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Protein

Zinc finger protein 536

Gene

Znf536

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3' (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri130 – 152C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri158 – 180C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri274 – 297C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri300 – 323C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri345 – 367C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri631 – 653C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri753 – 775C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri781 – 803C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 536
Gene namesi
Name:Znf536
Synonyms:Kiaa0390, Zfp536
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1926102. Zfp536.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002710421 – 1302Zinc finger protein 536Add BLAST1302

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei828PhosphoserineBy similarity1
Modified residuei829PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8K083.
MaxQBiQ8K083.
PaxDbiQ8K083.
PeptideAtlasiQ8K083.
PRIDEiQ8K083.

PTM databases

iPTMnetiQ8K083.
PhosphoSitePlusiQ8K083.

Expressioni

Gene expression databases

BgeeiENSMUSG00000043456.
CleanExiMM_ZFP536.
ExpressionAtlasiQ8K083. baseline and differential.
GenevisibleiQ8K083. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058468.

Structurei

3D structure databases

ProteinModelPortaliQ8K083.
SMRiQ8K083.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri130 – 152C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri158 – 180C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri274 – 297C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri300 – 323C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri345 – 367C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri631 – 653C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri753 – 775C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri781 – 803C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063100.
HOGENOMiHOG000155801.
HOVERGENiHBG080712.
InParanoidiQ8K083.
OMAiQSANEFR.
OrthoDBiEOG091G00MV.
PhylomeDBiQ8K083.
TreeFamiTF332241.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K083-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEASLCLGV SSTAPEAEPH LSGPVLNGQY AMSQKLHQIT SQLSHAFPEL
60 70 80 90 100
HPRPNPEEKT PAALEEKAHV PMSGQSMGSQ MALLANQLGR DVDNSLNGRV
110 120 130 140 150
DLQQFLNGQN LGIMSQMSDI EDDARKNRKY PCPLCGKRFR FNSILSLHMR
160 170 180 190 200
THTGEKPFKC PYCDHRAAQK GNLKIHLRTH KLGNLGKGRG RVREENRLLH
210 220 230 240 250
ELEERAILRD KQMKGSLLQP RSDLKPLAHA QQAPLATCNL ALPPNHSVPD
260 270 280 290 300
VAHPAPSPKP ANLQEDSVTP AAGFRCTFCK GKFKKREELD RHIRILHKPY
310 320 330 340 350
KCTLCDFAAS QEEELISHVE KAHITAESAQ GQGPNGGGEQ SANEFRCEVC
360 370 380 390 400
GQVFSQAWFL KGHMRKHKDS FEHCCQICGR RFKEPWFLKN HMKVHLNKLS
410 420 430 440 450
VKNKSPTEPE VAVPMGGLSQ EAHANLYSRY LSCLQSGFMA PDKASLNEPS
460 470 480 490 500
QLYGKGELPA KEKEVLGKLL SPISSMAHSV PEGDKHSLLG CLNLVPPLKS
510 520 530 540 550
SCIERLQAAA KAAEMDPVNS YQAWQLMARG MAMEHGFLSK EHQLSRNHED
560 570 580 590 600
PLANTGVLFD KEKREYVLVG ADGSKQKMPA DLVHSTKVGN QRDLPNKLDP
610 620 630 640 650
LEGSREFLSH GLNQTLDYNL QGPGNMKEKP TECPDCGRVF RTYHQVVVHS
660 670 680 690 700
RVHKRDRKSD EDALHVGVGL EERRGSGSDQ ESQSVSRSTT PGSSNVTEES
710 720 730 740 750
GAGGGLSQTG SAQEDSPHPS SPSSSDIGEE AGRAGGVQQQ ALLRDRNLGS
760 770 780 790 800
AMKDCPYCGK TFRTSHHLKV HLRIHTGEKP YKCPHCDYAG TQSASLKYHL
810 820 830 840 850
ERHHRERQNG AGPLSGQPPN QEHKDETSSK APMFIRPDIL RGAFKGLPGI
860 870 880 890 900
DFRGGPASQQ WTAGMLSSGD HSGQATGMPS ELSSDALKGS DLPSKSSHYS
910 920 930 940 950
EIGRAYQNIV SNGVNFQGSL QAFMDSFVLS SLKKKDTKDK VPSDAHPMKA
960 970 980 990 1000
HTAEGGEEKA SMKPSQRKSE KSQYEPLDLS VRPDAPTLPG SSVTVQDSIA
1010 1020 1030 1040 1050
WHGCLFCAFT TSSMELMALH LQANHLGRAK RKDHPTGVTV NCKEQGREAS
1060 1070 1080 1090 1100
KVSVLPSLQS NKEMALPSAV GVLDSAPEKL AQGPAKETLG DPKSGQWPNH
1110 1120 1130 1140 1150
MDPAFCTFPS DFYKQFGVYP AMVGSGAPGS CLNKNTEGKT HPDDDAPILI
1160 1170 1180 1190 1200
PETTNKNTTD DLSDIASSED MDSSKGENNE DEELDTEPEM TSKPLSALSK
1210 1220 1230 1240 1250
DGSSEGGDSL LSPGAPQPIQ GLVSPLAQAA EEQWHSPGLL PAQDPSAGLP
1260 1270 1280 1290 1300
KPERGPPGLE KPMSMLSVLR AYSADGLAAF NGLASSTANS GCIKRPDLCG

KF
Length:1,302
Mass (Da):141,576
Last modified:October 1, 2002 - v1
Checksum:iA9AF82D1D9481465
GO

Sequence cautioni

The sequence BAC65552 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti590N → Y in BAC65552 (PubMed:12693553).Curated1
Sequence conflicti899Y → F in BAC65552 (PubMed:12693553).Curated1
Sequence conflicti1036T → A in BAC65552 (PubMed:12693553).Curated1
Sequence conflicti1207G → S in BAC65552 (PubMed:12693553).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122270 mRNA. Translation: BAC65552.1. Different initiation.
AK030633 mRNA. Translation: BAC27055.1.
AK034508 mRNA. Translation: BAC28735.1.
BC033594 mRNA. Translation: AAH33594.1.
CCDSiCCDS21156.1.
RefSeqiNP_759017.1. NM_172385.2.
UniGeneiMm.322505.
Mm.378309.
Mm.388121.

Genome annotation databases

EnsembliENSMUST00000056338; ENSMUSP00000058468; ENSMUSG00000043456.
ENSMUST00000175941; ENSMUSP00000134778; ENSMUSG00000043456.
ENSMUST00000176114; ENSMUSP00000135681; ENSMUSG00000043456.
ENSMUST00000176205; ENSMUSP00000135068; ENSMUSG00000043456.
GeneIDi243937.
KEGGimmu:243937.
UCSCiuc009gkk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122270 mRNA. Translation: BAC65552.1. Different initiation.
AK030633 mRNA. Translation: BAC27055.1.
AK034508 mRNA. Translation: BAC28735.1.
BC033594 mRNA. Translation: AAH33594.1.
CCDSiCCDS21156.1.
RefSeqiNP_759017.1. NM_172385.2.
UniGeneiMm.322505.
Mm.378309.
Mm.388121.

3D structure databases

ProteinModelPortaliQ8K083.
SMRiQ8K083.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058468.

PTM databases

iPTMnetiQ8K083.
PhosphoSitePlusiQ8K083.

Proteomic databases

EPDiQ8K083.
MaxQBiQ8K083.
PaxDbiQ8K083.
PeptideAtlasiQ8K083.
PRIDEiQ8K083.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056338; ENSMUSP00000058468; ENSMUSG00000043456.
ENSMUST00000175941; ENSMUSP00000134778; ENSMUSG00000043456.
ENSMUST00000176114; ENSMUSP00000135681; ENSMUSG00000043456.
ENSMUST00000176205; ENSMUSP00000135068; ENSMUSG00000043456.
GeneIDi243937.
KEGGimmu:243937.
UCSCiuc009gkk.1. mouse.

Organism-specific databases

CTDi243937.
MGIiMGI:1926102. Zfp536.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063100.
HOGENOMiHOG000155801.
HOVERGENiHBG080712.
InParanoidiQ8K083.
OMAiQSANEFR.
OrthoDBiEOG091G00MV.
PhylomeDBiQ8K083.
TreeFamiTF332241.

Miscellaneous databases

PROiQ8K083.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043456.
CleanExiMM_ZFP536.
ExpressionAtlasiQ8K083. baseline and differential.
GenevisibleiQ8K083. MM.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN536_MOUSE
AccessioniPrimary (citable) accession number: Q8K083
Secondary accession number(s): Q80U15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.