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Protein

Intraflagellar transport protein 80 homolog

Gene

Ift80

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia.By similarity

GO - Biological processi

  • bone morphogenesis Source: MGI
  • chondrocyte differentiation Source: MGI
  • cilium assembly Source: MGI
  • intraciliary transport Source: MGI
  • negative regulation of epithelial cell proliferation Source: MGI
  • negative regulation of non-canonical Wnt signaling pathway Source: MGI
  • non-motile cilium assembly Source: MGI
  • osteoblast differentiation Source: MGI
  • positive regulation of smoothened signaling pathway Source: MGI
  • smoothened signaling pathway Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-5620924. Intraflagellar transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Intraflagellar transport protein 80 homolog
Alternative name(s):
WD repeat-containing protein 56
Gene namesi
Name:Ift80
Synonyms:Kiaa1374, Wdr56
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1915509. Ift80.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: MGI
  • ciliary basal body Source: MGI
  • cilium Source: MGI
  • cytoplasm Source: UniProtKB-SubCell
  • intraciliary transport particle B Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000510431 – 777Intraflagellar transport protein 80 homologAdd BLAST777

Proteomic databases

PaxDbiQ8K057.
PRIDEiQ8K057.

PTM databases

iPTMnetiQ8K057.
PhosphoSitePlusiQ8K057.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027778.
ExpressionAtlasiQ8K057. baseline and differential.
GenevisibleiQ8K057. MM.

Interactioni

Subunit structurei

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT88.1 Publication

Protein-protein interaction databases

BioGridi212765. 1 interactor.
STRINGi10090.ENSMUSP00000029347.

Structurei

3D structure databases

ProteinModelPortaliQ8K057.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati12 – 50WD 1Add BLAST39
Repeati104 – 143WD 2Add BLAST40
Repeati145 – 185WD 3Add BLAST41
Repeati186 – 225WD 4Add BLAST40
Repeati227 – 265WD 5Add BLAST39
Repeati267 – 306WD 6Add BLAST40
Repeati504 – 542WD 7Add BLAST39

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1524. Eukaryota.
COG2319. LUCA.
GeneTreeiENSGT00440000033499.
HOGENOMiHOG000256816.
HOVERGENiHBG056828.
InParanoidiQ8K057.
KOiK19678.
OMAiWRAHDGL.
OrthoDBiEOG091G03FC.
PhylomeDBiQ8K057.
TreeFamiTF106117.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
SSF50998. SSF50998. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8K057-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLKISLSKE PKHQELVSCV GWTTAEELYS CSDDHQIVKW NLLTSETSLI
60 70 80 90 100
VKLPDDIYPI DLHWFPKSLG IKKQTQAESF VLTSSDGKFH LISKLGRVEK
110 120 130 140 150
SVEAHCGAVL AGRWNYEGTA LVTVGEDGQV KIWSKTGMLR STLAQQGTPV
160 170 180 190 200
YSVAWGPDSE KVLYTAGKQL IIKPLQPNAK VLQWKAHDGI ILKVDWNSVN
210 220 230 240 250
DLILSAGEDC KYKVWDSYGR VLYGSQPHEH PITSVAWAPD GELFAVGSFH
260 270 280 290 300
TLRLCDKTGW SYALEKPNTG SIFNIAWSID GTQIAGACGN GHVVFAHVVE
310 320 330 340 350
QRWEWKNFQV TLTKRRTMQV RNVLNDAVDL LEFRDRVIKA SLNHAHLVVS
360 370 380 390 400
TSLQCYVFST KNWNTPLIFD LKEGTVSLIL QAERHFLLVD GGGIYLHSYE
410 420 430 440 450
GRFISSPKFP GMRTDILNAQ TVSLSNDTIA IKDKADEKII FLFEASTGKP
460 470 480 490 500
LGDGKLLSHK NEISEIALDQ KGLTNDRKIA FIDKNRDLYI TSVKRFGKEE
510 520 530 540 550
QIIKLGTMVH TLAWCDTCNI LCGIQDTRFT VWYYPNTIYV DRDILPKTLY
560 570 580 590 600
ERDASEYSKN PHIVSFVGNQ VTIRRADGSL VHISISPYPA ILHEYVSSSK
610 620 630 640 650
WEEAVRLCRF VKEQSMWACL AAMAVANRDM VTAEIAYAAV GEIDKVRYIN
660 670 680 690 700
AIKDLPSRES KMAHILMFSG NIQEAETVLL QAGLVYQAIQ ININLYNWER
710 720 730 740 750
ALELAVKYKT HVDTVLAYRQ KFLDTFGKQE TNKRYLQYAE GLQIDWEKIK
760 770
AKIEMEITKE RDRSSSGQSS KSVGLKH
Length:777
Mass (Da):87,811
Last modified:October 1, 2002 - v1
Checksum:i2B01621A12E660C4
GO
Isoform 2 (identifier: Q8K057-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     439-439: I → K
     440-440: Missing.

Note: No experimental confirmation available.
Show »
Length:776
Mass (Da):87,712
Checksum:iC87C1E4C6A91C300
GO

Sequence cautioni

The sequence BAC98149 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027991439I → K in isoform 2. 1 Publication1
Alternative sequenceiVSP_027992440Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129339 mRNA. Translation: BAC98149.1. Different initiation.
BC013814 mRNA. Translation: AAH13814.1.
BC034101 mRNA. Translation: AAH34101.1.
AK042231 mRNA. Translation: BAC31200.1.
CCDSiCCDS38451.1. [Q8K057-1]
RefSeqiNP_080917.1. NM_026641.2. [Q8K057-1]
XP_006502029.1. XM_006501966.3. [Q8K057-1]
UniGeneiMm.389451.

Genome annotation databases

EnsembliENSMUST00000029347; ENSMUSP00000029347; ENSMUSG00000027778. [Q8K057-1]
ENSMUST00000107812; ENSMUSP00000103442; ENSMUSG00000027778. [Q8K057-1]
ENSMUST00000169064; ENSMUSP00000133263; ENSMUSG00000027778. [Q8K057-1]
GeneIDi68259.
KEGGimmu:68259.
UCSCiuc033hub.1. mouse. [Q8K057-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129339 mRNA. Translation: BAC98149.1. Different initiation.
BC013814 mRNA. Translation: AAH13814.1.
BC034101 mRNA. Translation: AAH34101.1.
AK042231 mRNA. Translation: BAC31200.1.
CCDSiCCDS38451.1. [Q8K057-1]
RefSeqiNP_080917.1. NM_026641.2. [Q8K057-1]
XP_006502029.1. XM_006501966.3. [Q8K057-1]
UniGeneiMm.389451.

3D structure databases

ProteinModelPortaliQ8K057.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212765. 1 interactor.
STRINGi10090.ENSMUSP00000029347.

PTM databases

iPTMnetiQ8K057.
PhosphoSitePlusiQ8K057.

Proteomic databases

PaxDbiQ8K057.
PRIDEiQ8K057.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029347; ENSMUSP00000029347; ENSMUSG00000027778. [Q8K057-1]
ENSMUST00000107812; ENSMUSP00000103442; ENSMUSG00000027778. [Q8K057-1]
ENSMUST00000169064; ENSMUSP00000133263; ENSMUSG00000027778. [Q8K057-1]
GeneIDi68259.
KEGGimmu:68259.
UCSCiuc033hub.1. mouse. [Q8K057-1]

Organism-specific databases

CTDi57560.
MGIiMGI:1915509. Ift80.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1524. Eukaryota.
COG2319. LUCA.
GeneTreeiENSGT00440000033499.
HOGENOMiHOG000256816.
HOVERGENiHBG056828.
InParanoidiQ8K057.
KOiK19678.
OMAiWRAHDGL.
OrthoDBiEOG091G03FC.
PhylomeDBiQ8K057.
TreeFamiTF106117.

Enzyme and pathway databases

ReactomeiR-MMU-5620924. Intraflagellar transport.

Miscellaneous databases

ChiTaRSiIft80. mouse.
PROiQ8K057.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027778.
ExpressionAtlasiQ8K057. baseline and differential.
GenevisibleiQ8K057. MM.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
SSF50998. SSF50998. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIFT80_MOUSE
AccessioniPrimary (citable) accession number: Q8K057
Secondary accession number(s): Q6ZPT0, Q8C9F1, Q91YV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.