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Protein

Zinc finger and BTB domain-containing protein 6

Gene

Zbtb6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri300 – 32223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri325 – 34723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri353 – 37523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40424C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 6
Alternative name(s):
Zinc finger protein 482
Gene namesi
Name:Zbtb6
Synonyms:Zfp482, Znf482
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2442998. Zbtb6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423Zinc finger and BTB domain-containing protein 6PRO_0000047609Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei201 – 2011PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8K088.
PRIDEiQ8K088.

PTM databases

iPTMnetiQ8K088.
PhosphoSiteiQ8K088.

Expressioni

Gene expression databases

BgeeiQ8K088.
CleanExiMM_ZBTB6.
GenevisibleiQ8K088. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056100.

Structurei

3D structure databases

ProteinModelPortaliQ8K088.
SMRiQ8K088. Positions 23-127, 296-402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 9765BTBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri300 – 32223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri325 – 34723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri353 – 37523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40424C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000232051.
HOVERGENiHBG056199.
InParanoidiQ8K088.
KOiK10493.
OMAiEKLPRHD.
OrthoDBiEOG7Q8CN4.
PhylomeDBiQ8K088.
TreeFamiTF333162.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K088-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAESDVLHF QFEQQGDVVL QKMNLLRQQN LFCDVSIYIN DTEFQGHKVI
60 70 80 90 100
LAACSTFMRD QFLLTQSKHV RITILQSAEV GWKLLLSCYT GALEVKRKEL
110 120 130 140 150
LKYLTAASYL QMVHIVEKCT EALSKYLEID LSMKNNQHTD LCQSSDTDVK
160 170 180 190 200
NEEENSDKDC EIIEISEDSP VNLDFHVKEE ESNALQSAAE TLTSERMRMQ
210 220 230 240 250
SPELSAVDGG FKENEICILH VESISTDDVE NGQFSQPCTS SKAGIYFPET
260 270 280 290 300
QHSLINSTVE NRVTEVPGNT NQGLFSENSD GSHGTVNEIQ NLDENFSLRH
310 320 330 340 350
QCPRCPRGFL HVENYLRHLK MHKLFLCLQC GKTFTQKKNL NRHIRGHMGI
360 370 380 390 400
RPFQCTVCLK TFTAKSTLQD HLNIHSGDRP YKCHCCDMDF KHKSALKKHL
410 420
TSVHGRSSGE KLSRPDLKRQ NLL
Length:423
Mass (Da):48,188
Last modified:October 1, 2002 - v1
Checksum:i85C9CCF7B2309C1B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti397 – 3971K → E in BAC31788 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044125 mRNA. Translation: BAC31788.1.
AK050827 mRNA. Translation: BAC34426.1.
AK053443 mRNA. Translation: BAC35387.1.
AL953890 Genomic DNA. Translation: CAM20738.1.
BC032933 mRNA. Translation: AAH32933.1.
CCDSiCCDS16000.1.
RefSeqiNP_666365.1. NM_146253.5.
UniGeneiMm.330182.

Genome annotation databases

EnsembliENSMUST00000053098; ENSMUSP00000056100; ENSMUSG00000066798.
ENSMUST00000112932; ENSMUSP00000108554; ENSMUSG00000066798.
GeneIDi241322.
KEGGimmu:241322.
UCSCiuc008jms.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044125 mRNA. Translation: BAC31788.1.
AK050827 mRNA. Translation: BAC34426.1.
AK053443 mRNA. Translation: BAC35387.1.
AL953890 Genomic DNA. Translation: CAM20738.1.
BC032933 mRNA. Translation: AAH32933.1.
CCDSiCCDS16000.1.
RefSeqiNP_666365.1. NM_146253.5.
UniGeneiMm.330182.

3D structure databases

ProteinModelPortaliQ8K088.
SMRiQ8K088. Positions 23-127, 296-402.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056100.

PTM databases

iPTMnetiQ8K088.
PhosphoSiteiQ8K088.

Proteomic databases

PaxDbiQ8K088.
PRIDEiQ8K088.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053098; ENSMUSP00000056100; ENSMUSG00000066798.
ENSMUST00000112932; ENSMUSP00000108554; ENSMUSG00000066798.
GeneIDi241322.
KEGGimmu:241322.
UCSCiuc008jms.2. mouse.

Organism-specific databases

CTDi10773.
MGIiMGI:2442998. Zbtb6.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000232051.
HOVERGENiHBG056199.
InParanoidiQ8K088.
KOiK10493.
OMAiEKLPRHD.
OrthoDBiEOG7Q8CN4.
PhylomeDBiQ8K088.
TreeFamiTF333162.

Miscellaneous databases

PROiQ8K088.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K088.
CleanExiMM_ZBTB6.
GenevisibleiQ8K088. MM.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain cortex and Eye.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.

Entry informationi

Entry nameiZBTB6_MOUSE
AccessioniPrimary (citable) accession number: Q8K088
Secondary accession number(s): A2AWA4, Q8BLM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.