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Protein

Secretory carrier-associated membrane protein 1

Gene

Scamp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface (By similarity).By similarity

GO - Biological processi

  • exocytosis Source: MGI
  • protein transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Secretory carrier-associated membrane protein 1
Short name:
Secretory carrier membrane protein 1
Gene namesi
Name:Scamp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1349480. Scamp1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 155CytoplasmicSequence analysisAdd BLAST154
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Topological domaini177 – 181LumenalSequence analysis5
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Topological domaini203 – 218CytoplasmicSequence analysisAdd BLAST16
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 261LumenalSequence analysisAdd BLAST22
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Topological domaini283 – 338CytoplasmicSequence analysisAdd BLAST56

GO - Cellular componenti

  • cell junction Source: MGI
  • integral component of membrane Source: UniProtKB
  • intracellular membrane-bounded organelle Source: MGI
  • nucleoplasm Source: MGI
  • recycling endosome membrane Source: UniProtKB
  • synapse Source: MGI
  • synaptic vesicle Source: MGI
  • synaptic vesicle membrane Source: MGI
  • trans-Golgi network Source: UniProtKB
  • zymogen granule membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001912512 – 338Secretory carrier-associated membrane protein 1Add BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei45PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8K021.
MaxQBiQ8K021.
PaxDbiQ8K021.
PRIDEiQ8K021.

PTM databases

iPTMnetiQ8K021.
PhosphoSitePlusiQ8K021.
SwissPalmiQ8K021.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021687.
CleanExiMM_SCAMP1.
ExpressionAtlasiQ8K021. baseline and differential.
GenevisibleiQ8K021. MM.

Interactioni

Subunit structurei

Interacts with SYNRG, ITSN1 and SLC9A7.By similarity

Protein-protein interaction databases

BioGridi223555. 1 interactor.
IntActiQ8K021. 2 interactors.
MINTiMINT-1866014.
STRINGi10090.ENSMUSP00000022197.

Structurei

3D structure databases

ProteinModelPortaliQ8K021.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SCAMP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3088. Eukaryota.
ENOG410XSJN. LUCA.
GeneTreeiENSGT00390000014393.
HOGENOMiHOG000294221.
HOVERGENiHBG071938.
InParanoidiQ8K021.
KOiK19995.
OMAiQSAFKGN.
OrthoDBiEOG091G0ID2.
PhylomeDBiQ8K021.
TreeFamiTF313797.

Family and domain databases

InterProiIPR007273. SCAMP.
[Graphical view]
PfamiPF04144. SCAMP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K021-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDFDSNPFA DPDLNNPFKD PSVTQVTRNV PPGLDEYNPF SDSRTPPPGS
60 70 80 90 100
VKMPNVPNTQ PAIMKPTEEH PAYTQITKEH ALAQAELLKR QEELERKAAE
110 120 130 140 150
LDRREREMQN LSQHGRKNNW PPLPSNFPVG PCFYQDFSVD IPVEFQKTVK
160 170 180 190 200
LMYYLWMFHA VTLFLNIFGC LAWFCVDSSR AVDFGLSILW FLLFTPCSFV
210 220 230 240 250
CWYRPLYGAF RSDSSFRFFV FFFVYICQFA VHVLQAAGFH NWGNCGWISS
260 270 280 290 300
LTGLNKNIPV GIMMIIIAAL FTASAVISLV MFKKVHGLYR TTGASFEKAQ
310 320 330
QEFATGVMSN KTVQTAAANA ASTAATSAAQ NAFKGNQM
Length:338
Mass (Da):38,029
Last modified:October 1, 2002 - v1
Checksum:i7588A06064B23B9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034283 mRNA. Translation: AAH34283.1.
CCDSiCCDS36750.1.
RefSeqiNP_083429.1. NM_029153.1.
UniGeneiMm.201455.

Genome annotation databases

EnsembliENSMUST00000022197; ENSMUSP00000022197; ENSMUSG00000021687.
GeneIDi107767.
KEGGimmu:107767.
UCSCiuc007rlr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034283 mRNA. Translation: AAH34283.1.
CCDSiCCDS36750.1.
RefSeqiNP_083429.1. NM_029153.1.
UniGeneiMm.201455.

3D structure databases

ProteinModelPortaliQ8K021.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi223555. 1 interactor.
IntActiQ8K021. 2 interactors.
MINTiMINT-1866014.
STRINGi10090.ENSMUSP00000022197.

PTM databases

iPTMnetiQ8K021.
PhosphoSitePlusiQ8K021.
SwissPalmiQ8K021.

Proteomic databases

EPDiQ8K021.
MaxQBiQ8K021.
PaxDbiQ8K021.
PRIDEiQ8K021.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022197; ENSMUSP00000022197; ENSMUSG00000021687.
GeneIDi107767.
KEGGimmu:107767.
UCSCiuc007rlr.1. mouse.

Organism-specific databases

CTDi9522.
MGIiMGI:1349480. Scamp1.

Phylogenomic databases

eggNOGiKOG3088. Eukaryota.
ENOG410XSJN. LUCA.
GeneTreeiENSGT00390000014393.
HOGENOMiHOG000294221.
HOVERGENiHBG071938.
InParanoidiQ8K021.
KOiK19995.
OMAiQSAFKGN.
OrthoDBiEOG091G0ID2.
PhylomeDBiQ8K021.
TreeFamiTF313797.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiScamp1. mouse.
PROiQ8K021.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021687.
CleanExiMM_SCAMP1.
ExpressionAtlasiQ8K021. baseline and differential.
GenevisibleiQ8K021. MM.

Family and domain databases

InterProiIPR007273. SCAMP.
[Graphical view]
PfamiPF04144. SCAMP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCAM1_MOUSE
AccessioniPrimary (citable) accession number: Q8K021
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.