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Protein

Importin-13

Gene

Ipo13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Importin-13
Short name:
Imp13
Gene namesi
Name:Ipo13
Synonyms:Kiaa0724
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2385205. Ipo13.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001207591 – 963Importin-13Add BLAST963

Proteomic databases

PaxDbiQ8K0C1.
PeptideAtlasiQ8K0C1.
PRIDEiQ8K0C1.

PTM databases

iPTMnetiQ8K0C1.
PhosphoSitePlusiQ8K0C1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033365.
CleanExiMM_IPO13.
GenevisibleiQ8K0C1. MM.

Interactioni

Subunit structurei

Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035989.

Structurei

3D structure databases

ProteinModelPortaliQ8K0C1.
SMRiQ8K0C1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati24 – 54HEAT 1Add BLAST31
Domaini45 – 111Importin N-terminalPROSITE-ProRule annotationAdd BLAST67
Repeati56 – 88HEAT 2Add BLAST33
Repeati95 – 135HEAT 3Add BLAST41
Repeati142 – 179HEAT 4Add BLAST38
Repeati194 – 231HEAT 5Add BLAST38
Repeati236 – 268HEAT 6Add BLAST33
Repeati276 – 325HEAT 7Add BLAST50
Repeati330 – 372HEAT 8Add BLAST43
Repeati375 – 438HEAT 9Add BLAST64
Repeati440 – 476HEAT 10Add BLAST37
Repeati487 – 522HEAT 11Add BLAST36
Repeati524 – 558HEAT 12Add BLAST35
Repeati562 – 600HEAT 13Add BLAST39
Repeati603 – 648HEAT 14Add BLAST46
Repeati676 – 716HEAT 15Add BLAST41
Repeati720 – 754HEAT 16Add BLAST35
Repeati761 – 803HEAT 17Add BLAST43
Repeati815 – 845HEAT 18Add BLAST31
Repeati860 – 893HEAT 19Add BLAST34
Repeati897 – 931HEAT 20Add BLAST35

Sequence similaritiesi

Belongs to the importin beta family.Curated
Contains 20 HEAT repeats.Curated
Contains 1 importin N-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2022. Eukaryota.
ENOG410XT8Y. LUCA.
GeneTreeiENSGT00530000063347.
HOGENOMiHOG000049153.
HOVERGENiHBG052141.
InParanoidiQ8K0C1.
OMAiQMYSTIP.
OrthoDBiEOG091G01CP.
PhylomeDBiQ8K0C1.
TreeFamiTF314539.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013598. Exportin-1/Importin-b-like.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
PF08389. Xpo1. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8K0C1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERREEQLGA AGAGAAPALD FTVENVEKAL HQLYYDPNID NKNLAQKWLM
60 70 80 90 100
QAQVSPQAWH FSWQLLQPDK VPEIQYFGAS ALHIKISRYW SDIPTDQYES
110 120 130 140 150
LKAQLFTQIT RFASGSKIVL TRLCVALASL ALSMMPDAWP CAVADMVRLF
160 170 180 190 200
QAEDSPVDSQ GRCLALLELL TVLPEEFQTS RLPQYRKGLV RTSLAVECGT
210 220 230 240 250
VFPLLEQLLQ QPSSPSCVRQ KVLKCFSSWV QLEVPLQDCE ALIQAAFAAL
260 270 280 290 300
QDSELFDSSV EAIVNAISQP DAQRYVNTLL KLIPLVLGLQ EQLRQAVQNG
310 320 330 340 350
DMETSHGICR IAVALGENHS RALLDQVEHW QSFLALVNMI MFCTGIPGHY
360 370 380 390 400
PVNETTSSLT LTFWYTLQDD ILSFEAEKQA VYQQVYRPVY FQLVDVLLHK
410 420 430 440 450
AQFPSDEEYG FWSSDEKEQF RIYRVDISDT LMYVYEMLGA ELLSNLYDKL
460 470 480 490 500
GRLLTSSEEP YSWQHTEALL YGFQSIAETI DVNYSDVVPG LIGLIPRISI
510 520 530 540 550
SNVQLADTVM FTIGALSEWL ADHPVMINSV LPLVLHALGN PELSVSSVST
560 570 580 590 600
LKKICRECKY DLPPYAANIV AVSQDVLMKQ IHKTSQCMWL MQALGFLLSA
610 620 630 640 650
LQVEEILKNL HSLISPYIQQ LEKLAEEIPN PSNKLAIVHI LGLLSNLFTT
660 670 680 690 700
LDVSHHEDDH EGPELRKLPV PQGPNPVVVV LQQVFQLIQK VLSKWLNDAQ
710 720 730 740 750
VVEAVCAIFE KSVKTLLDDF APMVPQLCEM LGRMYSTVPQ ASALDLTRQL
760 770 780 790 800
VHIFAHEPAH FPPIEALFLL VTSVTLSLFQ QGPRDHPDIV DSFMQLLAQA
810 820 830 840 850
LKRKPDLFLC ERLDVKAVFQ CAVLALKFPE APTVKASCGF FTELLPRCGE
860 870 880 890 900
IESVGKVVQE DGRMLLIAVL EAIGGQASRS LMDCFADILF ALNKHCFSLL
910 920 930 940 950
SMWIKEALQP PGFPSARLSP EQKDTFSQQI LRERVNKRRV KEMVKEFTLL
960
CRGLHGTDYT ADY
Length:963
Mass (Da):108,229
Last modified:October 1, 2002 - v1
Checksum:i3ABBCE15668B6BCB
GO
Isoform 2 (identifier: Q8K0C1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     369-375: Missing.
     872-886: AIGGQASRSLMDCFA → VSWSKWLGVGRPSLLRRLALCCG

Show »
Length:964
Mass (Da):108,441
Checksum:iD48E0A1656F6CEF3
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010936369 – 375Missing in isoform 2. 1 Publication7
Alternative sequenceiVSP_010937872 – 886AIGGQ…MDCFA → VSWSKWLGVGRPSLLRRLAL CCG in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129200 Transcribed RNA. Translation: BAC98010.2.
BC031823 mRNA. Translation: AAH31823.1.
AK052257 mRNA. Translation: BAC34899.1.
CCDSiCCDS18542.1. [Q8K0C1-1]
RefSeqiNP_666264.1. NM_146152.3. [Q8K0C1-1]
UniGeneiMm.287810.

Genome annotation databases

EnsembliENSMUST00000036156; ENSMUSP00000035989; ENSMUSG00000033365. [Q8K0C1-1]
GeneIDi230673.
KEGGimmu:230673.
UCSCiuc008ujg.1. mouse. [Q8K0C1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129200 Transcribed RNA. Translation: BAC98010.2.
BC031823 mRNA. Translation: AAH31823.1.
AK052257 mRNA. Translation: BAC34899.1.
CCDSiCCDS18542.1. [Q8K0C1-1]
RefSeqiNP_666264.1. NM_146152.3. [Q8K0C1-1]
UniGeneiMm.287810.

3D structure databases

ProteinModelPortaliQ8K0C1.
SMRiQ8K0C1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035989.

PTM databases

iPTMnetiQ8K0C1.
PhosphoSitePlusiQ8K0C1.

Proteomic databases

PaxDbiQ8K0C1.
PeptideAtlasiQ8K0C1.
PRIDEiQ8K0C1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036156; ENSMUSP00000035989; ENSMUSG00000033365. [Q8K0C1-1]
GeneIDi230673.
KEGGimmu:230673.
UCSCiuc008ujg.1. mouse. [Q8K0C1-1]

Organism-specific databases

CTDi9670.
MGIiMGI:2385205. Ipo13.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2022. Eukaryota.
ENOG410XT8Y. LUCA.
GeneTreeiENSGT00530000063347.
HOGENOMiHOG000049153.
HOVERGENiHBG052141.
InParanoidiQ8K0C1.
OMAiQMYSTIP.
OrthoDBiEOG091G01CP.
PhylomeDBiQ8K0C1.
TreeFamiTF314539.

Miscellaneous databases

PROiQ8K0C1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033365.
CleanExiMM_IPO13.
GenevisibleiQ8K0C1. MM.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013598. Exportin-1/Importin-b-like.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
PF08389. Xpo1. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIPO13_MOUSE
AccessioniPrimary (citable) accession number: Q8K0C1
Secondary accession number(s): Q6ZQ60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.