Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8K078 (SO4A1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier organic anion transporter family member 4A1
Alternative name(s):
Organic anion-transporting polypeptide E
Short name=OATP-E
Sodium-independent organic anion transporter E
Solute carrier family 21 member 12
Gene names
Name:Slco4a1
Synonyms:Oatp4a1, Oatpe, Slc21a12
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length723 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates the Na+-independent transport of organic anions such as the thyroid hormone T3 (triiodo-L-thyronine) and of taurocholate By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the organo anion transporter (TC 2.A.60) family. [View classification]

Contains 1 Kazal-like domain.

Sequence caution

The sequence AAH33602.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_procession transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontransporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8K078-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8K078-2)

The sequence of this isoform differs from the canonical sequence as follows:
     629-632: SIPG → TAWG
     633-723: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 723723Solute carrier organic anion transporter family member 4A1
PRO_0000191068

Regions

Topological domain1 – 102102Cytoplasmic Potential
Transmembrane103 – 12321Helical; Name=1; Potential
Topological domain124 – 14219Extracellular Potential
Transmembrane143 – 16321Helical; Name=2; Potential
Topological domain164 – 1696Cytoplasmic Potential
Transmembrane170 – 19425Helical; Name=3; Potential
Topological domain195 – 22430Extracellular Potential
Transmembrane225 – 25531Helical; Name=4; Potential
Topological domain256 – 27419Cytoplasmic Potential
Transmembrane275 – 29521Helical; Name=5; Potential
Topological domain296 – 30914Extracellular Potential
Transmembrane310 – 33425Helical; Name=6; Potential
Topological domain335 – 38046Cytoplasmic Potential
Transmembrane381 – 40222Helical; Name=7; Potential
Topological domain403 – 42220Extracellular Potential
Transmembrane423 – 44624Helical; Name=8; Potential
Topological domain447 – 4504Cytoplasmic Potential
Transmembrane451 – 47323Helical; Name=9; Potential
Topological domain474 – 582109Extracellular Potential
Transmembrane583 – 60523Helical; Name=10; Potential
Topological domain606 – 6149Cytoplasmic Potential
Transmembrane615 – 64026Helical; Name=11; Potential
Topological domain641 – 67333Extracellular Potential
Transmembrane674 – 69118Helical; Name=12; Potential
Topological domain692 – 72332Cytoplasmic Potential
Domain500 – 55758Kazal-like

Amino acid modifications

Modified residue391Phosphoserine By similarity
Modified residue421Phosphoserine By similarity
Modified residue451Phosphoserine By similarity
Glycosylation2121N-linked (GlcNAc...) Potential
Glycosylation5661N-linked (GlcNAc...) Potential
Disulfide bond506 ↔ 532 By similarity
Disulfide bond511 ↔ 521 By similarity
Disulfide bond512 ↔ 536 By similarity

Natural variations

Alternative sequence629 – 6324SIPG → TAWG in isoform 2.
VSP_006157
Alternative sequence633 – 72391Missing in isoform 2.
VSP_006158

Experimental info

Sequence conflict281S → R in BAC28379. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 10, 2003. Version 2.
Checksum: 0856B45F02C4EBAC

FASTA72377,669
        10         20         30         40         50         60 
MPQHAMGDTH FLSLPKHLFT STSSATDSGC DTPPSSRASP ASLRSAHGTL GSSSQPLFEP 

        70         80         90        100        110        120 
QAEKRSSQTA REVQYVSSGP QNSLCGWQAF TPKCLQVFNT PKGFLFFLCA ASFLQGMTVN 

       130        140        150        160        170        180 
GFINTVITSI ERRFDLHSYQ SGLIASSYDI AACLCLTFVS YFGGNGHKPR WLGWGVLVLG 

       190        200        210        220        230        240 
IGSLVFALPH FTAGRYEVEM DEGLGTGTCL TNQSHVECKD SASGLSNYRL IFMLGQLLHG 

       250        260        270        280        290        300 
VGATPLYTLG VTYLDENVKS SYSPIYIAIF YTAAILGPAA GYLIGGAMLN VYTEVGQRTE 

       310        320        330        340        350        360 
LTTDSPLWVG AWWIGFLGTG IAAFLIAIPI LGYPRQLPGS QRYVVMRAAE TQQLKDHSRG 

       370        380        390        400        410        420 
AVSNPAFGKT VRDLPLSIWL LLRNPTFILL CLAGATEATL IAGMSTFGPK FFEAQFSLSA 

       430        440        450        460        470        480 
SEAATLFGYL VVPAGGGGTL LGGFLVNKFK LRGSGIIRFC LFCTLTSLLA FFVFLMHCPN 

       490        500        510        520        530        540 
VHMAGVTTGY VGSLLPKGQL DLKAACNAIY CCQPKHYSPL CGSDGTMYYS PCYAGCPADA 

       550        560        570        580        590        600 
ETDLGGQKVY RGCSCILEKA SSGWGNATAG KCASTCQSKP FLLVLVFVVI IFTFLSSIPA 

       610        620        630        640        650        660 
LTATLRCVSD RQRSFALGIQ WIVVRTLGSI PGPIAFGWVI DKACLLWQDQ CGHQGSCFVY 

       670        680        690        700        710        720 
ENEAMSRYML IAGLTFKVLG FLFFVAAYFL YKSPSVSSDG LEASLPSQSS ASDSPTEQLQ 


SNV 

« Hide

Isoform 2 [UniParc].

Checksum: CA2E830914998FD9
Show »

FASTA63267,751

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Cecum.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6.
Tissue: Retina.
[3]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK033598 mRNA. Translation: BAC28379.1.
BC030719 mRNA. Translation: AAH30719.1.
BC030720 mRNA. Translation: AAH30720.1.
BC033602 mRNA. Translation: AAH33602.1. Different initiation.
RefSeqNP_683735.1. NM_148933.1.
XP_006500610.1. XM_006500547.1.
UniGeneMm.133687.

3D structure databases

ProteinModelPortalQ8K078.
SMRQ8K078. Positions 141-166, 509-538, 603-642.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8K078.

Proteomic databases

PaxDbQ8K078.
PRIDEQ8K078.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000038225; ENSMUSP00000045023; ENSMUSG00000038963. [Q8K078-1]
ENSMUST00000038259; ENSMUSP00000046502; ENSMUSG00000038963. [Q8K078-1]
GeneID108115.
KEGGmmu:108115.
UCSCuc008ojc.2. mouse. [Q8K078-1]

Organism-specific databases

CTD28231.
MGIMGI:1351866. Slco4a1.

Phylogenomic databases

eggNOGNOG320775.
GeneTreeENSGT00740000115121.
HOGENOMHOG000231270.
HOVERGENHBG100565.
InParanoidQ8K078.
KOK14354.
OMAFKLRCSG.
OrthoDBEOG75TMBK.
PhylomeDBQ8K078.
TreeFamTF317540.

Gene expression databases

BgeeQ8K078.
GenevestigatorQ8K078.

Family and domain databases

InterProIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view]
PANTHERPTHR11388. PTHR11388. 1 hit.
PfamPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 3 hits.
TIGRFAMsTIGR00805. oat. 1 hit.
PROSITEPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio360096.
PROQ8K078.
SOURCESearch...

Entry information

Entry nameSO4A1_MOUSE
AccessionPrimary (citable) accession number: Q8K078
Secondary accession number(s): Q8BZT4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 10, 2003
Last modified: April 16, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot