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Q8K0C1

- IPO13_MOUSE

UniProt

Q8K0C1 - IPO13_MOUSE

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Protein
Importin-13
Gene
Ipo13, Kiaa0724
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus By similarity. Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13 By similarity.

GO - Biological processi

  1. protein import into nucleus Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Importin-13
Short name:
Imp13
Gene namesi
Name:Ipo13
Synonyms:Kiaa0724
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:2385205. Ipo13.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 963963Importin-13
PRO_0000120759Add
BLAST

Proteomic databases

PaxDbiQ8K0C1.
PRIDEiQ8K0C1.

PTM databases

PhosphoSiteiQ8K0C1.

Expressioni

Gene expression databases

BgeeiQ8K0C1.
CleanExiMM_IPO13.
GenevestigatoriQ8K0C1.

Interactioni

Subunit structurei

Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ8K0C1.
SMRiQ8K0C1. Positions 19-953.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati24 – 5431HEAT 1
Add
BLAST
Domaini45 – 11167Importin N-terminal
Add
BLAST
Repeati56 – 8833HEAT 2
Add
BLAST
Repeati95 – 13541HEAT 3
Add
BLAST
Repeati142 – 17938HEAT 4
Add
BLAST
Repeati194 – 23138HEAT 5
Add
BLAST
Repeati236 – 26833HEAT 6
Add
BLAST
Repeati276 – 32550HEAT 7
Add
BLAST
Repeati330 – 37243HEAT 8
Add
BLAST
Repeati375 – 43864HEAT 9
Add
BLAST
Repeati440 – 47637HEAT 10
Add
BLAST
Repeati487 – 52236HEAT 11
Add
BLAST
Repeati524 – 55835HEAT 12
Add
BLAST
Repeati562 – 60039HEAT 13
Add
BLAST
Repeati603 – 64846HEAT 14
Add
BLAST
Repeati676 – 71641HEAT 15
Add
BLAST
Repeati720 – 75435HEAT 16
Add
BLAST
Repeati761 – 80343HEAT 17
Add
BLAST
Repeati815 – 84531HEAT 18
Add
BLAST
Repeati860 – 89334HEAT 19
Add
BLAST
Repeati897 – 93135HEAT 20
Add
BLAST

Sequence similaritiesi

Belongs to the importin beta family.
Contains 20 HEAT repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG237172.
GeneTreeiENSGT00530000063347.
HOGENOMiHOG000049153.
HOVERGENiHBG052141.
OMAiQMYSTIP.
OrthoDBiEOG718KC9.
PhylomeDBiQ8K0C1.
TreeFamiTF314539.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013598. Exportin-1/Importin-b-like.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
PF08389. Xpo1. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8K0C1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MERREEQLGA AGAGAAPALD FTVENVEKAL HQLYYDPNID NKNLAQKWLM    50
QAQVSPQAWH FSWQLLQPDK VPEIQYFGAS ALHIKISRYW SDIPTDQYES 100
LKAQLFTQIT RFASGSKIVL TRLCVALASL ALSMMPDAWP CAVADMVRLF 150
QAEDSPVDSQ GRCLALLELL TVLPEEFQTS RLPQYRKGLV RTSLAVECGT 200
VFPLLEQLLQ QPSSPSCVRQ KVLKCFSSWV QLEVPLQDCE ALIQAAFAAL 250
QDSELFDSSV EAIVNAISQP DAQRYVNTLL KLIPLVLGLQ EQLRQAVQNG 300
DMETSHGICR IAVALGENHS RALLDQVEHW QSFLALVNMI MFCTGIPGHY 350
PVNETTSSLT LTFWYTLQDD ILSFEAEKQA VYQQVYRPVY FQLVDVLLHK 400
AQFPSDEEYG FWSSDEKEQF RIYRVDISDT LMYVYEMLGA ELLSNLYDKL 450
GRLLTSSEEP YSWQHTEALL YGFQSIAETI DVNYSDVVPG LIGLIPRISI 500
SNVQLADTVM FTIGALSEWL ADHPVMINSV LPLVLHALGN PELSVSSVST 550
LKKICRECKY DLPPYAANIV AVSQDVLMKQ IHKTSQCMWL MQALGFLLSA 600
LQVEEILKNL HSLISPYIQQ LEKLAEEIPN PSNKLAIVHI LGLLSNLFTT 650
LDVSHHEDDH EGPELRKLPV PQGPNPVVVV LQQVFQLIQK VLSKWLNDAQ 700
VVEAVCAIFE KSVKTLLDDF APMVPQLCEM LGRMYSTVPQ ASALDLTRQL 750
VHIFAHEPAH FPPIEALFLL VTSVTLSLFQ QGPRDHPDIV DSFMQLLAQA 800
LKRKPDLFLC ERLDVKAVFQ CAVLALKFPE APTVKASCGF FTELLPRCGE 850
IESVGKVVQE DGRMLLIAVL EAIGGQASRS LMDCFADILF ALNKHCFSLL 900
SMWIKEALQP PGFPSARLSP EQKDTFSQQI LRERVNKRRV KEMVKEFTLL 950
CRGLHGTDYT ADY 963
Length:963
Mass (Da):108,229
Last modified:October 1, 2002 - v1
Checksum:i3ABBCE15668B6BCB
GO
Isoform 2 (identifier: Q8K0C1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     369-375: Missing.
     872-886: AIGGQASRSLMDCFA → VSWSKWLGVGRPSLLRRLALCCG

Show »
Length:964
Mass (Da):108,441
Checksum:iD48E0A1656F6CEF3
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei369 – 3757Missing in isoform 2.
VSP_010936
Alternative sequencei872 – 88615AIGGQ…MDCFA → VSWSKWLGVGRPSLLRRLAL CCG in isoform 2.
VSP_010937Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK129200 Transcribed RNA. Translation: BAC98010.2.
BC031823 mRNA. Translation: AAH31823.1.
AK052257 mRNA. Translation: BAC34899.1.
CCDSiCCDS18542.1. [Q8K0C1-1]
RefSeqiNP_666264.1. NM_146152.3. [Q8K0C1-1]
UniGeneiMm.287810.

Genome annotation databases

EnsembliENSMUST00000036156; ENSMUSP00000035989; ENSMUSG00000033365. [Q8K0C1-1]
GeneIDi230673.
KEGGimmu:230673.
UCSCiuc008ujg.1. mouse. [Q8K0C1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK129200 Transcribed RNA. Translation: BAC98010.2 .
BC031823 mRNA. Translation: AAH31823.1 .
AK052257 mRNA. Translation: BAC34899.1 .
CCDSi CCDS18542.1. [Q8K0C1-1 ]
RefSeqi NP_666264.1. NM_146152.3. [Q8K0C1-1 ]
UniGenei Mm.287810.

3D structure databases

ProteinModelPortali Q8K0C1.
SMRi Q8K0C1. Positions 19-953.
ModBasei Search...

PTM databases

PhosphoSitei Q8K0C1.

Proteomic databases

PaxDbi Q8K0C1.
PRIDEi Q8K0C1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000036156 ; ENSMUSP00000035989 ; ENSMUSG00000033365 . [Q8K0C1-1 ]
GeneIDi 230673.
KEGGi mmu:230673.
UCSCi uc008ujg.1. mouse. [Q8K0C1-1 ]

Organism-specific databases

CTDi 9670.
MGIi MGI:2385205. Ipo13.
Rougei Search...

Phylogenomic databases

eggNOGi NOG237172.
GeneTreei ENSGT00530000063347.
HOGENOMi HOG000049153.
HOVERGENi HBG052141.
OMAi QMYSTIP.
OrthoDBi EOG718KC9.
PhylomeDBi Q8K0C1.
TreeFami TF314539.

Miscellaneous databases

NextBioi 380039.
PROi Q8K0C1.
SOURCEi Search...

Gene expression databases

Bgeei Q8K0C1.
CleanExi MM_IPO13.
Genevestigatori Q8K0C1.

Family and domain databases

Gene3Di 1.25.10.10. 3 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013598. Exportin-1/Importin-b-like.
IPR001494. Importin-beta_N.
[Graphical view ]
Pfami PF03810. IBN_N. 1 hit.
PF08389. Xpo1. 1 hit.
[Graphical view ]
SMARTi SM00913. IBN_N. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 2 hits.
PROSITEi PS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Embryo.
  2. Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Salivary gland.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Heart.

Entry informationi

Entry nameiIPO13_MOUSE
AccessioniPrimary (citable) accession number: Q8K0C1
Secondary accession number(s): Q6ZQ60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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