKDLKQYMDD CGNIMSMHNV KLFLYQILRG 300
LAYCHRRKVL HRDLKPQNLL INERGELKLA DFGLARAKSV PTKTYSNEVV 350
TLWYRPPDVL LGSSEYSTQI DMWGVGCIFF EMASGRPLFP GSTVEDELHL 400
IFRLLGTPSQ ETWPGVSSND EFKNYNFPKY KPQPLINHAP RLDSEGIELI 450
TKFLQYESKK RVPAEEAMKH VYFRSLGPRI HALPESVSIF SLKEIQLQKD 500
PGFRNSSYPE TGHGKNRRQS MLF 523
Length:523
Mass (Da):59,506
Last modified:June 21, 2004 - v2
Checksum:i847B045A3BCE4628
GO
Isoform 2 (identifier: Q8K0D0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.
     512-523: GHGKNRRQSMLF → ALS

Show »
Length:430
Mass (Da):48,974
Checksum:iA0386728D25CBC62
GO

Sequence cautioni

The sequence AAH31778.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8484Missing in isoform 2. VSP_010640Add
BLAST
Alternative sequencei512 – 52312GHGKN…QSMLF → ALS in isoform 2. VSP_010641Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC031778 mRNA. Translation: AAH31778.1. Different initiation.
BC064815 mRNA. Translation: AAH64815.1.
CCDSiCCDS48670.1. [Q8K0D0-1]
RefSeqiNP_666351.2. NM_146239.2. [Q8K0D0-1]
XP_006513690.1. XM_006513627.1. [Q8K0D0-1]
UniGeneiMm.217404.

Genome annotation databases

EnsembliENSMUST00000069965; ENSMUSP00000070355; ENSMUSG00000020015. [Q8K0D0-1]
GeneIDi237459.
KEGGimmu:237459.
UCSCiuc007gul.2. mouse. [Q8K0D0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC031778 mRNA. Translation: AAH31778.1 . Different initiation.
BC064815 mRNA. Translation: AAH64815.1 .
CCDSi CCDS48670.1. [Q8K0D0-1 ]
RefSeqi NP_666351.2. NM_146239.2. [Q8K0D0-1 ]
XP_006513690.1. XM_006513627.1. [Q8K0D0-1 ]
UniGenei Mm.217404.

3D structure databases

ProteinModelPortali Q8K0D0.
SMRi Q8K0D0. Positions 142-499.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 231880. 1 interaction.

PTM databases

PhosphoSitei Q8K0D0.

Proteomic databases

MaxQBi Q8K0D0.
PaxDbi Q8K0D0.
PRIDEi Q8K0D0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000069965 ; ENSMUSP00000070355 ; ENSMUSG00000020015 . [Q8K0D0-1 ]
GeneIDi 237459.
KEGGi mmu:237459.
UCSCi uc007gul.2. mouse. [Q8K0D0-1 ]

Organism-specific databases

CTDi 5128.
MGIi MGI:97517. Cdk17.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00600000083998.
HOGENOMi HOG000233024.
HOVERGENi HBG014652.
InParanoidi Q8K0D0.
KOi K15595.
OMAi MKHAYFR.
OrthoDBi EOG7966H8.
PhylomeDBi Q8K0D0.
TreeFami TF106508.

Miscellaneous databases

ChiTaRSi CDK17. mouse.
NextBioi 383378.
PROi Q8K0D0.
SOURCEi Search...

Gene expression databases

Bgeei Q8K0D0.
CleanExi MM_PCTK2.
Genevestigatori Q8K0D0.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Limb and Retina.
  2. Cited for: IDENTIFICATION IN A COMPLEX WITH CABLES1 AND TDRD7.
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137; SER-165 AND SER-180, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCDK17_MOUSE
AccessioniPrimary (citable) accession number: Q8K0D0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 21, 2004
Last modified: July 9, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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