Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8K0C1

- IPO13_MOUSE

UniProt

Q8K0C1 - IPO13_MOUSE

Protein

Importin-13

Gene

Ipo13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus By similarity. Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13 By similarity.By similarity

    GO - Biological processi

    1. protein import into nucleus Source: MGI

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Importin-13
    Short name:
    Imp13
    Gene namesi
    Name:Ipo13
    Synonyms:Kiaa0724
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:2385205. Ipo13.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 963963Importin-13PRO_0000120759Add
    BLAST

    Proteomic databases

    PaxDbiQ8K0C1.
    PRIDEiQ8K0C1.

    PTM databases

    PhosphoSiteiQ8K0C1.

    Expressioni

    Gene expression databases

    BgeeiQ8K0C1.
    CleanExiMM_IPO13.
    GenevestigatoriQ8K0C1.

    Interactioni

    Subunit structurei

    Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K0C1.
    SMRiQ8K0C1. Positions 19-953.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati24 – 5431HEAT 1Add
    BLAST
    Domaini45 – 11167Importin N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Repeati56 – 8833HEAT 2Add
    BLAST
    Repeati95 – 13541HEAT 3Add
    BLAST
    Repeati142 – 17938HEAT 4Add
    BLAST
    Repeati194 – 23138HEAT 5Add
    BLAST
    Repeati236 – 26833HEAT 6Add
    BLAST
    Repeati276 – 32550HEAT 7Add
    BLAST
    Repeati330 – 37243HEAT 8Add
    BLAST
    Repeati375 – 43864HEAT 9Add
    BLAST
    Repeati440 – 47637HEAT 10Add
    BLAST
    Repeati487 – 52236HEAT 11Add
    BLAST
    Repeati524 – 55835HEAT 12Add
    BLAST
    Repeati562 – 60039HEAT 13Add
    BLAST
    Repeati603 – 64846HEAT 14Add
    BLAST
    Repeati676 – 71641HEAT 15Add
    BLAST
    Repeati720 – 75435HEAT 16Add
    BLAST
    Repeati761 – 80343HEAT 17Add
    BLAST
    Repeati815 – 84531HEAT 18Add
    BLAST
    Repeati860 – 89334HEAT 19Add
    BLAST
    Repeati897 – 93135HEAT 20Add
    BLAST

    Sequence similaritiesi

    Belongs to the importin beta family.Curated
    Contains 20 HEAT repeats.Curated
    Contains 1 importin N-terminal domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG237172.
    GeneTreeiENSGT00530000063347.
    HOGENOMiHOG000049153.
    HOVERGENiHBG052141.
    OMAiQMYSTIP.
    OrthoDBiEOG718KC9.
    PhylomeDBiQ8K0C1.
    TreeFamiTF314539.

    Family and domain databases

    Gene3Di1.25.10.10. 3 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR013598. Exportin-1/Importin-b-like.
    IPR001494. Importin-beta_N.
    [Graphical view]
    PfamiPF03810. IBN_N. 1 hit.
    PF08389. Xpo1. 1 hit.
    [Graphical view]
    SMARTiSM00913. IBN_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 2 hits.
    PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8K0C1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MERREEQLGA AGAGAAPALD FTVENVEKAL HQLYYDPNID NKNLAQKWLM    50
    QAQVSPQAWH FSWQLLQPDK VPEIQYFGAS ALHIKISRYW SDIPTDQYES 100
    LKAQLFTQIT RFASGSKIVL TRLCVALASL ALSMMPDAWP CAVADMVRLF 150
    QAEDSPVDSQ GRCLALLELL TVLPEEFQTS RLPQYRKGLV RTSLAVECGT 200
    VFPLLEQLLQ QPSSPSCVRQ KVLKCFSSWV QLEVPLQDCE ALIQAAFAAL 250
    QDSELFDSSV EAIVNAISQP DAQRYVNTLL KLIPLVLGLQ EQLRQAVQNG 300
    DMETSHGICR IAVALGENHS RALLDQVEHW QSFLALVNMI MFCTGIPGHY 350
    PVNETTSSLT LTFWYTLQDD ILSFEAEKQA VYQQVYRPVY FQLVDVLLHK 400
    AQFPSDEEYG FWSSDEKEQF RIYRVDISDT LMYVYEMLGA ELLSNLYDKL 450
    GRLLTSSEEP YSWQHTEALL YGFQSIAETI DVNYSDVVPG LIGLIPRISI 500
    SNVQLADTVM FTIGALSEWL ADHPVMINSV LPLVLHALGN PELSVSSVST 550
    LKKICRECKY DLPPYAANIV AVSQDVLMKQ IHKTSQCMWL MQALGFLLSA 600
    LQVEEILKNL HSLISPYIQQ LEKLAEEIPN PSNKLAIVHI LGLLSNLFTT 650
    LDVSHHEDDH EGPELRKLPV PQGPNPVVVV LQQVFQLIQK VLSKWLNDAQ 700
    VVEAVCAIFE KSVKTLLDDF APMVPQLCEM LGRMYSTVPQ ASALDLTRQL 750
    VHIFAHEPAH FPPIEALFLL VTSVTLSLFQ QGPRDHPDIV DSFMQLLAQA 800
    LKRKPDLFLC ERLDVKAVFQ CAVLALKFPE APTVKASCGF FTELLPRCGE 850
    IESVGKVVQE DGRMLLIAVL EAIGGQASRS LMDCFADILF ALNKHCFSLL 900
    SMWIKEALQP PGFPSARLSP EQKDTFSQQI LRERVNKRRV KEMVKEFTLL 950
    CRGLHGTDYT ADY 963
    Length:963
    Mass (Da):108,229
    Last modified:October 1, 2002 - v1
    Checksum:i3ABBCE15668B6BCB
    GO
    Isoform 2 (identifier: Q8K0C1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         369-375: Missing.
         872-886: AIGGQASRSLMDCFA → VSWSKWLGVGRPSLLRRLALCCG

    Show »
    Length:964
    Mass (Da):108,441
    Checksum:iD48E0A1656F6CEF3
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei369 – 3757Missing in isoform 2. 1 PublicationVSP_010936
    Alternative sequencei872 – 88615AIGGQ…MDCFA → VSWSKWLGVGRPSLLRRLAL CCG in isoform 2. 1 PublicationVSP_010937Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129200 Transcribed RNA. Translation: BAC98010.2.
    BC031823 mRNA. Translation: AAH31823.1.
    AK052257 mRNA. Translation: BAC34899.1.
    CCDSiCCDS18542.1. [Q8K0C1-1]
    RefSeqiNP_666264.1. NM_146152.3. [Q8K0C1-1]
    UniGeneiMm.287810.

    Genome annotation databases

    EnsembliENSMUST00000036156; ENSMUSP00000035989; ENSMUSG00000033365. [Q8K0C1-1]
    GeneIDi230673.
    KEGGimmu:230673.
    UCSCiuc008ujg.1. mouse. [Q8K0C1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129200 Transcribed RNA. Translation: BAC98010.2 .
    BC031823 mRNA. Translation: AAH31823.1 .
    AK052257 mRNA. Translation: BAC34899.1 .
    CCDSi CCDS18542.1. [Q8K0C1-1 ]
    RefSeqi NP_666264.1. NM_146152.3. [Q8K0C1-1 ]
    UniGenei Mm.287810.

    3D structure databases

    ProteinModelPortali Q8K0C1.
    SMRi Q8K0C1. Positions 19-953.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8K0C1.

    Proteomic databases

    PaxDbi Q8K0C1.
    PRIDEi Q8K0C1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000036156 ; ENSMUSP00000035989 ; ENSMUSG00000033365 . [Q8K0C1-1 ]
    GeneIDi 230673.
    KEGGi mmu:230673.
    UCSCi uc008ujg.1. mouse. [Q8K0C1-1 ]

    Organism-specific databases

    CTDi 9670.
    MGIi MGI:2385205. Ipo13.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG237172.
    GeneTreei ENSGT00530000063347.
    HOGENOMi HOG000049153.
    HOVERGENi HBG052141.
    OMAi QMYSTIP.
    OrthoDBi EOG718KC9.
    PhylomeDBi Q8K0C1.
    TreeFami TF314539.

    Miscellaneous databases

    NextBioi 380039.
    PROi Q8K0C1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8K0C1.
    CleanExi MM_IPO13.
    Genevestigatori Q8K0C1.

    Family and domain databases

    Gene3Di 1.25.10.10. 3 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR013598. Exportin-1/Importin-b-like.
    IPR001494. Importin-beta_N.
    [Graphical view ]
    Pfami PF03810. IBN_N. 1 hit.
    PF08389. Xpo1. 1 hit.
    [Graphical view ]
    SMARTi SM00913. IBN_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 2 hits.
    PROSITEi PS50166. IMPORTIN_B_NT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Embryo.
    2. Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H.
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/N.
      Tissue: Salivary gland.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Heart.

    Entry informationi

    Entry nameiIPO13_MOUSE
    AccessioniPrimary (citable) accession number: Q8K0C1
    Secondary accession number(s): Q6ZQ60
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3