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Q8K057

- IFT80_MOUSE

UniProt

Q8K057 - IFT80_MOUSE

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Protein

Intraflagellar transport protein 80 homolog

Gene

Ift80

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia.By similarity

GO - Biological processi

  1. bone morphogenesis Source: MGI
  2. chondrocyte differentiation Source: MGI
  3. cilium assembly Source: MGI
  4. cilium morphogenesis Source: MGI
  5. intraciliary transport Source: MGI
  6. negative regulation of epithelial cell proliferation Source: MGI
  7. negative regulation of non-canonical Wnt signaling pathway Source: MGI
  8. osteoblast differentiation Source: MGI
  9. positive regulation of smoothened signaling pathway Source: MGI
  10. smoothened signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Intraflagellar transport protein 80 homolog
Alternative name(s):
WD repeat-containing protein 56
Gene namesi
Name:Ift80
Synonyms:Kiaa1374, Wdr56
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1915509. Ift80.

Subcellular locationi

Cytoplasm. Cytoplasmcytoskeletoncilium basal body. Cytoplasmcytoskeletoncilium axoneme
Note: Basal body and ciliary axoneme in the chondrocytic ATDC-5 cell line.

GO - Cellular componenti

  1. centrosome Source: MGI
  2. ciliary basal body Source: MGI
  3. cilium Source: MGI
  4. cytoplasm Source: UniProtKB-KW
  5. intraciliary transport particle B Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 777777Intraflagellar transport protein 80 homologPRO_0000051043Add
BLAST

Proteomic databases

MaxQBiQ8K057.
PaxDbiQ8K057.
PRIDEiQ8K057.

PTM databases

PhosphoSiteiQ8K057.

Expressioni

Gene expression databases

BgeeiQ8K057.
ExpressionAtlasiQ8K057. baseline and differential.
GenevestigatoriQ8K057.

Interactioni

Subunit structurei

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT88.1 Publication

Protein-protein interaction databases

BioGridi212765. 1 interaction.
STRINGi10090.ENSMUSP00000029347.

Structurei

3D structure databases

ProteinModelPortaliQ8K057.
SMRiQ8K057. Positions 25-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati12 – 5039WD 1Add
BLAST
Repeati104 – 14340WD 2Add
BLAST
Repeati145 – 18541WD 3Add
BLAST
Repeati186 – 22540WD 4Add
BLAST
Repeati227 – 26539WD 5Add
BLAST
Repeati267 – 30640WD 6Add
BLAST
Repeati504 – 54239WD 7Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00440000033499.
HOGENOMiHOG000256816.
HOVERGENiHBG056828.
InParanoidiQ8K057.
OMAiADELYSC.
OrthoDBiEOG7T4MJK.
PhylomeDBiQ8K057.
TreeFamiTF106117.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR011047. Quinonprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
SSF50998. SSF50998. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8K057-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLKISLSKE PKHQELVSCV GWTTAEELYS CSDDHQIVKW NLLTSETSLI
60 70 80 90 100
VKLPDDIYPI DLHWFPKSLG IKKQTQAESF VLTSSDGKFH LISKLGRVEK
110 120 130 140 150
SVEAHCGAVL AGRWNYEGTA LVTVGEDGQV KIWSKTGMLR STLAQQGTPV
160 170 180 190 200
YSVAWGPDSE KVLYTAGKQL IIKPLQPNAK VLQWKAHDGI ILKVDWNSVN
210 220 230 240 250
DLILSAGEDC KYKVWDSYGR VLYGSQPHEH PITSVAWAPD GELFAVGSFH
260 270 280 290 300
TLRLCDKTGW SYALEKPNTG SIFNIAWSID GTQIAGACGN GHVVFAHVVE
310 320 330 340 350
QRWEWKNFQV TLTKRRTMQV RNVLNDAVDL LEFRDRVIKA SLNHAHLVVS
360 370 380 390 400
TSLQCYVFST KNWNTPLIFD LKEGTVSLIL QAERHFLLVD GGGIYLHSYE
410 420 430 440 450
GRFISSPKFP GMRTDILNAQ TVSLSNDTIA IKDKADEKII FLFEASTGKP
460 470 480 490 500
LGDGKLLSHK NEISEIALDQ KGLTNDRKIA FIDKNRDLYI TSVKRFGKEE
510 520 530 540 550
QIIKLGTMVH TLAWCDTCNI LCGIQDTRFT VWYYPNTIYV DRDILPKTLY
560 570 580 590 600
ERDASEYSKN PHIVSFVGNQ VTIRRADGSL VHISISPYPA ILHEYVSSSK
610 620 630 640 650
WEEAVRLCRF VKEQSMWACL AAMAVANRDM VTAEIAYAAV GEIDKVRYIN
660 670 680 690 700
AIKDLPSRES KMAHILMFSG NIQEAETVLL QAGLVYQAIQ ININLYNWER
710 720 730 740 750
ALELAVKYKT HVDTVLAYRQ KFLDTFGKQE TNKRYLQYAE GLQIDWEKIK
760 770
AKIEMEITKE RDRSSSGQSS KSVGLKH
Length:777
Mass (Da):87,811
Last modified:October 1, 2002 - v1
Checksum:i2B01621A12E660C4
GO
Isoform 2 (identifier: Q8K057-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     439-439: I → K
     440-440: Missing.

Note: No experimental confirmation available.

Show »
Length:776
Mass (Da):87,712
Checksum:iC87C1E4C6A91C300
GO

Sequence cautioni

The sequence BAC98149.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei439 – 4391I → K in isoform 2. 1 PublicationVSP_027991
Alternative sequencei440 – 4401Missing in isoform 2. 1 PublicationVSP_027992

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK129339 mRNA. Translation: BAC98149.1. Different initiation.
BC013814 mRNA. Translation: AAH13814.1.
BC034101 mRNA. Translation: AAH34101.1.
AK042231 mRNA. Translation: BAC31200.1.
CCDSiCCDS38451.1. [Q8K057-1]
RefSeqiNP_080917.1. NM_026641.2. [Q8K057-1]
XP_006502029.1. XM_006501966.1. [Q8K057-1]
UniGeneiMm.389451.

Genome annotation databases

EnsembliENSMUST00000029347; ENSMUSP00000029347; ENSMUSG00000027778. [Q8K057-1]
ENSMUST00000107812; ENSMUSP00000103442; ENSMUSG00000027778. [Q8K057-1]
ENSMUST00000169064; ENSMUSP00000133263; ENSMUSG00000027778. [Q8K057-1]
GeneIDi68259.
KEGGimmu:68259.
UCSCiuc008plx.2. mouse. [Q8K057-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK129339 mRNA. Translation: BAC98149.1 . Different initiation.
BC013814 mRNA. Translation: AAH13814.1 .
BC034101 mRNA. Translation: AAH34101.1 .
AK042231 mRNA. Translation: BAC31200.1 .
CCDSi CCDS38451.1. [Q8K057-1 ]
RefSeqi NP_080917.1. NM_026641.2. [Q8K057-1 ]
XP_006502029.1. XM_006501966.1. [Q8K057-1 ]
UniGenei Mm.389451.

3D structure databases

ProteinModelPortali Q8K057.
SMRi Q8K057. Positions 25-293.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 212765. 1 interaction.
STRINGi 10090.ENSMUSP00000029347.

PTM databases

PhosphoSitei Q8K057.

Proteomic databases

MaxQBi Q8K057.
PaxDbi Q8K057.
PRIDEi Q8K057.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029347 ; ENSMUSP00000029347 ; ENSMUSG00000027778 . [Q8K057-1 ]
ENSMUST00000107812 ; ENSMUSP00000103442 ; ENSMUSG00000027778 . [Q8K057-1 ]
ENSMUST00000169064 ; ENSMUSP00000133263 ; ENSMUSG00000027778 . [Q8K057-1 ]
GeneIDi 68259.
KEGGi mmu:68259.
UCSCi uc008plx.2. mouse. [Q8K057-1 ]

Organism-specific databases

CTDi 57560.
MGIi MGI:1915509. Ift80.
Rougei Search...

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00440000033499.
HOGENOMi HOG000256816.
HOVERGENi HBG056828.
InParanoidi Q8K057.
OMAi ADELYSC.
OrthoDBi EOG7T4MJK.
PhylomeDBi Q8K057.
TreeFami TF106117.

Miscellaneous databases

NextBioi 326842.
PROi Q8K057.
SOURCEi Search...

Gene expression databases

Bgeei Q8K057.
ExpressionAtlasi Q8K057. baseline and differential.
Genevestigatori Q8K057.

Family and domain databases

Gene3Di 2.130.10.10. 2 hits.
InterProi IPR011047. Quinonprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 3 hits.
[Graphical view ]
SMARTi SM00320. WD40. 6 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 2 hits.
SSF50998. SSF50998. 1 hit.
PROSITEi PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Embryonic tail.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye and Mammary tumor.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-751 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Thymus.
  4. "IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy."
    Beales P.L., Bland E., Tobin J.L., Bacchelli C., Tuysuz B., Hill J., Rix S., Pearson C.G., Kai M., Hartley J., Johnson C., Irving M., Elcioglu N., Winey M., Tada M., Scambler P.J.
    Nat. Genet. 39:727-729(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  5. Cited for: IDENTIFICATION IN THE IFT COMPLEX B, INTERACTION WITH IFT88, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiIFT80_MOUSE
AccessioniPrimary (citable) accession number: Q8K057
Secondary accession number(s): Q6ZPT0, Q8C9F1, Q91YV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3