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Q8K078

- SO4A1_MOUSE

UniProt

Q8K078 - SO4A1_MOUSE

Protein

Solute carrier organic anion transporter family member 4A1

Gene

Slco4a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (10 Jan 2003)
      Previous versions | rss
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    Functioni

    Mediates the Na+-independent transport of organic anions such as the thyroid hormone T3 (triiodo-L-thyronine) and of taurocholate.By similarity

    GO - Molecular functioni

    1. transporter activity Source: InterPro

    GO - Biological processi

    1. ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_210189. Transport of organic anions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier organic anion transporter family member 4A1
    Alternative name(s):
    Organic anion-transporting polypeptide E
    Short name:
    OATP-E
    Sodium-independent organic anion transporter E
    Solute carrier family 21 member 12
    Gene namesi
    Name:Slco4a1
    Synonyms:Oatp4a1, Oatpe, Slc21a12
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1351866. Slco4a1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 723723Solute carrier organic anion transporter family member 4A1PRO_0000191068Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei39 – 391PhosphoserineBy similarity
    Modified residuei42 – 421PhosphoserineBy similarity
    Modified residuei45 – 451PhosphoserineBy similarity
    Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi506 ↔ 532PROSITE-ProRule annotation
    Disulfide bondi511 ↔ 521PROSITE-ProRule annotation
    Disulfide bondi512 ↔ 536PROSITE-ProRule annotation
    Glycosylationi566 – 5661N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ8K078.
    PRIDEiQ8K078.

    PTM databases

    PhosphoSiteiQ8K078.

    Expressioni

    Gene expression databases

    BgeeiQ8K078.
    GenevestigatoriQ8K078.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K078.
    SMRiQ8K078. Positions 509-535.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 102102CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini124 – 14219ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini164 – 1696CytoplasmicSequence Analysis
    Topological domaini195 – 22430ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini256 – 27419CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini296 – 30914ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini335 – 38046CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini403 – 42220ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini447 – 4504CytoplasmicSequence Analysis
    Topological domaini474 – 582109ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini606 – 6149CytoplasmicSequence Analysis
    Topological domaini641 – 67333ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini692 – 72332CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei103 – 12321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei170 – 19425Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei225 – 25531Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei275 – 29521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei310 – 33425Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei381 – 40222Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei423 – 44624Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei451 – 47323Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei583 – 60523Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei615 – 64026Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei674 – 69118Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini500 – 55758Kazal-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Kazal-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG320775.
    GeneTreeiENSGT00740000115121.
    HOGENOMiHOG000231270.
    HOVERGENiHBG100565.
    InParanoidiQ8K078.
    KOiK14354.
    OMAiFKLRCSG.
    OrthoDBiEOG75TMBK.
    PhylomeDBiQ8K078.
    TreeFamiTF317540.

    Family and domain databases

    InterProiIPR002350. Kazal_dom.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004156. OA_transporter.
    [Graphical view]
    PANTHERiPTHR11388. PTHR11388. 1 hit.
    PfamiPF07648. Kazal_2. 1 hit.
    PF03137. OATP. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 3 hits.
    TIGRFAMsiTIGR00805. oat. 1 hit.
    PROSITEiPS51465. KAZAL_2. 1 hit.
    PS50850. MFS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8K078-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPQHAMGDTH FLSLPKHLFT STSSATDSGC DTPPSSRASP ASLRSAHGTL    50
    GSSSQPLFEP QAEKRSSQTA REVQYVSSGP QNSLCGWQAF TPKCLQVFNT 100
    PKGFLFFLCA ASFLQGMTVN GFINTVITSI ERRFDLHSYQ SGLIASSYDI 150
    AACLCLTFVS YFGGNGHKPR WLGWGVLVLG IGSLVFALPH FTAGRYEVEM 200
    DEGLGTGTCL TNQSHVECKD SASGLSNYRL IFMLGQLLHG VGATPLYTLG 250
    VTYLDENVKS SYSPIYIAIF YTAAILGPAA GYLIGGAMLN VYTEVGQRTE 300
    LTTDSPLWVG AWWIGFLGTG IAAFLIAIPI LGYPRQLPGS QRYVVMRAAE 350
    TQQLKDHSRG AVSNPAFGKT VRDLPLSIWL LLRNPTFILL CLAGATEATL 400
    IAGMSTFGPK FFEAQFSLSA SEAATLFGYL VVPAGGGGTL LGGFLVNKFK 450
    LRGSGIIRFC LFCTLTSLLA FFVFLMHCPN VHMAGVTTGY VGSLLPKGQL 500
    DLKAACNAIY CCQPKHYSPL CGSDGTMYYS PCYAGCPADA ETDLGGQKVY 550
    RGCSCILEKA SSGWGNATAG KCASTCQSKP FLLVLVFVVI IFTFLSSIPA 600
    LTATLRCVSD RQRSFALGIQ WIVVRTLGSI PGPIAFGWVI DKACLLWQDQ 650
    CGHQGSCFVY ENEAMSRYML IAGLTFKVLG FLFFVAAYFL YKSPSVSSDG 700
    LEASLPSQSS ASDSPTEQLQ SNV 723
    Length:723
    Mass (Da):77,669
    Last modified:January 10, 2003 - v2
    Checksum:i0856B45F02C4EBAC
    GO
    Isoform 2 (identifier: Q8K078-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         629-632: SIPG → TAWG
         633-723: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:632
    Mass (Da):67,751
    Checksum:iCA2E830914998FD9
    GO

    Sequence cautioni

    The sequence AAH33602.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti28 – 281S → R in BAC28379. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei629 – 6324SIPG → TAWG in isoform 2. 1 PublicationVSP_006157
    Alternative sequencei633 – 72391Missing in isoform 2. 1 PublicationVSP_006158Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK033598 mRNA. Translation: BAC28379.1.
    BC030719 mRNA. Translation: AAH30719.1.
    BC030720 mRNA. Translation: AAH30720.1.
    BC033602 mRNA. Translation: AAH33602.1. Different initiation.
    CCDSiCCDS17176.1. [Q8K078-1]
    RefSeqiNP_683735.1. NM_148933.1. [Q8K078-1]
    XP_006500610.1. XM_006500547.1. [Q8K078-1]
    UniGeneiMm.133687.

    Genome annotation databases

    EnsembliENSMUST00000038225; ENSMUSP00000045023; ENSMUSG00000038963. [Q8K078-1]
    ENSMUST00000038259; ENSMUSP00000046502; ENSMUSG00000038963. [Q8K078-1]
    GeneIDi108115.
    KEGGimmu:108115.
    UCSCiuc008ojc.2. mouse. [Q8K078-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK033598 mRNA. Translation: BAC28379.1 .
    BC030719 mRNA. Translation: AAH30719.1 .
    BC030720 mRNA. Translation: AAH30720.1 .
    BC033602 mRNA. Translation: AAH33602.1 . Different initiation.
    CCDSi CCDS17176.1. [Q8K078-1 ]
    RefSeqi NP_683735.1. NM_148933.1. [Q8K078-1 ]
    XP_006500610.1. XM_006500547.1. [Q8K078-1 ]
    UniGenei Mm.133687.

    3D structure databases

    ProteinModelPortali Q8K078.
    SMRi Q8K078. Positions 509-535.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8K078.

    Proteomic databases

    PaxDbi Q8K078.
    PRIDEi Q8K078.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000038225 ; ENSMUSP00000045023 ; ENSMUSG00000038963 . [Q8K078-1 ]
    ENSMUST00000038259 ; ENSMUSP00000046502 ; ENSMUSG00000038963 . [Q8K078-1 ]
    GeneIDi 108115.
    KEGGi mmu:108115.
    UCSCi uc008ojc.2. mouse. [Q8K078-1 ]

    Organism-specific databases

    CTDi 28231.
    MGIi MGI:1351866. Slco4a1.

    Phylogenomic databases

    eggNOGi NOG320775.
    GeneTreei ENSGT00740000115121.
    HOGENOMi HOG000231270.
    HOVERGENi HBG100565.
    InParanoidi Q8K078.
    KOi K14354.
    OMAi FKLRCSG.
    OrthoDBi EOG75TMBK.
    PhylomeDBi Q8K078.
    TreeFami TF317540.

    Enzyme and pathway databases

    Reactomei REACT_210189. Transport of organic anions.

    Miscellaneous databases

    NextBioi 360096.
    PROi Q8K078.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8K078.
    Genevestigatori Q8K078.

    Family and domain databases

    InterProi IPR002350. Kazal_dom.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004156. OA_transporter.
    [Graphical view ]
    PANTHERi PTHR11388. PTHR11388. 1 hit.
    Pfami PF07648. Kazal_2. 1 hit.
    PF03137. OATP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 3 hits.
    TIGRFAMsi TIGR00805. oat. 1 hit.
    PROSITEi PS51465. KAZAL_2. 1 hit.
    PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Cecum.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6.
      Tissue: Retina.
    3. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSO4A1_MOUSE
    AccessioniPrimary (citable) accession number: Q8K078
    Secondary accession number(s): Q8BZT4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2003
    Last sequence update: January 10, 2003
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3