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Protein

GSK-3-binding protein FRAT2

Gene

Frat2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3.

GO - Biological processi

  • Wnt signaling pathway Source: MGI
Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-196299. Beta-catenin phosphorylation cascade.
R-MMU-4641262. Disassembly of the destruction complex and recruitment of AXIN to the membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
GSK-3-binding protein FRAT2
Alternative name(s):
Frequently rearranged in advanced T-cell lymphomas 2
Short name:
FRAT-2
Gene namesi
Name:Frat2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2673967. Frat2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000873351 – 231GSK-3-binding protein FRAT2Add BLAST231

Proteomic databases

PaxDbiQ8K025.
PRIDEiQ8K025.

PTM databases

PhosphoSitePlusiQ8K025.

Expressioni

Gene expression databases

BgeeiENSMUSG00000047604.
GenevisibleiQ8K025. MM.

Interactioni

Subunit structurei

Binds GSK-3 and prevents GSK-3-dependent phosphorylation.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052788.

Structurei

3D structure databases

ProteinModelPortaliQ8K025.
SMRiQ8K025.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni172 – 194Involved in GSK-3 bindingBy similarityAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 22Asp/Glu-rich (highly acidic)Add BLAST17
Compositional biasi6 – 10Poly-Glu5

Sequence similaritiesi

Belongs to the GSK-3-binding protein family.Curated

Phylogenomic databases

eggNOGiENOG410J5HI. Eukaryota.
ENOG410ZA2I. LUCA.
GeneTreeiENSGT00390000007081.
HOGENOMiHOG000112642.
HOVERGENiHBG051660.
InParanoidiQ8K025.
KOiK03096.
OMAiQRRWTQA.
OrthoDBiEOG091G0PDL.
PhylomeDBiQ8K025.
TreeFamiTF330804.

Family and domain databases

InterProiIPR008014. GSK3-bd.
[Graphical view]
PfamiPF05350. GSK-3_bind. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K025-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPCRREEEEE AGDEAEGEED DDSFLLLQQS VTLGGSTDVD RLIVQIGETL
60 70 80 90 100
QLDTAHDRPA SPCAAPGPPP APPRVLAALS ADKTGTPARR LLRPTGSAET
110 120 130 140 150
GDPAPPGAVR CVLGERGRVR GRSAPYCVAE IAPGASALPG PGRRGWLPGS
160 170 180 190 200
VASHRIQQRR WTAGGARAAD DDPHRLLQQL VLSGNLIKEA VRRLQRAVAA
210 220 230
VAATSPASAP GSGGGRSGPD SVTLQPSGAW L
Length:231
Mass (Da):23,914
Last modified:October 1, 2002 - v1
Checksum:i6C2C0164B9476C37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY518895 Genomic DNA. Translation: AAR99812.1.
AK081171 mRNA. Translation: BAC38155.1.
BC034214 mRNA. Translation: AAH34214.1.
BC085510 mRNA. Translation: AAH85510.1.
CCDSiCCDS29813.1.
RefSeqiNP_808271.1. NM_177603.3.
UniGeneiMm.222723.

Genome annotation databases

EnsembliENSMUST00000059231; ENSMUSP00000052788; ENSMUSG00000047604.
GeneIDi212398.
KEGGimmu:212398.
UCSCiuc008hmj.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY518895 Genomic DNA. Translation: AAR99812.1.
AK081171 mRNA. Translation: BAC38155.1.
BC034214 mRNA. Translation: AAH34214.1.
BC085510 mRNA. Translation: AAH85510.1.
CCDSiCCDS29813.1.
RefSeqiNP_808271.1. NM_177603.3.
UniGeneiMm.222723.

3D structure databases

ProteinModelPortaliQ8K025.
SMRiQ8K025.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052788.

PTM databases

PhosphoSitePlusiQ8K025.

Proteomic databases

PaxDbiQ8K025.
PRIDEiQ8K025.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059231; ENSMUSP00000052788; ENSMUSG00000047604.
GeneIDi212398.
KEGGimmu:212398.
UCSCiuc008hmj.3. mouse.

Organism-specific databases

CTDi23401.
MGIiMGI:2673967. Frat2.

Phylogenomic databases

eggNOGiENOG410J5HI. Eukaryota.
ENOG410ZA2I. LUCA.
GeneTreeiENSGT00390000007081.
HOGENOMiHOG000112642.
HOVERGENiHBG051660.
InParanoidiQ8K025.
KOiK03096.
OMAiQRRWTQA.
OrthoDBiEOG091G0PDL.
PhylomeDBiQ8K025.
TreeFamiTF330804.

Enzyme and pathway databases

ReactomeiR-MMU-196299. Beta-catenin phosphorylation cascade.
R-MMU-4641262. Disassembly of the destruction complex and recruitment of AXIN to the membrane.

Miscellaneous databases

ChiTaRSiFrat2. mouse.
PROiQ8K025.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047604.
GenevisibleiQ8K025. MM.

Family and domain databases

InterProiIPR008014. GSK3-bd.
[Graphical view]
PfamiPF05350. GSK-3_bind. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFRAT2_MOUSE
AccessioniPrimary (citable) accession number: Q8K025
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.