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Q8K057

- IFT80_MOUSE

UniProt

Q8K057 - IFT80_MOUSE

Protein

Intraflagellar transport protein 80 homolog

Gene

Ift80

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia.By similarity

    GO - Biological processi

    1. bone morphogenesis Source: MGI
    2. chondrocyte differentiation Source: MGI
    3. cilium assembly Source: MGI
    4. cilium morphogenesis Source: MGI
    5. intraciliary transport Source: MGI
    6. negative regulation of epithelial cell proliferation Source: MGI
    7. negative regulation of non-canonical Wnt signaling pathway Source: MGI
    8. osteoblast differentiation Source: MGI
    9. positive regulation of smoothened signaling pathway Source: MGI
    10. smoothened signaling pathway Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Intraflagellar transport protein 80 homolog
    Alternative name(s):
    WD repeat-containing protein 56
    Gene namesi
    Name:Ift80
    Synonyms:Kiaa1374, Wdr56
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1915509. Ift80.

    Subcellular locationi

    Cytoplasm. Cytoplasmcytoskeletoncilium basal body. Cytoplasmcytoskeletoncilium axoneme
    Note: Basal body and ciliary axoneme in the chondrocytic ATDC-5 cell line.

    GO - Cellular componenti

    1. centrosome Source: MGI
    2. ciliary basal body Source: MGI
    3. cilium Source: MGI
    4. cytoplasm Source: UniProtKB-SubCell
    5. intraciliary transport particle B Source: MGI

    Keywords - Cellular componenti

    Cell projection, Cilium, Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 777777Intraflagellar transport protein 80 homologPRO_0000051043Add
    BLAST

    Proteomic databases

    MaxQBiQ8K057.
    PaxDbiQ8K057.
    PRIDEiQ8K057.

    PTM databases

    PhosphoSiteiQ8K057.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8K057.
    BgeeiQ8K057.
    GenevestigatoriQ8K057.

    Interactioni

    Subunit structurei

    Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT88.1 Publication

    Protein-protein interaction databases

    BioGridi212765. 1 interaction.
    STRINGi10090.ENSMUSP00000029347.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K057.
    SMRiQ8K057. Positions 25-293.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati12 – 5039WD 1Add
    BLAST
    Repeati104 – 14340WD 2Add
    BLAST
    Repeati145 – 18541WD 3Add
    BLAST
    Repeati186 – 22540WD 4Add
    BLAST
    Repeati227 – 26539WD 5Add
    BLAST
    Repeati267 – 30640WD 6Add
    BLAST
    Repeati504 – 54239WD 7Add
    BLAST

    Sequence similaritiesi

    Contains 7 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    GeneTreeiENSGT00440000033499.
    HOGENOMiHOG000256816.
    HOVERGENiHBG056828.
    InParanoidiQ8K057.
    OMAiADELYSC.
    OrthoDBiEOG7T4MJK.
    PhylomeDBiQ8K057.
    TreeFamiTF106117.

    Family and domain databases

    Gene3Di2.130.10.10. 2 hits.
    InterProiIPR011047. Quinonprotein_ADH-like_supfam.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 3 hits.
    [Graphical view]
    SMARTiSM00320. WD40. 6 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 2 hits.
    SSF50998. SSF50998. 1 hit.
    PROSITEiPS50082. WD_REPEATS_2. 2 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8K057-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRLKISLSKE PKHQELVSCV GWTTAEELYS CSDDHQIVKW NLLTSETSLI    50
    VKLPDDIYPI DLHWFPKSLG IKKQTQAESF VLTSSDGKFH LISKLGRVEK 100
    SVEAHCGAVL AGRWNYEGTA LVTVGEDGQV KIWSKTGMLR STLAQQGTPV 150
    YSVAWGPDSE KVLYTAGKQL IIKPLQPNAK VLQWKAHDGI ILKVDWNSVN 200
    DLILSAGEDC KYKVWDSYGR VLYGSQPHEH PITSVAWAPD GELFAVGSFH 250
    TLRLCDKTGW SYALEKPNTG SIFNIAWSID GTQIAGACGN GHVVFAHVVE 300
    QRWEWKNFQV TLTKRRTMQV RNVLNDAVDL LEFRDRVIKA SLNHAHLVVS 350
    TSLQCYVFST KNWNTPLIFD LKEGTVSLIL QAERHFLLVD GGGIYLHSYE 400
    GRFISSPKFP GMRTDILNAQ TVSLSNDTIA IKDKADEKII FLFEASTGKP 450
    LGDGKLLSHK NEISEIALDQ KGLTNDRKIA FIDKNRDLYI TSVKRFGKEE 500
    QIIKLGTMVH TLAWCDTCNI LCGIQDTRFT VWYYPNTIYV DRDILPKTLY 550
    ERDASEYSKN PHIVSFVGNQ VTIRRADGSL VHISISPYPA ILHEYVSSSK 600
    WEEAVRLCRF VKEQSMWACL AAMAVANRDM VTAEIAYAAV GEIDKVRYIN 650
    AIKDLPSRES KMAHILMFSG NIQEAETVLL QAGLVYQAIQ ININLYNWER 700
    ALELAVKYKT HVDTVLAYRQ KFLDTFGKQE TNKRYLQYAE GLQIDWEKIK 750
    AKIEMEITKE RDRSSSGQSS KSVGLKH 777
    Length:777
    Mass (Da):87,811
    Last modified:October 1, 2002 - v1
    Checksum:i2B01621A12E660C4
    GO
    Isoform 2 (identifier: Q8K057-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         439-439: I → K
         440-440: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:776
    Mass (Da):87,712
    Checksum:iC87C1E4C6A91C300
    GO

    Sequence cautioni

    The sequence BAC98149.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei439 – 4391I → K in isoform 2. 1 PublicationVSP_027991
    Alternative sequencei440 – 4401Missing in isoform 2. 1 PublicationVSP_027992

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129339 mRNA. Translation: BAC98149.1. Different initiation.
    BC013814 mRNA. Translation: AAH13814.1.
    BC034101 mRNA. Translation: AAH34101.1.
    AK042231 mRNA. Translation: BAC31200.1.
    CCDSiCCDS38451.1. [Q8K057-1]
    RefSeqiNP_080917.1. NM_026641.2. [Q8K057-1]
    XP_006502029.1. XM_006501966.1. [Q8K057-1]
    UniGeneiMm.389451.

    Genome annotation databases

    EnsembliENSMUST00000029347; ENSMUSP00000029347; ENSMUSG00000027778. [Q8K057-1]
    ENSMUST00000107812; ENSMUSP00000103442; ENSMUSG00000027778. [Q8K057-1]
    ENSMUST00000169064; ENSMUSP00000133263; ENSMUSG00000027778. [Q8K057-1]
    GeneIDi68259.
    KEGGimmu:68259.
    UCSCiuc008plx.2. mouse. [Q8K057-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129339 mRNA. Translation: BAC98149.1 . Different initiation.
    BC013814 mRNA. Translation: AAH13814.1 .
    BC034101 mRNA. Translation: AAH34101.1 .
    AK042231 mRNA. Translation: BAC31200.1 .
    CCDSi CCDS38451.1. [Q8K057-1 ]
    RefSeqi NP_080917.1. NM_026641.2. [Q8K057-1 ]
    XP_006502029.1. XM_006501966.1. [Q8K057-1 ]
    UniGenei Mm.389451.

    3D structure databases

    ProteinModelPortali Q8K057.
    SMRi Q8K057. Positions 25-293.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 212765. 1 interaction.
    STRINGi 10090.ENSMUSP00000029347.

    PTM databases

    PhosphoSitei Q8K057.

    Proteomic databases

    MaxQBi Q8K057.
    PaxDbi Q8K057.
    PRIDEi Q8K057.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029347 ; ENSMUSP00000029347 ; ENSMUSG00000027778 . [Q8K057-1 ]
    ENSMUST00000107812 ; ENSMUSP00000103442 ; ENSMUSG00000027778 . [Q8K057-1 ]
    ENSMUST00000169064 ; ENSMUSP00000133263 ; ENSMUSG00000027778 . [Q8K057-1 ]
    GeneIDi 68259.
    KEGGi mmu:68259.
    UCSCi uc008plx.2. mouse. [Q8K057-1 ]

    Organism-specific databases

    CTDi 57560.
    MGIi MGI:1915509. Ift80.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG2319.
    GeneTreei ENSGT00440000033499.
    HOGENOMi HOG000256816.
    HOVERGENi HBG056828.
    InParanoidi Q8K057.
    OMAi ADELYSC.
    OrthoDBi EOG7T4MJK.
    PhylomeDBi Q8K057.
    TreeFami TF106117.

    Miscellaneous databases

    NextBioi 326842.
    PROi Q8K057.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K057.
    Bgeei Q8K057.
    Genevestigatori Q8K057.

    Family and domain databases

    Gene3Di 2.130.10.10. 2 hits.
    InterProi IPR011047. Quinonprotein_ADH-like_supfam.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 3 hits.
    [Graphical view ]
    SMARTi SM00320. WD40. 6 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 2 hits.
    SSF50998. SSF50998. 1 hit.
    PROSITEi PS50082. WD_REPEATS_2. 2 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Embryonic tail.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Eye and Mammary tumor.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-751 (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Thymus.
    4. "IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy."
      Beales P.L., Bland E., Tobin J.L., Bacchelli C., Tuysuz B., Hill J., Rix S., Pearson C.G., Kai M., Hartley J., Johnson C., Irving M., Elcioglu N., Winey M., Tada M., Scambler P.J.
      Nat. Genet. 39:727-729(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    5. Cited for: IDENTIFICATION IN THE IFT COMPLEX B, INTERACTION WITH IFT88, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiIFT80_MOUSE
    AccessioniPrimary (citable) accession number: Q8K057
    Secondary accession number(s): Q6ZPT0, Q8C9F1, Q91YV4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3