SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8K057

- IFT80_MOUSE

UniProt

Q8K057 - IFT80_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Intraflagellar transport protein 80 homolog
Gene
Ift80, Kiaa1374, Wdr56
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia By similarity.

GO - Biological processi

  1. bone morphogenesis Source: MGI
  2. chondrocyte differentiation Source: MGI
  3. cilium assembly Source: MGI
  4. cilium morphogenesis Source: MGI
  5. intraciliary transport Source: MGI
  6. negative regulation of epithelial cell proliferation Source: MGI
  7. negative regulation of non-canonical Wnt signaling pathway Source: MGI
  8. osteoblast differentiation Source: MGI
  9. positive regulation of smoothened signaling pathway Source: MGI
  10. smoothened signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Intraflagellar transport protein 80 homolog
Alternative name(s):
WD repeat-containing protein 56
Gene namesi
Name:Ift80
Synonyms:Kiaa1374, Wdr56
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1915509. Ift80.

Subcellular locationi

Cytoplasm. Cytoplasmcytoskeletoncilium basal body. Cytoplasmcytoskeletoncilium axoneme
Note: Basal body and ciliary axoneme in the chondrocytic ATDC-5 cell line.2 Publications

GO - Cellular componenti

  1. centrosome Source: MGI
  2. ciliary basal body Source: MGI
  3. cilium Source: MGI
  4. cytoplasm Source: UniProtKB-SubCell
  5. intraciliary transport particle B Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 777777Intraflagellar transport protein 80 homolog
PRO_0000051043Add
BLAST

Proteomic databases

MaxQBiQ8K057.
PaxDbiQ8K057.
PRIDEiQ8K057.

PTM databases

PhosphoSiteiQ8K057.

Expressioni

Gene expression databases

ArrayExpressiQ8K057.
BgeeiQ8K057.
GenevestigatoriQ8K057.

Interactioni

Subunit structurei

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT88.1 Publication

Protein-protein interaction databases

BioGridi212765. 1 interaction.
STRINGi10090.ENSMUSP00000029347.

Structurei

3D structure databases

ProteinModelPortaliQ8K057.
SMRiQ8K057. Positions 25-293.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati12 – 5039WD 1
Add
BLAST
Repeati104 – 14340WD 2
Add
BLAST
Repeati145 – 18541WD 3
Add
BLAST
Repeati186 – 22540WD 4
Add
BLAST
Repeati227 – 26539WD 5
Add
BLAST
Repeati267 – 30640WD 6
Add
BLAST
Repeati504 – 54239WD 7
Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00440000033499.
HOGENOMiHOG000256816.
HOVERGENiHBG056828.
InParanoidiQ8K057.
OMAiADELYSC.
OrthoDBiEOG7T4MJK.
PhylomeDBiQ8K057.
TreeFamiTF106117.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR011047. Quinonprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
SSF50998. SSF50998. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8K057-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRLKISLSKE PKHQELVSCV GWTTAEELYS CSDDHQIVKW NLLTSETSLI    50
VKLPDDIYPI DLHWFPKSLG IKKQTQAESF VLTSSDGKFH LISKLGRVEK 100
SVEAHCGAVL AGRWNYEGTA LVTVGEDGQV KIWSKTGMLR STLAQQGTPV 150
YSVAWGPDSE KVLYTAGKQL IIKPLQPNAK VLQWKAHDGI ILKVDWNSVN 200
DLILSAGEDC KYKVWDSYGR VLYGSQPHEH PITSVAWAPD GELFAVGSFH 250
TLRLCDKTGW SYALEKPNTG SIFNIAWSID GTQIAGACGN GHVVFAHVVE 300
QRWEWKNFQV TLTKRRTMQV RNVLNDAVDL LEFRDRVIKA SLNHAHLVVS 350
TSLQCYVFST KNWNTPLIFD LKEGTVSLIL QAERHFLLVD GGGIYLHSYE 400
GRFISSPKFP GMRTDILNAQ TVSLSNDTIA IKDKADEKII FLFEASTGKP 450
LGDGKLLSHK NEISEIALDQ KGLTNDRKIA FIDKNRDLYI TSVKRFGKEE 500
QIIKLGTMVH TLAWCDTCNI LCGIQDTRFT VWYYPNTIYV DRDILPKTLY 550
ERDASEYSKN PHIVSFVGNQ VTIRRADGSL VHISISPYPA ILHEYVSSSK 600
WEEAVRLCRF VKEQSMWACL AAMAVANRDM VTAEIAYAAV GEIDKVRYIN 650
AIKDLPSRES KMAHILMFSG NIQEAETVLL QAGLVYQAIQ ININLYNWER 700
ALELAVKYKT HVDTVLAYRQ KFLDTFGKQE TNKRYLQYAE GLQIDWEKIK 750
AKIEMEITKE RDRSSSGQSS KSVGLKH 777
Length:777
Mass (Da):87,811
Last modified:October 1, 2002 - v1
Checksum:i2B01621A12E660C4
GO
Isoform 2 (identifier: Q8K057-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     439-439: I → K
     440-440: Missing.

Note: No experimental confirmation available.

Show »
Length:776
Mass (Da):87,712
Checksum:iC87C1E4C6A91C300
GO

Sequence cautioni

The sequence BAC98149.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei439 – 4391I → K in isoform 2.
VSP_027991
Alternative sequencei440 – 4401Missing in isoform 2.
VSP_027992

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK129339 mRNA. Translation: BAC98149.1. Different initiation.
BC013814 mRNA. Translation: AAH13814.1.
BC034101 mRNA. Translation: AAH34101.1.
AK042231 mRNA. Translation: BAC31200.1.
CCDSiCCDS38451.1. [Q8K057-1]
RefSeqiNP_080917.1. NM_026641.2. [Q8K057-1]
XP_006502029.1. XM_006501966.1. [Q8K057-1]
UniGeneiMm.389451.

Genome annotation databases

EnsembliENSMUST00000029347; ENSMUSP00000029347; ENSMUSG00000027778. [Q8K057-1]
ENSMUST00000107812; ENSMUSP00000103442; ENSMUSG00000027778. [Q8K057-1]
ENSMUST00000169064; ENSMUSP00000133263; ENSMUSG00000027778. [Q8K057-1]
GeneIDi68259.
KEGGimmu:68259.
UCSCiuc008plx.2. mouse. [Q8K057-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK129339 mRNA. Translation: BAC98149.1 . Different initiation.
BC013814 mRNA. Translation: AAH13814.1 .
BC034101 mRNA. Translation: AAH34101.1 .
AK042231 mRNA. Translation: BAC31200.1 .
CCDSi CCDS38451.1. [Q8K057-1 ]
RefSeqi NP_080917.1. NM_026641.2. [Q8K057-1 ]
XP_006502029.1. XM_006501966.1. [Q8K057-1 ]
UniGenei Mm.389451.

3D structure databases

ProteinModelPortali Q8K057.
SMRi Q8K057. Positions 25-293.
ModBasei Search...

Protein-protein interaction databases

BioGridi 212765. 1 interaction.
STRINGi 10090.ENSMUSP00000029347.

PTM databases

PhosphoSitei Q8K057.

Proteomic databases

MaxQBi Q8K057.
PaxDbi Q8K057.
PRIDEi Q8K057.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029347 ; ENSMUSP00000029347 ; ENSMUSG00000027778 . [Q8K057-1 ]
ENSMUST00000107812 ; ENSMUSP00000103442 ; ENSMUSG00000027778 . [Q8K057-1 ]
ENSMUST00000169064 ; ENSMUSP00000133263 ; ENSMUSG00000027778 . [Q8K057-1 ]
GeneIDi 68259.
KEGGi mmu:68259.
UCSCi uc008plx.2. mouse. [Q8K057-1 ]

Organism-specific databases

CTDi 57560.
MGIi MGI:1915509. Ift80.
Rougei Search...

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00440000033499.
HOGENOMi HOG000256816.
HOVERGENi HBG056828.
InParanoidi Q8K057.
OMAi ADELYSC.
OrthoDBi EOG7T4MJK.
PhylomeDBi Q8K057.
TreeFami TF106117.

Miscellaneous databases

NextBioi 326842.
PROi Q8K057.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8K057.
Bgeei Q8K057.
Genevestigatori Q8K057.

Family and domain databases

Gene3Di 2.130.10.10. 2 hits.
InterProi IPR011047. Quinonprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 3 hits.
[Graphical view ]
SMARTi SM00320. WD40. 6 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 2 hits.
SSF50998. SSF50998. 1 hit.
PROSITEi PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Embryonic tail.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye and Mammary tumor.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-751 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Thymus.
  4. "IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy."
    Beales P.L., Bland E., Tobin J.L., Bacchelli C., Tuysuz B., Hill J., Rix S., Pearson C.G., Kai M., Hartley J., Johnson C., Irving M., Elcioglu N., Winey M., Tada M., Scambler P.J.
    Nat. Genet. 39:727-729(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  5. Cited for: IDENTIFICATION IN THE IFT COMPLEX B, INTERACTION WITH IFT88, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiIFT80_MOUSE
AccessioniPrimary (citable) accession number: Q8K057
Secondary accession number(s): Q6ZPT0, Q8C9F1, Q91YV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi