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Protein

Solute carrier organic anion transporter family member 4A1

Gene

Slco4a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the Na+-independent transport of organic anions such as the thyroid hormone T3 (triiodo-L-thyronine) and of taurocholate.By similarity

GO - Molecular functioni

  1. organic anion transmembrane transporter activity Source: MGI

GO - Biological processi

  1. organic anion transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_318911. Transport of organic anions.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 4A1
Alternative name(s):
Organic anion-transporting polypeptide E
Short name:
OATP-E
Sodium-independent organic anion transporter E
Solute carrier family 21 member 12
Gene namesi
Name:Slco4a1
Synonyms:Oatp4a1, Oatpe, Slc21a12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1351866. Slco4a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 102102CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei103 – 12321Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini124 – 14219ExtracellularSequence AnalysisAdd
BLAST
Transmembranei143 – 16321Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini164 – 1696CytoplasmicSequence Analysis
Transmembranei170 – 19425Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini195 – 22430ExtracellularSequence AnalysisAdd
BLAST
Transmembranei225 – 25531Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini256 – 27419CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei275 – 29521Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini296 – 30914ExtracellularSequence AnalysisAdd
BLAST
Transmembranei310 – 33425Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini335 – 38046CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei381 – 40222Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini403 – 42220ExtracellularSequence AnalysisAdd
BLAST
Transmembranei423 – 44624Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini447 – 4504CytoplasmicSequence Analysis
Transmembranei451 – 47323Helical; Name=9Sequence AnalysisAdd
BLAST
Topological domaini474 – 582109ExtracellularSequence AnalysisAdd
BLAST
Transmembranei583 – 60523Helical; Name=10Sequence AnalysisAdd
BLAST
Topological domaini606 – 6149CytoplasmicSequence Analysis
Transmembranei615 – 64026Helical; Name=11Sequence AnalysisAdd
BLAST
Topological domaini641 – 67333ExtracellularSequence AnalysisAdd
BLAST
Transmembranei674 – 69118Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini692 – 72332CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 723723Solute carrier organic anion transporter family member 4A1PRO_0000191068Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei39 – 391PhosphoserineBy similarity
Modified residuei42 – 421PhosphoserineBy similarity
Modified residuei45 – 451PhosphoserineBy similarity
Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi506 ↔ 532PROSITE-ProRule annotation
Disulfide bondi511 ↔ 521PROSITE-ProRule annotation
Disulfide bondi512 ↔ 536PROSITE-ProRule annotation
Glycosylationi566 – 5661N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8K078.
PRIDEiQ8K078.

PTM databases

PhosphoSiteiQ8K078.

Expressioni

Gene expression databases

BgeeiQ8K078.
GenevestigatoriQ8K078.

Structurei

3D structure databases

ProteinModelPortaliQ8K078.
SMRiQ8K078. Positions 509-535.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini500 – 55758Kazal-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320775.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231270.
HOVERGENiHBG100565.
InParanoidiQ8K078.
KOiK14354.
OMAiFKLRCSG.
OrthoDBiEOG75TMBK.
PhylomeDBiQ8K078.
TreeFamiTF317540.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8K078-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPQHAMGDTH FLSLPKHLFT STSSATDSGC DTPPSSRASP ASLRSAHGTL
60 70 80 90 100
GSSSQPLFEP QAEKRSSQTA REVQYVSSGP QNSLCGWQAF TPKCLQVFNT
110 120 130 140 150
PKGFLFFLCA ASFLQGMTVN GFINTVITSI ERRFDLHSYQ SGLIASSYDI
160 170 180 190 200
AACLCLTFVS YFGGNGHKPR WLGWGVLVLG IGSLVFALPH FTAGRYEVEM
210 220 230 240 250
DEGLGTGTCL TNQSHVECKD SASGLSNYRL IFMLGQLLHG VGATPLYTLG
260 270 280 290 300
VTYLDENVKS SYSPIYIAIF YTAAILGPAA GYLIGGAMLN VYTEVGQRTE
310 320 330 340 350
LTTDSPLWVG AWWIGFLGTG IAAFLIAIPI LGYPRQLPGS QRYVVMRAAE
360 370 380 390 400
TQQLKDHSRG AVSNPAFGKT VRDLPLSIWL LLRNPTFILL CLAGATEATL
410 420 430 440 450
IAGMSTFGPK FFEAQFSLSA SEAATLFGYL VVPAGGGGTL LGGFLVNKFK
460 470 480 490 500
LRGSGIIRFC LFCTLTSLLA FFVFLMHCPN VHMAGVTTGY VGSLLPKGQL
510 520 530 540 550
DLKAACNAIY CCQPKHYSPL CGSDGTMYYS PCYAGCPADA ETDLGGQKVY
560 570 580 590 600
RGCSCILEKA SSGWGNATAG KCASTCQSKP FLLVLVFVVI IFTFLSSIPA
610 620 630 640 650
LTATLRCVSD RQRSFALGIQ WIVVRTLGSI PGPIAFGWVI DKACLLWQDQ
660 670 680 690 700
CGHQGSCFVY ENEAMSRYML IAGLTFKVLG FLFFVAAYFL YKSPSVSSDG
710 720
LEASLPSQSS ASDSPTEQLQ SNV
Length:723
Mass (Da):77,669
Last modified:January 10, 2003 - v2
Checksum:i0856B45F02C4EBAC
GO
Isoform 2 (identifier: Q8K078-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     629-632: SIPG → TAWG
     633-723: Missing.

Note: No experimental confirmation available.

Show »
Length:632
Mass (Da):67,751
Checksum:iCA2E830914998FD9
GO

Sequence cautioni

The sequence AAH33602.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281S → R in BAC28379 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei629 – 6324SIPG → TAWG in isoform 2. 1 PublicationVSP_006157
Alternative sequencei633 – 72391Missing in isoform 2. 1 PublicationVSP_006158Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033598 mRNA. Translation: BAC28379.1.
BC030719 mRNA. Translation: AAH30719.1.
BC030720 mRNA. Translation: AAH30720.1.
BC033602 mRNA. Translation: AAH33602.1. Different initiation.
CCDSiCCDS17176.1. [Q8K078-1]
RefSeqiNP_683735.1. NM_148933.1. [Q8K078-1]
XP_006500610.1. XM_006500547.2. [Q8K078-1]
UniGeneiMm.133687.

Genome annotation databases

EnsembliENSMUST00000038225; ENSMUSP00000045023; ENSMUSG00000038963. [Q8K078-1]
ENSMUST00000038259; ENSMUSP00000046502; ENSMUSG00000038963. [Q8K078-1]
GeneIDi108115.
KEGGimmu:108115.
UCSCiuc008ojc.2. mouse. [Q8K078-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033598 mRNA. Translation: BAC28379.1.
BC030719 mRNA. Translation: AAH30719.1.
BC030720 mRNA. Translation: AAH30720.1.
BC033602 mRNA. Translation: AAH33602.1. Different initiation.
CCDSiCCDS17176.1. [Q8K078-1]
RefSeqiNP_683735.1. NM_148933.1. [Q8K078-1]
XP_006500610.1. XM_006500547.2. [Q8K078-1]
UniGeneiMm.133687.

3D structure databases

ProteinModelPortaliQ8K078.
SMRiQ8K078. Positions 509-535.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8K078.

Proteomic databases

PaxDbiQ8K078.
PRIDEiQ8K078.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038225; ENSMUSP00000045023; ENSMUSG00000038963. [Q8K078-1]
ENSMUST00000038259; ENSMUSP00000046502; ENSMUSG00000038963. [Q8K078-1]
GeneIDi108115.
KEGGimmu:108115.
UCSCiuc008ojc.2. mouse. [Q8K078-1]

Organism-specific databases

CTDi28231.
MGIiMGI:1351866. Slco4a1.

Phylogenomic databases

eggNOGiNOG320775.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231270.
HOVERGENiHBG100565.
InParanoidiQ8K078.
KOiK14354.
OMAiFKLRCSG.
OrthoDBiEOG75TMBK.
PhylomeDBiQ8K078.
TreeFamiTF317540.

Enzyme and pathway databases

ReactomeiREACT_318911. Transport of organic anions.

Miscellaneous databases

NextBioi360096.
PROiQ8K078.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K078.
GenevestigatoriQ8K078.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Cecum.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6.
    Tissue: Retina.
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSO4A1_MOUSE
AccessioniPrimary (citable) accession number: Q8K078
Secondary accession number(s): Q8BZT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 10, 2003
Last modified: April 1, 2015
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.