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Protein

Centromere protein O

Gene

Cenpo

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex (By similarity).By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-MMU-68877 Mitotic Prometaphase

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein O
Short name:
CENP-O
Gene namesi
Name:Cenpo
Synonyms:Mcm21r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1923800 Cenpo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002495031 – 298Centromere protein OAdd BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8K015
PeptideAtlasiQ8K015
PRIDEiQ8K015

PTM databases

iPTMnetiQ8K015
PhosphoSitePlusiQ8K015

Expressioni

Gene expression databases

BgeeiENSMUSG00000020652
CleanExiMM_CENPO
ExpressionAtlasiQ8K015 baseline and differential
GenevisibleiQ8K015 MM

Interactioni

Subunit structurei

Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU (By similarity).By similarity

Protein-protein interaction databases

IntActiQ8K015, 1 interactor
MINTiQ8K015
STRINGi10090.ENSMUSP00000119136

Structurei

3D structure databases

ProteinModelPortaliQ8K015
SMRiQ8K015
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili39 – 74Sequence analysisAdd BLAST36

Sequence similaritiesi

Belongs to the CENP-O/MCM21 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJSQ Eukaryota
ENOG4111RC4 LUCA
GeneTreeiENSGT00390000016702
HOGENOMiHOG000059658
HOVERGENiHBG080687
InParanoidiQ8K015
KOiK11507
OMAiQRNPLCN
OrthoDBiEOG091G0HS3
PhylomeDBiQ8K015
TreeFamiTF335524

Family and domain databases

InterProiView protein in InterPro
IPR018464 CENP-O
PfamiView protein in Pfam
PF09496 CENP-O, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8K015-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESANTLCPG RKCKGGVLAH LERLEAQTNI SNRKSEEPAV RKKESSLRTK
60 70 80 90 100
IRELRQQRDK LRAEVKQWGA RVKEPPAKED PSRTVISEQE VLEREWRNVD
110 120 130 140 150
AILEAYRFTG LSGKLTSRGV CMCISTAFEG NLLDSYFVDL VIEKPLRIHH
160 170 180 190 200
HSVPVFIPLE KIAAAHLQTD VQRFLFRLWE YLNAYAGRKY QADQLESDFC
210 220 230 240 250
DVLTGPLQRN ALCNLLSFTY KVEQRCQTFS FSARLLYEDP TAALPTNVTV
260 270 280 290
TRPGVEASSP PWEEHRASHQ MLFRTKPLHK VFASFSKETE KLHLNLVS
Length:298
Mass (Da):34,154
Last modified:October 1, 2002 - v1
Checksum:i6A616612463B31E9
GO
Isoform 2 (identifier: Q8K015-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-205: SDFCDVLTG → NWTADSPSR
     206-298: Missing.

Note: No experimental confirmation available.
Show »
Length:205
Mass (Da):23,604
Checksum:i926A9715F79C2631
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30I → V in AAH23148 (PubMed:15489334).Curated1
Sequence conflicti39A → T in AAH23148 (PubMed:15489334).Curated1
Sequence conflicti177R → S in AAH23148 (PubMed:15489334).Curated1
Sequence conflicti180E → A in AAH23148 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020447197 – 205SDFCDVLTG → NWTADSPSR in isoform 2. 1 Publication9
Alternative sequenceiVSP_020448206 – 298Missing in isoform 2. 1 PublicationAdd BLAST93

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013198 mRNA Translation: BAB28707.1
AK029226 mRNA Translation: BAC26354.1
AK134266 mRNA Translation: BAE22073.1
BC023148 mRNA Translation: AAH23148.1
BC034399 mRNA Translation: AAH34399.1
CCDSiCCDS25788.1 [Q8K015-1]
RefSeqiNP_598807.2, NM_134046.5 [Q8K015-1]
XP_006515215.1, XM_006515152.3 [Q8K015-2]
XP_011242186.1, XM_011243884.2 [Q8K015-2]
UniGeneiMm.70546

Genome annotation databases

EnsembliENSMUST00000111169; ENSMUSP00000106799; ENSMUSG00000020652 [Q8K015-2]
ENSMUST00000140975; ENSMUSP00000119136; ENSMUSG00000020652 [Q8K015-1]
GeneIDi52504
KEGGimmu:52504
UCSCiuc007mxn.1 mouse [Q8K015-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCENPO_MOUSE
AccessioniPrimary (citable) accession number: Q8K015
Secondary accession number(s): Q8R587, Q9CYY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: October 1, 2002
Last modified: February 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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