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Q8K015

- CENPO_MOUSE

UniProt

Q8K015 - CENPO_MOUSE

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Protein

Centromere protein O

Gene

Cenpo

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex (By similarity).By similarity

GO - Biological processi

  1. centromere complex assembly Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_198597. Deposition of new CENPA-containing nucleosomes at the centromere.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.
REACT_256756. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein O
Short name:
CENP-O
Gene namesi
Name:Cenpo
Synonyms:Mcm21r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1923800. Cenpo.

Subcellular locationi

Nucleus By similarity. Chromosomecentromere By similarity. Chromosomecentromerekinetochore By similarity
Note: Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex (By similarity).By similarity

GO - Cellular componenti

  1. kinetochore Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298Centromere protein OPRO_0000249503Add
BLAST

Proteomic databases

MaxQBiQ8K015.
PRIDEiQ8K015.

PTM databases

PhosphoSiteiQ8K015.

Expressioni

Gene expression databases

BgeeiQ8K015.
CleanExiMM_CENPO.
ExpressionAtlasiQ8K015. baseline and differential.
GenevestigatoriQ8K015.

Interactioni

Subunit structurei

Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU (By similarity).By similarity

Protein-protein interaction databases

IntActiQ8K015. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8K015.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili39 – 7436Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG39904.
GeneTreeiENSGT00390000016702.
HOGENOMiHOG000059658.
HOVERGENiHBG080687.
InParanoidiQ8K015.
KOiK11507.
OMAiALSTSWE.
PhylomeDBiQ8K015.
TreeFamiTF335524.

Family and domain databases

InterProiIPR018464. CENP-O.
[Graphical view]
PfamiPF09496. CENP-O. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8K015-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESANTLCPG RKCKGGVLAH LERLEAQTNI SNRKSEEPAV RKKESSLRTK
60 70 80 90 100
IRELRQQRDK LRAEVKQWGA RVKEPPAKED PSRTVISEQE VLEREWRNVD
110 120 130 140 150
AILEAYRFTG LSGKLTSRGV CMCISTAFEG NLLDSYFVDL VIEKPLRIHH
160 170 180 190 200
HSVPVFIPLE KIAAAHLQTD VQRFLFRLWE YLNAYAGRKY QADQLESDFC
210 220 230 240 250
DVLTGPLQRN ALCNLLSFTY KVEQRCQTFS FSARLLYEDP TAALPTNVTV
260 270 280 290
TRPGVEASSP PWEEHRASHQ MLFRTKPLHK VFASFSKETE KLHLNLVS
Length:298
Mass (Da):34,154
Last modified:October 1, 2002 - v1
Checksum:i6A616612463B31E9
GO
Isoform 2 (identifier: Q8K015-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-205: SDFCDVLTG → NWTADSPSR
     206-298: Missing.

Note: No experimental confirmation available.

Show »
Length:205
Mass (Da):23,604
Checksum:i926A9715F79C2631
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti30 – 301I → V in AAH23148. (PubMed:15489334)Curated
Sequence conflicti39 – 391A → T in AAH23148. (PubMed:15489334)Curated
Sequence conflicti177 – 1771R → S in AAH23148. (PubMed:15489334)Curated
Sequence conflicti180 – 1801E → A in AAH23148. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei197 – 2059SDFCDVLTG → NWTADSPSR in isoform 2. 1 PublicationVSP_020447
Alternative sequencei206 – 29893Missing in isoform 2. 1 PublicationVSP_020448Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013198 mRNA. Translation: BAB28707.1.
AK029226 mRNA. Translation: BAC26354.1.
AK134266 mRNA. Translation: BAE22073.1.
BC023148 mRNA. Translation: AAH23148.1.
BC034399 mRNA. Translation: AAH34399.1.
CCDSiCCDS25788.1. [Q8K015-1]
RefSeqiNP_598807.2. NM_134046.5. [Q8K015-1]
XP_006515213.1. XM_006515150.1. [Q8K015-1]
XP_006515215.1. XM_006515152.1. [Q8K015-2]
XP_006515216.1. XM_006515153.1. [Q8K015-2]
UniGeneiMm.70546.

Genome annotation databases

EnsembliENSMUST00000111169; ENSMUSP00000106799; ENSMUSG00000020652. [Q8K015-2]
ENSMUST00000140975; ENSMUSP00000119136; ENSMUSG00000020652. [Q8K015-1]
GeneIDi52504.
KEGGimmu:52504.
UCSCiuc007mxn.1. mouse. [Q8K015-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013198 mRNA. Translation: BAB28707.1 .
AK029226 mRNA. Translation: BAC26354.1 .
AK134266 mRNA. Translation: BAE22073.1 .
BC023148 mRNA. Translation: AAH23148.1 .
BC034399 mRNA. Translation: AAH34399.1 .
CCDSi CCDS25788.1. [Q8K015-1 ]
RefSeqi NP_598807.2. NM_134046.5. [Q8K015-1 ]
XP_006515213.1. XM_006515150.1. [Q8K015-1 ]
XP_006515215.1. XM_006515152.1. [Q8K015-2 ]
XP_006515216.1. XM_006515153.1. [Q8K015-2 ]
UniGenei Mm.70546.

3D structure databases

ProteinModelPortali Q8K015.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8K015. 1 interaction.

PTM databases

PhosphoSitei Q8K015.

Proteomic databases

MaxQBi Q8K015.
PRIDEi Q8K015.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000111169 ; ENSMUSP00000106799 ; ENSMUSG00000020652 . [Q8K015-2 ]
ENSMUST00000140975 ; ENSMUSP00000119136 ; ENSMUSG00000020652 . [Q8K015-1 ]
GeneIDi 52504.
KEGGi mmu:52504.
UCSCi uc007mxn.1. mouse. [Q8K015-1 ]

Organism-specific databases

CTDi 79172.
MGIi MGI:1923800. Cenpo.

Phylogenomic databases

eggNOGi NOG39904.
GeneTreei ENSGT00390000016702.
HOGENOMi HOG000059658.
HOVERGENi HBG080687.
InParanoidi Q8K015.
KOi K11507.
OMAi ALSTSWE.
PhylomeDBi Q8K015.
TreeFami TF335524.

Enzyme and pathway databases

Reactomei REACT_198597. Deposition of new CENPA-containing nucleosomes at the centromere.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.
REACT_256756. Mitotic Prometaphase.

Miscellaneous databases

ChiTaRSi Cenpo. mouse.
NextBioi 309055.
PROi Q8K015.
SOURCEi Search...

Gene expression databases

Bgeei Q8K015.
CleanExi MM_CENPO.
ExpressionAtlasi Q8K015. baseline and differential.
Genevestigatori Q8K015.

Family and domain databases

InterProi IPR018464. CENP-O.
[Graphical view ]
Pfami PF09496. CENP-O. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Forelimb and Head.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: Czech II.
    Tissue: Eye and Mammary tumor.

Entry informationi

Entry nameiCENPO_MOUSE
AccessioniPrimary (citable) accession number: Q8K015
Secondary accession number(s): Q8R587, Q9CYY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3