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Protein

Intraflagellar transport protein 80 homolog

Gene

Ift80

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia.By similarity

GO - Biological processi

  • bone morphogenesis Source: MGI
  • chondrocyte differentiation Source: MGI
  • cilium assembly Source: MGI
  • intraciliary transport Source: MGI
  • negative regulation of epithelial cell proliferation Source: MGI
  • negative regulation of non-canonical Wnt signaling pathway Source: MGI
  • non-motile cilium assembly Source: MGI
  • osteoblast differentiation Source: MGI
  • positive regulation of smoothened signaling pathway Source: MGI
  • smoothened signaling pathway Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-5620924 Intraflagellar transport

Names & Taxonomyi

Protein namesi
Recommended name:
Intraflagellar transport protein 80 homolog
Alternative name(s):
WD repeat-containing protein 56
Gene namesi
Name:Ift80
Synonyms:Kiaa1374, Wdr56
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1915509 Ift80

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000510431 – 777Intraflagellar transport protein 80 homologAdd BLAST777

Proteomic databases

PaxDbiQ8K057
PRIDEiQ8K057

PTM databases

iPTMnetiQ8K057
PhosphoSitePlusiQ8K057

Expressioni

Gene expression databases

BgeeiENSMUSG00000027778
ExpressionAtlasiQ8K057 baseline and differential
GenevisibleiQ8K057 MM

Interactioni

Subunit structurei

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT88.1 Publication

Protein-protein interaction databases

BioGridi212765, 1 interactor
STRINGi10090.ENSMUSP00000029347

Structurei

3D structure databases

ProteinModelPortaliQ8K057
SMRiQ8K057
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati12 – 50WD 1Add BLAST39
Repeati104 – 143WD 2Add BLAST40
Repeati145 – 185WD 3Add BLAST41
Repeati186 – 225WD 4Add BLAST40
Repeati227 – 265WD 5Add BLAST39
Repeati267 – 306WD 6Add BLAST40
Repeati504 – 542WD 7Add BLAST39

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1524 Eukaryota
COG2319 LUCA
GeneTreeiENSGT00440000033499
HOGENOMiHOG000256816
HOVERGENiHBG056828
InParanoidiQ8K057
KOiK19678
OMAiIRWRAHD
OrthoDBiEOG091G03FC
PhylomeDBiQ8K057
TreeFamiTF106117

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 2 hits
SSF50998 SSF50998, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8K057-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLKISLSKE PKHQELVSCV GWTTAEELYS CSDDHQIVKW NLLTSETSLI
60 70 80 90 100
VKLPDDIYPI DLHWFPKSLG IKKQTQAESF VLTSSDGKFH LISKLGRVEK
110 120 130 140 150
SVEAHCGAVL AGRWNYEGTA LVTVGEDGQV KIWSKTGMLR STLAQQGTPV
160 170 180 190 200
YSVAWGPDSE KVLYTAGKQL IIKPLQPNAK VLQWKAHDGI ILKVDWNSVN
210 220 230 240 250
DLILSAGEDC KYKVWDSYGR VLYGSQPHEH PITSVAWAPD GELFAVGSFH
260 270 280 290 300
TLRLCDKTGW SYALEKPNTG SIFNIAWSID GTQIAGACGN GHVVFAHVVE
310 320 330 340 350
QRWEWKNFQV TLTKRRTMQV RNVLNDAVDL LEFRDRVIKA SLNHAHLVVS
360 370 380 390 400
TSLQCYVFST KNWNTPLIFD LKEGTVSLIL QAERHFLLVD GGGIYLHSYE
410 420 430 440 450
GRFISSPKFP GMRTDILNAQ TVSLSNDTIA IKDKADEKII FLFEASTGKP
460 470 480 490 500
LGDGKLLSHK NEISEIALDQ KGLTNDRKIA FIDKNRDLYI TSVKRFGKEE
510 520 530 540 550
QIIKLGTMVH TLAWCDTCNI LCGIQDTRFT VWYYPNTIYV DRDILPKTLY
560 570 580 590 600
ERDASEYSKN PHIVSFVGNQ VTIRRADGSL VHISISPYPA ILHEYVSSSK
610 620 630 640 650
WEEAVRLCRF VKEQSMWACL AAMAVANRDM VTAEIAYAAV GEIDKVRYIN
660 670 680 690 700
AIKDLPSRES KMAHILMFSG NIQEAETVLL QAGLVYQAIQ ININLYNWER
710 720 730 740 750
ALELAVKYKT HVDTVLAYRQ KFLDTFGKQE TNKRYLQYAE GLQIDWEKIK
760 770
AKIEMEITKE RDRSSSGQSS KSVGLKH
Length:777
Mass (Da):87,811
Last modified:October 1, 2002 - v1
Checksum:i2B01621A12E660C4
GO
Isoform 2 (identifier: Q8K057-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     439-439: I → K
     440-440: Missing.

Note: No experimental confirmation available.
Show »
Length:776
Mass (Da):87,712
Checksum:iC87C1E4C6A91C300
GO

Sequence cautioni

The sequence BAC98149 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027991439I → K in isoform 2. 1 Publication1
Alternative sequenceiVSP_027992440Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129339 mRNA Translation: BAC98149.1 Different initiation.
BC013814 mRNA Translation: AAH13814.1
BC034101 mRNA Translation: AAH34101.1
AK042231 mRNA Translation: BAC31200.1
CCDSiCCDS38451.1 [Q8K057-1]
RefSeqiNP_080917.1, NM_026641.2 [Q8K057-1]
XP_006502029.1, XM_006501966.3 [Q8K057-1]
UniGeneiMm.389451

Genome annotation databases

EnsembliENSMUST00000029347; ENSMUSP00000029347; ENSMUSG00000027778 [Q8K057-1]
ENSMUST00000107812; ENSMUSP00000103442; ENSMUSG00000027778 [Q8K057-1]
ENSMUST00000169064; ENSMUSP00000133263; ENSMUSG00000027778 [Q8K057-1]
GeneIDi68259
KEGGimmu:68259
UCSCiuc033hub.1 mouse [Q8K057-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiIFT80_MOUSE
AccessioniPrimary (citable) accession number: Q8K057
Secondary accession number(s): Q6ZPT0, Q8C9F1, Q91YV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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