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Protein

GDP-mannose 4,6 dehydratase

Gene

Gmds

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.By similarity

Catalytic activityi

GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O.

Cofactori

NADP+By similarity

Pathwayi: GDP-L-fucose biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes GDP-L-fucose from GDP-alpha-D-mannose.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. GDP-mannose 4,6 dehydratase (Gmds)
  2. GDP-L-fucose synthase (Tsta3)
This subpathway is part of the pathway GDP-L-fucose biosynthesis via de novo pathway, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes GDP-L-fucose from GDP-alpha-D-mannose, the pathway GDP-L-fucose biosynthesis via de novo pathway and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei123NADPBy similarity1
Active sitei155By similarity1
Active sitei157NucleophileBy similarity1
Active sitei179NucleophileBy similarity1
Binding sitei183NADPBy similarity1
Binding sitei209NADPBy similarity1
Binding sitei214NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi30 – 35NADPBy similarity6
Nucleotide bindingi86 – 87NADPBy similarity2
Nucleotide bindingi108 – 112NADPBy similarity5

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiR-MMU-6787639. GDP-fucose biosynthesis.
UniPathwayiUPA00128; UER00190.

Names & Taxonomyi

Protein namesi
Recommended name:
GDP-mannose 4,6 dehydratase (EC:4.2.1.47)
Alternative name(s):
GDP-D-mannose dehydratase
Short name:
GMD
Gene namesi
Name:Gmds
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1891112. Gmds.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002017062 – 372GDP-mannose 4,6 dehydrataseAdd BLAST371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei323PhosphotyrosineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8K0C9.
MaxQBiQ8K0C9.
PaxDbiQ8K0C9.
PeptideAtlasiQ8K0C9.
PRIDEiQ8K0C9.

PTM databases

iPTMnetiQ8K0C9.
PhosphoSitePlusiQ8K0C9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000038372.
CleanExiMM_GMDS.
ExpressionAtlasiQ8K0C9. baseline and differential.
GenevisibleiQ8K0C9. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8K0C9. 1 interactor.
STRINGi10090.ENSMUSP00000036696.

Structurei

3D structure databases

ProteinModelPortaliQ8K0C9.
SMRiQ8K0C9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1372. Eukaryota.
COG1089. LUCA.
GeneTreeiENSGT00440000033640.
HOGENOMiHOG000168003.
HOVERGENiHBG000727.
InParanoidiQ8K0C9.
KOiK01711.
OMAiDPHERNV.
OrthoDBiEOG091G093Z.
PhylomeDBiQ8K0C9.
TreeFamiTF300682.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00955. GDP_Man_dehydratase. 1 hit.
InterProiIPR006368. GDP_Man_deHydtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF16363. GDP_Man_Dehyd. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01472. gmd. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K0C9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQAPAKCPS YPGSGDGEMG KLRKVALITG ITGQDGSYLA EFLLEKGYEV
60 70 80 90 100
HGIVRRSSSF NTGRIEHLYK NPQAHIEGNM KLHYGDLTDS TCLVKIINEV
110 120 130 140 150
KPTEIYNLGA QSHVKISFDL AEYTADVDGV GTLRLLDAIK TCGLINSVKF
160 170 180 190 200
YQASTSELYG KVQEIPQKET TPFYPRSPYG AAKLYAYWIV VNFREAYNLF
210 220 230 240 250
AVNGILFNHE SPRRGANFVT RKISRSVAKI YLGQLECFSL GNLDAKRDWG
260 270 280 290 300
HAKDYVEAMW LMLQNDEPED FVIATGEVHS VREFVEKSFM HIGKTIVWEG
310 320 330 340 350
KNENEVGRCK ETGKVHVTVD LKYYRPTEVD FLQGDCSKAQ QKLNWKPRVA
360 370
FDELVREMVQ ADVELMRTNP NA
Length:372
Mass (Da):41,985
Last modified:October 1, 2002 - v1
Checksum:iA53918200F1F4CE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645643
, AL645664, AL645697, AL645783, AL645763 Genomic DNA. Translation: CAI24766.1.
AL645664
, AL645643, AL645697, AL645783, AL645763 Genomic DNA. Translation: CAI25621.1.
AL645697
, AL645643, AL645664, AL645783, AL645763 Genomic DNA. Translation: CAI24852.1.
AL645763
, AL645643, AL645664, AL645697, AL645783 Genomic DNA. Translation: CAI24125.1.
AL645783
, AL645643, AL645664, AL645697, AL645763 Genomic DNA. Translation: CAI25768.1.
BC031788 mRNA. Translation: AAH31788.1.
BC093502 mRNA. Translation: AAH93502.1.
CCDSiCCDS26426.1.
RefSeqiNP_666153.1. NM_146041.2.
UniGeneiMm.247143.

Genome annotation databases

EnsembliENSMUST00000041859; ENSMUSP00000036696; ENSMUSG00000038372.
GeneIDi218138.
KEGGimmu:218138.
UCSCiuc007pzq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645643
, AL645664, AL645697, AL645783, AL645763 Genomic DNA. Translation: CAI24766.1.
AL645664
, AL645643, AL645697, AL645783, AL645763 Genomic DNA. Translation: CAI25621.1.
AL645697
, AL645643, AL645664, AL645783, AL645763 Genomic DNA. Translation: CAI24852.1.
AL645763
, AL645643, AL645664, AL645697, AL645783 Genomic DNA. Translation: CAI24125.1.
AL645783
, AL645643, AL645664, AL645697, AL645763 Genomic DNA. Translation: CAI25768.1.
BC031788 mRNA. Translation: AAH31788.1.
BC093502 mRNA. Translation: AAH93502.1.
CCDSiCCDS26426.1.
RefSeqiNP_666153.1. NM_146041.2.
UniGeneiMm.247143.

3D structure databases

ProteinModelPortaliQ8K0C9.
SMRiQ8K0C9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8K0C9. 1 interactor.
STRINGi10090.ENSMUSP00000036696.

PTM databases

iPTMnetiQ8K0C9.
PhosphoSitePlusiQ8K0C9.

Proteomic databases

EPDiQ8K0C9.
MaxQBiQ8K0C9.
PaxDbiQ8K0C9.
PeptideAtlasiQ8K0C9.
PRIDEiQ8K0C9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041859; ENSMUSP00000036696; ENSMUSG00000038372.
GeneIDi218138.
KEGGimmu:218138.
UCSCiuc007pzq.1. mouse.

Organism-specific databases

CTDi2762.
MGIiMGI:1891112. Gmds.

Phylogenomic databases

eggNOGiKOG1372. Eukaryota.
COG1089. LUCA.
GeneTreeiENSGT00440000033640.
HOGENOMiHOG000168003.
HOVERGENiHBG000727.
InParanoidiQ8K0C9.
KOiK01711.
OMAiDPHERNV.
OrthoDBiEOG091G093Z.
PhylomeDBiQ8K0C9.
TreeFamiTF300682.

Enzyme and pathway databases

UniPathwayiUPA00128; UER00190.
ReactomeiR-MMU-6787639. GDP-fucose biosynthesis.

Miscellaneous databases

PROiQ8K0C9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038372.
CleanExiMM_GMDS.
ExpressionAtlasiQ8K0C9. baseline and differential.
GenevisibleiQ8K0C9. MM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00955. GDP_Man_dehydratase. 1 hit.
InterProiIPR006368. GDP_Man_deHydtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF16363. GDP_Man_Dehyd. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01472. gmd. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGMDS_MOUSE
AccessioniPrimary (citable) accession number: Q8K0C9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.