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Q8K015 (CENPO_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Centromere protein O

Short name=CENP-O
Gene names
Name:Cenpo
Synonyms:Mcm21r
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length298 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex By similarity.

Subunit structure

Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU By similarity.

Subcellular location

Nucleus By similarity. Chromosomecentromere By similarity. Chromosomecentromerekinetochore By similarity. Note: Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex By similarity.

Ontologies

Keywords
   Cellular componentCentromere
Chromosome
Kinetochore
Nucleus
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcentromere complex assembly

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcondensed chromosome kinetochore

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8K015-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8K015-2)

The sequence of this isoform differs from the canonical sequence as follows:
     197-205: SDFCDVLTG → NWTADSPSR
     206-298: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 298298Centromere protein O
PRO_0000249503

Regions

Coiled coil39 – 7436 Potential

Natural variations

Alternative sequence197 – 2059SDFCDVLTG → NWTADSPSR in isoform 2.
VSP_020447
Alternative sequence206 – 29893Missing in isoform 2.
VSP_020448

Experimental info

Sequence conflict301I → V in AAH23148. Ref.2
Sequence conflict391A → T in AAH23148. Ref.2
Sequence conflict1771R → S in AAH23148. Ref.2
Sequence conflict1801E → A in AAH23148. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 6A616612463B31E9

FASTA29834,154
        10         20         30         40         50         60 
MESANTLCPG RKCKGGVLAH LERLEAQTNI SNRKSEEPAV RKKESSLRTK IRELRQQRDK 

        70         80         90        100        110        120 
LRAEVKQWGA RVKEPPAKED PSRTVISEQE VLEREWRNVD AILEAYRFTG LSGKLTSRGV 

       130        140        150        160        170        180 
CMCISTAFEG NLLDSYFVDL VIEKPLRIHH HSVPVFIPLE KIAAAHLQTD VQRFLFRLWE 

       190        200        210        220        230        240 
YLNAYAGRKY QADQLESDFC DVLTGPLQRN ALCNLLSFTY KVEQRCQTFS FSARLLYEDP 

       250        260        270        280        290 
TAALPTNVTV TRPGVEASSP PWEEHRASHQ MLFRTKPLHK VFASFSKETE KLHLNLVS 

« Hide

Isoform 2 [UniParc].

Checksum: 926A9715F79C2631
Show »

FASTA20523,604

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Forelimb and Head.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: Czech II.
Tissue: Eye and Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK013198 mRNA. Translation: BAB28707.1.
AK029226 mRNA. Translation: BAC26354.1.
AK134266 mRNA. Translation: BAE22073.1.
BC023148 mRNA. Translation: AAH23148.1.
BC034399 mRNA. Translation: AAH34399.1.
RefSeqNP_598807.2. NM_134046.5.
XP_006515213.1. XM_006515150.1.
XP_006515215.1. XM_006515152.1.
XP_006515216.1. XM_006515153.1.
UniGeneMm.70546.

3D structure databases

ProteinModelPortalQ8K015.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8K015. 1 interaction.

PTM databases

PhosphoSiteQ8K015.

Proteomic databases

PRIDEQ8K015.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000111169; ENSMUSP00000106799; ENSMUSG00000020652. [Q8K015-2]
ENSMUST00000140975; ENSMUSP00000119136; ENSMUSG00000020652. [Q8K015-1]
GeneID52504.
KEGGmmu:52504.
UCSCuc007mxn.1. mouse. [Q8K015-1]

Organism-specific databases

CTD79172.
MGIMGI:1923800. Cenpo.

Phylogenomic databases

eggNOGNOG39904.
GeneTreeENSGT00390000016702.
HOGENOMHOG000059658.
HOVERGENHBG080687.
InParanoidQ8K015.
KOK11507.
OMAALSTSWE.
PhylomeDBQ8K015.
TreeFamTF335524.

Gene expression databases

ArrayExpressQ8K015.
BgeeQ8K015.
CleanExMM_CENPO.
GenevestigatorQ8K015.

Family and domain databases

InterProIPR018464. CENP-O.
[Graphical view]
PfamPF09496. CENP-O. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCENPO. mouse.
NextBio309055.
PROQ8K015.
SOURCESearch...

Entry information

Entry nameCENPO_MOUSE
AccessionPrimary (citable) accession number: Q8K015
Secondary accession number(s): Q8R587, Q9CYY6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot