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Q8K015

- CENPO_MOUSE

UniProt

Q8K015 - CENPO_MOUSE

Protein

Centromere protein O

Gene

Cenpo

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex By similarity.By similarity

    GO - Biological processi

    1. centromere complex assembly Source: InterPro

    Enzyme and pathway databases

    ReactomeiREACT_198597. Deposition of new CENPA-containing nucleosomes at the centromere.
    REACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_207679. Separation of Sister Chromatids.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Centromere protein O
    Short name:
    CENP-O
    Gene namesi
    Name:Cenpo
    Synonyms:Mcm21r
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1923800. Cenpo.

    Subcellular locationi

    Nucleus By similarity. Chromosomecentromere By similarity. Chromosomecentromerekinetochore By similarity
    Note: Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex By similarity.By similarity

    GO - Cellular componenti

    1. condensed chromosome kinetochore Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Centromere, Chromosome, Kinetochore, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 298298Centromere protein OPRO_0000249503Add
    BLAST

    Proteomic databases

    PRIDEiQ8K015.

    PTM databases

    PhosphoSiteiQ8K015.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8K015.
    BgeeiQ8K015.
    CleanExiMM_CENPO.
    GenevestigatoriQ8K015.

    Interactioni

    Subunit structurei

    Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ8K015. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K015.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili39 – 7436Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG39904.
    GeneTreeiENSGT00390000016702.
    HOGENOMiHOG000059658.
    HOVERGENiHBG080687.
    InParanoidiQ8K015.
    KOiK11507.
    OMAiALSTSWE.
    PhylomeDBiQ8K015.
    TreeFamiTF335524.

    Family and domain databases

    InterProiIPR018464. CENP-O.
    [Graphical view]
    PfamiPF09496. CENP-O. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8K015-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MESANTLCPG RKCKGGVLAH LERLEAQTNI SNRKSEEPAV RKKESSLRTK    50
    IRELRQQRDK LRAEVKQWGA RVKEPPAKED PSRTVISEQE VLEREWRNVD 100
    AILEAYRFTG LSGKLTSRGV CMCISTAFEG NLLDSYFVDL VIEKPLRIHH 150
    HSVPVFIPLE KIAAAHLQTD VQRFLFRLWE YLNAYAGRKY QADQLESDFC 200
    DVLTGPLQRN ALCNLLSFTY KVEQRCQTFS FSARLLYEDP TAALPTNVTV 250
    TRPGVEASSP PWEEHRASHQ MLFRTKPLHK VFASFSKETE KLHLNLVS 298
    Length:298
    Mass (Da):34,154
    Last modified:October 1, 2002 - v1
    Checksum:i6A616612463B31E9
    GO
    Isoform 2 (identifier: Q8K015-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         197-205: SDFCDVLTG → NWTADSPSR
         206-298: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:205
    Mass (Da):23,604
    Checksum:i926A9715F79C2631
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti30 – 301I → V in AAH23148. (PubMed:15489334)Curated
    Sequence conflicti39 – 391A → T in AAH23148. (PubMed:15489334)Curated
    Sequence conflicti177 – 1771R → S in AAH23148. (PubMed:15489334)Curated
    Sequence conflicti180 – 1801E → A in AAH23148. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei197 – 2059SDFCDVLTG → NWTADSPSR in isoform 2. 1 PublicationVSP_020447
    Alternative sequencei206 – 29893Missing in isoform 2. 1 PublicationVSP_020448Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK013198 mRNA. Translation: BAB28707.1.
    AK029226 mRNA. Translation: BAC26354.1.
    AK134266 mRNA. Translation: BAE22073.1.
    BC023148 mRNA. Translation: AAH23148.1.
    BC034399 mRNA. Translation: AAH34399.1.
    CCDSiCCDS25788.1. [Q8K015-1]
    RefSeqiNP_598807.2. NM_134046.5. [Q8K015-1]
    XP_006515213.1. XM_006515150.1. [Q8K015-1]
    XP_006515215.1. XM_006515152.1. [Q8K015-2]
    XP_006515216.1. XM_006515153.1. [Q8K015-2]
    UniGeneiMm.70546.

    Genome annotation databases

    EnsembliENSMUST00000111169; ENSMUSP00000106799; ENSMUSG00000020652. [Q8K015-2]
    ENSMUST00000140975; ENSMUSP00000119136; ENSMUSG00000020652. [Q8K015-1]
    GeneIDi52504.
    KEGGimmu:52504.
    UCSCiuc007mxn.1. mouse. [Q8K015-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK013198 mRNA. Translation: BAB28707.1 .
    AK029226 mRNA. Translation: BAC26354.1 .
    AK134266 mRNA. Translation: BAE22073.1 .
    BC023148 mRNA. Translation: AAH23148.1 .
    BC034399 mRNA. Translation: AAH34399.1 .
    CCDSi CCDS25788.1. [Q8K015-1 ]
    RefSeqi NP_598807.2. NM_134046.5. [Q8K015-1 ]
    XP_006515213.1. XM_006515150.1. [Q8K015-1 ]
    XP_006515215.1. XM_006515152.1. [Q8K015-2 ]
    XP_006515216.1. XM_006515153.1. [Q8K015-2 ]
    UniGenei Mm.70546.

    3D structure databases

    ProteinModelPortali Q8K015.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8K015. 1 interaction.

    PTM databases

    PhosphoSitei Q8K015.

    Proteomic databases

    PRIDEi Q8K015.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000111169 ; ENSMUSP00000106799 ; ENSMUSG00000020652 . [Q8K015-2 ]
    ENSMUST00000140975 ; ENSMUSP00000119136 ; ENSMUSG00000020652 . [Q8K015-1 ]
    GeneIDi 52504.
    KEGGi mmu:52504.
    UCSCi uc007mxn.1. mouse. [Q8K015-1 ]

    Organism-specific databases

    CTDi 79172.
    MGIi MGI:1923800. Cenpo.

    Phylogenomic databases

    eggNOGi NOG39904.
    GeneTreei ENSGT00390000016702.
    HOGENOMi HOG000059658.
    HOVERGENi HBG080687.
    InParanoidi Q8K015.
    KOi K11507.
    OMAi ALSTSWE.
    PhylomeDBi Q8K015.
    TreeFami TF335524.

    Enzyme and pathway databases

    Reactomei REACT_198597. Deposition of new CENPA-containing nucleosomes at the centromere.
    REACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_207679. Separation of Sister Chromatids.

    Miscellaneous databases

    ChiTaRSi CENPO. mouse.
    NextBioi 309055.
    PROi Q8K015.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K015.
    Bgeei Q8K015.
    CleanExi MM_CENPO.
    Genevestigatori Q8K015.

    Family and domain databases

    InterProi IPR018464. CENP-O.
    [Graphical view ]
    Pfami PF09496. CENP-O. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Forelimb and Head.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: Czech II.
      Tissue: Eye and Mammary tumor.

    Entry informationi

    Entry nameiCENPO_MOUSE
    AccessioniPrimary (citable) accession number: Q8K015
    Secondary accession number(s): Q8R587, Q9CYY6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3