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Protein

G-protein coupled receptor 1

Gene

Gpr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1 (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 1
Gene namesi
Name:Gpr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2385324. Gpr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141ExtracellularSequence analysisAdd
BLAST
Transmembranei42 – 6221Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini63 – 7311CytoplasmicSequence analysisAdd
BLAST
Transmembranei74 – 9421Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini95 – 11218ExtracellularSequence analysisAdd
BLAST
Transmembranei113 – 13321Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini134 – 15421CytoplasmicSequence analysisAdd
BLAST
Transmembranei155 – 17521Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini176 – 21035ExtracellularSequence analysisAdd
BLAST
Transmembranei211 – 23121Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini232 – 24716CytoplasmicSequence analysisAdd
BLAST
Transmembranei248 – 26821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini269 – 28618ExtracellularSequence analysisAdd
BLAST
Transmembranei287 – 30721Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini308 – 35346CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 353353G-protein coupled receptor 1PRO_0000069508Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence analysis
Disulfide bondi110 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8K087.
PRIDEiQ8K087.

PTM databases

PhosphoSiteiQ8K087.

Expressioni

Gene expression databases

BgeeiQ8K087.
CleanExiMM_GPR1.
GenevisibleiQ8K087. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051417.

Structurei

3D structure databases

ProteinModelPortaliQ8K087.
SMRiQ8K087. Positions 44-314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGAX. Eukaryota.
ENOG410XQ5U. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
HOVERGENiHBG107927.
InParanoidiQ8K087.
KOiK04310.
OMAiTWLCKAN.
OrthoDBiEOG7C5M8T.
PhylomeDBiQ8K087.
TreeFamiTF330976.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002275. GPR1_orph_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01146. GPR1ORPHANR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K087-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVSKEMLFE ELDNYSYALD YYSQESDPEE KVYLGLVHWI SLFLYALAFV
60 70 80 90 100
LGIPGNAIVI WLMGFKWKKT VTTLWFLNLA IADFIFVLFL PLYISYVALS
110 120 130 140 150
FHWPFGLWLC KVNSFIAQLN MFSSVFFLTV ISLDRYIHLL HPGLSHRHRT
160 170 180 190 200
LKSSLVVVIL VWLLASLLGG PTLYFRDTME VNNHIICYNN FQEHELTLMR
210 220 230 240 250
HHVLTWVKFL FGYLFPLLTM SSCYLCLIFK MKKRNILISR KHLWMILSVV
260 270 280 290 300
IAFLVCWTPY HLFSIWELSI HHNSSFQNVL QGGIPLSTGL AFLNSCLNPI
310 320 330 340 350
LYVLISKTFQ ARFRASVAEV LKRSLWEASC SGTVSEQLRS AETKSLSLLE

TAQ
Length:353
Mass (Da):40,951
Last modified:October 1, 2002 - v1
Checksum:iA7793FEC0409C0A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645950 Genomic DNA. Translation: CAI24122.1.
BC032934 mRNA. Translation: AAH32934.1.
CCDSiCCDS14998.1.
RefSeqiNP_666362.1. NM_146250.2.
XP_006496043.1. XM_006495980.2.
XP_006496044.1. XM_006495981.2.
XP_011236820.1. XM_011238518.1.
XP_011236821.1. XM_011238519.1.
UniGeneiMm.103354.

Genome annotation databases

EnsembliENSMUST00000050536; ENSMUSP00000051417; ENSMUSG00000046856.
GeneIDi241070.
KEGGimmu:241070.
UCSCiuc007bga.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645950 Genomic DNA. Translation: CAI24122.1.
BC032934 mRNA. Translation: AAH32934.1.
CCDSiCCDS14998.1.
RefSeqiNP_666362.1. NM_146250.2.
XP_006496043.1. XM_006495980.2.
XP_006496044.1. XM_006495981.2.
XP_011236820.1. XM_011238518.1.
XP_011236821.1. XM_011238519.1.
UniGeneiMm.103354.

3D structure databases

ProteinModelPortaliQ8K087.
SMRiQ8K087. Positions 44-314.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051417.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8K087.

Proteomic databases

PaxDbiQ8K087.
PRIDEiQ8K087.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050536; ENSMUSP00000051417; ENSMUSG00000046856.
GeneIDi241070.
KEGGimmu:241070.
UCSCiuc007bga.3. mouse.

Organism-specific databases

CTDi2825.
MGIiMGI:2385324. Gpr1.

Phylogenomic databases

eggNOGiENOG410IGAX. Eukaryota.
ENOG410XQ5U. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
HOVERGENiHBG107927.
InParanoidiQ8K087.
KOiK04310.
OMAiTWLCKAN.
OrthoDBiEOG7C5M8T.
PhylomeDBiQ8K087.
TreeFamiTF330976.

Miscellaneous databases

NextBioi384855.
PROiQ8K087.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K087.
CleanExiMM_GPR1.
GenevisibleiQ8K087. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002275. GPR1_orph_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01146. GPR1ORPHANR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.

Entry informationi

Entry nameiGPR1_MOUSE
AccessioniPrimary (citable) accession number: Q8K087
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2002
Last modified: May 11, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.