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Protein

Zymogen granule membrane protein 16

Gene

Zg16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Zymogen granule membrane protein 16
Short name:
Zymogen granule protein 16
Alternative name(s):
Secretory lectin ZG16
Gene namesi
Name:Zg16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1916286. Zg16.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Extracellular matrix, Golgi apparatus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616By similarityAdd
BLAST
Chaini17 – 167151Zymogen granule membrane protein 16PRO_0000017571Add
BLAST

Proteomic databases

PaxDbiQ8K0C5.
PeptideAtlasiQ8K0C5.
PRIDEiQ8K0C5.

PTM databases

iPTMnetiQ8K0C5.
PhosphoSiteiQ8K0C5.

Expressioni

Gene expression databases

BgeeiQ8K0C5.
CleanExiMM_1810010M01RIK.
GenevisibleiQ8K0C5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056916.

Structurei

3D structure databases

ProteinModelPortaliQ8K0C5.
SMRiQ8K0C5. Positions 36-158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 159136Jacalin-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the jacalin lectin family.PROSITE-ProRule annotationCurated
Contains 1 jacalin-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IE5W. Eukaryota.
ENOG41122DQ. LUCA.
GeneTreeiENSGT00530000063886.
HOGENOMiHOG000015245.
HOVERGENiHBG079379.
InParanoidiQ8K0C5.
OMAiVRYGTVW.
OrthoDBiEOG73FQQ7.
PhylomeDBiQ8K0C5.
TreeFamiTF333440.

Family and domain databases

Gene3Di2.100.10.30. 1 hit.
InterProiIPR001229. Jacalin-like_lectin_dom.
IPR033563. ZG16.
[Graphical view]
PANTHERiPTHR33589:SF3. PTHR33589:SF3. 1 hit.
PfamiPF01419. Jacalin. 1 hit.
[Graphical view]
SMARTiSM00915. Jacalin. 1 hit.
[Graphical view]
SUPFAMiSSF51101. SSF51101. 1 hit.
PROSITEiPS51752. JACALIN_LECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K0C5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAVALLVLL CASASANSIQ SRTSSYSGEY GGKGGKRFSH SGNQLDGPIT
60 70 80 90 100
AFRIRVNRYY IVGLQVRYGT VWSDYVGGTQ GDLEEIFLHP GESVIQVSGK
110 120 130 140 150
YKSYVKQMIF VTDKGRYLPF GKASGTSFNA VPLHPNTVLR FISGRSGSAI
160
DSISLHWDTY PSHCNTC
Length:167
Mass (Da):18,210
Last modified:October 1, 2002 - v1
Checksum:iC1D42C5468B86475
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031800 mRNA. Translation: AAH31800.1.
CCDSiCCDS21856.1.
RefSeqiNP_081194.1. NM_026918.2.
XP_006508238.1. XM_006508175.2.
UniGeneiMm.21835.

Genome annotation databases

EnsembliENSMUST00000051122; ENSMUSP00000056916; ENSMUSG00000049350.
ENSMUST00000205424; ENSMUSP00000145876; ENSMUSG00000049350.
GeneIDi69036.
KEGGimmu:69036.
UCSCiuc009jue.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031800 mRNA. Translation: AAH31800.1.
CCDSiCCDS21856.1.
RefSeqiNP_081194.1. NM_026918.2.
XP_006508238.1. XM_006508175.2.
UniGeneiMm.21835.

3D structure databases

ProteinModelPortaliQ8K0C5.
SMRiQ8K0C5. Positions 36-158.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056916.

PTM databases

iPTMnetiQ8K0C5.
PhosphoSiteiQ8K0C5.

Proteomic databases

PaxDbiQ8K0C5.
PeptideAtlasiQ8K0C5.
PRIDEiQ8K0C5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051122; ENSMUSP00000056916; ENSMUSG00000049350.
ENSMUST00000205424; ENSMUSP00000145876; ENSMUSG00000049350.
GeneIDi69036.
KEGGimmu:69036.
UCSCiuc009jue.1. mouse.

Organism-specific databases

CTDi653808.
MGIiMGI:1916286. Zg16.

Phylogenomic databases

eggNOGiENOG410IE5W. Eukaryota.
ENOG41122DQ. LUCA.
GeneTreeiENSGT00530000063886.
HOGENOMiHOG000015245.
HOVERGENiHBG079379.
InParanoidiQ8K0C5.
OMAiVRYGTVW.
OrthoDBiEOG73FQQ7.
PhylomeDBiQ8K0C5.
TreeFamiTF333440.

Miscellaneous databases

ChiTaRSiZg16. mouse.
PROiQ8K0C5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K0C5.
CleanExiMM_1810010M01RIK.
GenevisibleiQ8K0C5. MM.

Family and domain databases

Gene3Di2.100.10.30. 1 hit.
InterProiIPR001229. Jacalin-like_lectin_dom.
IPR033563. ZG16.
[Graphical view]
PANTHERiPTHR33589:SF3. PTHR33589:SF3. 1 hit.
PfamiPF01419. Jacalin. 1 hit.
[Graphical view]
SMARTiSM00915. Jacalin. 1 hit.
[Graphical view]
SUPFAMiSSF51101. SSF51101. 1 hit.
PROSITEiPS51752. JACALIN_LECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver, Lung, Pancreas and Spleen.

Entry informationi

Entry nameiZG16_MOUSE
AccessioniPrimary (citable) accession number: Q8K0C5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.