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Q8K0C9 (GMDS_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GDP-mannose 4,6 dehydratase
EC=4.2.1.47
Alternative name(s):
GDP-D-mannose dehydratase
Short name=GMD
Gene names
Name:Gmds
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Conversion of GDP-D-mannose to GDP-4-keto-6-D-deoxymannose.

Catalytic activity

GDP-mannose = GDP-4-dehydro-6-deoxy-D-mannose + H2O.

Cofactor

NADP By similarity.

Pathway

Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 1/2.

Sequence similarities

Belongs to the GDP-mannose 4,6-dehydratase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 372371GDP-mannose 4,6 dehydratase
PRO_0000201706

Sites

Active site1551 By similarity
Active site1571Nucleophile By similarity
Active site1791Nucleophile By similarity
Binding site1831NADP By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8K0C9 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: A53918200F1F4CE2

FASTA37241,985
        10         20         30         40         50         60 
MAQAPAKCPS YPGSGDGEMG KLRKVALITG ITGQDGSYLA EFLLEKGYEV HGIVRRSSSF 

        70         80         90        100        110        120 
NTGRIEHLYK NPQAHIEGNM KLHYGDLTDS TCLVKIINEV KPTEIYNLGA QSHVKISFDL 

       130        140        150        160        170        180 
AEYTADVDGV GTLRLLDAIK TCGLINSVKF YQASTSELYG KVQEIPQKET TPFYPRSPYG 

       190        200        210        220        230        240 
AAKLYAYWIV VNFREAYNLF AVNGILFNHE SPRRGANFVT RKISRSVAKI YLGQLECFSL 

       250        260        270        280        290        300 
GNLDAKRDWG HAKDYVEAMW LMLQNDEPED FVIATGEVHS VREFVEKSFM HIGKTIVWEG 

       310        320        330        340        350        360 
KNENEVGRCK ETGKVHVTVD LKYYRPTEVD FLQGDCSKAQ QKLNWKPRVA FDELVREMVQ 

       370 
ADVELMRTNP NA

« Hide

References

[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon and Salivary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL645643 expand/collapse EMBL AC list , AL645664, AL645697, AL645783, AL645763 Genomic DNA. Translation: CAI24766.1.
AL645664 expand/collapse EMBL AC list , AL645643, AL645697, AL645783, AL645763 Genomic DNA. Translation: CAI25621.1.
AL645697 expand/collapse EMBL AC list , AL645643, AL645664, AL645783, AL645763 Genomic DNA. Translation: CAI24852.1.
AL645763 expand/collapse EMBL AC list , AL645643, AL645664, AL645697, AL645783 Genomic DNA. Translation: CAI24125.1.
AL645783 expand/collapse EMBL AC list , AL645643, AL645664, AL645697, AL645763 Genomic DNA. Translation: CAI25768.1.
BC031788 mRNA. Translation: AAH31788.1.
BC093502 mRNA. Translation: AAH93502.1.
IPIIPI00169546.
RefSeqNP_666153.1. NM_146041.2.
UniGeneMm.247143.

3D structure databases

ProteinModelPortalQ8K0C9.
SMRQ8K0C9. Positions 23-369.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8K0C9.

PTM databases

PhosphoSiteQ8K0C9.

Proteomic databases

PRIDEQ8K0C9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000041859; ENSMUSP00000036696; ENSMUSG00000038372.
GeneID218138.
KEGGmmu:218138.
UCSCuc007pzq.1. mouse.

Organism-specific databases

CTD2762.
MGIMGI:1891112. Gmds.

Phylogenomic databases

eggNOGroNOG11976.
GeneTreeENSGT00440000033640.
HOGENOMHBG755066.
HOVERGENHBG000727.
InParanoidQ8K0C9.
OMAQDPHEKD.
OrthoDBEOG4FXR7M.
PhylomeDBQ8K0C9.

Gene expression databases

ArrayExpressQ8K0C9.
BgeeQ8K0C9.
CleanExMM_GMDS.
GenevestigatorQ8K0C9.
GermOnlineENSMUSG00000038372. Mus musculus.

Family and domain databases

InterProIPR001509. Epimerase_deHydtase.
IPR006368. GDP_Man_deHydtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK01711.
PANTHERPTHR10366:SF32. GDP_mann_dehyd. 1 hit.
PfamPF01370. Epimerase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01472. Gmd. 1 hit.
ProtoNetSearch...

Other

NextBio376160.
SOURCESearch...

Entry information

Entry nameGMDS_MOUSE
AccessionPrimary (citable) accession number: Q8K0C9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 1, 2002
Last modified: November 16, 2011
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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